UBE2N antibody (pAb) | Active Motif 39224 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

UBE2N antibody (pAb)

catalog :

39224

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunoprecipitation

product information

Catalog Number :

39224

Product Name :

UBE2N antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ug

Isotype :

IgG

CrossReactivity :

Human

Background :

UBE2N (UBC13, BLU, ubiquitin-conjugating enzyme E2N) heterodimer with UBE2V2 catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. UBE2N mediates transcriptional activation of target genes and plays a role in the control of progress through the cell cycle and differentiation. UBE2N also plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage and acts together with the E3 ligase SHPRH in the poly-ubiquitination of PCNA 'Lys-164' upon genotoxic stress, which is required for DNA repair.

Immunogen :

This antibody was raised against a mixture of synthetic peptides corresponding to amino acid residues 2-19 and 131-148 of human UBE2N.

Uses :

IP, WB

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.