Histone H3ac (pan-acetyl) antibody (pAb) | Active Motif 39139 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Histone H3ac (pan-acetyl) antibody (pAb)

catalog :

39139

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunoprecipitation, chromatin immunoprecipitation

citations: 10

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 2b	Zhang X, Li B, Rezaeian A, Xu X, Chou P, Jin G, et al. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nat Commun. 2017;8:14799 pubmed publisher
western blot; human; loading ...; fig 3e	Wong B, Wang X, Zecchin A, Thienpont B, Cornelissen I, Kalucka J, et al. The role of fatty acid ?-oxidation in lymphangiogenesis. Nature. 2017;542:49-54 pubmed publisher
western blot; human; 1:500; loading ...; fig 6b	Nettersheim D, Jostes S, Fabry M, Honecker F, Schumacher V, Kirfel J, et al. A signaling cascade including ARID1A, GADD45B and DUSP1 induces apoptosis and affects the cell cycle of germ cell cancers after romidepsin treatment. Oncotarget. 2016;7:74931-74946 pubmed publisher
western blot; human; 1:500; tbl 1	Nettersheim D, Arndt I, Sharma R, Riesenberg S, Jostes S, Schneider S, et al. The cancer/testis-antigen PRAME supports the pluripotency network and represses somatic and germ cell differentiation programs in seminomas. Br J Cancer. 2016;115:454-64 pubmed publisher
chromatin immunoprecipitation; mouse; fig 3	Vishwakarma B, Nguyen N, Makishima H, Hosono N, Gudmundsson K, Negi V, et al. Runx1 repression by histone deacetylation is critical for Setbp1-induced mouse myeloid leukemia development. Leukemia. 2016;30:200-8 pubmed publisher
	Rico T, Gilles M, Chauderlier A, Comptdaer T, Magnez R, Chwastyniak M, et al. Tau Stabilizes Chromatin Compaction. Front Cell Dev Biol. 2021;9:740550 pubmed publisher
	Wu M, Li J, Yue L, Bai L, Li Y, Chen J, et al. Establishment of Cre-mediated HBV recombinant cccDNA (rcccDNA) cell line for cccDNA biology and antiviral screening assays. Antiviral Res. 2018;152:45-52 pubmed publisher
	Zhao M, Tan Y, Peng Q, Huang C, Guo Y, Liang G, et al. IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. Nat Commun. 2018;9:583 pubmed publisher
	Chen X, Rinsma M, Janssen J, Liu J, Maggio I, Gonçalves M. Probing the impact of chromatin conformation on genome editing tools. Nucleic Acids Res. 2016;44:6482-92 pubmed publisher
	Prokesch A, Pelzmann H, Pessentheiner A, Huber K, Madreiter Sokolowski C, Drougard A, et al. N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes. Sci Rep. 2016;6:23723 pubmed publisher

product information

Catalog Number :

39139

Product Name :

Histone H3ac (pan-acetyl) antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Acetylated

Size :

200 ul

Isotype :

Serum

CrossReactivity :

Human, Other (Wide Range)

Background :

Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.Lysine N-M-NM-5-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in chromatin remodeling and in the regulation of gene expression in various cellular functions. Acetylation of histone H3 occurs at several different lysine positions in the histone tail, and is performed by Histone Acetyltransferases (HATs) such as CBP/p300. Acetylation of histones is often associated with transcriptional activation.

Immunogen :

This Histone H3 acetyl antibody was raised against a peptide including acetyl-lysines contained in the N-terminal tail of histone H3.

Uses :

ChIP, DB, IP, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.