Histone H3K9ac antibody (pAb) | Active Motif 39137 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Histone H3K9ac antibody (pAb)

catalog :

39137

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, ChIP-Seq

citations: 12

Published Application/Species/Sample/Dilution	Reference
ChIP-Seq; mouse; loading ...; fig s4a	Mews P, Egervári G, Nativio R, Sidoli S, Donahue G, Lombroso S, et al. Alcohol metabolism contributes to brain histone acetylation. Nature. 2019;574:717-721 pubmed publisher
ChIP-Seq; mouse; loading ...; fig 5a	Wu H, Gordon J, Whitfield T, Tai P, Van Wijnen A, Stein J, et al. Chromatin dynamics regulate mesenchymal stem cell lineage specification and differentiation to osteogenesis. Biochim Biophys Acta Gene Regul Mech. 2017;1860:438-449 pubmed publisher
immunocytochemistry; human; 1:1000; fig 4	Singh N, Johnstone D, Martin K, Tempera I, Kaplan M, Denny M. Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Dis Model Mech. 2016;9:885-97 pubmed publisher
	Busby T, Chen Y, Godfrey T, Rehan M, Wildman B, Smith C, et al. Baf45a Mediated Chromatin Remodeling Promotes Transcriptional Activation for Osteogenesis and Odontogenesis. Front Endocrinol (Lausanne). 2021;12:763392 pubmed publisher
	Fitz James M, Tong P, Pidoux A, Özadam H, Yang L, White S, et al. Large domains of heterochromatin direct the formation of short mitotic chromosome loops. elife. 2020;9: pubmed publisher
	Levine D, Hong H, Weidemann B, Ramsey K, Affinati A, Schmidt M, et al. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Mol Cell. 2020;78:835-849.e7 pubmed publisher
	Hsu J, Arand J, Chaikovsky A, Mooney N, Demeter J, Brison C, et al. E2F4 regulates transcriptional activation in mouse embryonic stem cells independently of the RB family. Nat Commun. 2019;10:2939 pubmed publisher
	Chung Y, Zhu Y, Wu M, Simonini S, Kuhn A, Armenta Medina A, et al. Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS. Nat Commun. 2019;10:886 pubmed publisher
	Piazza R, Magistroni V, Redaelli S, Mauri M, Massimino L, Sessa A, et al. SETBP1 induces transcription of a network of development genes by acting as an epigenetic hub. Nat Commun. 2018;9:2192 pubmed publisher
	Freire Benéitez V, Price R, Buscaino A. The Chromatin of Candida albicans Pericentromeres Bears Features of Both Euchromatin and Heterochromatin. Front Microbiol. 2016;7:759 pubmed publisher
	Freire BenÃ©itez V, Price R, Tarrant D, Berman J, Buscaino A. Candida albicans repetitive elements display epigenetic diversity and plasticity. Sci Rep. 2016;6:22989 pubmed publisher
	Castonguay E, White S, Kagansky A, St Cyr D, Castillo A, Brugger C, et al. Panspecies small-molecule disruptors of heterochromatin-mediated transcriptional gene silencing. Mol Cell Biol. 2015;35:662-74 pubmed publisher

product information

Catalog Number :

39137

Product Name :

Histone H3K9ac antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Acetylated

Size :

200 ul

Isotype :

Serum

CrossReactivity :

Human, Other (Wide Range)

Background :

Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.Lysine N-M-NM-5-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in chromatin remodeling and in the regulation of gene expression in various cellular functions.Histone H3 Lys9 can also be mono-, di- or trimethylated. The methylation of this residue is often associated with transcriptional repression. However, acetylation of histone H3 Lys9 is associated with transcriptional activation of the genes.

Immunogen :

This Histone H3 acetyl Lys9 antibody was raised against a peptide including acetyl-lysine 9 of histone H3.

Uses :

ChIP, ChIP-chip, ChIP-Seq, DB, IP, WB

Storage :

Antibodies in solution can be stored at -200C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody has been used as described below:ChIP-Seq: Egelhofer T. et al. (2011) Nature Structural & Molecular Biology 18: 91-93.