This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Active Motif
other brands :
Geneka Biotechnology
product type :
antibody
product name :
Histone H3K27ac antibody (pAb)
catalog :
39133
quantity :
200 ug
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, zebrafish , Xenopus laevis
application :
western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, ChIP-Seq
citations: 98
Published Application/Species/Sample/DilutionReference
  • ChIP-Seq; mouse; loading ...; fig 1f
Chandrasekaran S, Espeso Gil S, Loh Y, Javidfar B, Kassim B, Zhu Y, et al. Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions. Nat Commun. 2021;12:7243 pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:1000; fig 1a
Reddy N, Majidi S, Kong L, Nemera M, Ferguson C, Moore M, et al. CHARGE syndrome protein CHD7 regulates epigenomic activation of enhancers in granule cell precursors and gyrification of the cerebellum. Nat Commun. 2021;12:5702 pubmed publisher
  • ChIP-Seq; human; loading ...; fig 2b
Huang C, Lingadahalli S, Morova T, Ozturan D, Hu E, Yu I, et al. Functional mapping of androgen receptor enhancer activity. Genome Biol. 2021;22:149 pubmed publisher
  • immunocytochemistry; mouse; fig s5d
Takei Y, Yun J, Zheng S, Ollikainen N, Pierson N, White J, et al. Integrated spatial genomics reveals global architecture of single nuclei. Nature. 2021;590:344-350 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 4b
Zhao Z, Zhang Z, Li J, Dong Q, Xiong J, Li Y, et al. Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness. elife. 2020;9: pubmed publisher
  • ChIP-Seq; human; fig 5a
Casanova M, Moscatelli M, Chauvière L, Huret C, Samson J, Liyakat Ali T, et al. A primate-specific retroviral enhancer wires the XACT lncRNA into the core pluripotency network in humans. Nat Commun. 2019;10:5652 pubmed publisher
  • immunocytochemistry; human; 1:500; loading ...; fig 1a
Farhy C, Hariharan S, Ylanko J, Orozco L, Zeng F, Pass I, et al. Improving drug discovery using image-based multiparametric analysis of the epigenetic landscape. elife. 2019;8: pubmed publisher
  • ChIP-Seq; Xenopus laevis; loading ...; fig 3e
Kuznetsov J, Agüero T, Owens D, Kurtenbach S, Field M, Durante M, et al. BAP1 regulates epigenetic switch from pluripotency to differentiation in developmental lineages giving rise to BAP1-mutant cancers. Sci Adv. 2019;5:eaax1738 pubmed publisher
  • ChIP-Seq; human; fig s6b
Sin Chan P, Mumal I, Suwal T, Ho B, Fan X, Singh I, et al. A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor. Cancer Cell. 2019;36:51-67.e7 pubmed publisher
  • ChIP-Seq; human; loading ...; fig 3a
O Geen H, Bates S, Carter S, Nisson K, Halmai J, Fink K, et al. Ezh2-dCas9 and KRAB-dCas9 enable engineering of epigenetic memory in a context-dependent manner. Epigenetics Chromatin. 2019;12:26 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3c
Chowdhry S, Zanca C, Rajkumar U, Koga T, Diao Y, Raviram R, et al. NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling. Nature. 2019;569:570-575 pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig 6g
Rajderkar S, Mann J, Panaretos C, Yumoto K, Li H, Mishina Y, et al. Trim33 is required for appropriate development of pre-cardiogenic mesoderm. Dev Biol. 2019;450:101-114 pubmed publisher
  • ChIP-Seq; human; loading ...; fig 5b
Stewart E, McEvoy J, Wang H, Chen X, Honnell V, Ocarz M, et al. Identification of Therapeutic Targets in Rhabdomyosarcoma through Integrated Genomic, Epigenomic, and Proteomic Analyses. Cancer Cell. 2018;34:411-426.e19 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 8a
Alabdi L, He M, Yang Q, Norvil A, Gowher H. The transcription factor Vezf1 represses the expression of the antiangiogenic factor Cited2 in endothelial cells. J Biol Chem. 2018;293:11109-11118 pubmed publisher
  • ChIP-Seq; human; loading ...; fig 3d
Noutsou M, Li J, Ling J, Jones J, Wang Y, Chen Y, et al. The Cohesin Complex Is Necessary for Epidermal Progenitor Cell Function through Maintenance of Self-Renewal Genes. Cell Rep. 2017;20:3005-3013 pubmed publisher
  • western blot; human; loading ...; fig 4e
Yuen K, Slaughter B, Gerton J. Condensin II is anchored by TFIIIC and H3K4me3 in the mammalian genome and supports the expression of active dense gene clusters. Sci Adv. 2017;3:e1700191 pubmed publisher
  • western blot; human; loading ...; fig 2a
Zhang X, Li B, Rezaeian A, Xu X, Chou P, Jin G, et al. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nat Commun. 2017;8:14799 pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig 1b
Cruz Molina S, Respuela P, Tebartz C, Kolovos P, Nikolic M, Fueyo R, et al. PRC2 Facilitates the Regulatory Topology Required for Poised Enhancer Function during Pluripotent Stem Cell Differentiation. Cell Stem Cell. 2017;20:689-705.e9 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3f
  • western blot; human; loading ...; fig 3a
Sherman M, Yu R, Tseng T, Sousa C, Liu S, Truitt M, et al. Stromal cues regulate the pancreatic cancer epigenome and metabolome. Proc Natl Acad Sci U S A. 2017;114:1129-1134 pubmed publisher
  • immunocytochemistry; human; 1:1000; fig 4
Singh N, Johnstone D, Martin K, Tempera I, Kaplan M, Denny M. Alterations in nuclear structure promote lupus autoimmunity in a mouse model. Dis Model Mech. 2016;9:885-97 pubmed publisher
  • chromatin immunoprecipitation; human; 1:100; fig 2
Weigel C, Veldwijk M, Oakes C, Seibold P, Slynko A, Liesenfeld D, et al. Epigenetic regulation of diacylglycerol kinase alpha promotes radiation-induced fibrosis. Nat Commun. 2016;7:10893 pubmed publisher
  • ChIP-Seq; zebrafish ; fig 1
Lin C, Erkek S, Tong Y, Yin L, Federation A, Zapatka M, et al. Active medulloblastoma enhancers reveal subgroup-specific cellular origins. Nature. 2016;530:57-62 pubmed publisher
  • chromatin immunoprecipitation; human; fig 3
Flavahan W, Drier Y, Liau B, Gillespie S, Venteicher A, Stemmer Rachamimov A, et al. Insulator dysfunction and oncogene activation in IDH mutant gliomas. Nature. 2016;529:110-4 pubmed publisher
Yuan B, Zhou X, Suzuki K, Ramos Mandujano G, Wang M, Tehseen M, et al. Wiskott-Aldrich syndrome protein forms nuclear condensates and regulates alternative splicing. Nat Commun. 2022;13:3646 pubmed publisher
O Geen H, Tomková M, Combs J, Tilley E, Segal D. Determinants of heritable gene silencing for KRAB-dCas9 + DNMT3 and Ezh2-dCas9 + DNMT3 hit-and-run epigenome editing. Nucleic Acids Res. 2022;50:3239-3253 pubmed publisher
Benbarche S, Lopez C, Salataj E, Aid Z, Thirant C, Laiguillon M, et al. Screening of ETO2-GLIS2-induced Super Enhancers identifies targetable cooperative dependencies in acute megakaryoblastic leukemia. Sci Adv. 2022;8:eabg9455 pubmed publisher
Hota S, Rao K, Blair A, Khalilimeybodi A, Hu K, Thomas R, et al. Brahma safeguards canalization of cardiac mesoderm differentiation. Nature. 2022;602:129-134 pubmed publisher
Liu Y, Wu Z, Zhou J, Ramadurai D, Mortenson K, Aguilera Jimenez E, et al. A predominant enhancer co-amplified with the SOX2 oncogene is necessary and sufficient for its expression in squamous cancer. Nat Commun. 2021;12:7139 pubmed publisher
Geusz R, Wang A, Lam D, Vinckier N, Alysandratos K, Roberts D, et al. Sequence logic at enhancers governs a dual mechanism of endodermal organ fate induction by FOXA pioneer factors. Nat Commun. 2021;12:6636 pubmed publisher
Crispatzu G, Rehimi R, Pachano T, Bleckwehl T, Cruz Molina S, Xiao C, et al. The chromatin, topological and regulatory properties of pluripotency-associated poised enhancers are conserved in vivo. Nat Commun. 2021;12:4344 pubmed publisher
Liu C, Toth R, Bakr A, Goyal A, Islam M, Breuer K, et al. Epigenetic Modulation of Radiation-Induced Diacylglycerol Kinase Alpha Expression Prevents Pro-Fibrotic Fibroblast Response. Cancers (Basel). 2021;13: pubmed publisher
Setten R, Chomchan P, Epps E, Burnett J, Rossi J. CRED9: A differentially expressed elncRNA regulates expression of transcription factor CEBPA. RNA. 2021;: pubmed publisher
Olsen R, Ireland A, Kastner D, Groves S, Spainhower K, Pozo K, et al. ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer. Genes Dev. 2021;35:847-869 pubmed publisher
Andrade J, Shi C, Costa A, Choi J, Kim J, Doddaballapur A, et al. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol. 2021;23:413-423 pubmed publisher
Leistico J, Saini P, Futtner C, Hejna M, Omura Y, Soni P, et al. Epigenomic tensor predicts disease subtypes and reveals constrained tumor evolution. Cell Rep. 2021;34:108927 pubmed publisher
Reizel Y, Morgan A, Gao L, Schug J, Mukherjee S, Garcia M, et al. FoxA-dependent demethylation of DNA initiates epigenetic memory of cellular identity. Dev Cell. 2021;56:602-612.e4 pubmed publisher
Geusz R, Wang A, Chiou J, Lancman J, Wetton N, Kefalopoulou S, et al. Pancreatic progenitor epigenome maps prioritize type 2 diabetes risk genes with roles in development. elife. 2021;10: pubmed publisher
Pomella S, Sreenivas P, Gryder B, Wang L, Milewski D, Cassandri M, et al. Interaction between SNAI2 and MYOD enhances oncogenesis and suppresses differentiation in Fusion Negative Rhabdomyosarcoma. Nat Commun. 2021;12:192 pubmed publisher
Kubo N, Ishii H, Xiong X, Bianco S, Meitinger F, Hu R, et al. Promoter-proximal CTCF binding promotes distal enhancer-dependent gene activation. Nat Struct Mol Biol. 2021;28:152-161 pubmed publisher
Wilson M, Reske J, Holladay J, Neupane S, Ngo J, Cuthrell N, et al. ARID1A Mutations Promote P300-Dependent Endometrial Invasion through Super-Enhancer Hyperacetylation. Cell Rep. 2020;33:108366 pubmed publisher
Gomes A, Ilter D, Low V, Endress J, Fernández García J, Rosenzweig A, et al. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020;585:283-287 pubmed publisher
Marques J, Gryder B, Pavlovic B, Chung Y, Ngo Q, Frommelt F, et al. NuRD subunit CHD4 regulates super-enhancer accessibility in rhabdomyosarcoma and represents a general tumor dependency. elife. 2020;9: pubmed publisher
Prager B, Vasudevan H, Dixit D, Bernatchez J, Wu Q, Wallace L, et al. The Meningioma Enhancer Landscape Delineates Novel Subgroups and Drives Druggable Dependencies. Cancer Discov. 2020;: pubmed publisher
Martire S, Nguyen J, Sundaresan A, Banaszynski L. Differential contribution of p300 and CBP to regulatory element acetylation in mESCs. BMC Mol Cell Biol. 2020;21:55 pubmed publisher
Vander Velde R, Yoon N, Marusyk V, Durmaz A, Dhawan A, Miroshnychenko D, et al. Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures. Nat Commun. 2020;11:2393 pubmed publisher
Levine D, Hong H, Weidemann B, Ramsey K, Affinati A, Schmidt M, et al. NAD+ Controls Circadian Reprogramming through PER2 Nuclear Translocation to Counter Aging. Mol Cell. 2020;78:835-849.e7 pubmed publisher
Nanavaty V, Abrash E, Hong C, Park S, Fink E, Li Z, et al. DNA Methylation Regulates Alternative Polyadenylation via CTCF and the Cohesin Complex. Mol Cell. 2020;78:752-764.e6 pubmed publisher
Catizone A, Uzunbas G, Celadova P, Kuang S, Bose D, Sammons M. Locally acting transcription factors regulate p53-dependent cis-regulatory element activity. Nucleic Acids Res. 2020;48:4195-4213 pubmed publisher
Huang Y, Mouttet B, Warnatz H, Risch T, Rietmann F, Frommelt F, et al. The Leukemogenic TCF3-HLF Complex Rewires Enhancers Driving Cellular Identity and Self-Renewal Conferring EP300 Vulnerability. Cancer Cell. 2019;36:630-644.e9 pubmed publisher
Peghaire C, Dufton N, Lang M, Salles Crawley I, Ahnström J, Kalna V, et al. The transcription factor ERG regulates a low shear stress-induced anti-thrombotic pathway in the microvasculature. Nat Commun. 2019;10:5014 pubmed publisher
Mukai J, Cannavó E, Crabtree G, Sun Z, Diamantopoulou A, Thakur P, et al. Recapitulation and Reversal of Schizophrenia-Related Phenotypes in Setd1a-Deficient Mice. Neuron. 2019;104:471-487.e12 pubmed publisher
Nagaraja S, Quezada M, Gillespie S, Arzt M, Lennon J, Woo P, et al. Histone Variant and Cell Context Determine H3K27M Reprogramming of the Enhancer Landscape and Oncogenic State. Mol Cell. 2019;76:965-980.e12 pubmed publisher
Ginley Hidinger M, Carleton J, Rodriguez A, Berrett K, Gertz J. Sufficiency analysis of estrogen responsive enhancers using synthetic activators. Life Sci Alliance. 2019;2: pubmed publisher
Stine R, Sakers A, Teslaa T, Kissig M, Stine Z, Kwon C, et al. PRDM16 Maintains Homeostasis of the Intestinal Epithelium by Controlling Region-Specific Metabolism. Cell Stem Cell. 2019;25:830-845.e8 pubmed publisher
Jameson N, Ma J, Benitez J, Izurieta A, Han J, Mendez R, et al. Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. Mol Cancer Res. 2019;17:2208-2220 pubmed publisher
Martire S, Gogate A, Whitmill A, Tafessu A, Nguyen J, Teng Y, et al. Phosphorylation of histone H3.3 at serine 31 promotes p300 activity and enhancer acetylation. Nat Genet. 2019;51:941-946 pubmed publisher
Lin Shiao E, Lan Y, Welzenbach J, Alexander K, Zhang Z, Knapp M, et al. p63 establishes epithelial enhancers at critical craniofacial development genes. Sci Adv. 2019;5:eaaw0946 pubmed publisher
Lalioti M, Arbi M, Loukas I, Kaplani K, Kalogeropoulou A, Lokka G, et al. GemC1 governs multiciliogenesis through direct interaction with and transcriptional regulation of p73. J Cell Sci. 2019;132: pubmed publisher
Todd C, Deniz O, Taylor D, Branco M. Functional evaluation of transposable elements as enhancers in mouse embryonic and trophoblast stem cells. elife. 2019;8: pubmed publisher
Sala D, Cunningham T, Stec M, Etxaniz U, Nicoletti C, Dall Agnese A, et al. The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. Nat Commun. 2019;10:1796 pubmed publisher
Greenberg M, Teissandier A, Walter M, Noordermeer D, Bourc his D. Dynamic enhancer partitioning instructs activation of a growth-related gene during exit from naïve pluripotency. elife. 2019;8: pubmed publisher
Ebrahimi A, Sevinç K, Gürhan Sevinç G, Cribbs A, Philpott M, Uyulur F, et al. Bromodomain inhibition of the coactivators CBP/EP300 facilitate cellular reprogramming. Nat Chem Biol. 2019;15:519-528 pubmed publisher
Augert A, Eastwood E, Ibrahim A, Wu N, Grunblatt E, Basom R, et al. Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition. Sci Signal. 2019;12: pubmed publisher
Xiong L, Wu F, Wu Q, Xu L, Cheung O, Kang W, et al. Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming. Nat Commun. 2019;10:335 pubmed publisher
Garcia Moreno S, Futtner C, Salamone I, Gonen N, Lovell Badge R, Maatouk D. Gonadal supporting cells acquire sex-specific chromatin landscapes during mammalian sex determination. Dev Biol. 2019;446:168-179 pubmed publisher
Watanabe S, Shimada S, Akiyama Y, Ishikawa Y, Ogura T, Ogawa K, et al. Loss of KDM6A characterizes a poor prognostic subtype of human pancreatic cancer and potentiates HDAC inhibitor lethality. Int J Cancer. 2019;145:192-205 pubmed publisher
Hong H, Maury E, Ramsey K, Perelis M, Marcheva B, Omura C, et al. Requirement for NF-κB in maintenance of molecular and behavioral circadian rhythms in mice. Genes Dev. 2018;32:1367-1379 pubmed publisher
Guo Y, Perez A, Hazelett D, Coetzee G, Rhie S, Farnham P. CRISPR-mediated deletion of prostate cancer risk-associated CTCF loop anchors identifies repressive chromatin loops. Genome Biol. 2018;19:160 pubmed publisher
Heinz S, Texari L, Hayes M, Urbanowski M, Chang M, Givarkes N, et al. Transcription Elongation Can Affect Genome 3D Structure. Cell. 2018;174:1522-1536.e22 pubmed publisher
Lopes R, Korkmaz G, Revilla S, van Vliet R, Nagel R, Custers L, et al. CUEDC1 is a primary target of ER? essential for the growth of breast cancer cells. Cancer Lett. 2018;436:87-95 pubmed publisher
Yu Z, Jiang K, Xu Z, Huang H, Qian N, Lu Z, et al. Hoxc-Dependent Mesenchymal Niche Heterogeneity Drives Regional Hair Follicle Regeneration. Cell Stem Cell. 2018;23:487-500.e6 pubmed publisher
Fuentes D, Swigut T, Wysocka J. Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation. elife. 2018;7: pubmed publisher
Nikopoulou C, Panagopoulos G, Sianidis G, Psarra E, Ford E, Thanos D. The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression. Mol Cell. 2018;71:352-361.e5 pubmed publisher
Liu C, Wang R, He Z, Osteil P, Wilkie E, Yang X, et al. Suppressing Nodal Signaling Activity Predisposes Ectodermal Differentiation of Epiblast Stem Cells. Stem Cell Reports. 2018;11:43-57 pubmed publisher
Hsu E, Pennella M, Zemke N, Eng C, Berk A. Adenovirus E1A Activation Domain Regulates H3 Acetylation Affecting Varied Steps in Transcription at Different Viral Promoters. J Virol. 2018;92: pubmed publisher
Kim H, Tan Y, Ma W, Merkurjev D, Destici E, Ma Q, et al. Pluripotency factors functionally premark cell-type-restricted enhancers in ES cells. Nature. 2018;556:510-514 pubmed publisher
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Jiang Y, Liu Y, Lu H, Sun S, Jin W, Wang X, et al. Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28. Nat Commun. 2018;9:1424 pubmed publisher
Feld C, Sahu P, Frech M, Finkernagel F, Nist A, Stiewe T, et al. Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1. Nucleic Acids Res. 2018;46:3412-3428 pubmed publisher
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Carleton J, Berrett K, Gertz J. Multiplex Enhancer Interference Reveals Collaborative Control of Gene Regulation by Estrogen Receptor α-Bound Enhancers. Cell Syst. 2017;5:333-344.e5 pubmed publisher
Mendoza A, Astapova I, Shimizu H, Gallop M, Al Sowaimel L, MacGowan S, et al. NCoR1-independent mechanism plays a role in the action of the unliganded thyroid hormone receptor. Proc Natl Acad Sci U S A. 2017;114:E8458-E8467 pubmed publisher
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Jiang Y, Loh Y, Rajarajan P, Hirayama T, Liao W, Kassim B, et al. The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain. Nat Genet. 2017;49:1239-1250 pubmed publisher
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Tak Y, Hung Y, Yao L, Grimmer M, Do A, Bhakta M, et al. Effects on the transcriptome upon deletion of a distal element cannot be predicted by the size of the H3K27Ac peak in human cells. Nucleic Acids Res. 2016;44:4123-33 pubmed publisher
product information
Catalog Number :
39133
Product Name :
Histone H3K27ac antibody (pAb)
Host Species :
Rabbit
Clonality :
Polyclonal
Antigen Modification :
Acetylated
Size :
200 ug
Isotype :
IgG
CrossReactivity :
Budding Yeast, Human, Other (Wide Range)
Background :
Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.Lysine N-M-NM-5-acetylation is a dynamic, reversible and tightly regulated protein and histone modification that plays a major role in chromatin remodeling and in the regulation of gene expression in various cellular functions. Histone acetylation is often associated with transcriptional activation.Lysine 27 of histone H3 can also be mono-, di- or trimethylated by different histone methyltransferases, such as EZH2 or NSD3. While histone methylation can be associated with transcriptional activation or repression, methylation of Lysine 27 of histone H3 is mainly associated with transcriptional repression.
Immunogen :
This Histone H3 acetyl Lys27 antibody was raised against a peptide including acetyl-lysine 27 of histone H3.
Uses :
ChIP, ChIP-chip, ChIP-Seq, DB, IF, IP, WB
Storage :
Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Product References :
References: This antibody has been used as described below:ChIP-Seq: Egelhofer T. et al. (2011) Nature Structural & Molecular Biology 18: 91-93.
company information
Active Motif
1914 Palomar Oaks Way, Suite 150
Carlsbad, CA 92008
sales@activemotif.com
http://www.activemotif.com
1-760-431-1263
headquarters: USA