Histone H2A.XS139ph antibody (pAb) | Active Motif 39117 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Histone H2A.XS139ph antibody (pAb)

catalog :

39117

quantity :

200 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:750; loading ...; fig 4d	Maskey R, Flatten K, Sieben C, Peterson K, Baker D, Nam H, et al. Spartan deficiency causes accumulation of Topoisomerase 1 cleavage complexes and tumorigenesis. Nucleic Acids Res. 2017;45:4564-4576 pubmed publisher
immunocytochemistry; human; 1:500; loading ...; fig 2c	Dmitriev P, Bou Saada Y, Dib C, Ansseau E, Barat A, Hamade A, et al. DUX4-induced constitutive DNA damage and oxidative stress contribute to aberrant differentiation of myoblasts from FSHD patients. Free Radic Biol Med. 2016;99:244-258 pubmed publisher
immunohistochemistry - frozen section; mouse; 1:100; fig s3	Mardaryev A, Liu B, Rapisarda V, Poterlowicz K, Malashchuk I, Rudolf J, et al. Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol. 2016;212:77-89 pubmed publisher
	Onyango D, Howard S, Neherin K, Yanez D, Stark J. Tetratricopeptide repeat factor XAB2 mediates the end resection step of homologous recombination. Nucleic Acids Res. 2016;44:5702-16 pubmed publisher

product information

Catalog Number :

39117

Product Name :

Histone H2A.XS139ph antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Size :

200 ug

Isotype :

IgG

CrossReactivity :

Human, Other (Wide Range)

Background :

Histone H2AX phospho Ser139 (H2AX, H2A histone family member X) replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries that require DNA as a template. Histones thereby play a central role in transcriptional regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called the histone code, and nucleosome remodeling. Histone H2AX is required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation, and for efficient repair of DNA double-strand breaks (DSBs), specifically when modified by C-terminal phosphorylation.

Immunogen :

This Histone H2AX phospho Ser139 antibody was raised against a peptide including phospho-serine 139 of histone H2AX.

Uses :

DB, IF, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.