Histone H2A/H4S1ph antibody (pAb) | Active Motif 39115 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Histone H2A/H4S1ph antibody (pAb)

catalog :

39115

quantity :

200 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5a	Krapivinsky G, Krapivinsky L, Renthal N, Santa Cruz A, Manasian Y, Clapham D. Histone phosphorylation by TRPM6's cleaved kinase attenuates adjacent arginine methylation to regulate gene expression. Proc Natl Acad Sci U S A. 2017;114:E7092-E7100 pubmed publisher

product information

Catalog Number :

39115

Product Name :

Histone H2A/H4S1ph antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Antigen Modification :

Phosphorylated

Size :

200 ul

Isotype :

Serum

CrossReactivity :

Human, Other (Wide Range)

Background :

Histones H2A and H4 are core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.The first five amino acids of histone H2A and histone H4 are identical in metazoans and include an amino-terminal serine residue. Histone H2A phosphorylation at serine 1 is enriched during mitosis, while H4 phosphorylation increases subsequent to DNA double-strand breaks.

Immunogen :

This Histone H2A/H4 phospho Ser1 antibody was raised against a peptide including phospho-serine 1 of human histone H2A.

Uses :

DB, WB

Storage :

Antibodies in solution can be stored at -20M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.