Histone H3S28ph antibody (mAb) | Active Motif 39098 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Histone H3S28ph antibody (mAb)

catalog :

39098

quantity :

100 ul

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

HTA28

The same clone is also sold as:

BD Biosciences: 558217, 558613, 560606, 558610, 558609
MilliporeSigma: H9908
Abcam: ab10543

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; fig 3a	Otsuka K, Suzuki K. Differences in Radiation Dose Response between Small and Large Intestinal Crypts. Radiat Res. 2016;186:302-14 pubmed publisher

product information

Catalog Number :

39098

Product Name :

Histone H3S28ph antibody (mAb)

Host Species :

Rat

Clonality :

Monoclonal

Antigen Modification :

Phosphorylated

Size :

100 ul

Clone :

HTA28

Isotype :

IgG2a

CrossReactivity :

Human, Mouse, Rat

Background :

Histone H3 is one of the core components of the nucleosome. The nucleosome is the smallest subunit of chromatin and consists of 147 base pairs of DNA wrapped around an octamer of core histone proteins (two each of Histone H2A, Histone H2B, Histone H3 and Histone H4). Chromatin is subject to a variety of chemical modifications, including post-translational modifications of the histone proteins and the methylation of cytosine residues in the DNA. Reported histone modifications include acetylation, methylation, phosphorylation, ubiquitylation, glycosylation, ADP-ribosylation, carbonylation and SUMOylation; these modifications play a major role in regulating gene expression.Ser10 phosphorylation and Ser28 phosphorylation in the tail of H3 have very similar kinetics. Both phosphorylations occur early in mitosis when chromosomes begin to condense and during premature chromosome condensation induced in S-phase cells. These phosphorylated serines are excellent mitotic markers. In contrast to Ser10 phosphorylation, Ser28 phosphorylation has never been observed in interphase.

Immunogen :

This Histone H3 phospho Ser28 antibody was raised in rat against a peptide corresponding to amino acid residues 23-35 (phospho Ser 28) of human Histone H3.

Uses :

ELISA, IF, WB

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.