Sp1 antibody (pAb) | Active Motif 39058 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Active Motif

other brands :

Geneka Biotechnology

product type :

antibody

product name :

Sp1 antibody (pAb)

catalog :

39058

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
chromatin immunoprecipitation; mouse; loading ...; fig s7f	Ji L, Zhao Y, He L, Zhao J, Gao T, Liu F, et al. AKAP1 Deficiency Attenuates Diet-Induced Obesity and Insulin Resistance by Promoting Fatty Acid Oxidation and Thermogenesis in Brown Adipocytes. Adv Sci (Weinh). 2021;8:2002794 pubmed publisher
western blot; human; loading ...; fig 5f	Gomes A, Ilter D, Low V, Rosenzweig A, Shen Z, Schild T, et al. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019;36:402-417.e13 pubmed publisher
immunocytochemistry; human; 1:100; loading ...; fig s2b western blot; human; 1:1000; loading ...; fig s2a	Khanal T, Choi K, Leung Y, Wang J, Kim D, Janakiram V, et al. Loss of NR2E3 represses AHR by LSD1 reprogramming, is associated with poor prognosis in liver cancer. Sci Rep. 2017;7:10662 pubmed publisher

product information

Catalog Number :

39058

Product Name :

Sp1 antibody (pAb)

Host Species :

Rabbit

Clonality :

Polyclonal

Size :

100 ul

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

Sp1 (specificity protein 1) is a human transcription factor involved in gene expression in the early development of an organism. The protein is 785 amino acids long, with a molecular weight of 81 kDa. The SP1 transcription factor contains a zinc finger protein motif, by which it binds directly to DNA and enhances gene transcription. Its zinc fingers are of the Cys2/His2 type and bind the consensus sequence 5M-bM-^@M-2-(G/T)GGGCGG(G/A)(G/A)(C/T)-3M-bM-^@M-2 (GC box element). It was discovered in 1983 and has since been modified to form Sp1C, which has a zinc finger protein DNA binding domain.

Immunogen :

This Sp1 antibody was raised against a synthetic peptide corresponding to amino acid residues 520-534 of human Sp1.

Uses :

ChIP, IP, WB

Storage :

Antibodies in solution can be stored at -80M-BM-0C for 2 years. Avoid repeated freeze/thaw cycles and keep on ice when not in storage.

Product References :

References: This antibody was used in ChIP assays as described in Liu, M. et al. (2006) Clin Can Res 12(2): 608M-bM-^@M-^S616.