TNFSF13B recombinant monoclonal antibody, clone Tabalumab

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Abnova

product type :

antibody

product name :

TNFSF13B recombinant monoclonal antibody, clone Tabalumab

catalog :

RAB01137

quantity :

200 ug

clonality :

monoclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

product information

Catalog Number :

RAB01137

Product Name :

TNFSF13B recombinant monoclonal antibody, clone Tabalumab

Product Type :

antibody

Host Species :

Rabbit

Clonality :

monoclonal

Conjugation :

Unconjugated

Antigen Modification :

Size :

200 ug

Product Description :

Recombinant rabbit monoclonal antibody raised against human CD257.

Immunogen :

Original antibody is raised against by immunizing human immunoglobulin transgenic mice with soluble human BAFF (amino acids 133??85). Eight mice producing serum antibody titers to human BAFF were injected intravenously with 10 繕g human BAFF in phosphate buffered saline. The spleen was harvested 3 days later from each mouse and fused with myeloma cells. 20 Hybridomas were tested for specific binding to human BAFF and to make sure they were expressing human immunoglobulin heavy and light chains by enzyme-linked immunosorbent assay (ELISA). The hybridoma producing the antibody that eventually became tabalumab was a human IgG1 isotype. The antibody was then engineered to a human IgG4 isotype for complete neutralization of BAFF without depletion of BAFF-expressing cells.