HLA-DP/HLA-DR monoclonal antibody, clone Bra-14 | Abnova MAB13303 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Abnova

product type :

antibody

product name :

HLA-DP/HLA-DR monoclonal antibody, clone Bra-14

catalog :

MAB13303

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Bra-14

reactivity :

human

application :

immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

catalog id :

MAB13303

product name :

HLA-DP/HLA-DR monoclonal antibody, clone Bra-14

product description :

Mouse monoclonal antibody raised against native human HLA-DP/HLA-DR.

clone name :

Bra-14

isotype :

IgG3, kappa

gene name :

HLA-DPB1

gene alias :

DPB1 HLA-DP1B

gene description :

major histocompatibility complex, class II, DP beta 1

immunogen :

Human REH cells.

protein accession :

P04440;P01903

form :

Liquid

recommend dilutions :

Flow Cytometry (0.5-1 ug/10 6 cells in 0.1 mL). Immunofluorescence (0.5-1 ug/mL). Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL). The optimal working dilution should be determined by the end user.

storage buffer :

In 10 mM PBS (0.05% BSA, 0.05% sodium azide).

storage instruction :

Store at 4 C.

note :

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

type clonality :

Antibody

raised in host species :

Mouse

antigen species target species :

Human

specificity :

Reacts with a common epitope of human major histocompatibility (MHC) class II antigens, HLA-DP and HLA-DR. Human MHC class II antigens are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, and thymic epithelial cells and are also present on activated T lymphocytes. Human MHC class II genes are located in the HLA-D region that encodes at least six and ten chain genes. Three loci, DP, DQ and DR, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T helper cells. They, therefore, have a critical role in the initiation of the immune response. It has been shown that some autoimmune diseases are associated with certain class II alleles.

species reactivity cross reactivity :

Human

application key :

IHC-P,IF,Flow Cyt

size :

100 ug

autodate :

2016-03-31

updatetime :

2016-03-31 10:05:49