HLA-DQ monoclonal antibody, clone SPM422 | Abnova MAB13077 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Abnova

product type :

antibody

product name :

HLA-DQ monoclonal antibody, clone SPM422

catalog :

MAB13077

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SPM422

reactivity :

human

application :

immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

product information

catalog id :

MAB13077

product name :

HLA-DQ monoclonal antibody, clone SPM422

product description :

Mouse monoclonal antibody raised against native human HLA-DQ.

clone name :

SPM422

isotype :

IgG2a, kappa

gene name :

HLA-DQA1

gene alias :

CD CELIAC1 DQ-A1 FLJ27088 FLJ27328 GSE HLA-DQA MGC149527

gene description :

major histocompatibility complex, class II, DQ alpha 1

immunogen :

T4-positive CTL clone HG-38.

protein accession :

P01908;P01909;P01920

form :

Liquid

recommend dilutions :

Flow Cytometry (0.5-1 ug/10 6 cells in 0.1 mL). Immunofluorescence (0.5-1 ug/mL). Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (0.5-1 ug/mL). The optimal working dilution should be determined by the end user.

storage buffer :

In 10 mM PBS (0.05% BSA, 0.05% sodium azide).

storage instruction :

Store at 4 C.

note :

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

type clonality :

Antibody

raised in host species :

Mouse

antigen species target species :

Human

specificity :

Recognizes a DQ antigen, which is a dimer of 60 kDa. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. This monoclonal antibody strongly blocks cytotoxicity activity of T4 + cytotoxic T cell clones.

species reactivity cross reactivity :

Human

application key :

IHC-P,IF,Flow Cyt

size :

100 ug

autodate :

2016-02-26

updatetime :

2016-02-26 17:44:06