HLA-B monoclonal antibody, clone SPM420 | Abnova MAB13073 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Abnova

product type :

antibody

product name :

HLA-B monoclonal antibody, clone SPM420

catalog :

MAB13073

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SPM420

reactivity :

human

application :

immunocytochemistry, flow cytometry

product information

catalog id :

MAB13073

product name :

HLA-B monoclonal antibody, clone SPM420

product description :

Mouse monoclonal antibody raised against native human HLA-B.

clone name :

SPM420

isotype :

IgG3, kappa

gene name :

HLA-B

gene alias :

AS HLA-B-7301 HLA-B73 HLAB HLAC SPDA1

gene description :

major histocompatibility complex, class I, B

immunogen :

Normal human peripheral blood lymphocytes.

protein accession :

P01889

form :

Liquid

recommend dilutions :

Flow Cytometry (0.5-1 ug/10 6 cells in 0.1 mL). Immunofluorescence (0.5-1 ug/mL). The optimal working dilution should be determined by the end user.

storage buffer :

In 10 mM PBS (0.05% BSA, 0.05% sodium azide).

storage instruction :

Store at 4 C.

note :

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

type clonality :

Antibody

raised in host species :

Mouse

antigen species target species :

Human

specificity :

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described.

species reactivity cross reactivity :

Human

application key :

IF,Flow Cyt

size :

100 ug

autodate :

2016-02-26

updatetime :

2016-02-26 17:44:06