CHFR monoclonal antibody (M01), clone 1H3-A12 | Abnova H00055743-M01 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Abnova

product type :

antibody

product name :

CHFR monoclonal antibody (M01), clone 1H3-A12

catalog :

H00055743-M01

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1H3-A12

reactivity :

human

application :

western blot, ELISA, immunohistochemistry - paraffin section

citations: 7

Reference
Kashima L, Idogawa M, Mita H, Shitashige M, Yamada T, Ogi K, et al. CHFR protein regulates mitotic checkpoint by targeting PARP-1 protein for ubiquitination and degradation. J Biol Chem. 2012;287:12975-84 pubmed publisher
Fujita A, Yamamoto H, Imamura M, Nakamura N, Maehara Y, Tsuneyoshi M, et al. Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach. Virchows Arch. 2012;460:163-9 pubmed publisher
Hu S, Huang D, Sun Y, Wu L, Xu W, Yin S, et al. Pathobiologic implications of methylation and expression status of Runx3 and CHFR genes in gastric cancer. Med Oncol. 2011;28:447-54 pubmed publisher
Gao Y, Xin Y, Zhang J, Zhou J. Mechanism and pathobiologic implications of CHFR promoter methylation in gastric carcinoma. World J Gastroenterol. 2008;14:5000-7 pubmed
Privette L, Weier J, Nguyen H, Yu X, Petty E. Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint. Neoplasia. 2008;10:643-52 pubmed
Privette L, Gonzalez M, Ding L, Kleer C, Petty E. Altered expression of the early mitotic checkpoint protein, CHFR, in breast cancers: implications for tumor suppression. Cancer Res. 2007;67:6064-74 pubmed
Milne A, Sitarz R, Carvalho R, Polak M, Ligtenberg M, Pauwels P, et al. Molecular analysis of primary gastric cancer, corresponding xenografts, and 2 novel gastric carcinoma cell lines reveals novel alterations in gastric carcinogenesis. Hum Pathol. 2007;38:903-13 pubmed

product information

catalog id :

H00055743-M01

product name :

CHFR monoclonal antibody (M01), clone 1H3-A12

product description :

Mouse monoclonal antibody raised against a full length recombinant CHFR.

clone name :

1H3-A12

isotype :

IgG1 Kappa

gene name :

CHFR

gene alias :

FLJ10796 FLJ33629 RNF116 RNF196

gene description :

checkpoint with forkhead and ring finger domains

genbank accession :

BC012072

immunogen :

CHFR (AAH12072.1, 1 a.a. ~ 652 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

immunogen sequence protein sequence :

MERPEEGKQSPPPQPWGRLLRLGAEEGEPHVLLRKREWT
IGRRRGCDLSFPSNKLVSGDHCRIVVDEKSGQVTLEDTS
TSGTVINKLKVVKKQTCPLQTGDVIYLVYRKNEPEHNVA
YLYESLSEKQGMTQESFDTSGAGAGRGADPRVPPSSPAT
QVCFEEPQPSTSTSDLFPTASASSTEPSPAGRERSSSCG
SGGGGISPKGSGPSVASDEVSSFASALPDRKTASFSSLE
PQDQEDLEPVKKKMRGDGDLDLNGQLLVAQPRRNAQTVH
EDVRAAAGKPDKMEETLTCIICQDLLHDCVSLQPCMHTF
CAACYSGWMERSSLCPTCRCPVERICKNHILNNLVEAYL
IQHPDKSRSEEDVQSMDARNKITQDMLQPKVRRSFSDEE
GSSEDLLELSDVDSESSDISQPYVVCRQCPEYRRQAAQP
PHCPAPEGEPGAPQALGDAPSTSVSLTTAVQDYVCPLQG
SHALCTCCFQPMPDRRVEREQDPRVAPQQCAVCLQPFCH
LYWGCTRTGCYGCLAPFCELNLGDKCLDGVLNNNSYESD
ILKNYLATRGLTWKNMLTESLVALQRGVFLLSDYRVTGD
TVLCYCCGLRSFRELTYQYRQNIPASELPVAVTSRPDCY
WGRNCRTQVKAHHAMKFNHICEQTRFKN

protein accession :

AAH12072.1

storage buffer :

In 1x PBS, pH 7.4

storage instruction :

Store at -20 C or lower. Aliquot to avoid repeated freezing and thawing

quality control testing :

Antibody Reactive Against Recombinant Protein

type clonality :

Antibody

raised in host species :

Mouse

antigen species target species :

Human

species reactivity cross reactivity :

Human

application key :

WB-Ce,IHC-P,S-ELISA,ELISA,WB-Re,WB-Tr,RNAi-Ab

size :

100 ug

autodate :

2008-04-18

updatetime :

2013-11-15 18:40:03