MFN1 monoclonal antibody (M04), clone 3C9 | Abnova H00055669-M04 product information

product summary

company name :

Abnova

product type :

antibody

product name :

MFN1 monoclonal antibody (M04), clone 3C9

catalog :

H00055669-M04

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3C9

reactivity :

human, mouse

application :

western blot, ELISA

more info or order :

Abnova product webpage

citations: 13

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000	Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, et al. Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease. Nat Commun. 2021;12:5305 pubmed publisher
western blot; mouse; 1:2000; loading ...; fig s2g	Zhang X, Wang R, Hu D, Sun X, Fujioka H, Lundberg K, et al. Oligodendroglial glycolytic stress triggers inflammasome activation and neuropathology in Alzheimer's disease. Sci Adv. 2020;6: pubmed publisher
western blot; human; fig 4	Shiba Fukushima K, Ishikawa K, Inoshita T, Izawa N, Takanashi M, Sato S, et al. Evidence that phosphorylated ubiquitin signaling is involved in the etiology of Parkinson's disease. Hum Mol Genet. 2017;26:3172-3185 pubmed publisher
western blot; mouse; 1:1000; fig 1a	Guo X, Qi X. VCP cooperates with UBXD1 to degrade mitochondrial outer membrane protein MCL1 in model of Huntington's disease. Biochim Biophys Acta Mol Basis Dis. 2017;1863:552-559 pubmed publisher
western blot; mouse; fig 3	Furuya N, Ikeda S, Sato S, Soma S, Ezaki J, Oliva Trejo J, et al. PARK2/Parkin-mediated mitochondrial clearance contributes to proteasome activation during slow-twitch muscle atrophy via NFE2L1 nuclear translocation. Autophagy. 2014;10:631-41 pubmed publisher
	Hu D, Sun X, Liao X, Zhang X, Zarabi S, Schimmer A, et al. Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity. Acta Neuropathol. 2019;137:939-960 pubmed publisher
	Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, et al. Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior. J Neurosci. 2019;39:1588-1604 pubmed publisher
	Wei Q, Sun H, Song S, Liu Y, Liu P, Livingston M, et al. MicroRNA-668 represses MTP18 to preserve mitochondrial dynamics in ischemic acute kidney injury. J Clin Invest. 2018;128:5448-5464 pubmed publisher
	Guedouari H, Daigle T, Scorrano L, Hébert Chatelain E. Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation. Biochim Biophys Acta Mol Cell Res. 2017;1864:169-176 pubmed publisher
	Fülöp L, Rajki A, Katona D, Szanda G, Spät A. Extramitochondrial OPA1 and adrenocortical function. Mol Cell Endocrinol. 2013;381:70-9 pubmed publisher
	Bui M, Gilady S, Fitzsimmons R, Benson M, Lynes E, Gesson K, et al. Rab32 modulates apoptosis onset and mitochondria-associated membrane (MAM) properties. J Biol Chem. 2010;285:31590-602 pubmed publisher
	Holloway G, Perry C, Thrush A, Heigenhauser G, Dyck D, Bonen A, et al. PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein. Am J Physiol Endocrinol Metab. 2008;294:E1060-9 pubmed publisher
	Zanna C, Ghelli A, Porcelli A, Karbowski M, Youle R, Schimpf S, et al. OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain. 2008;131:352-67 pubmed publisher

product information

catalog id :

H00055669-M04

product name :

MFN1 monoclonal antibody (M04), clone 3C9

product description :

Mouse monoclonal antibody raised against a full length recombinant MFN1.

clone name :

3C9

isotype :

IgG2a Kappa

gene name :

MFN1

gene alias :

DKFZp762F247 FLJ20693 MGC41806 hfzo1 hfzo2

gene description :

mitofusin 1

genbank accession :

BC040557

immunogen :

MFN1 (AAH40557, 1 a.a. ~ 741 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

immunogen sequence protein sequence :

MAEPVSPLKHFVLAKKAITAIFDQLLEFVTEGSHFVEAT
YKNPELDRIATEDDLVEMQGYKDKLSIIGEVLSRRHMKV
AFFGRTSSGKSSVINAMLWDKVLPSGIGHITNCFLSVEG
TDGDKAYLMTEGSDEKKSVKTVNQLAHALHMDKDLKAGC
LVRVFWPKAKCALLRDDLVLVDSPGTDVTTELDSWIDKF
CLDADVFVLVANSESTLMNTEKHFFHKVNERLSKPNIFI
LNNRWDASASEPEYMEDVRRQHMERCLHFLVEELKVVNA
LEAQNRIFFVSAKEVLSARKQKAQGMPESGVALAEGFHA
RLQEFQNFEQIFEECISQSAVKTKFEQHTIRAKQILATV
KNIMDSVNLAAEDKRHYSVEEREDQIDRLDFIRNQMNLL
TLDVKKKIKEVTEEVANKVSCAMTDEICRLSVLVDEFCS
EFHPNPDVLKIYKSELNKHIEDGMGRNLADRCTDEVNAL
VLQTQQEIIENLKPLLPAGIQDKLHTLIPCKKFDLSYNL
NYHKLCSDFQEDIVFRFSLGWSSLVHRFLGPRNAQRVLL
GLSEPIFQLPRSLASTPTAPTTPATPDNASQEELMITLV
TGLASVTSRTSMGIIIVGGVIWKTIGWKLLSVSLTMYGA
LYLYERLSWTTHAKERAFKQQFVNYATEKLRMIVSSTSA
NCSHQVKQQIATTFARLCQQVDITQKQLEEEIARLPKEI
DQLEKIQNNSKLLRNKAVQLENELENFTKQFLPSSNEES

protein accession :

AAH40557

storage buffer :

In 1x PBS, pH 7.4

storage instruction :

Store at -20 C or lower. Aliquot to avoid repeated freezing and thawing

quality control testing :

Antibody Reactive Against Recombinant Protein

type clonality :

Antibody

raised in host species :

Mouse

antigen species target species :

Human

specificity :

This antibody may cross react with MFN2 protein.

species reactivity cross reactivity :

Human

application key :

WB-Ce,S-ELISA,WB-Tr,RNAi-Ab,ELISA,WB-Re

size :

100 ug

autodate :

10/10/06

updatetime :

5/21/19 16:02

more info or order :

Abnova product webpage