product summary
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company name :
Abnova
product type :
antibody
product name :
MFN2 monoclonal antibody (M03), clone 4H8
catalog :
H00009927-M03
quantity :
100 ug
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4H8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry - paraffin section
more info or order :
citations: 11
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 2c
Mattie S, Riemer J, Wideman J, McBride H. A new mitofusin topology places the redox-regulated C terminus in the mitochondrial intermembrane space. J Cell Biol. 2018;217:507-515 pubmed publisher
  • western blot; mouse; loading ...; fig 5j
Zhao Y, Chen Y, Miao G, Zhao H, Qu W, Li D, et al. The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation. Mol Cell. 2017;67:974-989.e6 pubmed publisher
  • western blot; mouse; fig 6
Oettinghaus B, D Alonzo D, Barbieri E, Restelli L, Savoia C, Licci M, et al. DRP1-dependent apoptotic mitochondrial fission occurs independently of BAX, BAK and APAF1 to amplify cell death by BID and oxidative stress. Biochim Biophys Acta. 2016;1857:1267-1276 pubmed publisher
  • western blot; human
Jacobs R, Lundby A, Fenk S, Gehrig S, Siebenmann C, Flück D, et al. Twenty-eight days of exposure to 3454 m increases mitochondrial volume density in human skeletal muscle. J Physiol. 2016;594:1151-66 pubmed publisher
  • western blot; human
Sawyer S, Cheuk Him Ng A, Innes A, Wagner J, Dyment D, Tetreault M, et al. Homozygous mutations in MFN2 cause multiple symmetric lipomatosis associated with neuropathy. Hum Mol Genet. 2015;24:5109-14 pubmed publisher
Donkervoort S, Sabouny R, Yun P, Gauquelin L, Chao K, Hu Y, et al. MSTO1 mutations cause mtDNA depletion, manifesting as muscular dystrophy with cerebellar involvement. Acta Neuropathol. 2019;138:1013-1031 pubmed publisher
Costa R, Peruzzo R, Bachmann M, Montà G, Vicario M, Santinon G, et al. Impaired Mitochondrial ATP Production Downregulates Wnt Signaling via ER Stress Induction. Cell Rep. 2019;28:1949-1960.e6 pubmed publisher
Ishikawa K, Yamamoto S, Hattori S, Nishimura N, Tani H, Mito T, et al. Acquired Expression of Mutant Mitofusin 2 Causes Progressive Neurodegeneration and Abnormal Behavior. J Neurosci. 2019;39:1588-1604 pubmed publisher
Cosson P, Marchetti A, Ravazzola M, Orci L. Mitofusin-2 independent juxtaposition of endoplasmic reticulum and mitochondria: an ultrastructural study. PLoS ONE. 2012;7:e46293 pubmed publisher
Moran M, Rivera H, Sánchez Aragó M, Blazquez A, Merinero B, Ugalde C, et al. Mitochondrial bioenergetics and dynamics interplay in complex I-deficient fibroblasts. Biochim Biophys Acta. 2010;1802:443-53 pubmed publisher
Holloway G, Perry C, Thrush A, Heigenhauser G, Dyck D, Bonen A, et al. PGC-1alpha's relationship with skeletal muscle palmitate oxidation is not present with obesity despite maintained PGC-1alpha and PGC-1beta protein. Am J Physiol Endocrinol Metab. 2008;294:E1060-9 pubmed publisher
product information
catalog id :
H00009927-M03
product name :
MFN2 monoclonal antibody (M03), clone 4H8
product description :
Mouse monoclonal antibody raised against a partial recombinant MFN2.
clone name :
4H8
isotype :
IgG2a Kappa
gene name :
MFN2
gene alias :
CMT2A CMT2A2 CPRP1 HSG KIAA0214 MARF
gene description :
mitofusin 2
genbank accession :
NM_014874
immunogen :
MFN2 (NP_055689, 661 a.a. ~ 757 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
immunogen sequence protein sequence :
FKRQFVEHASEKLQLVISYTGSNCSHQVQQELSGTFAHL
CQQVDVTRENLEQEIAAMNKKIEVLDSLQSKAKLLRNKA
GWLDSELNMFTHQYLQPSR
protein accession :
NP_055689
storage buffer :
In 1x PBS, pH 7.4
storage instruction :
Store at -20 C or lower. Aliquot to avoid repeated freezing and thawing
quality control testing :
Antibody Reactive Against Recombinant Protein
type clonality :
Antibody
raised in host species :
Mouse
antigen species target species :
Human
species reactivity cross reactivity :
Human,Rat
application key :
WB-Tr,S-ELISA,RNAi-Ab,ELISA,WB-Re,WB-Ce,IHC-P
size :
100 ug
autodate :
4/24/08
updatetime :
11/15/13 18:40
more info or order :
company information
Abnova
9th Fl., No.108, Jhouzih St.
Neihu District. Taipei City
114 Taiwan
sales@abnova.com
https://www.abnova.com
877-853-6098