| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; mouse; 1:100; fig 4b
- western blot; mouse; 1:1000; fig 4a
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- other; mouse; loading ...; fig 6m, 7m
| Vessey K, Jobling A, Tran M, Wang A, Greferath U, Fletcher E. Treatments targeting autophagy ameliorate the age-related macular degeneration phenotype in mice lacking APOE (apolipoprotein E). Autophagy. 2022;18:2368-2384 pubmed publisher |
- western blot; mouse; loading ...; fig 4b
| Sun H, Ni H, McCracken J, Akakpo J, Fulte S, McKeen T, et al. Liver-specific deletion of mechanistic target of rapamycin does not protect against acetaminophen-induced liver injury in mice. Liver Res. 2021;5:79-87 pubmed publisher |
- western blot; mouse; loading ...
| Silva Rojas R, Charles A, Djeddi S, Geny B, Laporte J, Böhm J. Pathophysiological Effects of Overactive STIM1 on Murine Muscle Function and Structure. Cells. 2021;10: pubmed publisher |
- immunocytochemistry; rat; 1:500; loading ...; fig s4c
| Özkan N, Koppers M, van Soest I, van Harten A, Jurriens D, Liv N, et al. ER - lysosome contacts at a pre-axonal region regulate axonal lysosome availability. Nat Commun. 2021;12:4493 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 8a, 8b, 8c, 8d
| Anandhan A, Nguyen N, Syal A, Dreher L, Dodson M, Zhang D, et al. NRF2 Loss Accentuates Parkinsonian Pathology and Behavioral Dysfunction in Human α-Synuclein Overexpressing Mice. Aging Dis. 2021;12:964-982 pubmed publisher |
- western blot; mouse; loading ...; fig 4b
| Satoh K, Takemura Y, Satoh M, Ozaki K, Kubota S. Loss of FYCO1 leads to cataract formation. Sci Rep. 2021;11:13771 pubmed publisher |
- western blot; human; 1:1000; loading ...; fig s5a, s5b
- western blot; mouse; 1:1000; loading ...; fig 4h
| Wojnarowicz P, Escolano M, Huang Y, Desai B, Chin Y, Shah R, et al. Anti-tumor effects of an ID antagonist with no observed acquired resistance. NPJ Breast Cancer. 2021;7:58 pubmed publisher |
- immunocytochemistry; mouse; loading ...; fig 2c
- western blot; mouse; loading ...; fig 2a
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- immunohistochemistry - free floating section; rat; 1:500; loading ...; fig 3a
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- western blot; rat; 1:5000; loading ...
| Ormeño F, Hormazabal J, Moreno J, Riquelme F, Rios J, Criollo A, et al. Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation. Front Mol Neurosci. 2020;13:19 pubmed publisher |
- western blot; mouse; loading ...; fig 2c
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- western blot; human; loading ...; fig 3b
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- western blot; mouse; loading ...; fig 2f
| Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano A, Monfregola J, et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 2017;127:3717-3729 pubmed publisher |
- western blot; mouse; loading ...; fig 2c
| Rocchi A, Yamamoto S, Ting T, Fan Y, SADLEIR K, Wang Y, et al. A Becn1 mutation mediates hyperactive autophagic sequestration of amyloid oligomers and improved cognition in Alzheimer's disease. PLoS Genet. 2017;13:e1006962 pubmed publisher |
- western blot; human; loading ...; fig 4f
| Potes Y, de Luxán Delgado B, Rodríguez González S, Guimarães M, Solano J, Fernández Fernández M, et al. Overweight in elderly people induces impaired autophagy in skeletal muscle. Free Radic Biol Med. 2017;110:31-41 pubmed publisher |
- western blot; human; loading ...; fig 5b
| Zhang Y, Nguyen D, Olzomer E, Poon G, Cole N, Puvanendran A, et al. Rescue of Pink1 Deficiency by Stress-Dependent Activation of Autophagy. Cell Chem Biol. 2017;24:471-480.e4 pubmed publisher |
- western blot; human; 1:5000; loading ...; fig 3d
| Cooper H, Yang Y, Ylikallio E, Khairullin R, Woldegebriel R, Lin K, et al. ATPase-deficient mitochondrial inner membrane protein ATAD3A disturbs mitochondrial dynamics in dominant hereditary spastic paraplegia. Hum Mol Genet. 2017;26:1432-1443 pubmed publisher |
- western blot; mouse; 1:2000; loading ...; fig 2A
| Redmann M, Wani W, Volpicelli Daley L, Darley Usmar V, Zhang J. Trehalose does not improve neuronal survival on exposure to alpha-synuclein pre-formed fibrils. Redox Biol. 2017;11:429-437 pubmed publisher |
- western blot; human; loading ...; fig 5j
- western blot; mouse; loading ...; fig 5a
| Pietrocola F, Demont Y, Castoldi F, Enot D, Durand S, Semeraro M, et al. Metabolic effects of fasting on human and mouse blood in vivo. Autophagy. 2017;13:567-578 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 4a
| Sambri I, D Alessio R, Ezhova Y, Giuliano T, Sorrentino N, Cacace V, et al. Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases. EMBO Mol Med. 2017;9:112-132 pubmed publisher |
- western blot; mouse; loading ...; fig s10b
| Newberry E, Xie Y, Kennedy S, Graham M, Crooke R, Jiang H, et al. Prevention of hepatic fibrosis with liver microsomal triglyceride transfer protein deletion in liver fatty acid binding protein null mice. Hepatology. 2017;65:836-852 pubmed publisher |
- western blot; mouse; loading ...; fig 3f
| Fan Y, Wang N, Rocchi A, Zhang W, Vassar R, Zhou Y, et al. Identification of natural products with neuronal and metabolic benefits through autophagy induction. Autophagy. 2017;13:41-56 pubmed publisher |
- western blot; mouse; loading ...; fig 8a
| Conlon D, Thomas T, Fedotova T, Hernandez Ono A, Di Paolo G, Chan R, et al. Inhibition of apolipoprotein B synthesis stimulates endoplasmic reticulum autophagy that prevents steatosis. J Clin Invest. 2016;126:3852-3867 pubmed publisher |
- western blot; human; fig 3
| Kuramoto K, Wang N, Fan Y, Zhang W, Schoenen F, Frankowski K, et al. Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids. Autophagy. 2016;12:1460-71 pubmed publisher |
- western blot; mouse; 1:2000; fig 2
| Seiferling D, Szczepanowska K, Becker C, Senft K, Hermans S, Maiti P, et al. Loss of CLPP alleviates mitochondrial cardiomyopathy without affecting the mammalian UPRmt. EMBO Rep. 2016;17:953-64 pubmed publisher |
- western blot; mouse; fig s1
| Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher |
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- immunohistochemistry - paraffin section; mouse; fig s13
- immunocytochemistry; mouse; fig s1
- western blot; mouse; 1:3000; fig s4
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- western blot; human; fig 7g
| Nezich C, Wang C, Fogel A, Youle R. MiT/TFE transcription factors are activated during mitophagy downstream of Parkin and Atg5. J Cell Biol. 2015;210:435-50 pubmed publisher |
- western blot; human; fig 2
| Hermanova I, Arruabarrena Aristorena A, Valis K, Nůsková H, Alberich Jorda M, Fiser K, et al. Pharmacological inhibition of fatty-acid oxidation synergistically enhances the effect of l-asparaginase in childhood ALL cells. Leukemia. 2016;30:209-18 pubmed publisher |
- western blot; human; fig 7
| Shi Y, Tan S, Ng S, Zhou J, Yang N, Koo G, et al. Critical role of CAV1/caveolin-1 in cell stress responses in human breast cancer cells via modulation of lysosomal function and autophagy. Autophagy. 2015;11:769-84 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:500
| Porta S, Kwong L, Trojanowski J, Lee V. Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases. J Neuropathol Exp Neurol. 2015;74:380-7 pubmed publisher |
- western blot; human; 1:5000; fig 1
- western blot; mouse; 1:5000; fig 2
| Pedro J, Wei Y, Sica V, Maiuri M, Zou Z, Kroemer G, et al. BAX and BAK1 are dispensable for ABT-737-induced dissociation of the BCL2-BECN1 complex and autophagy. Autophagy. 2015;11:452-9 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:200
- western blot; mouse
| Ni H, Bhakta A, Wang S, Li Z, Manley S, Huang H, et al. Role of hypoxia inducing factor-1β in alcohol-induced autophagy, steatosis and liver injury in mice. PLoS ONE. 2014;9:e115849 pubmed publisher |
| Manley S, Ni H, Williams J, Kong B, DiTacchio L, Guo G, et al. Farnesoid X receptor regulates forkhead Box O3a activation in ethanol-induced autophagy and hepatotoxicity. Redox Biol. 2014;2:991-1002 pubmed publisher |
- western blot; mouse; fig 8
| Liang N, Zhang C, Dill P, Panasyuk G, Pion D, Koka V, et al. Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex. J Exp Med. 2014;211:2249-63 pubmed publisher |
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| Mancias J, Wang X, Gygi S, Harper J, Kimmelman A. Quantitative proteomics identifies NCOA4 as the cargo receptor mediating ferritinophagy. Nature. 2014;509:105-9 pubmed publisher |
| de Luxán Delgado B, Caballero B, Potes Y, Rubio González A, Rodríguez I, Gutiérrez Rodríguez J, et al. Melatonin administration decreases adipogenesis in the liver of ob/ob mice through autophagy modulation. J Pineal Res. 2014;56:126-33 pubmed publisher |
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| Demirbag Sarikaya S, Akkoç Y, Turgut S, Erbil Bilir S, Kocaturk N, Dengjel J, et al. A novel ATG5 interaction with Ku70 potentiates DNA repair upon genotoxic stress. Sci Rep. 2022;12:8134 pubmed publisher |
| Mu Y, Maharjan Y, Kumar Dutta R, Wei X, Kim J, Son J, et al. Pharmacological inhibition of catalase induces peroxisome leakage and suppression of LPS induced inflammatory response in Raw 264.7 cell. PLoS ONE. 2021;16:e0245799 pubmed publisher |
| Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed publisher |
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| Liu S, Jiang Y, Ballou L, Zong W, Lin R. Activation of Gαq in Cardiomyocytes Increases Vps34 Activity and Stimulates Autophagy. J Cardiovasc Pharmacol. 2017;69:198-211 pubmed publisher |
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| Jin H, Hong S, Park J, Chang Y, Hong Y, Park I, et al. Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors. Sci Rep. 2016;6:28945 pubmed publisher |
| Dou Z, Xu C, Donahue G, Shimi T, Pan J, Zhu J, et al. Autophagy mediates degradation of nuclear lamina. Nature. 2015;527:105-9 pubmed publisher |
| Lapash Daniels C, Paffenroth E, Austin E, Glebov K, Lewis D, Walter J, et al. Lithium Decreases Glial Fibrillary Acidic Protein in a Mouse Model of Alexander Disease. PLoS ONE. 2015;10:e0138132 pubmed publisher |
| Yang H, Peng Y, Ni H, Li Y, Shi Y, Ding W, et al. Basal Autophagy and Feedback Activation of Akt Are Associated with Resistance to Metformin-Induced Inhibition of Hepatic Tumor Cell Growth. PLoS ONE. 2015;10:e0130953 pubmed publisher |
| Li P, Shi J, He Q, Hu Q, Wang Y, Zhang L, et al. Streptococcus pneumoniae induces autophagy through the inhibition of the PI3K-I/Akt/mTOR pathway and ROS hypergeneration in A549 cells. PLoS ONE. 2015;10:e0122753 pubmed publisher |
| Morgan M, Gamez G, Menke C, Hernandez A, Thorburn J, Gidan F, et al. Regulation of autophagy and chloroquine sensitivity by oncogenic RAS in vitro is context-dependent. Autophagy. 2014;10:1814-26 pubmed publisher |
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| Macvicar T, Lane J. Impaired OMA1-dependent cleavage of OPA1 and reduced DRP1 fission activity combine to prevent mitophagy in cells that are dependent on oxidative phosphorylation. J Cell Sci. 2014;127:2313-25 pubmed publisher |
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| Jang B, Choi B, Kim J, Kim M, Sohn M, Suh S. Impairment of autophagic flux promotes glucose reperfusion-induced neuro2A cell death after glucose deprivation. PLoS ONE. 2013;8:e76466 pubmed publisher |
| Chang M, Morgado M, Warren C, Hinton C, Farach Carson M, DELK N. p62/SQSTM1 is required for cell survival of apoptosis-resistant bone metastatic prostate cancer cell lines. Prostate. 2014;74:149-63 pubmed publisher |
| Tardif N, Klaude M, Lundell L, Thorell A, Rooyackers O. Autophagic-lysosomal pathway is the main proteolytic system modified in the skeletal muscle of esophageal cancer patients. Am J Clin Nutr. 2013;98:1485-92 pubmed publisher |
| B chir W, Maurin A, Carraro V, Averous J, Jousse C, Muranishi Y, et al. The eIF2?/ATF4 pathway is essential for stress-induced autophagy gene expression. Nucleic Acids Res. 2013;41:7683-99 pubmed publisher |
| Cabrera S, Fernández A, Mariño G, Aguirre A, Suarez M, Español Y, et al. ATG4B/autophagin-1 regulates intestinal homeostasis and protects mice from experimental colitis. Autophagy. 2013;9:1188-200 pubmed publisher |
| Betin V, Singleton B, Parsons S, Anstee D, Lane J. Autophagy facilitates organelle clearance during differentiation of human erythroblasts: evidence for a role for ATG4 paralogs during autophagosome maturation. Autophagy. 2013;9:881-93 pubmed publisher |
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| Vandergaast R, Fredericksen B. West Nile virus (WNV) replication is independent of autophagy in mammalian cells. PLoS ONE. 2012;7:e45800 pubmed publisher |
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| Lai A, McLaurin J. Inhibition of amyloid-beta peptide aggregation rescues the autophagic deficits in the TgCRND8 mouse model of Alzheimer disease. Biochim Biophys Acta. 2012;1822:1629-37 pubmed publisher |
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| Marchbank K, Waters S, Roberts R, Solomon E, Whitehouse C. MAP1B Interaction with the FW Domain of the Autophagic Receptor Nbr1 Facilitates Its Association to the Microtubule Network. Int J Cell Biol. 2012;2012:208014 pubmed publisher |
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| Levy J, Thorburn A. Modulation of pediatric brain tumor autophagy and chemosensitivity. J Neurooncol. 2012;106:281-90 pubmed publisher |
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