product summary
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company name :
Abnova
product type :
antibody
product name :
GCH1 monoclonal antibody (M01), clone 4A12
catalog :
H00002643-M01
quantity :
100 ug
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
4A12
reactivity :
human, mouse
application :
western blot, ELISA, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 9
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:500; loading ...; fig 4c
Xia N, Horke S, Habermeier A, Closs E, Reifenberg G, Gericke A, et al. Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice. Arterioscler Thromb Vasc Biol. 2016;36:78-85 pubmed publisher
Pickert G, Lim H, Weigert A, Häussler A, Myrczek T, Waldner M, et al. Inhibition of GTP cyclohydrolase attenuates tumor growth by reducing angiogenesis and M2-like polarization of tumor associated macrophages. Int J Cancer. 2013;132:591-604 pubmed publisher
Kröller Schön S, Schulz E, Wenzel P, Kleschyov A, Hortmann M, Torzewski M, et al. Differential effects of heart rate reduction with ivabradine in two models of endothelial dysfunction and oxidative stress. Basic Res Cardiol. 2011;106:1147-58 pubmed publisher
Schuhmacher S, Oelze M, Bollmann F, Kleinert H, Otto C, Heeren T, et al. Vascular dysfunction in experimental diabetes is improved by pentaerithrityl tetranitrate but not isosorbide-5-mononitrate therapy. Diabetes. 2011;60:2608-16 pubmed publisher
Teng R, Du J, Xu H, Bakhutashvili I, Eis A, Shi Y, et al. Sepiapterin improves angiogenesis of pulmonary artery endothelial cells with in utero pulmonary hypertension by recoupling endothelial nitric oxide synthase. Am J Physiol Lung Cell Mol Physiol. 2011;301:L334-45 pubmed publisher
Oelze M, Knorr M, Schuhmacher S, Heeren T, Otto C, Schulz E, et al. Vascular dysfunction in streptozotocin-induced experimental diabetes strictly depends on insulin deficiency. J Vasc Res. 2011;48:275-84 pubmed publisher
Seujange Y, Eiam Ong S, Tirawatnapong T, Eiam Ong S. Role of angiotensin II on dihydrofolate reductase, GTP-cyclohydrolase 1 and nitric oxide synthase expressions in renal ischemia-reperfusion. Am J Nephrol. 2008;28:692-700 pubmed publisher
Wenzel P, Daiber A, Oelze M, Brandt M, Closs E, Xu J, et al. Mechanisms underlying recoupling of eNOS by HMG-CoA reductase inhibition in a rat model of streptozotocin-induced diabetes mellitus. Atherosclerosis. 2008;198:65-76 pubmed
Widder J, Chen W, Li L, Dikalov S, Thony B, Hatakeyama K, et al. Regulation of tetrahydrobiopterin biosynthesis by shear stress. Circ Res. 2007;101:830-8 pubmed
product information
catalog id :
H00002643-M01
product name :
GCH1 monoclonal antibody (M01), clone 4A12
product description :
Mouse monoclonal antibody raised against a partial recombinant GCH1.
clone name :
4A12
isotype :
IgG2a Kappa
gene name :
GCH1
gene alias :
DYT14 DYT5 GCH GTP-CH-1 GTPCH1
gene description :
GTP cyclohydrolase 1
genbank accession :
NM_000161
immunogen :
GCH1 (NP_000152, 84 a.a. ~ 172 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
immunogen sequence protein sequence :
ENPQRQGLLKTPWRAASAMQFFTKGYQETISDVLNDAIF
DEDHDEMVIVKDIDMFSMCEHHLVPFVGKVHIGYLPNKQ
VLGLSKLARIV
protein accession :
NP_000152
storage buffer :
In 1x PBS, pH 7.4
storage instruction :
Store at -20 C or lower. Aliquot to avoid repeated freezing and thawing
quality control testing :
Antibody Reactive Against Recombinant Protein
type clonality :
Antibody
raised in host species :
Mouse
antigen species target species :
Human
species reactivity cross reactivity :
Human
application key :
WB-Tr,IP,S-ELISA,ELISA,WB-Re,WB-Ce,IHC-P
size :
100 ug
autodate :
10/10/06
updatetime :
11/15/13 18:29
more info or order :
company information
Abnova
9th Fl., No.108, Jhouzih St.
Neihu District. Taipei City
114 Taiwan
sales@abnova.com
https://www.abnova.com
877-853-6098