ATG5 Antibody (C-term) | Abcepta AP1812b product information

product summary

company name :

Abcepta

product type :

antibody

product name :

ATG5 Antibody (C-term)

catalog :

AP1812b

quantity :

0.1 mg

price :

235.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry

more info or order :

Abcepta product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 5	Zhang Q, Gao M, Zhang Y, Song Y, Cheng H, Zhou R. The germline-enriched Ppp1r36 promotes autophagy. Sci Rep. 2016;6:24609 pubmed publisher
	Al Zeer M, Al Younes H, Lauster D, Abu Lubad M, Meyer T. Autophagy restricts Chlamydia trachomatis growth in human macrophages via IFNG-inducible guanylate binding proteins. Autophagy. 2013;9:50-62 pubmed publisher

product information

Catalog Number :

AP1812b

Product Name :

ATG5 Antibody (C-term)

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary Antibody

Size :

0.1 mg

List Price :

235.00 USD

Clone :

RB12891

Isotype :

Rabbit Ig

Product Description :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

CrossReactivity :

Background :

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). APG4 is a cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.

ALTnames :

APG4B, AUTL1, MGC1353, APG4 autophagy 4 homolog B; AUT-like 1 cysteine endopeptidase; autophagin-1; autophagy-related cysteine endopeptidase 1; autophagy-related protein 4 homolog B; cysteine protease ATG4B; hAPG4B

Immunogen :

This ATG4B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 245~274 amino acids from amino acid residues surrounding G254 of human APG4B.

Buffer :

This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from amino acid residues surrounding G254 of human APG4B.

Concentration :

0.25 mg/ml

Application Summary :

WB, IHC, E

Storage :

Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.

more info or order :

Abcepta product webpage