Cleaved LC3A Antibody | Abcepta AP1805a product information

product summary

company name :

Abcepta

product type :

antibody

product name :

Cleaved LC3A Antibody

catalog :

AP1805a

quantity :

0.1 mg

price :

235.00 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, bovine

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Abcepta product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; human; 1:100; loading ...; fig 5b	Jacquin E, Leclerc Mercier S, Judon C, Blanchard E, Fraitag S, Florey O. Pharmacological modulators of autophagy activate a parallel noncanonical pathway driving unconventional LC3 lipidation. Autophagy. 2017;13:854-867 pubmed publisher
	Whelan K, Chandramouleeswaran P, Tanaka K, Natsuizaka M, Guha M, Srinivasan S, et al. Autophagy supports generation of cells with high CD44 expression via modulation of oxidative stress and Parkin-mediated mitochondrial clearance. Oncogene. 2017;36:4843-4858 pubmed publisher
	Tavera Mendoza L, Westerling T, Libby E, Marusyk A, Cato L, Cassani R, et al. Vitamin D receptor regulates autophagy in the normal mammary gland and in luminal breast cancer cells. Proc Natl Acad Sci U S A. 2017;114:E2186-E2194 pubmed publisher
	Tazi M, Dakhlallah D, Caution K, Gerber M, Chang S, Khalil H, et al. Elevated Mirc1/Mir17-92 cluster expression negatively regulates autophagy and CFTR (cystic fibrosis transmembrane conductance regulator) function in CF macrophages. Autophagy. 2016;12:2026-2037 pubmed

product information

Catalog Number :

AP1805a

Product Name :

Cleaved LC3A Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Product Type :

Primary Antibody

Size :

0.1 mg

List Price :

235.00 USD

Clone :

RB11841

Isotype :

Rabbit Ig

Product Description :

Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)

CrossReactivity :

Background :

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3a is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

ALTnames :

MAP1LC3A, microtubule-associated protein 1 light chain 3 alpha, RP11-346K17.1, LC3, LC3A, MAP1ALC3, MAP1BLC3, MAP1 light chain 3-like protein 1; MAP1A/1B light chain 3 A; MAP1A/MAP1B LC3 A; MAP1A/MAP1B light chain 3 A; OTTHUMP00000030698; autophagy-related protein LC3 A; autophagy-related ubiquitin-like modifier LC3 A; microtubule-associated proteins 1A/1B light chain 3; microtubule-associated proteins 1A/1B light chain 3A

Immunogen :

This LC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 22~51 amino acids from the N-terminal region of human LC3 (APG8a).

Buffer :

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Concentration :

0.25 mg/ml

Application Summary :

WB, IHC, E

Storage :

Maintain refrigerated at 2-8 deg C for up to 6 months. For long term storage store at -20 deg C in small aliquots to prevent freeze-thaw cycles.

more info or order :

Abcepta product webpage