This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-activated Notch1 antibody
catalog :
ab8925
quantity :
200 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other
citations: 36
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:600; loading ...; fig 3c
Ding X, Hu H, Huang K, Wei R, Min J, Qi C, et al. Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma. Cancer Sci. 2020;111:489-501 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1a
  • western blot; human; loading ...; fig s2c, s2d, s2e, s2f
Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, et al. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019;18:156 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 5e
Duhachek Muggy S, Bhat K, Medina P, Cheng F, He L, Alli C, et al. Radiation Mitigation of the Intestinal Acute Radiation Injury in Mice by 1-[(4-Nitrophenyl)Sulfonyl]-4-Phenylpiperazine. Stem Cells Transl Med. 2019;: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Wu K, Zou J, Lin C, Jie Z. MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling. Biosci Rep. 2019;: pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4o
Nakagawa N, Li J, Yabuno Nakagawa K, Eom T, Cowles M, Mapp T, et al. APC sets the Wnt tone necessary for cerebral cortical progenitor development. Genes Dev. 2017;31:1679-1692 pubmed publisher
  • other; mouse; loading ...; fig 6f
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5c
Zhu X, Yuan X, Wang M, Fang Y, Liu Y, Zhang X, et al. A Wnt/Notch/Pax7 signaling network supports tissue integrity in tongue development. J Biol Chem. 2017;292:9409-9419 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 7a
Delhove J, Buckley S, Perocheau D, Karda R, Arbuthnot P, Henderson N, et al. Longitudinal in vivo bioimaging of hepatocyte transcription factor activity following cholestatic liver injury in mice. Sci Rep. 2017;7:41874 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2a
  • western blot; human; loading ...; fig 2c
García Heredia J, Lucena Cacace A, Verdugo Sivianes E, Pérez M, Carnero A. The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB. Clin Cancer Res. 2017;23:3871-3883 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 7e
Yue F, Bi P, Wang C, Shan T, Nie Y, Ratliff T, et al. Pten is necessary for the quiescence and maintenance of adult muscle stem cells. Nat Commun. 2017;8:14328 pubmed publisher
  • western blot; rat; fig 4a
Li F, Li Z, Jiang Z, Tian Y, Wang Z, Yi W, et al. Enhancement of early cardiac differentiation of dedifferentiated fat cells by dimethyloxalylglycine via notch signaling pathway. Am J Transl Res. 2016;8:4791-4801 pubmed
  • immunohistochemistry; rat; 1:1000; fig 5
Zhang S, Wang P, Ren L, Hu C, Bi J. Protective effect of melatonin on soluble A?1-42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus. Alzheimers Res Ther. 2016;8:40 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 4a
  • western blot; mouse; loading ...; fig 1h
Bi P, Yue F, Karki A, Castro B, Wirbisky S, Wang C, et al. Notch activation drives adipocyte dedifferentiation and tumorigenic transformation in mice. J Exp Med. 2016;213:2019-37 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 1
Li Z, Hodgkinson T, Gothard E, Boroumand S, Lamb R, Cummins I, et al. Epidermal Notch1 recruits RORγ(+) group 3 innate lymphoid cells to orchestrate normal skin repair. Nat Commun. 2016;7:11394 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 1g
  • western blot; rat; 1:500; fig 4c
Del Debbio C, Mir Q, Parameswaran S, Mathews S, Xia X, Zheng L, et al. Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1. PLoS ONE. 2016;11:e0152025 pubmed publisher
  • western blot; mouse; fig 1
Liu B, Ma A, Zhang F, Wang Y, Li Z, Li Q, et al. MAZ mediates the cross-talk between CT-1 and NOTCH1 signaling during gliogenesis. Sci Rep. 2016;6:21534 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 8
  • immunocytochemistry; human; 1:100; fig 1
  • western blot; human; 1:250; fig 1
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies F, et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun. 2016;7:10533 pubmed publisher
Jung E, Osswald M, Ratliff M, Dogan H, Xie R, Weil S, et al. Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma. Nat Commun. 2021;12:1014 pubmed publisher
Ni X, Zhang Y, Jia L, Lu W, Zhu Q, Ren J, et al. Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway. Aging (Albany NY). 2021;13:5164-5184 pubmed publisher
Jiang H, Li X, Wang W, Dong H. Long non-coding RNA SNHG3 promotes breast cancer cell proliferation and metastasis by binding to microRNA-154-3p and activating the notch signaling pathway. BMC Cancer. 2020;20:838 pubmed publisher
Tsai I, Adams K, Tzeng J, Shennib O, Tan P, Katsanis N. Genome-wide suppressor screen identifies USP35/USP38 as therapeutic candidates for ciliopathies. JCI Insight. 2019;4: pubmed publisher
Luque Molina I, Shi Y, Abdullah Y, Monaco S, Hölzl Wenig G, Mandl C, et al. The Orphan Nuclear Receptor TLX Represses Hes1 Expression, Thereby Affecting NOTCH Signaling and Lineage Progression in the Adult SEZ. Stem Cell Reports. 2019;: pubmed publisher
Liu Z, Tu H, Kang Y, Xue Y, Ma D, Zhao C, et al. Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish. Nat Commun. 2019;10:1839 pubmed publisher
Wang J, Xu S, Duan J, Yi L, Guo Y, Shi Y, et al. Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1-SOX2 positive-feedback loop. Nat Neurosci. 2019;22:91-105 pubmed publisher
Dökümcü K, Simonian M, Farahani R. miR4673 improves fitness profile of neoplastic cells by induction of autophagy. Cell Death Dis. 2018;9:1068 pubmed publisher
Gharibeh L, Komati H, Bosse Y, Boodhwani M, Heydarpour M, Fortier M, et al. GATA6 Regulates Aortic Valve Remodeling and its Haploinsufficiency Leads to RL-Type Bicuspid Aortic Valve. Circulation. 2018;: pubmed publisher
Khan O, Carvalho J, Spencer Dene B, Mitter R, Frith D, Snijders A, et al. The deubiquitinase USP9X regulates FBW7 stability and suppresses colorectal cancer. J Clin Invest. 2018;128:1326-1337 pubmed publisher
Simón Carrasco L, Grana O, Salmón M, Jacob H, Gutierrez A, Jiménez G, et al. Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma. Genes Dev. 2017;31:1456-1468 pubmed publisher
Yang X, Yang S, Wang C, Kuang S. The hypoxia-inducible factors HIF1α and HIF2α are dispensable for embryonic muscle development but essential for postnatal muscle regeneration. J Biol Chem. 2017;292:5981-5991 pubmed publisher
Zhong Y, Shen S, Zhou Y, Mao F, Lin Y, Guan J, et al. NOTCH1 is a poor prognostic factor for breast cancer and is associated with breast cancer stem cells. Onco Targets Ther. 2016;9:6865-6871 pubmed
Liu Z, Fu Q, Fu H, Wang Z, Xu L, An H, et al. A three-molecule score based on Notch pathway predicts poor prognosis in non-metastasis clear cell renal cell carcinoma. Oncotarget. 2016;7:68559-68570 pubmed publisher
Liu Y, Wang S, Long Y, Chen S, Li Y, Zhang J. KRASG12 mutant induces the release of the WSTF/NRG3 complex, and contributes to an oncogenic paracrine signaling pathway. Oncotarget. 2016;7:53153-53164 pubmed publisher
Dou G, Li N, Chang T, Zhang P, Gao X, Yan X, et al. Myeloid-Specific Blockade of Notch Signaling Attenuates Choroidal Neovascularization through Compromised Macrophage Infiltration and Polarization in Mice. Sci Rep. 2016;6:28617 pubmed publisher
Miller S, Perera S, Benito C, Stott S, Baker C. Evidence for a Notch1-mediated transition during olfactory ensheathing cell development. J Anat. 2016;229:369-83 pubmed publisher
Boareto M, Jolly M, Goldman A, Pietila M, Mani S, Sengupta S, et al. Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype. J R Soc Interface. 2016;13: pubmed publisher
Merrill M, Edwards N, Lonser R. Notch receptor and effector expression in von Hippel-Lindau disease-associated central nervous system hemangioblastomas. J Neurosurg. 2011;115:512-7 pubmed publisher
Niimi H, Pardali K, Vanlandewijck M, Heldin C, Moustakas A. Notch signaling is necessary for epithelial growth arrest by TGF-beta. J Cell Biol. 2007;176:695-707 pubmed
product information
CatalogNumber :
ab8925
ItemName :
Anti-activated Notch1 antibody
Category :
Antibody
Host :
Rabbit
Clonality :
Polyclonal
Conjugate :
Unconjugated
Size :
200 µl
SpeciesSummary :
Hu, Ms
Application Summary :
Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK