product summary
request information :
company name :
Abcam
other brands :
Ascent Scientific
product type :
antibody
product name :
Bcl2 antibody
catalog :
ab7973
quantity :
1 ml
clonality :
polyclonal
host :
rabbit
reactivity :
human, mouse, rat, cow
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
publications citing this reagent :
total: 45
  1. Laothong U, Hiraku Y, Oikawa S, Intuyod K, Murata M, Pinlaor S. Melatonin induces apoptosis in cholangiocarcinoma cell lines by activating the reactive oxygen species-mediated mitochondrial pathway. Oncol Rep. 2015;33:1443-9 pubmed publisher
  2. rat (western blot)
    Bharti S, Rani N, Bhatia J, Arya D. 5-HT2B receptor blockade attenuates β-adrenergic receptor-stimulated myocardial remodeling in rats via inhibiting apoptosis: role of MAPKs and HSPs. Apoptosis. 2015;20:455-65 pubmed publisher
  3. Li A, Yang Q, Yang K. miR-133a mediates the hypoxia-induced apoptosis by inhibiting TAGLN2 expression in cardiac myocytes. Mol Cell Biochem. 2015;400:173-81 pubmed publisher
  4. Liu Y, Zhao L, Ju Y, Li W, Zhang M, Jiao Y, et al. A novel androstenedione derivative induces ROS-mediated autophagy and attenuates drug resistance in osteosarcoma by inhibiting macrophage migration inhibitory factor (MIF). Cell Death Dis. 2014;5:e1361 pubmed publisher
  5. human (western blot)
    Zhao X, Gao S, Ren H, Huang H, Ji W, Hao J. Inhibition of autophagy strengthens celastrol-induced apoptosis in human pancreatic cancer in vitro and in vivo models. Curr Mol Med. 2014;14:555-63 pubmed
  6. mouse (western blot(1:1000))
    Bhattacharyya S, Ghosh S, Sil P. Amelioration of aspirin induced oxidative impairment and apoptotic cell death by a novel antioxidant protein molecule isolated from the herb Phyllanthus niruri. PLoS ONE. 2014;9:e89026 pubmed publisher
  7. He Y, Wang N, Shen Y, Zheng Z, Xu X. Inhibition of high glucose-induced apoptosis by uncoupling protein 2 in human umbilical vein endothelial cells. Int J Mol Med. 2014;33:1275-81 pubmed publisher
  8. Wang C, Yang A, Zhang B, Yin Q, Huang H, Chen M, et al. PANC-1 pancreatic cancer cell growth inhibited by cucurmosin alone and in combination with an epidermal growth factor receptor-targeted drug. Pancreas. 2014;43:291-7 pubmed publisher
  9. Zhang P, Pan H, Wang J, Liu X, Hu X. Telomerase activity-independent function of telomerase reverse transcriptase is involved in acrylamide-induced neuron damage. Biotech Histochem. 2014;89:327-35 pubmed publisher
  10. rat (western blot)
    Lu H, Zhang L, Wang S, Wang W, Zhao B. The study of the Oxytropis kansuensis-induced apoptotic pathway in the cerebrum of SD rats. BMC Vet Res. 2013;9:217 pubmed publisher
more info or order :
product information
Catalog Number :
ab7973
Product Name :
Bcl2 antibody
Host Species :
Rabbit
Clonality :
polyclonal
Product Type :
Primary antibodies
Size :
1 ml
SwissProtID :
P10415
Isotype :
IgG
CrossReactivity :
Reacts with: Human, Mouse, Rat, Cow.
Application Summary :
ICC, IHC-Fr, IHC-P, IP, WB
publications citing this reagent :
  1. Zheng L, Zhu K, Jiao H, Zhao Z, Zhang L, Liu M, et al. PTHrP expression in human MDA-MB-231 breast cancer cells is critical for tumor growth and survival and osteoblast inhibition. Int J Biol Sci. 2013;9:830-41 pubmed publisher
  2. Xie J, Wang C, Zhang B, Yang A, Yin Q, Huang H, et al. Cucurmosin induces the apoptosis of human pancreatic cancer CFPAC-1 cells by inactivating the PDGFR-β signalling pathway. Pharmacol Rep. 2013;65:682-8 pubmed
  3. Wang X, Chen Y, Zuo X, Ding N, Zeng H, Zou X, et al. Microcystin (-LR) induced testicular cell apoptosis via up-regulating apoptosis-related genes in vivo. Food Chem Toxicol. 2013;60:309-17 pubmed publisher
  4. Zhang Y, Wang L. Characterization of the mitochondrial localization of the nuclear receptor SHP and regulation of its subcellular distribution by interaction with Bcl2 and HNF4α. PLoS ONE. 2013;8:e68491 pubmed publisher
  5. Montagnaro S, Ciarcia R, de Martinis C, Pacilio C, Sasso S, Puzio M, et al. Modulation of apoptosis by caprine herpesvirus 1 infection in a neuronal cell line. J Cell Biochem. 2013;114:2809-22 pubmed publisher
  6. Bhattacharyya S, Pal P, Sil P. A 35 kD Phyllanthus niruri protein modulates iron mediated oxidative impairment to hepatocytes via the inhibition of ERKs, p38 MAPKs and activation of PI3k/Akt pathway. Food Chem Toxicol. 2013;56:119-30 pubmed publisher
  7. Hwang I, Kim J, Lee Y, Kwak M, Choi Y, Kang B, et al. Protective effects of gomisin A isolated from Schisandra chinensis against CCl(4)-induced hepatic and renal injury. Int J Mol Med. 2013;31:888-98 pubmed publisher
  8. Chen F, Liu Q, Zhang Z, Zhu X. Co-delivery of G-CSF and EPO released from fibrin gel for therapeutic neovascularization in rat hindlimb ischemia model. Microcirculation. 2013;20:416-24 pubmed publisher
  9. human (western blot)
    Al-Zoubi M, Salem A, Martinez-Outschoorn U, Whitaker-Menezes D, Lamb R, Hulit J, et al. Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo. Cell Cycle. 2013;12:480-90 pubmed publisher
  10. human (western blot)
    Wang Y, Wang M, Luo Y, Shen Y, Wei Z. Lentivirus-mediated shRNA interference targeting SLUG inhibits lung cancer growth and metastasis. Asian Pac J Cancer Prev. 2012;13:4947-51 pubmed
  11. Sanchez A, Tripathy D, Luo J, Yin X, Martinez J, Grammas P. Neurovascular unit and the effects of dosage in VEGF toxicity: role for oxidative stress and thrombin. J Alzheimers Dis. 2013;34:281-91 pubmed publisher
  12. Xie J, Wang C, Yang A, Zhang B, Yin Q, Huang H, et al. Cucurmosin kills human pancreatic cancer SW-1990 cells in vitro and in vivo. Anticancer Agents Med Chem. 2013;13:952-6 pubmed
  13. Zhai C, Zhang M, Zhang Y, Xu H, Wang J, An G, et al. Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway. Acta Pharmacol Sin. 2012;33:1477-87 pubmed publisher
  14. Moghtadaei M, Habibey R, Ajami M, Soleimani M, Ebrahimi S, Pazoki-Toroudi H. Skeletal muscle post-conditioning by diazoxide, anti-oxidative and anti-apoptotic mechanisms. Mol Biol Rep. 2012;39:11093-103 pubmed publisher
  15. Farahini H, Habibey R, Ajami M, Davoodi S, Azad N, Soleimani M, et al. Late anti-apoptotic effect of K(ATP) channel opening in skeletal muscle. Clin Exp Pharmacol Physiol. 2012;39:909-16 pubmed publisher
  16. Ajami M, Davoodi S, Habibey R, Namazi N, Soleimani M, Pazoki-Toroudi H. Effect of DHA+EPA on oxidative stress and apoptosis induced by ischemia-reperfusion in rat kidneys. Fundam Clin Pharmacol. 2013;27:593-602 pubmed publisher
  17. Sun J, Xie C, Liu W, Lu D, Qiao W, Huang Q, et al. The effects of simvastatin on hippocampal caspase-3 and Bcl-2 expression following kainate-induced seizures in rats. Int J Mol Med. 2012;30:739-46 pubmed publisher
  18. Bhattacharyya S, Ghosh J, Sil P. Iron induces hepatocytes death via MAPK activation and mitochondria-dependent apoptotic pathway: beneficial role of glycine. Free Radic Res. 2012;46:1296-307 pubmed publisher
  19. Hacioglu G, Seval-Celik Y, Tanriover G, Ozsoy O, Saka-Topcuoglu E, Balkan S, et al. Docosahexaenoic acid provides protective mechanism in bilaterally MPTP-lesioned rat model of Parkinson's disease. Folia Histochem Cytobiol. 2012;50:228-38 pubmed
  20. Jing C, Wang L, Liu P, Wu C, Ruan D, Chen G. Autophagy activation is associated with neuroprotection against apoptosis via a mitochondrial pathway in a rat model of subarachnoid hemorrhage. Neuroscience. 2012;213:144-53 pubmed publisher
  21. Jones K, Salah Z, Del Mare S, Galasso M, Gaudio E, Nuovo G, et al. miRNA signatures associate with pathogenesis and progression of osteosarcoma. Cancer Res. 2012;72:1865-77 pubmed publisher
  22. Sanchez A, Tripathy D, Yin X, Luo J, Martinez J, Grammas P. Pigment epithelium-derived factor (PEDF) protects cortical neurons in vitro from oxidant injury by activation of extracellular signal-regulated kinase (ERK) 1/2 and induction of Bcl-2. Neurosci Res. 2012;72:1-8 pubmed publisher
  23. Kelsen S, Hall J, Chade A. Endothelin-A receptor blockade slows the progression of renal injury in experimental renovascular disease. Am J Physiol Renal Physiol. 2011;301:F218-25 pubmed publisher
  24. Salvetti N, Stangaferro M, Palomar M, Alfaro N, Rey F, Gimeno E, et al. Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Anim Reprod Sci. 2010;122:98-110 pubmed publisher
  25. Sanchez A, Wadhwani S, Grammas P. Multiple neurotrophic effects of VEGF on cultured neurons. Neuropeptides. 2010;44:323-31 pubmed publisher
  26. Sahin K, Akdemir F, Tuzcu M, Sahin N, Onderci M, Ozercan R, et al. Genistein suppresses spontaneous oviduct tumorigenesis in quail. Nutr Cancer. 2009;61:799-806 pubmed publisher
  27. Beilke L, Aleksunes L, Olson E, Besselsen D, Klaassen C, Dvorak K, et al. Decreased apoptosis during CAR-mediated hepatoprotection against lithocholic acid-induced liver injury in mice. Toxicol Lett. 2009;188:38-44 pubmed publisher
  28. Lepsch L, Munhoz C, Kawamoto E, Yshii L, Lima L, Curi-Boaventura M, et al. Cocaine induces cell death and activates the transcription nuclear factor kappa-B in PC12 cells. Mol Brain. 2009;2:3 pubmed publisher
  29. Benadiba M, Miyake J, Colquhoun A. Gamma-linolenic acid alters Ku80, E2F1, and bax expression and induces micronucleus formation in C6 glioma cells in vitro. IUBMB Life. 2009;61:244-51 pubmed
  30. Sanchez A, Rao H, Grammas P. PACAP38 protects rat cortical neurons against the neurotoxicity evoked by sodium nitroprusside and thrombin. Regul Pept. 2009;152:33-40 pubmed publisher
  31. Brito P, Simões N, Almeida L, Dinis T. Resveratrol disrupts peroxynitrite-triggered mitochondrial apoptotic pathway: a role for Bcl-2. Apoptosis. 2008;13:1043-53 pubmed publisher
  32. Desai A, Zhao Y, Warren J. Development of atherosclerosis in Balb/c apolipoprotein E-deficient mice. Cardiovasc Pathol. 2008;17:233-40 pubmed publisher
  33. Dufour C, Holy X, Marie P. Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab. 2008;294:E794-801 pubmed publisher
  34. Stathopoulos G, Sherrill T, Cheng D, Scoggins R, Han W, Polosukhin V, et al. Epithelial NF-kappaB activation promotes urethane-induced lung carcinogenesis. Proc Natl Acad Sci U S A. 2007;104:18514-9 pubmed
  35. Murray F, Hutson P. Hippocampal Bcl-2 expression is selectively increased following chronic but not acute treatment with antidepressants, 5-HT(1A) or 5-HT(2C/2B) receptor antagonists. Eur J Pharmacol. 2007;569:41-7 pubmed
more info or order :
company information
Abcam
330 Cambridge Science Park
Cambridge
CB4 0FL UK
orders@abcam.com
44 (0)1223 696000

1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
us.orders@abcam.com
617 225 2272, 888-77-ABCAM (22226)

www.abcam.com
888-7722226
headquarters: UK