This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Insulin antibody
catalog :
ab7842
quantity :
250 µl
clonality :
polyclonal
host :
guinea-pigs
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 44
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; loading ...
Viloria K, Nasteska D, Briant L, Heising S, Larner D, Fine N, et al. Vitamin-D-Binding Protein Contributes to the Maintenance of α Cell Function and Glucagon Secretion. Cell Rep. 2020;31:107761 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig 1a
Zhu K, Lai Y, Cao H, Bai X, Liu C, Yan Q, et al. Kindlin-2 modulates MafA and β-catenin expression to regulate β-cell function and mass in mice. Nat Commun. 2020;11:484 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 2b
Zhang Y, Parajuli K, Fava G, Gupta R, Xu W, Nguyen L, et al. GLP-1 Receptor in Pancreatic α-Cells Regulates Glucagon Secretion in a Glucose-Dependent Bidirectional Manner. Diabetes. 2019;68:34-44 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig st1
Biggs E, Liang L, Naylor J, Madalli S, Collier R, Coghlan M, et al. Development and characterisation of a novel glucagon like peptide-1 receptor antibody. Diabetologia. 2018;61:711-721 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 2a
Murao N, Yokoi N, Honda K, Han G, Hayami T, Gheni G, et al. Essential roles of aspartate aminotransferase 1 and vesicular glutamate transporters in β-cell glutamate signaling for incretin-induced insulin secretion. PLoS ONE. 2017;12:e0187213 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 3d
Yamaguchi T, Sato H, Kato Itoh M, Goto T, Hara H, Sanbo M, et al. Interspecies organogenesis generates autologous functional islets. Nature. 2017;542:191-196 pubmed publisher
  • immunocytochemistry; human; fig 2i
Chandravanshi B, Bhonde R. Shielding Engineered Islets With Mesenchymal Stem Cells Enhance Survival Under Hypoxia. J Cell Biochem. 2017;118:2672-2683 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2
Graus Nunes F, Marinho T, Barbosa da Silva S, Aguila M, Mandarim de Lacerda C, Souza Mello V. Differential effects of angiotensin receptor blockers on pancreatic islet remodelling and glucose homeostasis in diet-induced obese mice. Mol Cell Endocrinol. 2017;439:54-64 pubmed publisher
  • immunohistochemistry; human; fig 2D
Muraro M, Dharmadhikari G, Grün D, Groen N, Dielen T, Jansen E, et al. A Single-Cell Transcriptome Atlas of the Human Pancreas. Cell Syst. 2016;3:385-394.e3 pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig s3a
Yan S, Du F, Wu L, Zhang Z, Zhong C, Yu Q, et al. F1F0 ATP Synthase-Cyclophilin D Interaction Contributes to Diabetes-Induced Synaptic Dysfunction and Cognitive Decline. Diabetes. 2016;65:3482-3494 pubmed
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 7b
Grün D, Muraro M, Boisset J, Wiebrands K, Lyubimova A, Dharmadhikari G, et al. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data. Cell Stem Cell. 2016;19:266-277 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4c
Roth Flach R, Danai L, DiStefano M, Kelly M, Menendez L, Jurczyk A, et al. Protein Kinase Mitogen-activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Promotes Obesity-induced Hyperinsulinemia. J Biol Chem. 2016;291:16221-30 pubmed publisher
  • immunohistochemistry; mouse; 1:200; fig 4
Choudhury S, Fitzpatrick Z, Harris A, Maitland S, Ferreira J, Zhang Y, et al. In Vivo Selection Yields AAV-B1 Capsid for Central Nervous System and Muscle Gene Therapy. Mol Ther. 2016;24:1247-57 pubmed publisher
  • immunohistochemistry; mouse; 1:150; loading ...; fig 5b
Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, et al. Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. Diabetologia. 2016;59:1533-1541 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Singhal G, Fisher F, Chee M, Tan T, El Ouaamari A, Adams A, et al. Fibroblast Growth Factor 21 (FGF21) Protects against High Fat Diet Induced Inflammation and Islet Hyperplasia in Pancreas. PLoS ONE. 2016;11:e0148252 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 2
Vegas A, Veiseh O, Gürtler M, Millman J, Pagliuca F, Bader A, et al. Long-term glycemic control using polymer-encapsulated human stem cell-derived beta cells in immune-competent mice. Nat Med. 2016;22:306-11 pubmed publisher
Krüger C, Waldeck Weiermair M, Kaynert J, Pokrant T, Komaragiri Y, Otto O, et al. AQP8 is a crucial H2O2 transporter in insulin-producing RINm5F cells. Redox Biol. 2021;43:101962 pubmed publisher
Martinez Valbuena I, Valenti Azcarate R, Amat Villegas I, Marcilla I, Martí Andrés G, Caballero M, et al. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathol Commun. 2021;9:64 pubmed publisher
Zhao Q, Zhou J, Pan Y, Ju H, Zhu L, Liu Y, et al. The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body 18F-FDG PET/CT study. Acta Diabetol. 2020;57:1383-1393 pubmed publisher
Kim H, Kim D, Yoon H, Choi C, Oh Y, Jun H. Prevention of Oxidative Stress-Induced Pancreatic Beta Cell Damage by Broussonetia Kazinoki Siebold Fruit Extract Via the ERK-Nox4 Pathway. Antioxidants (Basel). 2020;9: pubmed publisher
Zhu L, Zhong Q, Yang T, Xiao X. Improved therapeutic effects on diabetic foot by human mesenchymal stem cells expressing MALAT1 as a sponge for microRNA-205-5p. Aging (Albany NY). 2019;11:12236-12245 pubmed publisher
Azzarelli R, Rulands S, Nestorowa S, Davies J, Campinoti S, Gillotin S, et al. Neurogenin3 phosphorylation controls reprogramming efficiency of pancreatic ductal organoids into endocrine cells. Sci Rep. 2018;8:15374 pubmed publisher
Li Z, Li Y, Overstreet J, Chung S, Niu A, Fan X, et al. Inhibition of Epidermal Growth Factor Receptor Activation Is Associated With Improved Diabetic Nephropathy and Insulin Resistance in Type 2 Diabetes. Diabetes. 2018;67:1847-1857 pubmed publisher
Ruiz L, Gurlo T, Ravier M, Wojtusciszyn A, Mathieu J, Brown M, et al. Proteasomal degradation of the histone acetyl transferase p300 contributes to beta-cell injury in a diabetes environment. Cell Death Dis. 2018;9:600 pubmed publisher
Grote C, Wilson N, Katz N, Guilford B, Ryals J, Novikova L, et al. Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels. Exp Neurol. 2018;305:97-107 pubmed publisher
Lee J, Shanina I, Chu Y, Horwitz M, Johnson J. Carbamazepine, a beta-cell protecting drug, reduces type 1 diabetes incidence in NOD mice. Sci Rep. 2018;8:4588 pubmed publisher
Kong Y, Sharma R, Ly S, Stamateris R, Jesdale W, Alonso L. CDKN2A/B T2D Genome-Wide Association Study Risk SNPs Impact Locus Gene Expression and Proliferation in Human Islets. Diabetes. 2018;67:872-884 pubmed publisher
Katoh M, Jung Y, Ugboma C, Shimbo M, Kuno A, Basha W, et al. MafB Is Critical for Glucagon Production and Secretion in Mouse Pancreatic α Cells In Vivo. Mol Cell Biol. 2018;38: pubmed publisher
Siniscalco D, Trotta M, Brigida A, Maisto R, Luongo M, Ferraraccio F, et al. Intraperitoneal Administration of Oxygen/Ozone to Rats Reduces the Pancreatic Damage Induced by Streptozotocin. Biology (Basel). 2018;7: pubmed publisher
Liao H, Hatanaka F, Araoka T, Reddy P, Wu M, Sui Y, et al. In Vivo Target Gene Activation via CRISPR/Cas9-Mediated Trans-epigenetic Modulation. Cell. 2017;171:1495-1507.e15 pubmed publisher
Fan J, Wang Y, Liu L, Zhang H, Zhang F, Shi L, et al. cTAGE5 deletion in pancreatic β cells impairs proinsulin trafficking and insulin biogenesis in mice. J Cell Biol. 2017;216:4153-4164 pubmed publisher
Ludwig B, Ludwig S, Steffen A, Knauf Y, Zimerman B, Heinke S, et al. Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes. Proc Natl Acad Sci U S A. 2017;114:11745-11750 pubmed publisher
Widjaja Adhi M, Palczewski G, Dale K, Knauss E, Kelly M, Golczak M, et al. Transcription factor ISX mediates the cross talk between diet and immunity. Proc Natl Acad Sci U S A. 2017;114:11530-11535 pubmed publisher
Rodriguez Rodriguez P, Sandebring Matton A, Merino Serrais P, Parrado Fernandez C, Rabano A, Winblad B, et al. Tau hyperphosphorylation induces oligomeric insulin accumulation and insulin resistance in neurons. Brain. 2017;: pubmed publisher
Harrington S, Williams S, Otte V, Barchman S, Jones C, Ramachandran K, et al. Improved yield of canine islet isolation from deceased donors. BMC Vet Res. 2017;13:264 pubmed publisher
Babinsky V, Hannan F, Ramracheya R, Zhang Q, Nesbit M, Hugill A, et al. Mutant Mice With Calcium-Sensing Receptor Activation Have Hyperglycemia That Is Rectified by Calcilytic Therapy. Endocrinology. 2017;158:2486-2502 pubmed publisher
Carrasco Pozo C, Tan K, Reyes Farias M, De La Jara N, Ngo S, Garcia Diaz D, et al. The deleterious effect of cholesterol and protection by quercetin on mitochondrial bioenergetics of pancreatic ?-cells, glycemic control and inflammation: In vitro and in vivo studies. Redox Biol. 2016;9:229-243 pubmed publisher
Ku S, Sung S, Choung J, Choi J, Shin Y, Kim J. Anti-obesity and anti-diabetic effects of a standardized potato extract in ob/ob mice. Exp Ther Med. 2016;12:354-364 pubmed
Zha J, Chi X, Yu X, Liu X, Liu D, Zhu J, et al. Interleukin-1β-Targeted Vaccine Improves Glucose Control and β-Cell Function in a Diabetic KK-Ay Mouse Model. PLoS ONE. 2016;11:e0154298 pubmed publisher
Walls G, Stevenson M, Soukup B, Lines K, Grossman A, Schmid H, et al. Pasireotide Therapy of Multiple Endocrine Neoplasia Type 1-Associated Neuroendocrine Tumors in Female Mice Deleted for an Men1 Allele Improves Survival and Reduces Tumor Progression. Endocrinology. 2016;157:1789-98 pubmed publisher
Molven A, Hollister Lock J, Hu J, Martinez R, Njølstad P, Liew C, et al. The Hypoglycemic Phenotype Is Islet Cell-Autonomous in Short-Chain Hydroxyacyl-CoA Dehydrogenase-Deficient Mice. Diabetes. 2016;65:1672-8 pubmed publisher
Farhat B, Almelkar A, Ramachandran K, Williams S, Huang H, Zamierowksi D, et al. Small human islets comprised of more β-cells with higher insulin content than large islets. Islets. 2013;5:87-94 pubmed publisher
Bramswig N, Everett L, Schug J, Dorrell C, Liu C, Luo Y, et al. Epigenomic plasticity enables human pancreatic ? to ? cell reprogramming. J Clin Invest. 2013;123:1275-84 pubmed publisher
Huang H, Novikova L, Williams S, Smirnova I, Stehno Bittel L. Low insulin content of large islet population is present in situ and in isolated islets. Islets. 2011;3:6-13 pubmed publisher
product information
CatalogNumber :
ab7842
ItemName :
Anti-Insulin antibody
Product Type :
Antibody
Host Species :
Guinea pig
Clonality :
Polyclonal
Conjugate :
Unconjugated
Size :
250 µl
SpeciesSummary :
Hu, Ms, Other, Rat, SHm
Application Summary :
Flow Cyt, ICC/IF, IHC-FoFr, IHC-Fr, IHC-P, IP
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK