This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-ZO1 tight junction protein antibody
catalog :
ab59720
quantity :
50 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog, chicken, pig
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, reverse phase protein lysate microarray
citations: 31
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:200; fig 8a
Xu X, Zhu Q, Zhang R, Wang Y, Niu F, Wang W, et al. ITRAQ-Based Proteomics Analysis of Acute Lung Injury Induced by Oleic Acid in Mice. Cell Physiol Biochem. 2017;44:1949-1964 pubmed publisher
  • western blot; mouse; 1:80; loading ...; fig 7c
Van Hove I, Lefevere E, De Groef L, Sergeys J, Salinas Navarro M, Libert C, et al. MMP-3 Deficiency Alleviates Endotoxin-Induced Acute Inflammation in the Posterior Eye Segment. Int J Mol Sci. 2016;17: pubmed
  • western blot; mouse; fig 6
Pang J, Wu Y, Peng J, Yang P, Kuai L, Qin X, et al. Potential implications of Apolipoprotein E in early brain injury after experimental subarachnoid hemorrhage: Involvement in the modulation of blood-brain barrier integrity. Oncotarget. 2016;7:56030-56044 pubmed publisher
  • western blot; pig; 1:50; fig 6b
Yang G, Zhu Y, Zhang W, Zhou D, Zhai C, Wang J. Influence of orally fed a select mixture of Bacillus probiotics on intestinal T-cell migration in weaned MUC4 resistant pigs following Escherichia coli challenge. Vet Res. 2016;47:71 pubmed publisher
  • ELISA; mouse; 1:100; fig 4
  • western blot; mouse; 1:100; fig 4
Löffler T, Flunkert S, Temmel M, Hutter Paier B. Decreased Plasma A? in Hyperlipidemic APPSL Transgenic Mice Is Associated with BBB Dysfunction. Front Neurosci. 2016;10:232 pubmed publisher
  • flow cytometry; mouse; loading ...; fig st1
  • immunocytochemistry; mouse; loading ...; fig st1
Itkin T, Gur Cohen S, Spencer J, Schajnovitz A, Ramasamy S, Kusumbe A, et al. Distinct bone marrow blood vessels differentially regulate haematopoiesis. Nature. 2016;532:323-8 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 3
An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed publisher
  • western blot; human; fig 6
Ibrahim A, Mander S, Hussein K, Elsherbiny N, Smith S, Al Shabrawey M, et al. Hyperhomocysteinemia disrupts retinal pigment epithelial structure and function with features of age-related macular degeneration. Oncotarget. 2016;7:8532-45 pubmed publisher
  • immunocytochemistry; human; fig s1a
  • western blot; human; 1:1000; fig 2d
Chen Y, Statt S, Wu R, Chang H, Liao J, Wang C, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815 pubmed publisher
  • immunohistochemistry; mouse; fig 5
  • immunocytochemistry; rat; fig 4
Egan C, Sodhi C, Good M, Lin J, Jia H, Yamaguchi Y, et al. Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis. J Clin Invest. 2016;126:495-508 pubmed
  • immunocytochemistry; human; fig 1
Telias M, Mayshar Y, Amit A, Ben Yosef D. Molecular mechanisms regulating impaired neurogenesis of fragile X syndrome human embryonic stem cells. Stem Cells Dev. 2015;24:2353-65 pubmed publisher
  • western blot; pig; loading ...; fig 7a
Zhang W, Zhu Y, Yang J, Yang G, Zhou D, Wang J. A Selected Lactobacillus rhamnosus Strain Promotes EGFR-Independent Akt Activation in an Enterotoxigenic Escherichia coli K88-Infected IPEC-J2 Cell Model. PLoS ONE. 2015;10:e0125717 pubmed publisher
  • flow cytometry; mouse; 1:100; fig 2
Elahy M, Jackaman C, Mamo J, Lam V, Dhaliwal S, Giles C, et al. Blood-brain barrier dysfunction developed during normal aging is associated with inflammation and loss of tight junctions but not with leukocyte recruitment. Immun Ageing. 2015;12:2 pubmed publisher
  • western blot; human; 1:100
Wong A, Chin S, Xia S, Garner J, Bear C, Rossant J. Efficient generation of functional CFTR-expressing airway epithelial cells from human pluripotent stem cells. Nat Protoc. 2015;10:363-81 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 5
  • western blot; human; 1:100; fig 2
Chen M, Yang T, Meng X, Sun T. Azithromycin attenuates cigarette smoke extract-induced oxidative stress injury in human alveolar epithelial cells. Mol Med Rep. 2015;11:3414-22 pubmed publisher
  • western blot; mouse
Duan J, Yin J, Ren W, Wu M, Chen S, Cui Z, et al. Pyrrolidine dithiocarbamate restores gastric damages and suppressive autophagy induced by hydrogen peroxide. Free Radic Res. 2015;49:210-8 pubmed publisher
  • western blot; human; 1:1000; fig 5
Zhang F, Man X, Yu H, Liu L, Li Y. Synergistic protective effects of escin and low‑dose glucocorticoids against vascular endothelial growth factor‑induced blood‑retinal barrier breakdown in retinal pigment epithelial and umbilical vein endothelial cells. Mol Med Rep. 2015;11:1372-7 pubmed publisher
  • western blot; human; fig 3
Milara J, Peiró T, Serrano A, Artigues E, Aparicio J, Tenor H, et al. Simvastatin Increases the Ability of Roflumilast N-oxide to Inhibit Cigarette Smoke-Induced Epithelial to Mesenchymal Transition in Well-differentiated Human Bronchial Epithelial Cells in vitro. COPD. 2015;12:320-31 pubmed publisher
  • immunohistochemistry; mouse; 1:250
  • western blot; mouse; 1:100
Tawfik A, Markand S, Al Shabrawey M, Mayo J, Reynolds J, Bearden S, et al. Alterations of retinal vasculature in cystathionine-?-synthase heterozygous mice: a model of mild to moderate hyperhomocysteinemia. Am J Pathol. 2014;184:2573-85 pubmed publisher
  • reverse phase protein lysate microarray; human; 1:500
Milara J, Peiró T, Serrano A, Guijarro R, Zaragozá C, Tenor H, et al. Roflumilast N-oxide inhibits bronchial epithelial to mesenchymal transition induced by cigarette smoke in smokers with COPD. Pulm Pharmacol Ther. 2014;28:138-48 pubmed publisher
  • western blot; human; 1:50
Xu R, Li Q, Zhou J, Zhou X, Perelman J, Kolosov V. The degradation of airway tight junction protein under acidic conditions is probably mediated by transient receptor potential vanilloid 1 receptor. Biosci Rep. 2013;33: pubmed publisher
  • immunohistochemistry; mouse; 1:200
Bittner S, Ruck T, Schuhmann M, Herrmann A, Moha Ou Maati H, Bobak N, et al. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med. 2013;19:1161-5 pubmed publisher
  • immunocytochemistry; rat
Watson P, Paterson J, Thom G, Ginman U, Lundquist S, Webster C. Modelling the endothelial blood-CNS barriers: a method for the production of robust in vitro models of the rat blood-brain barrier and blood-spinal cord barrier. BMC Neurosci. 2013;14:59 pubmed publisher
  • western blot; human; 1:100
Xu R, Li Q, Zhou X, Perelman J, Kolosov V. Oxidative stress mediates the disruption of airway epithelial tight junctions through a TRPM2-PLC?1-PKC? signaling pathway. Int J Mol Sci. 2013;14:9475-86 pubmed publisher
Li J, Qu J, Shi Y, Perfetto M, Ping Z, Christian L, et al. Nicotinic acid inhibits glioma invasion by facilitating Snail1 degradation. Sci Rep. 2017;7:43173 pubmed publisher
Wang Y, Fan X, Tang T, Fan R, Zhang C, Huang Z, et al. Rhein and rhubarb similarly protect the blood-brain barrier after experimental traumatic brain injury via gp91phox subunit of NADPH oxidase/ROS/ERK/MMP-9 signaling pathway. Sci Rep. 2016;6:37098 pubmed publisher
Huang D, Duan H, Huang H, Tong X, Han Y, Ru G, et al. Cisplatin resistance in gastric cancer cells is associated with HER2 upregulation-induced epithelial-mesenchymal transition. Sci Rep. 2016;6:20502 pubmed publisher
Cao G, Ye X, Xu Y, Yin M, Chen H, Kou J, et al. YiQiFuMai powder injection ameliorates blood-brain barrier dysfunction and brain edema after focal cerebral ischemia-reperfusion injury in mice. Drug Des Devel Ther. 2016;10:315-25 pubmed publisher
Xiao X, Tang W, Yuan Q, Peng L, Yu P. Epigenetic repression of Krüppel-like factor 4 through Dnmt1 contributes to EMT in renal fibrosis. Int J Mol Med. 2015;35:1596-602 pubmed publisher
Luhmann U, Carvalho L, Holthaus S, Cowing J, Greenaway S, Chu C, et al. The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors. Hum Mol Genet. 2015;24:128-41 pubmed publisher
Leung C, Shaheen F, Bernatchez P, Hackett T. Expression of myoferlin in human airway epithelium and its role in cell adhesion and zonula occludens-1 expression. PLoS ONE. 2012;7:e40478 pubmed publisher
product information
CatalogNumber :
ab59720
ItemName :
Anti-ZO1 tight junction protein antibody
Product Type :
Antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Unconjugated
Size :
50 µg
SpeciesSummary :
Chk, Dog, Hu
Application Summary :
Flow Cyt, ICC/IF, WB
company information
Abcam
330 Cambridge Science Park
Cambridge
CB4 0FL UK
orders@abcam.com
44 (0)1223 696000

1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
us.orders@abcam.com
617 225 2272, 888-77-ABCAM (22226)

www.abcam.com
888-7722226
headquarters: UK