This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-PGC1 alpha antibody
catalog :
ab54481
quantity :
50 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
citations: 72
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 8a
  • western blot; mouse; 1:1000; loading ...; fig 8b
Yeh C, Liu H, Lee M, Leu Y, Chiang W, Chang H, et al. Phytochemical‑rich herbal formula ATG‑125 protects against sucrose‑induced gastrocnemius muscle atrophy by rescuing Akt signaling and improving mitochondrial dysfunction in young adult mice. Mol Med Rep. 2022;25: pubmed publisher
  • immunocytochemistry; human; 1:1000
Hu D, Sun X, Magpusao A, Fedorov Y, Thompson M, Wang B, et al. Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington's disease. Nat Commun. 2021;12:5305 pubmed publisher
  • immunoprecipitation; mouse; loading ...; fig 3d
  • western blot; mouse; 1:500-1:2000; loading ...; fig 3b
Chiang S, Braidy N, Maleki S, Lal S, Richardson D, Huang M. Mechanisms of impaired mitochondrial homeostasis and NAD+ metabolism in a model of mitochondrial heart disease exhibiting redox active iron accumulation. Redox Biol. 2021;46:102038 pubmed publisher
  • western blot; mouse; 1:1000; loading ...
Vieira Lara M, Dommerholt M, Zhang W, Blankestijn M, Wolters J, Abegaz F, et al. Age-related susceptibility to insulin resistance arises from a combination of CPT1B decline and lipid overload. BMC Biol. 2021;19:154 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s3b
Liu H, Zang P, Lee I, Anderson B, Christiani A, Strait Bodey L, et al. Growth hormone secretagogue receptor-1a mediates ghrelin's effects on attenuating tumour-induced loss of muscle strength but not muscle mass. J Cachexia Sarcopenia Muscle. 2021;12:1280-1295 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 2b, 2g
Mu W, Qian S, Song Y, Yang L, Song S, Yang Q, et al. BMP4-mediated browning of perivascular adipose tissue governs an anti-inflammatory program and prevents atherosclerosis. Redox Biol. 2021;43:101979 pubmed publisher
  • western blot; mouse; 1:100; loading ...; fig 4g
Rupert J, Narasimhan A, Jengelley D, Jiang Y, Liu J, Au E, et al. Tumor-derived IL-6 and trans-signaling among tumor, fat, and muscle mediate pancreatic cancer cachexia. J Exp Med. 2021;218: pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig s1f
Hsiao Y, Shimizu I, Wakasugi T, Yoshida Y, Ikegami R, Hayashi Y, et al. Cardiac mitofusin-1 is reduced in non-responding patients with idiopathic dilated cardiomyopathy. Sci Rep. 2021;11:6722 pubmed publisher
  • western blot; mouse; 1:50; loading ...; fig 3d
Miao Y, Qin H, Zhong Y, Huang K, Rao C. Novel adipokine asprosin modulates browning and adipogenesis in white adipose tissue. J Endocrinol. 2021;249:83-93 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3c
Wallace M, Aguirre N, Marcotte G, Marshall A, Baehr L, Hughes D, et al. The ketogenic diet preserves skeletal muscle with aging in mice. Aging Cell. 2021;20:e13322 pubmed publisher
  • western blot; human; fig 2k
Galbraith L, Mui E, Nixon C, Hedley A, Strachan D, Mackay G, et al. PPAR-gamma induced AKT3 expression increases levels of mitochondrial biogenesis driving prostate cancer. Oncogene. 2021;40:2355-2366 pubmed publisher
  • immunocytochemistry; human; 1:300
Mehta A, Gregory J, Dando O, Carter R, Burr K, Nanda J, et al. Mitochondrial bioenergetic deficits in C9orf72 amyotrophic lateral sclerosis motor neurons cause dysfunctional axonal homeostasis. Acta Neuropathol. 2021;141:257-279 pubmed publisher
  • western blot; rat; fig 3d
Shah D, Nisr R, Stretton C, Krasteva Christ G, Hundal H. Caveolin-3 deficiency associated with the dystrophy P104L mutation impairs skeletal muscle mitochondrial form and function. J Cachexia Sarcopenia Muscle. 2020;11:838-858 pubmed publisher
  • western blot; mouse; loading ...; fig 4d
Ghosh A, Bhattacharjee S, Chowdhuri S, Mallick A, Rehman I, Basu S, et al. SCAN1-TDP1 trapping on mitochondrial DNA promotes mitochondrial dysfunction and mitophagy. Sci Adv. 2019;5:eaax9778 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3b
Zuo Z, Liu Z, Gao T, Yin Y, Wang Z, Hou Y, et al. Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice. Sci Total Environ. 2019;668:310-317 pubmed publisher
  • western blot; human; loading ...; fig 4d
Zhang C, Deng J, Liu D, Tuo X, Xiao L, Lai B, et al. Nuciferine ameliorates hepatic steatosis in high-fat diet/streptozocin-induced diabetic mice through a PPARα/PPARγ coactivator-1α pathway. Br J Pharmacol. 2018;175:4218-4228 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Vargas D, Lopez C, Acero E, Benítez E, Wintaco A, Camacho J, et al. Thermogenic capacity of human periaortic adipose tissue is transformed by body weight. PLoS ONE. 2018;13:e0194269 pubmed publisher
  • western blot; human; loading ...; fig 1a
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, et al. Detachment from the primary site and suspension in ascites as the initial step in metabolic reprogramming and metastasis to the omentum in ovarian cancer. Oncol Lett. 2018;15:1357-1361 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1f
Velázquez Villegas L, Perino A, Lemos V, Zietak M, Nomura M, Pols T, et al. TGR5 signalling promotes mitochondrial fission and beige remodelling of white adipose tissue. Nat Commun. 2018;9:245 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3b
Lizcano F, Vargas D, Gomez A, Torrado A. Human ADMC-Derived Adipocyte Thermogenic Capacity Is Regulated by IL-4 Receptor. Stem Cells Int. 2017;2017:2767916 pubmed publisher
  • western blot; mouse; loading ...; fig 2d
Le N, Kim C, Tu T, Kim B, Park T, Park J, et al. Absence of 4-1BB reduces obesity-induced atrophic response in skeletal muscle. J Inflamm (Lond). 2017;14:9 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...; fig 6B
Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, et al. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice. PLoS ONE. 2017;12:e0173661 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher
  • western blot; mouse; 1:2000; fig 6d
Doan K, Kinyua A, Yang D, Ko C, Moh S, Shong K, et al. FoxO1 in dopaminergic neurons regulates energy homeostasis and targets tyrosine hydroxylase. Nat Commun. 2016;7:12733 pubmed publisher
  • western blot; mouse; loading ...; fig 5f
Zhang C, Weng Y, Shi F, Jin W. The Engrailed-1 Gene Stimulates Brown Adipogenesis. Stem Cells Int. 2016;2016:7369491 pubmed publisher
  • western blot; mouse; 1:1000; fig S7
Basisty N, Dai D, Gagnidze A, Gitari L, Fredrickson J, Maina Y, et al. Mitochondrial-targeted catalase is good for the old mouse proteome, but not for the young: 'reverse' antagonistic pleiotropy?. Aging Cell. 2016;15:634-45 pubmed publisher
  • western blot; rat; fig 4
Huang Y, Chen C, Tang K, Sheen J, Tiao M, Tain Y, et al. Postnatal High-Fat Diet Increases Liver Steatosis and Apoptosis Threatened by Prenatal Dexamethasone through the Oxidative Effect. Int J Mol Sci. 2016;17:369 pubmed publisher
  • western blot; mouse; fig 6
Liu Z, Gan L, Chen Y, Luo D, Zhang Z, Cao W, et al. Mark4 promotes oxidative stress and inflammation via binding to PPARγ and activating NF-κB pathway in mice adipocytes. Sci Rep. 2016;6:21382 pubmed publisher
  • western blot; human; fig 5
Audet Walsh Ã, Papadopoli D, Gravel S, Yee T, Bridon G, Caron M, et al. The PGC-1α/ERRα Axis Represses One-Carbon Metabolism and Promotes Sensitivity to Anti-folate Therapy in Breast Cancer. Cell Rep. 2016;14:920-931 pubmed publisher
  • western blot; rat; 1:1500; loading ...; fig 4b
Zhang H, Wang X, Wu Z, Liu H, Chen W, Zhang Z, et al. Beneficial effect of farnesoid X receptor activation on metabolism in a diabetic rat model. Mol Med Rep. 2016;13:2135-42 pubmed publisher
Guo Y, Guan T, Yu Q, Sanghai N, Shafiq K, Li M, et al. ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging. Redox Biol. 2024;69:102972 pubmed publisher
Feng Y, Xu J, Shi M, Liu R, Zhao L, Chen X, et al. COX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism. Cell Death Dis. 2022;13:988 pubmed publisher
Chatterjee A, Sakallioglu I, Murthy D, Kosmacek E, Singh P, McDonald J, et al. MnTE-2-PyP protects fibroblast mitochondria from hyperglycemia and radiation exposure. Redox Biol. 2022;52:102301 pubmed publisher
Yin Z, Sun J, Cui H, Jiang C, Zhang Y, Lee S, et al. Tannin Supplementation Improves Oocyte Cytoplasmic Maturation and Subsequent Embryo Development in Pigs. Antioxidants (Basel). 2021;10: pubmed publisher
Hsieh P, Yu C, Chu P, Hsieh P. Verbascoside Protects Gingival Cells against High Glucose-Induced Oxidative Stress via PKC/HMGB1/RAGE/NFκB Pathway. Antioxidants (Basel). 2021;10: pubmed publisher
Martinez Bernabe T, Sastre Serra J, Ciobu N, Oliver J, Pons D, Roca P. Estrogen Receptor Beta (ERβ) Maintains Mitochondrial Network Regulating Invasiveness in an Obesity-Related Inflammation Condition in Breast Cancer. Antioxidants (Basel). 2021;10: pubmed publisher
Khin P, Hong Y, Yeon M, Lee D, Lee J, Jun H. Dulaglutide improves muscle function by attenuating inflammation through OPA-1-TLR-9 signaling in aged mice. Aging (Albany NY). 2021;13:21962-21974 pubmed publisher
Jo D, Yoon G, Song J. Role of Exendin-4 in Brain Insulin Resistance, Mitochondrial Function, and Neurite Outgrowth in Neurons under Palmitic Acid-Induced Oxidative Stress. Antioxidants (Basel). 2021;10: pubmed publisher
Kato M, Abdollahi M, Tunduguru R, Tsark W, Chen Z, Wu X, et al. miR-379 deletion ameliorates features of diabetic kidney disease by enhancing adaptive mitophagy via FIS1. Commun Biol. 2021;4:30 pubmed publisher
Li Y, Zou S, Ding H, Hao N, Huang Y, Tang J, et al. Low Expression of Sirtuin 1 in the Dairy Cows with Mild Fatty Liver Alters Hepatic Lipid Metabolism. Animals (Basel). 2020;10: pubmed publisher
Li J, Yu D, Chen S, Liu Y, Shi J, Zhang J, et al. Sirt6 opposes glycochenodeoxycholate-induced apoptosis of biliary epithelial cells through the AMPK/PGC-1α pathway. Cell Biosci. 2020;10:43 pubmed publisher
Liu D, Ma Z, Xu L, Zhang X, Qiao S, Yuan J. PGC1α activation by pterostilbene ameliorates acute doxorubicin cardiotoxicity by reducing oxidative stress via enhancing AMPK and SIRT1 cascades. Aging (Albany NY). 2019;11:10061-10073 pubmed publisher
Zhao L, Chen X, Feng Y, Wang G, Nawaz I, Hu L, et al. COX7A1 suppresses the viability of human non-small cell lung cancer cells via regulating autophagy. Cancer Med. 2019;8:7762-7773 pubmed publisher
Miao J, Liu J, Niu J, Zhang Y, Shen W, Luo C, et al. Wnt/β-catenin/RAS signaling mediates age-related renal fibrosis and is associated with mitochondrial dysfunction. Aging Cell. 2019;18:e13004 pubmed publisher
Lee G, Uddin M, Kim Y, Ko M, Yu I, Ha H. PGC-1α, a potential therapeutic target against kidney aging. Aging Cell. 2019;18:e12994 pubmed publisher
Reyes Fermín L, Avila Rojas S, Aparicio Trejo O, Tapia E, Rivero I, Pedraza Chaverri J. The Protective Effect of Alpha-Mangostin against Cisplatin-Induced Cell Death in LLC-PK1 Cells is Associated to Mitochondrial Function Preservation. Antioxidants (Basel). 2019;8: pubmed publisher
Zhuang C, Zhuang C, Luo X, Huang X, Yao L, Li J, et al. N6-methyladenosine demethylase FTO suppresses clear cell renal cell carcinoma through a novel FTO-PGC-1α signalling axis. J Cell Mol Med. 2019;23:2163-2173 pubmed publisher
Ivarsson N, Mattsson C, Cheng A, Bruton J, Ekblom B, Lanner J, et al. SR Ca2+ leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance. J Gen Physiol. 2019;151:567-577 pubmed publisher
McMurphy T, Huang W, Liu X, Siu J, Queen N, Xiao R, et al. Hypothalamic gene transfer of BDNF promotes healthy aging in mice. Aging Cell. 2019;18:e12846 pubmed publisher
Choi J, Song N, Lee A, Lee D, Seo M, Kim S, et al. Oxyresveratrol Increases Energy Expenditure through Foxo3a-Mediated Ucp1 Induction in High-Fat-Diet-Induced Obese Mice. Int J Mol Sci. 2018;20: pubmed publisher
Wahl D, Solon Biet S, Wang Q, Wali J, Pulpitel T, Clark X, et al. Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice. Cell Rep. 2018;25:2234-2243.e6 pubmed publisher
Wang S, Zhao Z, Feng X, Cheng Z, Xiong Z, Wang T, et al. Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition. J Cell Mol Med. 2018;22:5132-5144 pubmed publisher
McMurphy T, Huang W, Queen N, Ali S, Widstrom K, Liu X, et al. Implementation of environmental enrichment after middle age promotes healthy aging. Aging (Albany NY). 2018;10:1698-1721 pubmed publisher
Yu B, Huo L, Liu Y, Deng P, Szymanski J, Li J, et al. PGC-1α Controls Skeletal Stem Cell Fate and Bone-Fat Balance in Osteoporosis and Skeletal Aging by Inducing TAZ. Cell Stem Cell. 2018;23:193-209.e5 pubmed publisher
Bae J. Aerobic Exercise Increases Meteorin-Like Protein in Muscle and Adipose Tissue of Chronic High-Fat Diet-Induced Obese Mice. Biomed Res Int. 2018;2018:6283932 pubmed publisher
Yamashita Y, Nakada S, Yoshihara T, Nara T, Furuya N, Miida T, et al. Perlecan, a heparan sulfate proteoglycan, regulates systemic metabolism with dynamic changes in adipose tissue and skeletal muscle. Sci Rep. 2018;8:7766 pubmed publisher
He F, Jin J, Qin Q, Zheng Y, Li T, Zhang Y, et al. Resistin Regulates Fatty Acid Β Oxidation by Suppressing Expression of Peroxisome Proliferator Activator Receptor Gamma-Coactivator 1α (PGC-1α). Cell Physiol Biochem. 2018;46:2165-2172 pubmed publisher
Kuang Y, Han X, Xu M, Yang Q. Oxaloacetate induces apoptosis in HepG2 cells via inhibition of glycolysis. Cancer Med. 2018;7:1416-1429 pubmed publisher
Drury E, Zsengellér Z, Stillman I, Khankin E, Pavlakis M, Parikh S. Renal PGC1α May Be Associated with Recovery after Delayed Graft Function. Nephron. 2018;138:303-309 pubmed publisher
Ishimoto Y, Inagi R, Yoshihara D, Kugita M, Nagao S, Shimizu A, et al. Mitochondrial Abnormality Facilitates Cyst Formation in Autosomal Dominant Polycystic Kidney Disease. Mol Cell Biol. 2017;37: pubmed publisher
Kim S, Yang C, Lee H, Kim J, Kim Y, Kim Y, et al. ESRRA (estrogen-related receptor α) is a key coordinator of transcriptional and post-translational activation of autophagy to promote innate host defense. Autophagy. 2018;14:152-168 pubmed publisher
Guo X, Li F, Xu Z, Yin A, Yin H, Li C, et al. DOCK2 deficiency mitigates HFD-induced obesity by reducing adipose tissue inflammation and increasing energy expenditure. J Lipid Res. 2017;58:1777-1784 pubmed publisher
De Jong A, Carreira S, Na N, Carillion A, Jiang C, Beuvin M, et al. Diaphragmatic function is enhanced in fatty and diabetic fatty rats. PLoS ONE. 2017;12:e0174043 pubmed publisher
Martin J, Kephart W, Haun C, McCloskey A, Shake J, Mobley C, et al. Impact of external pneumatic compression target inflation pressure on transcriptome-wide RNA expression in skeletal muscle. Physiol Rep. 2016;4: pubmed
Dölle C, Flønes I, Nido G, Miletic H, Osuagwu N, Kristoffersen S, et al. Defective mitochondrial DNA homeostasis in the substantia nigra in Parkinson disease. Nat Commun. 2016;7:13548 pubmed publisher
Shintaku J, Peterson J, Talbert E, Gu J, Ladner K, Williams D, et al. MyoD Regulates Skeletal Muscle Oxidative Metabolism Cooperatively with Alternative NF-?B. Cell Rep. 2016;17:514-526 pubmed publisher
Chen M, Wang M, Yang Q, Wang M, Wang Z, Zhu Y, et al. Antioxidant effects of hydroxysafflor yellow A and acetyl-11-keto-?-boswellic acid in combination on isoproterenol-induced myocardial injury in rats. Int J Mol Med. 2016;37:1501-10 pubmed publisher
Guan Y, Cui Z, Sun B, Han L, Li C, Chen L. Celastrol attenuates oxidative stress in the skeletal muscle of diabetic rats by regulating the AMPK-PGC1?-SIRT3 signaling pathway. Int J Mol Med. 2016;37:1229-38 pubmed publisher
Tran M, Zsengellér Z, Berg A, Khankin E, Bhasin M, Kim W, et al. PGC1α drives NAD biosynthesis linking oxidative metabolism to renal protection. Nature. 2016;531:528-32 pubmed publisher
Camarda R, Zhou A, Kohnz R, Balakrishnan S, Mahieu C, Anderton B, et al. Inhibition of fatty acid oxidation as a therapy for MYC-overexpressing triple-negative breast cancer. Nat Med. 2016;22:427-32 pubmed publisher
Zhou Y, Gu P, Shi W, Li J, Hao Q, Cao X, et al. MicroRNA-29a induces insulin resistance by targeting PPARδ in skeletal muscle cells. Int J Mol Med. 2016;37:931-8 pubmed publisher
Vargas D, Shimokawa N, Kaneko R, Rosales W, Parra A, Castellanos Ã, et al. Regulation of human subcutaneous adipocyte differentiation by EID1. J Mol Endocrinol. 2016;56:113-22 pubmed publisher
product information
CatalogNumber :
ab54481
ItemName :
Anti-PGC1 alpha antibody
Category :
Antibody
Host :
Rabbit
Clonality :
Polyclonal
Conjugate :
Unconjugated
Size :
50 µl
SpeciesSummary :
Hu, Ms, Rat, Zfsh
Application Summary :
ELISA, ICC/IF, IHC-P, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
Stefan.Pritchard@abcam.com, eCommerce@abcam.com, Vicky.Yang@abcam.com
https://www.abcam.com
888-7722226
headquarters: UK