This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1]
catalog :
ab48508
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
N45.1
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 35
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:500; loading ...; fig 5b
Liu M, Rao H, Liu J, Li X, Feng W, Gui L, et al. The histone methyltransferase SETD2 modulates oxidative stress to attenuate experimental colitis. Redox Biol. 2021;43:102004 pubmed publisher
  • immunocytochemistry; human; 1:50; loading ...; fig 6f
Cuello F, Knaust A, Saleem U, Loos M, Raabe J, Mosqueira D, et al. Impairment of the ER/mitochondria compartment in human cardiomyocytes with PLN p.Arg14del mutation. EMBO Mol Med. 2021;13:e13074 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 6a
Lin Z, Huang W, He Q, Li D, Wang Z, Feng Y, et al. FOXC1 promotes HCC proliferation and metastasis by Upregulating DNMT3B to induce DNA Hypermethylation of CTH promoter. J Exp Clin Cancer Res. 2021;40:50 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 5a
Che H, Li J, Li Y, Ma C, Liu H, Qin J, et al. p16 deficiency attenuates intervertebral disc degeneration by adjusting oxidative stress and nucleus pulposus cell cycle. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 2g
Taguchi K, Yamagishi S, Yokoro M, Ito S, Kodama G, Kaida Y, et al. RAGE-aptamer attenuates deoxycorticosterone acetate/salt-induced renal injury in mice. Sci Rep. 2018;8:2686 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig s4
McPherson N, Fullston T, Kang W, Sandeman L, Corbett M, Owens J, et al. Paternal under-nutrition programs metabolic syndrome in offspring which can be reversed by antioxidant/vitamin food fortification in fathers. Sci Rep. 2016;6:27010 pubmed publisher
  • immunohistochemistry; mouse; fig 7
Cicchini M, Chakrabarti R, Kongara S, Price S, Nahar R, Lozy F, et al. Autophagy regulator BECN1 suppresses mammary tumorigenesis driven by WNT1 activation and following parity. Autophagy. 2014;10:2036-52 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:3000
Huang E, Wang F, Chen Y, Chen Y, Wang C, Lin I, et al. Amifostine alleviates radiation-induced lethal small bowel damage via promotion of 14-3-3σ-mediated nuclear p53 accumulation. Oncotarget. 2014;5:9756-69 pubmed
  • immunohistochemistry - paraffin section; human; 1.25 ug/ml
Chen H, Hu Y, Fang Y, Djukic Z, Yamamoto M, Shaheen N, et al. Nrf2 deficiency impairs the barrier function of mouse oesophageal epithelium. Gut. 2014;63:711-9 pubmed publisher
Wang M, Liu J, Liao X, Yi Y, Xue Y, Yang L, et al. The SGK3-Catalase antioxidant signaling axis drives cervical cancer growth and therapy resistance. Redox Biol. 2023;67:102931 pubmed publisher
Tanushi X, Pinna G, Vandamme M, Siberchicot C, D Augustin O, Di Guilmi A, et al. OGG1 competitive inhibitors show important off-target effects by directly inhibiting efflux pumps and disturbing mitotic progression. Front Cell Dev Biol. 2023;11:1124960 pubmed publisher
Hanna B, Michel M, Helleday T, Mortusewicz O. NEIL1 and NEIL2 Are Recruited as Potential Backup for OGG1 upon OGG1 Depletion or Inhibition by TH5487. Int J Mol Sci. 2021;22: pubmed publisher
Li Q, Xu Q, Tan J, Hu L, Ge C, Xu M. Carminic acid supplementation protects against fructose-induced kidney injury mainly through suppressing inflammation and oxidative stress via improving Nrf-2 signaling. Aging (Albany NY). 2021;13:10326-10353 pubmed publisher
Zhou Z, Liu X, Zhang S, Qi X, Zhang Q, Yard B, et al. Correlation between serum carnosinase concentration and renal damage in diabetic nephropathy patients. Amino Acids. 2021;53:687-700 pubmed publisher
Garcia Mesa Y, Xu H, Vance P, Gruenewald A, Garza R, Midkiff C, et al. Dimethyl Fumarate, an Approved Multiple Sclerosis Treatment, Reduces Brain Oxidative Stress in SIV-Infected Rhesus Macaques: Potential Therapeutic Repurposing for HIV Neuroprotection. Antioxidants (Basel). 2021;10: pubmed publisher
Lebraud E, Pinna G, Siberchicot C, Depagne J, Busso D, Fantini D, et al. Chromatin recruitment of OGG1 requires cohesin and mediator and is essential for efficient 8-oxoG removal. Nucleic Acids Res. 2020;48:9082-9097 pubmed publisher
Ge C, Hu L, Lou D, Li Q, Feng J, Wu Y, et al. Nrf2 deficiency aggravates PM2.5-induced cardiomyopathy by enhancing oxidative stress, fibrosis and inflammation via RIPK3-regulated mitochondrial disorder. Aging (Albany NY). 2020;12:4836-4865 pubmed publisher
Zhuang K, Zuo Y, Sherchan P, Wang J, Yan X, Liu F. Hydrogen Inhalation Attenuates Oxidative Stress Related Endothelial Cells Injury After Subarachnoid Hemorrhage in Rats. Front Neurosci. 2019;13:1441 pubmed publisher
Metzger J, Matsoff H, Zinnen A, Fleddermann R, Bondarenko V, Simmons H, et al. Post mortem evaluation of inflammation, oxidative stress, and PPARγ activation in a nonhuman primate model of cardiac sympathetic neurodegeneration. PLoS ONE. 2020;15:e0226999 pubmed publisher
Wang Y, Zhang J, Ren S, Sun D, Huang H, Wang H, et al. Branched-Chain Amino Acid Metabolic Reprogramming Orchestrates Drug Resistance to EGFR Tyrosine Kinase Inhibitors. Cell Rep. 2019;28:512-525.e6 pubmed publisher
Rodriguez J, Zhang Y, Li T, Xie C, Sun Y, Xu Y, et al. Lack of the brain-specific isoform of apoptosis-inducing factor aggravates cerebral damage in a model of neonatal hypoxia-ischemia. Cell Death Dis. 2018;10:3 pubmed publisher
Bahar E, Lee G, Bhattarai K, Lee H, Choi M, Rashid H, et al. Polyphenolic Extract of Euphorbia supina Attenuates Manganese-Induced Neurotoxicity by Enhancing Antioxidant Activity through Regulation of ER Stress and ER Stress-Mediated Apoptosis. Int J Mol Sci. 2017;18: pubmed publisher
Chaisiriwong L, Wanitphakdeedecha R, Sitthinamsuwan P, Sampattavanich S, Chatsiricharoenkul S, Manuskiatti W, et al. A Case-Control Study of Involvement of Oxidative DNA Damage and Alteration of Antioxidant Defense System in Patients with Basal Cell Carcinoma: Modulation by Tumor Removal. Oxid Med Cell Longev. 2016;2016:5934024 pubmed publisher
Matosevic P, Klepac Pulanić T, Kinda E, Augustin G, Brcic I, Jakic Razumovic J. Immunohistochemical expression of 8-oxo-7,8-dihydro-2'-deoxyguanosine in cytoplasm of tumour and adjacent normal mucosa cells in patients with colorectal cancer. World J Surg Oncol. 2015;13:241 pubmed publisher
Vilahur G, Casani L, Pena E, Juan Babot O, Mendieta G, Crespo J, et al. HMG-CoA reductase inhibition prior reperfusion improves reparative fibrosis post-myocardial infarction in a preclinical experimental model. Int J Cardiol. 2014;175:528-38 pubmed publisher
Klebe S, Callahan T, Power J. Peroxiredoxin I and II in human eyes: cellular distribution and association with pterygium and DNA damage. J Histochem Cytochem. 2014;62:85-96 pubmed publisher
Wu L, Li X, Zhu H, Xu P, Gao X. A prescribed Chinese herbal medicine improves glucose profile and ameliorates oxidative stress in Goto-Kakisaki rats fed with high fat diet. PLoS ONE. 2013;8:e60262 pubmed publisher
Negrato E, Vascellari M, Capolongo F, Binato G, Da Dalt L, Boscolo Papo M, et al. Expression of 8-OHdG in Zosterisessor ophiocephalus from the Venetian lagoon, Italy. Eur J Histochem. 2013;57:e8 pubmed publisher
Rittinghausen S, Bellmann B, Creutzenberg O, Ernst H, Kolling A, Mangelsdorf I, et al. Evaluation of immunohistochemical markers to detect the genotoxic mode of action of fine and ultrafine dusts in rat lungs. Toxicology. 2013;303:177-86 pubmed publisher
de Carvalho L, Abrao M, Biscotti C, Sharma R, Agarwal A, Falcone T. Mapping histological levels of 8-hydroxy-2'-deoxyguanosine in female reproductive organs. J Mol Histol. 2013;44:111-6 pubmed publisher
Forbes M, Thornhill B, Minor J, Gordon K, Galarreta C, Chevalier R. Fight-or-flight: murine unilateral ureteral obstruction causes extensive proximal tubular degeneration, collecting duct dilatation, and minimal fibrosis. Am J Physiol Renal Physiol. 2012;303:F120-9 pubmed publisher
Sukhanov S, Higashi Y, Shai S, Blackstock C, Galvez S, Vaughn C, et al. Differential requirement for nitric oxide in IGF-1-induced anti-apoptotic, anti-oxidant and anti-atherosclerotic effects. FEBS Lett. 2011;585:3065-72 pubmed publisher
DeNicola G, Karreth F, Humpton T, Gopinathan A, Wei C, Frese K, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. 2011;475:106-9 pubmed publisher
Fedirko V, Bostick R, Long Q, Flanders W, McCullough M, Sidelnikov E, et al. Effects of supplemental vitamin D and calcium on oxidative DNA damage marker in normal colorectal mucosa: a randomized clinical trial. Cancer Epidemiol Biomarkers Prev. 2010;19:280-91 pubmed publisher
Huang E, Wang F, Lin I, Yang K. Aminoguanidine alleviates radiation-induced small-bowel damage through its antioxidant effect. Int J Radiat Oncol Biol Phys. 2009;74:237-44 pubmed publisher
product information
CatalogNumber :
ab48508
ItemName :
Anti-8-Hydroxy-2'-deoxyguanosine antibody [N45.1]
Category :
Antibody
Host :
Mouse
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
N45.1
Size :
50 µg
Application Summary :
ICC/IF, IHC-P
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
Stefan.Pritchard@abcam.com, eCommerce@abcam.com, Vicky.Yang@abcam.com
https://www.abcam.com
888-7722226
headquarters: UK