This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Histone H3 (acetyl K9) antibody - ChIP Grade
catalog :
ab4441
quantity :
50 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, chromatin immunoprecipitation, immunohistochemistry - paraffin section, ChIP-Seq, dot blot
citations: 63
Published Application/Species/Sample/DilutionReference
  • chromatin immunoprecipitation; human; loading ...; fig s6d, s6e
Yu B, Su J, Shi Q, Liu Q, Ma J, Ru G, et al. KMT5A-methylated SNIP1 promotes triple-negative breast cancer metastasis by activating YAP signaling. Nat Commun. 2022;13:2192 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 2g
Jin Q, Hu H, Yan S, Jin L, Pan Y, Li X, et al. lncRNA MIR22HG-Derived miR-22-5p Enhances the Radiosensitivity of Hepatocellular Carcinoma by Increasing Histone Acetylation Through the Inhibition of HDAC2 Activity. Front Oncol. 2021;11:572585 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 6f
Zheng F, Chen J, Zhang X, Wang Z, Chen J, Lin X, et al. The HIF-1α antisense long non-coding RNA drives a positive feedback loop of HIF-1α mediated transactivation and glycolysis. Nat Commun. 2021;12:1341 pubmed publisher
  • western blot; rat; 1:3000; loading ...; fig 5h
Xu S, Tao H, Cao W, Cao L, Lin Y, Zhao S, et al. Ketogenic diets inhibit mitochondrial biogenesis and induce cardiac fibrosis. Signal Transduct Target Ther. 2021;6:54 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 4c
Chu S, Chabon J, Matovina C, Minehart J, Chen B, Zhang J, et al. Loss of H3K36 Methyltransferase SETD2 Impairs V(D)J Recombination during Lymphoid Development. iScience. 2020;23:100941 pubmed publisher
  • ChIP-Seq; mouse; ; loading ...; fig 1a
  • chromatin immunoprecipitation; mouse; ; loading ...; fig s4b
Kuang Z, Wang Y, Li Y, Ye C, Ruhn K, Behrendt C, et al. The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3. Science. 2019;365:1428-1434 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 4b
Shan C, Lu Z, Li Z, Sheng H, Fan J, Qi Q, et al. 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell Death Dis. 2019;10:525 pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig 3f
Vodnala S, Eil R, Kishton R, Sukumar M, Yamamoto T, Ha N, et al. T cell stemness and dysfunction in tumors are triggered by a common mechanism. Science. 2019;363: pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig 2
Zhang S, Deng T, Tang W, He B, Furusawa T, Ambs S, et al. Epigenetic regulation of REX1 expression and chromatin binding specificity by HMGNs. Nucleic Acids Res. 2019;47:4449-4461 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig s1e
Bianchi Smiraglia A, Bagati A, Fink E, Affronti H, Lipchick B, Moparthy S, et al. Inhibition of the aryl hydrocarbon receptor/polyamine biosynthesis axis suppresses multiple myeloma. J Clin Invest. 2018;128:4682-4696 pubmed publisher
  • western blot; mouse; fig 5a
Ka M, Kim W. ANKRD11 associated with intellectual disability and autism regulates dendrite differentiation via the BDNF/TrkB signaling pathway. Neurobiol Dis. 2018;111:138-152 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 4f
Zhang S, Takaku M, Zou L, Gu A, Chou W, Zhang G, et al. Reversing SKI-SMAD4-mediated suppression is essential for TH17 cell differentiation. Nature. 2017;551:105-109 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3h
Ye M, Fang Z, Gu H, Song R, Ye J, Li H, et al. Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1? under hypoxia condition. Tumour Biol. 2017;39:1010428317705034 pubmed publisher
  • ChIP-Seq; human; 1:125; fig 4b
Monteagudo S, Cornelis F, Aznar López C, Yibmantasiri P, Guns L, Carmeliet P, et al. DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. Nat Commun. 2017;8:15889 pubmed publisher
  • ChIP-Seq; mouse; loading ...; fig s2f
  • western blot; mouse; loading ...; fig s6b
Mews P, Donahue G, Drake A, Luczak V, Abel T, Berger S. Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory. Nature. 2017;546:381-386 pubmed publisher
  • chromatin immunoprecipitation; mouse; loading ...; fig 3j
  • western blot; mouse; fig sf6e
Yuan X, Qi H, Li X, Wu F, Fang J, Bober E, et al. Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest. 2017;127:2235-2248 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 5b
Na T, Kim G, Oh H, Lee M, Han Y, Kim K, et al. The trisaccharide raffinose modulates epidermal differentiation through activation of liver X receptor. Sci Rep. 2017;7:43823 pubmed publisher
  • western blot; human; loading ...; fig 6a
Meisenberg C, Ashour M, El Shafie L, Liao C, Hodgson A, Pilborough A, et al. Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan. Nucleic Acids Res. 2017;45:1159-1176 pubmed publisher
  • chromatin immunoprecipitation; human; loading ...; fig 3c
  • western blot; human; loading ...; fig 3a
Sherman M, Yu R, Tseng T, Sousa C, Liu S, Truitt M, et al. Stromal cues regulate the pancreatic cancer epigenome and metabolome. Proc Natl Acad Sci U S A. 2017;114:1129-1134 pubmed publisher
  • chromatin immunoprecipitation; mouse; 1:50; loading ...; fig 7F
Chakraborty K, Raundhal M, Chen B, Morse C, Tyurina Y, Khare A, et al. The mito-DAMP cardiolipin blocks IL-10 production causing persistent inflammation during bacterial pneumonia. Nat Commun. 2017;8:13944 pubmed publisher
  • western blot; human; loading ...; fig s4a
Zhong J, Li X, Cai W, Wang Y, Dong S, Yang J, et al. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. Nucleic Acids Res. 2017;45:672-684 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig 6d
  • western blot; human; 1:1000; loading ...; fig 2b
Bharathy N, Suriyamurthy S, Rao V, Ow J, Lim H, Chakraborty P, et al. P/CAF mediates PAX3-FOXO1-dependent oncogenesis in alveolar rhabdomyosarcoma. J Pathol. 2016;240:269-281 pubmed publisher
Xiang J, Fan C, Dong H, Ma Y, Xu P. A CRISPR-based rapid DNA repositioning strategy and the early intranuclear life of HSV-1. elife. 2023;12: pubmed publisher
Nieborak A, Lukauskas S, Capellades J, Heyn P, Santos G, Motzler K, et al. Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis. Mol Metab. 2023;74:101748 pubmed publisher
Princov xe1 J, Salat Canela C, Dan x11b k P, Mare x161 ov xe1 A, de Cubas L, B xe4 hler J, et al. Perturbed fatty-acid metabolism is linked to localized chromatin hyperacetylation, increased stress-response gene expression and resistance to oxidative stress. PLoS Genet. 2023;19:e1010582 pubmed publisher
Yan F, Li J, Milosević J, Petroni R, Liu S, Shi Z, et al. KAT6A and ENL form an epigenetic transcriptional control module to drive critical leukemogenic gene expression programs. Cancer Discov. 2021;: pubmed publisher
Hogg S, Motorna O, Cluse L, Johanson T, Coughlan H, Raviram R, et al. Targeting histone acetylation dynamics and oncogenic transcription by catalytic P300/CBP inhibition. Mol Cell. 2021;81:2183-2200.e13 pubmed publisher
Kent O, Saha M, Coyaud E, Burston H, Law N, Dadson K, et al. Haploinsufficiency of RREB1 causes a Noonan-like RASopathy via epigenetic reprogramming of RAS-MAPK pathway genes. Nat Commun. 2020;11:4673 pubmed publisher
Gomes A, Ilter D, Low V, Endress J, Fernández García J, Rosenzweig A, et al. Age-induced accumulation of methylmalonic acid promotes tumour progression. Nature. 2020;585:283-287 pubmed publisher
Wei Y, Tian C, Zhao Y, Liu X, Liu F, Li S, et al. MRG15 orchestrates rhythmic epigenomic remodelling and controls hepatic lipid metabolism. Nat Metab. 2020;2:447-460 pubmed publisher
Martire S, Nguyen J, Sundaresan A, Banaszynski L. Differential contribution of p300 and CBP to regulatory element acetylation in mESCs. BMC Mol Cell Biol. 2020;21:55 pubmed publisher
Cárdenas H, Jiang G, Thomes Pepin J, Parker J, Condello S, Nephew K, et al. Interferon-γ signaling is associated with BRCA1 loss-of-function mutations in high grade serous ovarian cancer. NPJ Precis Oncol. 2019;3:32 pubmed publisher
Liu N, Yin Y, Wang H, Zhou Z, Sheng X, Fu H, et al. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling. PLoS Genet. 2019;15:e1008368 pubmed publisher
Han Y, Shin K, Kim J, Khadka D, Kim H, Lee Y, et al. A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis. J Clin Invest. 2019;130:1684-1698 pubmed publisher
Yuan Z, Vanderwielen B, Giaimo B, Pan L, Collins C, Turkiewicz A, et al. Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Cell Rep. 2019;26:845-854.e6 pubmed publisher
Vítor A, Sridhara S, Sabino J, Afonso A, Grosso A, Martin R, et al. Single-molecule imaging of transcription at damaged chromatin. Sci Adv. 2019;5:eaau1249 pubmed publisher
Ma X, Yang T, Luo Y, Wu L, Jiang Y, Song Z, et al. TRIM28 promotes HIV-1 latency by SUMOylating CDK9 and inhibiting P-TEFb. elife. 2019;8: pubmed publisher
Tian P, Zhu Y, Zhang C, Guo X, Zhang P, Xue H. Ras-ERK1/2 signaling contributes to the development of colorectal cancer via regulating H3K9ac. BMC Cancer. 2018;18:1286 pubmed publisher
Hajduskova M, Baytek G, Kolundžić E, Gosdschan A, Kazmierczak M, Ofenbauer A, et al. MRG-1/MRG15 Is a Barrier for Germ Cell to Neuron Reprogramming in Caenorhabditis elegans. Genetics. 2019;211:121-139 pubmed publisher
Damodaran K, Venkatachalapathy S, Alisafaei F, Radhakrishnan A, Sharma Jokhun D, Shenoy V, et al. Compressive force induces reversible chromatin condensation and cell geometry dependent transcriptional response. Mol Biol Cell. 2018;:mbcE18040256 pubmed publisher
Haynes P, Bomsztyk K, Miller D. Sporadic DUX4 expression in FSHD myocytes is associated with incomplete repression by the PRC2 complex and gain of H3K9 acetylation on the contracted D4Z4 allele. Epigenetics Chromatin. 2018;11:47 pubmed publisher
Watanabe T, Cui X, Yuan Z, Qi H, Lin H. MIWI2 targets RNAs transcribed from piRNA-dependent regions to drive DNA methylation in mouse prospermatogonia. EMBO J. 2018;37: pubmed publisher
Vincek A, Patel J, Jaganathan A, Green A, Pierre Louis V, Arora V, et al. Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3. Molecules. 2018;23: pubmed publisher
Chen X, Zhang M, Gan H, Wang H, Lee J, Fang D, et al. A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma. Nat Commun. 2018;9:2949 pubmed publisher
Ahmed M, Streit A. Lsd1 interacts with cMyb to demethylate repressive histone marks and maintain inner ear progenitor identity. Development. 2018;145: pubmed publisher
Gawrzak S, Rinaldi L, Gregorio S, Arenas E, Salvador F, Urosevic J, et al. MSK1 regulates luminal cell differentiation and metastatic dormancy in ER+ breast cancer. Nat Cell Biol. 2018;20:211-221 pubmed publisher
Yu S, Chang Y, Chen Y. Deletion of ADA2 Increases Antifungal Drug Susceptibility and Virulence in Candida glabrata. Antimicrob Agents Chemother. 2018;62: pubmed publisher
Kalin J, Wu M, Gómez A, Song Y, Das J, Hayward D, et al. Targeting the CoREST complex with dual histone deacetylase and demethylase inhibitors. Nat Commun. 2018;9:53 pubmed publisher
Lercher L, Danilenko N, Kirkpatrick J, Carlomagno T. Structural characterization of the Asf1-Rtt109 interaction and its role in histone acetylation. Nucleic Acids Res. 2018;46:2279-2289 pubmed publisher
Sanchez G, Richmond P, Bunker E, Karman S, Azofeifa J, Garnett A, et al. Genome-wide dose-dependent inhibition of histone deacetylases studies reveal their roles in enhancer remodeling and suppression of oncogenic super-enhancers. Nucleic Acids Res. 2017;: pubmed publisher
Tang S, Fang Y, Huang G, Xu X, Padilla Banks E, Fan W, et al. Methionine metabolism is essential for SIRT1-regulated mouse embryonic stem cell maintenance and embryonic development. EMBO J. 2017;36:3175-3193 pubmed publisher
Hamed M, Khilji S, Dixon K, Blais A, Ioshikhes I, Chen J, et al. Insights into interplay between rexinoid signaling and myogenic regulatory factor-associated chromatin state in myogenic differentiation. Nucleic Acids Res. 2017;45:11236-11248 pubmed publisher
Bagati A, Bianchi Smiraglia A, Moparthy S, Kolesnikova K, Fink E, Lipchick B, et al. Melanoma Suppressor Functions of the Carcinoma Oncogene FOXQ1. Cell Rep. 2017;20:2820-2832 pubmed publisher
Li X, Seidel C, Szerszen L, Lange J, Workman J, Abmayr S. Enzymatic modules of the SAGA chromatin-modifying complex play distinct roles in Drosophila gene expression and development. Genes Dev. 2017;31:1588-1600 pubmed publisher
Sun M, Tong P, Kong W, Dong B, Huang Y, Park I, et al. HNF1B Loss Exacerbates the Development of Chromophobe Renal Cell Carcinomas. Cancer Res. 2017;77:5313-5326 pubmed publisher
Keck K, Moquin S, He A, Fernandez S, Somberg J, Liu S, et al. Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps. J Biol Chem. 2017;292:13284-13295 pubmed publisher
Kataruka S, Akhade V, Kayyar B, Rao M. Mrhl Long Noncoding RNA Mediates Meiotic Commitment of Mouse Spermatogonial Cells by Regulating Sox8 Expression. Mol Cell Biol. 2017;37: pubmed publisher
Chronis C, Fiziev P, Papp B, Butz S, Bonora G, Sabri S, et al. Cooperative Binding of Transcription Factors Orchestrates Reprogramming. Cell. 2017;168:442-459.e20 pubmed publisher
Ferreira R, Popova E, James J, Briones M, Zhang S, Barnstable C. Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina. J Biol Chem. 2017;292:2422-2440 pubmed publisher
Rasmussen R, Gajjar M, Tučková L, Jensen K, Maya Mendoza A, Holst C, et al. BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity. Nat Commun. 2016;7:13398 pubmed publisher
Cuella Martin R, Oliveira C, Lockstone H, Snellenberg S, Grolmusova N, Chapman J. 53BP1 Integrates DNA Repair and p53-Dependent Cell Fate Decisions via Distinct Mechanisms. Mol Cell. 2016;64:51-64 pubmed publisher
Xiao T, Wongtrakoongate P, TRAINOR C, Felsenfeld G. CTCF Recruits Centromeric Protein CENP-E to the Pericentromeric/Centromeric Regions of Chromosomes through Unusual CTCF-Binding Sites. Cell Rep. 2015;12:1704-14 pubmed publisher
Bodai L, Zsindely N, Gáspár R, Kristó I, Komonyi O, Boros I. Ecdysone induced gene expression is associated with acetylation of histone H3 lysine 23 in Drosophila melanogaster. PLoS ONE. 2012;7:e40565 pubmed publisher
product information
CatalogNumber :
ab4441
ItemName :
Anti-Histone H3 (acetyl K9) antibody - ChIP Grade
Product Type :
Antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Unconjugated
Size :
50 µg
SpeciesSummary :
Ce, Dm, Hu, Ms, Rat, S pom, Tet, Tx gg, Xl
Purity :
Protein A purified
Application Summary :
ChIP, Dot, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
Stefan.Pritchard@abcam.com, eCommerce@abcam.com, Vicky.Yang@abcam.com
https://www.abcam.com
888-7722226
headquarters: UK