This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Aggrecan ARGxx antibody [BC-3]
catalog :
ab3773
quantity :
1 ml
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
BC-3
reactivity :
human, mouse, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 36
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:200; loading ...; fig 3f
Novais E, Tran V, Johnston S, Darris K, Roupas A, Sessions G, et al. Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice. Nat Commun. 2021;12:5213 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 5j
Tessier S, Doolittle A, Sao K, Rotty J, Bear J, Ulici V, et al. Arp2/3 inactivation causes intervertebral disc and cartilage degeneration with dysregulated TonEBP-mediated osmoadaptation. JCI Insight. 2020;5: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4b
Gorth D, Shapiro I, Risbud M. Transgenic mice overexpressing human TNF-α experience early onset spontaneous intervertebral disc herniation in the absence of overt degeneration. Cell Death Dis. 2018;10:7 pubmed publisher
  • western blot; human; loading ...; fig 3a
Lu W, Shi J, Zhang J, Lv Z, Guo F, Huang H, et al. CXCL12/CXCR4 Axis Regulates Aggrecanase Activation and Cartilage Degradation in a Post-Traumatic Osteoarthritis Rat Model. Int J Mol Sci. 2016;17: pubmed
  • immunocytochemistry; human; 1:200
Luo Z, Jiang L, Xu Y, Li H, Xu W, Wu S, et al. Mechano growth factor (MGF) and transforming growth factor (TGF)-β3 functionalized silk scaffolds enhance articular hyaline cartilage regeneration in rabbit model. Biomaterials. 2015;52:463-75 pubmed publisher
  • immunohistochemistry - frozen section; bovine; 1:250; fig 5
Shimomura K, Bean A, Lin H, Nakamura N, Tuan R. In Vitro Repair of Meniscal Radial Tear Using Aligned Electrospun Nanofibrous Scaffold. Tissue Eng Part A. 2015;21:2066-75 pubmed publisher
  • western blot; human
Ismail H, Yamamoto K, Vincent T, Nagase H, Troeberg L, Saklatvala J. Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes. Arthritis Rheumatol. 2015;67:1826-36 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:40
Hasegawa A, Nakahara H, Kinoshita M, Asahara H, Koziol J, Lotz M. Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis. Arthritis Res Ther. 2013;15:R29 pubmed publisher
Lindberg G, Cui X, Durham M, Veenendaal L, Schon B, Hooper G, et al. Probing Multicellular Tissue Fusion of Cocultured Spheroids-A 3D-Bioassembly Model. Adv Sci (Weinh). 2021;8:e2103320 pubmed publisher
Park S, Lee D, Lee S, Lee C, Kim S. Noise exposure alters MMP9 and brevican expression in the rat primary auditory cortex. BMC Neurosci. 2020;21:16 pubmed publisher
Sirong S, Yang C, Taoran T, Songhang L, Shiyu L, Yuxin Z, et al. Effects of tetrahedral framework nucleic acid/wogonin complexes on osteoarthritis. Bone Res. 2020;8:6 pubmed publisher
Liu X, Liu L, Zhang H, Shao Y, Chen Z, Feng X, et al. MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin. Aging (Albany NY). 2019;11:6014-6028 pubmed publisher
Kumar S, Chen M, Li Y, Wong F, Thiam C, Hossain M, et al. Loss of ADAMTS4 reduces high fat diet-induced atherosclerosis and enhances plaque stability in ApoE(-/-) mice. Sci Rep. 2016;6:31130 pubmed publisher
Leung V, Aladin D, Lv F, Tam V, Sun Y, Lau R, et al. Mesenchymal stem cells reduce intervertebral disc fibrosis and facilitate repair. Stem Cells. 2014;32:2164-77 pubmed publisher
Chen P, Zhu S, Wang Y, Mu Q, Wu Y, Xia Q, et al. The amelioration of cartilage degeneration by ADAMTS-5 inhibitor delivered in a hyaluronic acid hydrogel. Biomaterials. 2014;35:2827-36 pubmed publisher
Zhang E, Yan X, Zhang M, Chang X, Bai Z, He Y, et al. Aggrecanases in the human synovial fluid at different stages of osteoarthritis. Clin Rheumatol. 2013;32:797-803 pubmed publisher
Thoms B, Dudek K, Lafont J, Murphy C. Hypoxia promotes the production and inhibits the destruction of human articular cartilage. Arthritis Rheum. 2013;65:1302-12 pubmed publisher
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, et al. Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice. Arthritis Rheum. 2013;65:743-52 pubmed publisher
Wang L, Pawlak E, Johnson P, Belknap J, Alfandari D, Black S. Effects of cleavage by a disintegrin and metalloproteinase with thrombospondin motifs-4 on gene expression and protein content of versican and aggrecan in the digital laminae of horses with starch gruel-induced laminitis. Am J Vet Res. 2012;73:1047-56 pubmed publisher
Pawlak E, Wang L, Johnson P, Nuovo G, Taye A, Belknap J, et al. Distribution and processing of a disintegrin and metalloproteinase with thrombospondin motifs-4, aggrecan, versican, and hyaluronan in equine digital laminae. Am J Vet Res. 2012;73:1035-46 pubmed publisher
Funck Brentano T, Lin H, Hay E, Ah Kioon M, Schiltz C, Hannouche D, et al. Targeting bone alleviates osteoarthritis in osteopenic mice and modulates cartilage catabolism. PLoS ONE. 2012;7:e33543 pubmed publisher
Wang J, Markova D, Anderson D, Zheng Z, Shapiro I, Risbud M. TNF-? and IL-1? promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem. 2011;286:39738-49 pubmed publisher
Lee C, Cook J, Mendelson A, Moioli E, Yao H, Mao J. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet. 2010;376:440-8 pubmed publisher
Madsen S, Sumer E, Bay Jensen A, Sondergaard B, Qvist P, Karsdal M. Aggrecanase- and matrix metalloproteinase-mediated aggrecan degradation is associated with different molecular characteristics of aggrecan and separated in time ex vivo. Biomarkers. 2010;15:266-76 pubmed publisher
Sondergaard B, Schultz N, Madsen S, Bay Jensen A, Kassem M, Karsdal M. MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation--divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation. Osteoarthritis Cartilage. 2010;18:279-88 pubmed publisher
Torzilli P, Bhargava M, Park S, Chen C. Mechanical load inhibits IL-1 induced matrix degradation in articular cartilage. Osteoarthritis Cartilage. 2010;18:97-105 pubmed publisher
Echtermeyer F, Bertrand J, Dreier R, Meinecke I, Neugebauer K, Fuerst M, et al. Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis. Nat Med. 2009;15:1072-6 pubmed publisher
Pockert A, Richardson S, Le Maitre C, Lyon M, Deakin J, Buttle D, et al. Modified expression of the ADAMTS enzymes and tissue inhibitor of metalloproteinases 3 during human intervertebral disc degeneration. Arthritis Rheum. 2009;60:482-91 pubmed publisher
Karsdal M, Madsen S, Christiansen C, Henriksen K, Fosang A, Sondergaard B. Cartilage degradation is fully reversible in the presence of aggrecanase but not matrix metalloproteinase activity. Arthritis Res Ther. 2008;10:R63 pubmed publisher
Rousseau J, Sumer E, Hein G, Sondergaard B, Madsen S, Pedersen C, et al. Patients with rheumatoid arthritis have an altered circulatory aggrecan profile. BMC Musculoskelet Disord. 2008;9:74 pubmed publisher
Llamazares M, Obaya A, Moncada Pazos A, Heljasvaara R, Espada J, Lopez Otin C, et al. The ADAMTS12 metalloproteinase exhibits anti-tumorigenic properties through modulation of the Ras-dependent ERK signalling pathway. J Cell Sci. 2007;120:3544-52 pubmed
Suzuki D, Takahashi M, Abe M, Sarukawa J, Tamura H, Tokura S, et al. Comparison of various mixtures of beta-chitin and chitosan as a scaffold for three-dimensional culture of rabbit chondrocytes. J Mater Sci Mater Med. 2008;19:1307-15 pubmed
Karsdal M, Sumer E, Wulf H, Madsen S, Christiansen C, Fosang A, et al. Induction of increased cAMP levels in articular chondrocytes blocks matrix metalloproteinase-mediated cartilage degradation, but not aggrecanase-mediated cartilage degradation. Arthritis Rheum. 2007;56:1549-58 pubmed
Shao X, Hunter C. Developing an alginate/chitosan hybrid fiber scaffold for annulus fibrosus cells. J Biomed Mater Res A. 2007;82:701-10 pubmed
Innes J, Little C, Hughes C, Caterson B. Products resulting from cleavage of the interglobular domain of aggrecan in samples of synovial fluid collected from dogs with early- and late-stage osteoarthritis. Am J Vet Res. 2005;66:1679-85 pubmed
. Molecular Approaches to Osteoarthritis Research. Abstracts of the Kennedy Institute of Rheumatology Symposium, London, United Kingdom, April 18-20, 2004. Scand J Rheumatol Suppl. 2005;120:1-41 pubmed
product information
CatalogNumber :
ab3773
ItemName :
Anti-Aggrecan ARGxx antibody [BC-3]
Category :
Antibody
Host :
Mouse
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
BC-3
Size :
1 ml
SpeciesSummary :
Cat, Cow, Dog, Gpig, Hrs, Hu, Pig, Rat, Rb, Shp
Application Summary :
ELISA, ICC/IF, IHC-Fr, IHC-P, sELISA, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
Stefan.Pritchard@abcam.com, eCommerce@abcam.com, Vicky.Yang@abcam.com
https://www.abcam.com
888-7722226
headquarters: UK