This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Rac1 antibody [23A8]
catalog :
ab33186
quantity :
125 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
23A8
reactivity :
Clostridioides difficile, human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 32
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 4c
  • western blot; human; 1:1000; loading ...; fig 4b
Kou W, Xu X, Ji S, Chen M, Liu D, Wang K, et al. The inhibition of the effect and mechanism of vascular intimal hyperplasia in Tiam1 knockout mice. Biochem Biophys Res Commun. 2018;497:248-255 pubmed publisher
  • western blot; rat; loading ...; fig 6
Zhai L, Liu M, Wang T, Zhang H, Li S, Guo Y. Picroside II protects the blood-brain barrier by inhibiting the oxidative signaling pathway in cerebral ischemia-reperfusion injury. PLoS ONE. 2017;12:e0174414 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s2g
Gaitanos T, Koerner J, Klein R. Tiam-Rac signaling mediates trans-endocytosis of ephrin receptor EphB2 and is important for cell repulsion. J Cell Biol. 2016;214:735-52 pubmed publisher
  • western blot; Clostridioides difficile; fig 4
Quesada Gómez C, López Ureña D, Chumbler N, Kroh H, Castro Peña C, Rodriguez C, et al. Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. Infect Immun. 2016;84:856-65 pubmed publisher
  • western blot; human; 1:1000
Maurya V, Sangappa C, Kumar V, Mahfooz S, Singh A, Rajender S, et al. Expression and activity of Rac1 is negatively affected in the dehydroepiandrosterone induced polycystic ovary of mouse. J Ovarian Res. 2014;7:32 pubmed publisher
Alshammari E, Aljagthmi A, Stacy A, Bottomley M, Shamma H, Kadakia M, et al. ERK3 is transcriptionally upregulated by ∆Np63α and mediates the role of ∆Np63α in suppressing cell migration in non-melanoma skin cancers. BMC Cancer. 2021;21:155 pubmed publisher
Li Z, Wang Q, Peng S, Yao K, Chen J, Tao Y, et al. The metastatic promoter DEPDC1B induces epithelial-mesenchymal transition and promotes prostate cancer cell proliferation via Rac1-PAK1 signaling. Clin Transl Med. 2020;10:e191 pubmed publisher
Kuhn S, Bergqvist J, Gil M, Valenzuela C, Barrio L, Lebreton S, et al. Actin Assembly around the Shigella-Containing Vacuole Promotes Successful Infection. Cell Rep. 2020;31:107638 pubmed publisher
Singh V, Davidson A, Hume P, Koronakis V. Pathogenic Escherichia coli Hijacks GTPase-Activated p21-Activated Kinase for Actin Pedestal Formation. MBio. 2019;10: pubmed publisher
Jenie R, Handayani S, Susidarti R, Udin L, Meiyanto E. The Cytotoxic and Antimigratory Activity of Brazilin-Doxorubicin on MCF-7/HER2 Cells. Adv Pharm Bull. 2018;8:507-516 pubmed publisher
Zou Y, Xu S, Xiao Y, Qiu Q, Shi M, Wang J, et al. Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation. J Clin Invest. 2018;128:4510-4524 pubmed publisher
Brooks A, Humphreys D, Singh V, Davidson A, Arden S, Buss F, et al. MYO6 is targeted by Salmonella virulence effectors to trigger PI3-kinase signaling and pathogen invasion into host cells. Proc Natl Acad Sci U S A. 2017;114:3915-3920 pubmed publisher
Li Y, Zhao L, Gu B, Cai J, Lv Y, Yu L. Aerobic exercise regulates Rho/cofilin pathways to rescue synaptic loss in aged rats. PLoS ONE. 2017;12:e0171491 pubmed publisher
Kempf S, Janik D, Barjaktarovic Z, Braga Tanaka I, Tanaka S, Neff F, et al. Chronic low-dose-rate ionising radiation affects the hippocampal phosphoproteome in the ApoE-/- Alzheimer's mouse model. Oncotarget. 2016;7:71817-71832 pubmed publisher
Geng J, Sun X, Wang P, Zhang S, Wang X, Wu H, et al. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nat Immunol. 2015;16:1142-52 pubmed publisher
Kempf S, Casciati A, Buratovic S, Janik D, von Toerne C, Ueffing M, et al. The cognitive defects of neonatally irradiated mice are accompanied by changed synaptic plasticity, adult neurogenesis and neuroinflammation. Mol Neurodegener. 2014;9:57 pubmed publisher
Skvortsov S, Dudas J, Eichberger P, Witsch Baumgartner M, Loeffler Ragg J, Pritz C, et al. Rac1 as a potential therapeutic target for chemo-radioresistant head and neck squamous cell carcinomas (HNSCC). Br J Cancer. 2014;110:2677-87 pubmed publisher
Paul C, Robaire B. Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases. PLoS ONE. 2013;8:e84354 pubmed publisher
Humphreys D, Davidson A, Hume P, Makin L, Koronakis V. Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells. Proc Natl Acad Sci U S A. 2013;110:16880-5 pubmed publisher
Yang Q, Luo G, Li Y, Shan H, Wang H, Xu G. Expression of Rac-1 related to tumor depth, lymph node metastasis and patient prognosis in esophageal squamous cell carcinoma. Med Oncol. 2013;30:689 pubmed publisher
Ljubimova J, Kleinman M, Karabalin N, Inoue S, Konda B, Gangalum P, et al. Gene expression changes in rat brain after short and long exposures to particulate matter in Los Angeles basin air: Comparison with human brain tumors. Exp Toxicol Pathol. 2013;65:1063-71 pubmed publisher
Imam J, Plyler J, Bansal H, Prajapati S, Bansal S, Rebeles J, et al. Genomic loss of tumor suppressor miRNA-204 promotes cancer cell migration and invasion by activating AKT/mTOR/Rac1 signaling and actin reorganization. PLoS ONE. 2012;7:e52397 pubmed publisher
Pescatore L, Bonatto D, Forti F, Sadok A, Kovacic H, Laurindo F. Protein disulfide isomerase is required for platelet-derived growth factor-induced vascular smooth muscle cell migration, Nox1 NADPH oxidase expression, and RhoGTPase activation. J Biol Chem. 2012;287:29290-300 pubmed publisher
Jacobs V, Liu Y, De Leo J. Propentofylline targets TROY, a novel microglial signaling pathway. PLoS ONE. 2012;7:e37955 pubmed publisher
Kim J, Oh M, Bernard L, Macara I, Zhang H. The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons. J Biol Chem. 2011;286:37615-24 pubmed publisher
Du X, Wang S, Lu J, Wang Q, Song N, Yang T, et al. Clinical value of Tiam1-Rac1 signaling in primary gallbladder carcinoma. Med Oncol. 2012;29:1873-8 pubmed publisher
Chatterjee S, Feinstein S, Dodia C, Sorokina E, Lien Y, Nguyen S, et al. Peroxiredoxin 6 phosphorylation and subsequent phospholipase A2 activity are required for agonist-mediated activation of NADPH oxidase in mouse pulmonary microvascular endothelium and alveolar macrophages. J Biol Chem. 2011;286:11696-706 pubmed publisher
Zanca C, Cozzolino F, Quintavalle C, Di Costanzo S, Ricci Vitiani L, Santoriello M, et al. PED interacts with Rac1 and regulates cell migration/invasion processes in human non-small cell lung cancer cells. J Cell Physiol. 2010;225:63-72 pubmed publisher
Yang W, Lv S, Liu X, Liu H, Yang W, Hu F. Up-regulation of Tiam1 and Rac1 correlates with poor prognosis in hepatocellular carcinoma. Jpn J Clin Oncol. 2010;40:1053-9 pubmed publisher
Huesa G, Baltrons M, Gómez Ramos P, Morán A, Garcia A, Hidalgo J, et al. Altered distribution of RhoA in Alzheimer's disease and AbetaPP overexpressing mice. J Alzheimers Dis. 2010;19:37-56 pubmed publisher
Qi Y, Huang B, Yu L, Wang Q, Lan G, Zhang Q. Prognostic value of Tiam1 and Rac1 overexpression in nasopharyngeal carcinoma. ORL J Otorhinolaryngol Relat Spec. 2009;71:163-71 pubmed publisher
Smith T, Hager H, Francis R, Kilkenny D, Lo C, Bader D. Bves directly interacts with GEFT, and controls cell shape and movement through regulation of Rac1/Cdc42 activity. Proc Natl Acad Sci U S A. 2008;105:8298-303 pubmed publisher
product information
CatalogNumber :
ab33186
ItemName :
Anti-Rac1 antibody [23A8]
Category :
Antibody
Host :
Mouse
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
23A8
Size :
125 µg
SpeciesSummary :
Hu, Ms, Rat, Rb
Application Summary :
ELISA, Flow Cyt, ICC/IF, IHC (PFA fixed), IHC-Fr, IHC-P, IP, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK