This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Actin antibody [ACTN05 (C4)]
catalog :
ab3280
quantity :
500 ul
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
ACTN05
reactivity :
human, mouse, rat, dog, cow, Caenorhabditis elegans
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 163
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:2000; fig 2
Golovko A, Kojukhov A, Guan B, Morpurgo B, Merrick W, Mazumder B, et al. The eIF2A knockout mouse. Cell Cycle. 2016;15:3115-3120 pubmed
  • western blot; mouse; 1:2500; fig 5
Pereira M, Tourlomousis P, Wright J, P Monie T, Bryant C. CARD9 negatively regulates NLRP3-induced IL-1? production on Salmonella infection of macrophages. Nat Commun. 2016;7:12874 pubmed publisher
  • western blot; Caenorhabditis elegans; fig 4
Lehrbach N, Ruvkun G. Proteasome dysfunction triggers activation of SKN-1A/Nrf1 by the aspartic protease DDI-1. elife. 2016;5: pubmed publisher
  • western blot; mouse; fig s5
Kuwahara T, Inoue K, D Agati V, Fujimoto T, Eguchi T, Saha S, et al. LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts. Sci Rep. 2016;6:29945 pubmed publisher
  • immunocytochemistry; rat
Zhu J, Carozzi V, Reed N, Mi R, Marmiroli P, Cavaletti G, et al. Ethoxyquin provides neuroprotection against cisplatin-induced neurotoxicity. Sci Rep. 2016;6:28861 pubmed publisher
  • western blot; human; fig 5
  • western blot; mouse; fig 3
Wang L, Lee A, Wigg J, Peshavariya H, Liu P, Zhang H. miR-126 Regulation of Angiogenesis in Age-Related Macular Degeneration in CNV Mouse Model. Int J Mol Sci. 2016;17: pubmed publisher
  • western blot; mouse; 1:2000; fig s4e
Pawar A, Meier J, Dasgupta A, Diwanji N, Deshpande N, Saxena K, et al. Ral-Arf6 crosstalk regulates Ral dependent exocyst trafficking and anchorage independent growth signalling. Cell Signal. 2016;28:1225-36 pubmed publisher
  • western blot; human; fig 1
Gilmore J, Sardiu M, Groppe B, Thornton J, Liu X, Dayebgadoh G, et al. WDR76 Co-Localizes with Heterochromatin Related Proteins and Rapidly Responds to DNA Damage. PLoS ONE. 2016;11:e0155492 pubmed publisher
  • western blot; mouse; fig 1
Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, et al. Deacetylation of TFEB promotes fibrillar A? degradation by upregulating lysosomal biogenesis in microglia. Protein Cell. 2016;7:417-33 pubmed publisher
  • western blot; mouse; fig 1
Jadav R, Kumar D, Buwa N, Ganguli S, Thampatty S, Balasubramanian N, et al. Deletion of inositol hexakisphosphate kinase 1 (IP6K1) reduces cell migration and invasion, conferring protection from aerodigestive tract carcinoma in mice. Cell Signal. 2016;28:1124-36 pubmed publisher
  • western blot; human; fig 2
Ramanathan A, Gusarova V, Stahl N, Gurnett Bander A, Kyratsous C. Alirocumab, a Therapeutic Human Antibody to PCSK9, Does Not Affect CD81 Levels or Hepatitis C Virus Entry and Replication into Hepatocytes. PLoS ONE. 2016;11:e0154498 pubmed publisher
  • western blot; mouse; fig 1b
  • western blot; human; fig 1a
O Sullivan C, Schubart A, Mir A, Dev K. The dual S1PR1/S1PR5 drug BAF312 (Siponimod) attenuates demyelination in organotypic slice cultures. J Neuroinflammation. 2016;13:31 pubmed publisher
  • western blot; mouse; 1:1000; fig 5
Heyward F, Gilliam D, Coleman M, Gavin C, Wang J, Kaas G, et al. Obesity Weighs down Memory through a Mechanism Involving the Neuroepigenetic Dysregulation of Sirt1. J Neurosci. 2016;36:1324-35 pubmed publisher
  • western blot; mouse
Gao X, Krokowski D, Guan B, Bederman I, Majumder M, Parisien M, et al. Quantitative H2S-mediated protein sulfhydration reveals metabolic reprogramming during the integrated stress response. elife. 2015;4:e10067 pubmed publisher
  • western blot; human; 1:5000; fig 4
Chaumet A, Wright G, Seet S, Tham K, Gounko N, Bard F. Nuclear envelope-associated endosomes deliver surface proteins to the nucleus. Nat Commun. 2015;6:8218 pubmed publisher
  • western blot; human; 1:1000; fig 1
Wu H, Jiang Z, Ding P, Shao L, Liu R. Hypoxia-induced autophagy mediates cisplatin resistance in lung cancer cells. Sci Rep. 2015;5:12291 pubmed publisher
  • western blot; human; 1:1000
Lu Q, Schafer D, Adler P. The Drosophila planar polarity gene multiple wing hairs directly regulates the actin cytoskeleton. Development. 2015;142:2478-86 pubmed publisher
  • western blot; mouse; 1:3000; fig s1a
Mangia A, Caldarola L, Dell Endice S, Scarpi E, Saragoni L, Monti M, et al. The potential predictive role of nuclear NHERF1 expression in advanced gastric cancer patients treated with epirubicin/oxaliplatin/capecitabine first line chemotherapy. Cancer Biol Ther. 2015;16:1140-7 pubmed publisher
  • western blot; mouse; 1:3000; fig s1a
Asinof S, Sukoff Rizzo S, Buckley A, Beyer B, Letts V, Frankel W, et al. Independent Neuronal Origin of Seizures and Behavioral Comorbidities in an Animal Model of a Severe Childhood Genetic Epileptic Encephalopathy. PLoS Genet. 2015;11:e1005347 pubmed publisher
  • western blot; mouse
Balzamino B, Esposito G, Marino R, Keller F, Micera A. NGF Expression in Reelin-Deprived Retinal Cells: A Potential Neuroprotective Effect. Neuromolecular Med. 2015;17:314-25 pubmed publisher
  • western blot; human; 1:1000; fig 3
Cheng H, Liang Y, Kuo Y, Chuu C, Lin C, Lee M, et al. Identification of thioridazine, an antipsychotic drug, as an antiglioblastoma and anticancer stem cell agent using public gene expression data. Cell Death Dis. 2015;6:e1753 pubmed publisher
  • western blot; mouse; fig 4
Boncompagni S, Arthurton L, Akujuru E, Pearson T, Steverding D, Protasi F, et al. Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres. J Physiol. 2015;593:2679-92 pubmed publisher
  • western blot; rat; 1:2500; fig 2
Jadhav S, Katina S, Kovac A, Kazmerova Z, Novak M, Zilka N. Truncated tau deregulates synaptic markers in rat model for human tauopathy. Front Cell Neurosci. 2015;9:24 pubmed publisher
  • western blot; human; fig 4
Cotney J, Muhle R, Sanders S, Liu L, Willsey A, Niu W, et al. The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment. Nat Commun. 2015;6:6404 pubmed publisher
  • western blot; human; fig 3
Aguilar Arnal L, Katada S, Orozco Solis R, Sassone Corsi P. NAD(+)-SIRT1 control of H3K4 trimethylation through circadian deacetylation of MLL1. Nat Struct Mol Biol. 2015;22:312-8 pubmed publisher
  • western blot; human; 1:5000; fig s1
Mo J, Meng Z, Kim Y, Park H, Hansen C, Kim S, et al. Cellular energy stress induces AMPK-mediated regulation of YAP and the Hippo pathway. Nat Cell Biol. 2015;17:500-10 pubmed publisher
  • western blot; human; fig 8
Li C, Cheng P, Liang M, Chen Y, Lu Q, Wang J, et al. MicroRNA-188 regulates age-related switch between osteoblast and adipocyte differentiation. J Clin Invest. 2015;125:1509-22 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 2, 4, 5
Trasino S, Benoit Y, Gudas L. Vitamin A deficiency causes hyperglycemia and loss of pancreatic β-cell mass. J Biol Chem. 2015;290:1456-73 pubmed publisher
  • western blot; human; 1:5000; fig 5
Kim M, Jung H, Kim S, Park J, Seo Y. Electromagnetic fields and nanomagnetic particles increase the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells. Int J Mol Med. 2015;35:153-60 pubmed publisher
  • western blot; human; fig 2
Kim M, Tan Y, Cheng W, Kingsbury T, Heimfeld S, Civin C. MIR144 and MIR451 regulate human erythropoiesis via RAB14. Br J Haematol. 2015;168:583-97 pubmed publisher
  • western blot; human
Yim D, Ghosh S, Guy G, Virshup D. Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling. Oncogene. 2015;34:474-84 pubmed publisher
  • western blot; human
Vermeire K, Bell T, Van Puyenbroeck V, Giraut A, Noppen S, Liekens S, et al. Signal peptide-binding drug as a selective inhibitor of co-translational protein translocation. PLoS Biol. 2014;12:e1002011 pubmed publisher
  • western blot; human; 1:1000
Gou W, Zhao Y, Lu H, Yang X, Xiu Y, Zhao S, et al. The role of RhoC in epithelial-to-mesenchymal transition of ovarian carcinoma cells. BMC Cancer. 2014;14:477 pubmed publisher
  • immunoprecipitation; human
  • immunocytochemistry; human
Williams K, McNeilly R, Coppolino M. SNAP23, Syntaxin4, and vesicle-associated membrane protein 7 (VAMP7) mediate trafficking of membrane type 1-matrix metalloproteinase (MT1-MMP) during invadopodium formation and tumor cell invasion. Mol Biol Cell. 2014;25:2061-70 pubmed publisher
  • western blot; mouse
Tong Q, He S, Xie F, Mochizuki K, Liu Y, Mochizuki I, et al. Ezh2 regulates transcriptional and posttranslational expression of T-bet and promotes Th1 cell responses mediating aplastic anemia in mice. J Immunol. 2014;192:5012-22 pubmed publisher
  • western blot; mouse; 1:1000
Chesarino N, McMichael T, Hach J, Yount J. Phosphorylation of the antiviral protein interferon-inducible transmembrane protein 3 (IFITM3) dually regulates its endocytosis and ubiquitination. J Biol Chem. 2014;289:11986-92 pubmed publisher
  • western blot; rat; 1:1,000
Zuidema J, Hyzinski García M, Van Vlasselaer K, Zaccor N, Plopper G, Mongin A, et al. Enhanced GLT-1 mediated glutamate uptake and migration of primary astrocytes directed by fibronectin-coated electrospun poly-L-lactic acid fibers. Biomaterials. 2014;35:1439-49 pubmed publisher
  • western blot; mouse
Man S, Tourlomousis P, Hopkins L, Monie T, Fitzgerald K, Bryant C. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1? production. J Immunol. 2013;191:5239-46 pubmed publisher
  • western blot; human; 1:2000
Zhu Q, Feng C, Liao W, Zhang Y, Tang S. Target delivery of MYCN siRNA by folate-nanoliposomes delivery system in a metastatic neuroblastoma model. Cancer Cell Int. 2013;13:65 pubmed publisher
  • immunocytochemistry; mouse; 1:1000
Taylor Weiner H, Schwarzbauer J, Engler A. Defined extracellular matrix components are necessary for definitive endoderm induction. Stem Cells. 2013;31:2084-94 pubmed publisher
  • western blot; human; fig 6
Benediktsdóttir B, Gudjonsson T, Baldursson O, Másson M. N-alkylation of highly quaternized chitosan derivatives affects the paracellular permeation enhancement in bronchial epithelia in vitro. Eur J Pharm Biopharm. 2014;86:55-63 pubmed publisher
  • western blot; mouse; 1:5000
  • western blot; human; 1:5000
Sigurdsson V, Ingthorsson S, Hilmarsdottir B, Gustafsdottir S, Franzdóttir S, Arason A, et al. Expression and functional role of sprouty-2 in breast morphogenesis. PLoS ONE. 2013;8:e60798 pubmed publisher
Brown K, Svendsen J, Tucci R, Montgomery B, Montgomery T. ALG-5 is a miRNA-associated Argonaute required for proper developmental timing in the Caenorhabditis elegans germline. Nucleic Acids Res. 2017;45:9093-9107 pubmed publisher
Bischoff F, Werner A, John D, Boeckel J, Melissari M, Grote P, et al. Identification and Functional Characterization of Hypoxia-Induced Endoplasmic Reticulum Stress Regulating lncRNA (HypERlnc) in Pericytes. Circ Res. 2017;121:368-375 pubmed publisher
Shemesh K, Sebesta M, Pacesa M, Sau S, Bronstein A, Parnas O, et al. A structure-function analysis of the yeast Elg1 protein reveals the importance of PCNA unloading in genome stability maintenance. Nucleic Acids Res. 2017;45:3189-3203 pubmed publisher
Tang S, Wang D, Zhang Q, Li L. miR-218 suppresses gastric cancer cell proliferation and invasion via regulation of angiopoietin-2. Exp Ther Med. 2016;12:3837-3842 pubmed publisher
Shen K, Xi Z, Xie J, Wang H, Xie C, Lee C, et al. Guttiferone K suppresses cell motility and metastasis of hepatocellular carcinoma by restoring aberrantly reduced profilin 1. Oncotarget. 2016;7:56650-56663 pubmed publisher
Rousseau A, Bertolotti A. An evolutionarily conserved pathway controls proteasome homeostasis. Nature. 2016;536:184-9 pubmed
Anunobi C, Koli K, Saxena G, Banjo A, Ogbureke K. Expression of the SIBLINGs and their MMP partners in human benign and malignant prostate neoplasms. Oncotarget. 2016;7:48038-48049 pubmed publisher
Jensen N, Agama K, Roy A, Smith D, Pfister T, Rømer M, et al. Characterization of DNA topoisomerase I in three SN-38 resistant human colon cancer cell lines reveals a new pair of resistance-associated mutations. J Exp Clin Cancer Res. 2016;35:56 pubmed publisher
Dang Y, Mu Y, Wang K, Xu K, Yang J, Zhu Y, et al. Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway. Drug Des Devel Ther. 2016;10:851-9 pubmed publisher
Lee D, Wang Y, Kalaitzidis D, Ramachandran J, Eda H, Sykes D, et al. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest. 2016;126:1300-10 pubmed publisher
Stindt S, Cebula P, Albrecht U, Keitel V, Schulte Am Esch J, Knoefel W, et al. Hepatitis C Virus Activates a Neuregulin-Driven Circuit to Modify Surface Expression of Growth Factor Receptors of the ErbB Family. PLoS ONE. 2016;11:e0148711 pubmed publisher
Teplyuk N, Uhlmann E, Gabriely G, Volfovsky N, Wang Y, Teng J, et al. Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016;8:268-87 pubmed publisher
Cohen A, Weindling E, Rabinovich E, Nachman I, Fuchs S, Chuartzman S, et al. Water-Transfer Slows Aging in Saccharomyces cerevisiae. PLoS ONE. 2016;11:e0148650 pubmed publisher
Zhao Y, Hou J, Mi P, Mao L, Xu L, Zhang Y, et al. Exo70 is transcriptionally up-regulated by hepatic nuclear factor 4α and contributes to cell cycle control in hepatoma cells. Oncotarget. 2016;7:9150-62 pubmed publisher
McGonigle S, Chen Z, Wu J, Chang P, Kolber Simonds D, Ackermann K, et al. E7449: A dual inhibitor of PARP1/2 and tankyrase1/2 inhibits growth of DNA repair deficient tumors and antagonizes Wnt signaling. Oncotarget. 2015;6:41307-23 pubmed publisher
Radko S, Jung R, Olanubi O, Pelka P. Effects of Adenovirus Type 5 E1A Isoforms on Viral Replication in Arrested Human Cells. PLoS ONE. 2015;10:e0140124 pubmed publisher
Chesarino N, McMichael T, Yount J. E3 Ubiquitin Ligase NEDD4 Promotes Influenza Virus Infection by Decreasing Levels of the Antiviral Protein IFITM3. PLoS Pathog. 2015;11:e1005095 pubmed publisher
Hong S, Moreno Navarrete J, Wei X, Kikukawa Y, Tzameli I, Prasad D, et al. Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization. Nat Med. 2015;21:887-94 pubmed publisher
Yuan Y, Yao Y, Hu S, Gao J, Zhang L. MiR-133a Is Functionally Involved in Doxorubicin-Resistance in Breast Cancer Cells MCF-7 via Its Regulation of the Expression of Uncoupling Protein 2. PLoS ONE. 2015;10:e0129843 pubmed publisher
Hirst J, Edgar J, Esteves T, Darios F, Madeo M, Chang J, et al. Loss of AP-5 results in accumulation of aberrant endolysosomes: defining a new type of lysosomal storage disease. Hum Mol Genet. 2015;24:4984-96 pubmed publisher
Ježek J, Dlasková A, Zelenka J, Jabůrek M, Ježek P. H₂O₂-Activated Mitochondrial Phospholipase iPLA₂γ Prevents Lipotoxic Oxidative Stress in Synergy with UCP2, Amplifies Signaling via G-Protein-Coupled Receptor GPR40, and Regulates Insulin Secretion in Pancreatic β-Cells. Antioxid Redox Signal. 2015;23:958-72 pubmed publisher
Teplyuk N, Uhlmann E, Wong A, Karmali P, Basu M, Gabriely G, et al. MicroRNA-10b inhibition reduces E2F1-mediated transcription and miR-15/16 activity in glioblastoma. Oncotarget. 2015;6:3770-83 pubmed
Kaulich M, Lee Y, Lönn P, Springer A, Meade B, Dowdy S. Efficient CRISPR-rAAV engineering of endogenous genes to study protein function by allele-specific RNAi. Nucleic Acids Res. 2015;43:e45 pubmed publisher
Wang X, Guo Z, Ding Z, Khaidakov M, Lin J, Xu Z, et al. Endothelin-1 upregulation mediates aging-related cardiac fibrosis. J Mol Cell Cardiol. 2015;80:101-9 pubmed publisher
Joshi A, Bobylev I, Zhang G, Sheikh K, Lehmann H. Inhibition of Rho-kinase differentially affects axon regeneration of peripheral motor and sensory nerves. Exp Neurol. 2015;263:28-38 pubmed publisher
Yang S, Xia C, Li S, Du L, Zhang L, Zhou R. Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity. Redox Biol. 2014;3:63-71 pubmed publisher
Nussbaum I, Weindling E, Jubran R, Cohen A, Bar Nun S. Deteriorated stress response in stationary-phase yeast: Sir2 and Yap1 are essential for Hsf1 activation by heat shock and oxidative stress, respectively. PLoS ONE. 2014;9:e111505 pubmed publisher
Yang L, Zhang R, Li M, Wu X, Wang J, Huang L, et al. A functional MiR-124 binding-site polymorphism in IQGAP1 affects human cognitive performance. PLoS ONE. 2014;9:e107065 pubmed publisher
Xu J, Ren G, Zhao D, Li B, Cai C, Zhou Y, et al. Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells. Oncol Rep. 2014;32:1947-56 pubmed publisher
Moczulska K, Pichler P, Schutzbier M, Schleiffer A, Rumpel S, Mechtler K. Deep and precise quantification of the mouse synaptosomal proteome reveals substantial remodeling during postnatal maturation. J Proteome Res. 2014;13:4310-24 pubmed publisher
Dang Y, Xu Y, Wu W, Li W, Sun Y, Yang J, et al. Tetrandrine suppresses lipopolysaccharide-induced microglial activation by inhibiting NF-κB and ERK signaling pathways in BV2 cells. PLoS ONE. 2014;9:e102522 pubmed publisher
So J, Kim G, Song M, Lee C, Park E, Kim H, et al. 6-Methoxyflavone inhibits NFAT translocation into the nucleus and suppresses T cell activation. J Immunol. 2014;193:2772-83 pubmed publisher
Morales Diaz H. Down syndrome cell adhesion molecule is important for early development in Xenopus tropicalis. Genesis. 2014;52:849-57 pubmed publisher
Okal A, Matissek K, Matissek S, Price R, Salama M, Janát Amsbury M, et al. Re-engineered p53 activates apoptosis in vivo and causes primary tumor regression in a dominant negative breast cancer xenograft model. Gene Ther. 2014;21:903-12 pubmed publisher
Garcia S, Tabach Y, Lourenco G, Armakola M, Ruvkun G. Identification of genes in toxicity pathways of trinucleotide-repeat RNA in C. elegans. Nat Struct Mol Biol. 2014;21:712-20 pubmed publisher
Sand K, Landsverk O, Berg Larsen A, Bakke O, Gregers T. The human-specific invariant chain isoform Iip35 modulates Iip33 trafficking and function. Immunol Cell Biol. 2014;92:791-8 pubmed publisher
Shang L, Huang J, Ding W, Chen S, Xue L, Ma R, et al. Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevated hydrostatic pressure. BMC Neurosci. 2014;15:63 pubmed publisher
Carrera S, Senra J, Acosta M, Althubiti M, Hammond E, De Verdier P, et al. The role of the HIF-1? transcription factor in increased cell division at physiological oxygen tensions. PLoS ONE. 2014;9:e97938 pubmed publisher
Zhou Y, Zhang T, Zhang Q, Jiang Y, Xu D, Zhang M, et al. Unstable expression of transgene is associated with the methylation of CAG promoter in the offspring from the same litter of homozygous transgenic mice. Mol Biol Rep. 2014;41:5177-86 pubmed publisher
Vandergaast R, Hoover L, Zheng K, Fredericksen B. Generation of West Nile virus infectious clones containing amino acid insertions between capsid and capsid anchor. Viruses. 2014;6:1637-53 pubmed publisher
Serradj N, Paixão S, Sobocki T, Feinberg M, Klein R, Kullander K, et al. EphA4-mediated ipsilateral corticospinal tract misprojections are necessary for bilateral voluntary movements but not bilateral stereotypic locomotion. J Neurosci. 2014;34:5211-21 pubmed publisher
Nabti I, Marangos P, Bormann J, Kudo N, Carroll J. Dual-mode regulation of the APC/C by CDK1 and MAPK controls meiosis I progression and fidelity. J Cell Biol. 2014;204:891-900 pubmed publisher
Son J, Shen S, Margueron R, Reinberg D. Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin. Genes Dev. 2013;27:2663-77 pubmed publisher
Du L, Wang Y, Xu C, Cao J, Wang Q, Zhao H, et al. Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells. Int J Mol Sci. 2013;14:24087-96 pubmed publisher
Goossens D, da Silva N, Metral S, Cortes U, Callebaut I, Picot J, et al. Mice expressing RHAG and RHD human blood group genes. PLoS ONE. 2013;8:e80460 pubmed publisher
Tan T, Lu B, Zhang J, Niu Y, Si W, Wei Q, et al. Notch1 signaling antagonizes transforming growth factor-? pathway and induces apoptosis in rabbit trophoblast stem cells. Stem Cells Dev. 2014;23:813-22 pubmed publisher
Nguyen H, Geens M, Mertzanidou A, Jacobs K, Heirman C, Breckpot K, et al. Gain of 20q11.21 in human embryonic stem cells improves cell survival by increased expression of Bcl-xL. Mol Hum Reprod. 2014;20:168-77 pubmed publisher
Li X, Liu C, Liang W, Ye H, Chen W, Lin R, et al. Millimeter wave promotes the synthesis of extracellular matrix and the proliferation of chondrocyte by regulating the voltage-gated K+ channel. J Bone Miner Metab. 2014;32:367-77 pubmed publisher
Li Y, Man X, You L, Xiang Q, Li H, Xu B, et al. Downregulation of PTEN expression in psoriatic lesions. Int J Dermatol. 2014;53:855-60 pubmed publisher
Aguilar Arnal L, Hakim O, Patel V, Baldi P, Hager G, Sassone Corsi P. Cycles in spatial and temporal chromosomal organization driven by the circadian clock. Nat Struct Mol Biol. 2013;20:1206-13 pubmed publisher
Rondahl V, Holmlund C, Karlsson T, Wang B, Faraz M, Henriksson R, et al. Lrig2-deficient mice are protected against PDGFB-induced glioma. PLoS ONE. 2013;8:e73635 pubmed publisher
Li S, Du L, Zhang L, Hu Y, Xia W, Wu J, et al. Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line. J Biol Chem. 2013;288:30094-104 pubmed publisher
Zhu G, Huang C, Feng Z, Lv X, Qiu Z. Hypoxia-induced snail expression through transcriptional regulation by HIF-1? in pancreatic cancer cells. Dig Dis Sci. 2013;58:3503-15 pubmed publisher
Chan B, VanderLaan P, Sukhatme V. 6-Phosphogluconate dehydrogenase regulates tumor cell migration in vitro by regulating receptor tyrosine kinase c-Met. Biochem Biophys Res Commun. 2013;439:247-51 pubmed publisher
Okal A, Mossalam M, Matissek K, Dixon A, Moos P, Lim C. A chimeric p53 evades mutant p53 transdominant inhibition in cancer cells. Mol Pharm. 2013;10:3922-33 pubmed publisher
Pérez M, Cormack J, Mallinson D, Mutungi G. A membrane glucocorticoid receptor mediates the rapid/non-genomic actions of glucocorticoids in mammalian skeletal muscle fibres. J Physiol. 2013;591:5171-85 pubmed publisher
Camacho A, Huang J, Delint Ramirez I, Yew Tan C, Fuller M, Lelliott C, et al. Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis. Eur J Neurosci. 2013;38:2672-83 pubmed publisher
Russell R, Tian Y, Yuan H, Park H, Chang Y, Kim J, et al. ULK1 induces autophagy by phosphorylating Beclin-1 and activating VPS34 lipid kinase. Nat Cell Biol. 2013;15:741-50 pubmed publisher
Molina Berríos A, Campos Estrada C, Henriquez N, Faundez M, Torres G, Castillo C, et al. Protective role of acetylsalicylic acid in experimental Trypanosoma cruzi infection: evidence of a 15-epi-lipoxin A?-mediated effect. PLoS Negl Trop Dis. 2013;7:e2173 pubmed publisher
Shavva V, Mogilenko D, Dizhe E, Oleinikova G, Perevozchikov A, Orlov S. Hepatic nuclear factor 4? positively regulates complement C3 expression and does not interfere with TNF?-mediated stimulation of C3 expression in HepG2 cells. Gene. 2013;524:187-92 pubmed publisher
Le P, Maranon D, Altina N, Battaglia C, Bailey S. TERRA, hnRNP A1, and DNA-PKcs Interactions at Human Telomeres. Front Oncol. 2013;3:91 pubmed publisher
Cain J, McCaw A, Jayasekara W, Rossello F, Marini K, Irving A, et al. Sustained Low-Dose Treatment with the Histone Deacetylase Inhibitor LBH589 Induces Terminal Differentiation of Osteosarcoma Cells. Sarcoma. 2013;2013:608964 pubmed publisher
Wang W, Zhao F, Fang Y, Li X, Shen L, Cao T, et al. Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response. Crit Care. 2013;17:R44 pubmed publisher
Yu H, Usmani S, Borch A, Kr mer J, St rzel C, Khalid M, et al. The efficiency of Vpx-mediated SAMHD1 antagonism does not correlate with the potency of viral control in HIV-2-infected individuals. Retrovirology. 2013;10:27 pubmed publisher
Shabaneh T, Downey S, Goddard A, Screen M, Lucas M, Eastman A, et al. Molecular basis of differential sensitivity of myeloma cells to clinically relevant bolus treatment with bortezomib. PLoS ONE. 2013;8:e56132 pubmed publisher
Carrera S, Cuadrado Castano S, Samuel J, Jones G, Villar E, Lee S, et al. Stra6, a retinoic acid-responsive gene, participates in p53-induced apoptosis after DNA damage. Cell Death Differ. 2013;20:910-9 pubmed publisher
Reaz S, Mossalam M, Okal A, Lim C. A single mutant, A276S of p53, turns the switch to apoptosis. Mol Pharm. 2013;10:1350-9 pubmed publisher
Maier H, Cottam E, Stevenson Leggett P, Wilkinson J, Harte C, Wileman T, et al. Visualizing the autophagy pathway in avian cells and its application to studying infectious bronchitis virus. Autophagy. 2013;9:496-509 pubmed publisher
Ohnishi R, Matsui Yuasa I, Deguchi Y, Yaku K, Tabuchi M, Munakata H, et al. 1'-acetoxychavicol acetate inhibits adipogenesis in 3T3-L1 adipocytes and in high fat-fed rats. Am J Chin Med. 2012;40:1189-204 pubmed publisher
Ehrensberger K, Mason C, Corkins M, Anderson C, Dutrow N, Cairns B, et al. Zinc-dependent regulation of the Adh1 antisense transcript in fission yeast. J Biol Chem. 2013;288:759-69 pubmed publisher
Wagnon J, Briese M, Sun W, Mahaffey C, Curk T, Rot G, et al. CELF4 regulates translation and local abundance of a vast set of mRNAs, including genes associated with regulation of synaptic function. PLoS Genet. 2012;8:e1003067 pubmed publisher
Jevnikar Z, Rojnik M, Jamnik P, Doljak B, Fonović U, Kos J. Cathepsin H mediates the processing of talin and regulates migration of prostate cancer cells. J Biol Chem. 2013;288:2201-9 pubmed publisher
Kracklauer M, Feng H, Jiang W, Lin J, Lin J, Jin J. Discontinuous thoracic venous cardiomyocytes and heart exhibit synchronized developmental switch of troponin isoforms. FEBS J. 2013;280:880-91 pubmed publisher
Mogilenko D, Kudriavtsev I, Shavva V, Dizhe E, Vilenskaya E, Efremov A, et al. Peroxisome proliferator-activated receptor ? positively regulates complement C3 expression but inhibits tumor necrosis factor ?-mediated activation of C3 gene in mammalian hepatic-derived cells. J Biol Chem. 2013;288:1726-38 pubmed publisher
Burnham Marusich A, Snodgrass C, Johnson A, Kiyoshi C, Buzby S, Gruner M, et al. Metabolic labeling of Caenorhabditis elegans primary embryonic cells with azido-sugars as a tool for glycoprotein discovery. PLoS ONE. 2012;7:e49020 pubmed publisher
Qin H, Zhu X, Liang J, Wu J, Yang Y, Wang S, et al. MicroRNA-29b contributes to DNA hypomethylation of CD4+ T cells in systemic lupus erythematosus by indirectly targeting DNA methyltransferase 1. J Dermatol Sci. 2013;69:61-7 pubmed publisher
Bowens N, Dohare P, Kuo Y, Mongin A. DCPIB, the proposed selective blocker of volume-regulated anion channels, inhibits several glutamate transport pathways in glial cells. Mol Pharmacol. 2013;83:22-32 pubmed publisher
Guo S, Guo W, Ding Y, Gong J, Zou Q, Xie D, et al. Comparative study of human dental follicle cell sheets and periodontal ligament cell sheets for periodontal tissue regeneration. Cell Transplant. 2013;22:1061-73 pubmed publisher
Inoue K, Rispoli J, Kaphzan H, Klann E, Chen E, Kim J, et al. Macroautophagy deficiency mediates age-dependent neurodegeneration through a phospho-tau pathway. Mol Neurodegener. 2012;7:48 pubmed publisher
Nguyen T, Lee S, Hatzirodos N, Hummitzsch K, Sullivan T, Rodgers R, et al. Spatial differences within the membrana granulosa in the expression of focimatrix and steroidogenic capacity. Mol Cell Endocrinol. 2012;363:62-73 pubmed publisher
Yao L, Li F, Tang Z, Gao S, Wu Q. Smad4 expression in hepatocellular carcinoma differs by hepatitis status. Asian Pac J Cancer Prev. 2012;13:1297-303 pubmed
Sukhatme V, Chan B. Glycolytic cancer cells lacking 6-phosphogluconate dehydrogenase metabolize glucose to induce senescence. FEBS Lett. 2012;586:2389-95 pubmed publisher
Smirnova O, Isaguliants M, Hyvonen M, Keinänen T, Tunitskaya V, Vepsalainen J, et al. Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N1-acetyltransferase in human hepatoma HUH7 cells. Biochimie. 2012;94:1876-83 pubmed publisher
Chen M, Zhang H, Wu J, Xu L, Xu D, Sun J, et al. Promotion of the induction of cell pluripotency through metabolic remodeling by thyroid hormone triiodothyronine-activated PI3K/AKT signal pathway. Biomaterials. 2012;33:5514-23 pubmed publisher
Montgomery T, Rim Y, Zhang C, Dowen R, Phillips C, Fischer S, et al. PIWI associated siRNAs and piRNAs specifically require the Caenorhabditis elegans HEN1 ortholog henn-1. PLoS Genet. 2012;8:e1002616 pubmed publisher
Lane S, Yun Y, Jones K. Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension. Development. 2012;139:1947-55 pubmed publisher
Rice S, Patel B, Bano G, Ugwumadu A, Whitehead S. Aromatase expression in abdominal omental/visceral and subcutaneous fat depots: a comparison of pregnant and obese women. Fertil Steril. 2012;97:1460-6.e1 pubmed publisher
Yan K, Gao J, Yang T, Ma Q, Qiu X, Fan Q, et al. MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PLoS ONE. 2012;7:e33778 pubmed publisher
Knapp P, Chabowski A, Błachnio Zabielska A, Jarzabek K, Wołczyński S. Altered peroxisome-proliferator activated receptors expression in human endometrial cancer. PPAR Res. 2012;2012:471524 pubmed publisher
Landsverk O, Ottesen A, Berg Larsen A, Appel S, Bakke O. Differential regulation of MHC II and invariant chain expression during maturation of monocyte-derived dendritic cells. J Leukoc Biol. 2012;91:729-37 pubmed publisher
Mogilenko D, Kudriavtsev I, Trulioff A, Shavva V, Dizhe E, Missyul B, et al. Modified low density lipoprotein stimulates complement C3 expression and secretion via liver X receptor and Toll-like receptor 4 activation in human macrophages. J Biol Chem. 2012;287:5954-68 pubmed publisher
Labbe C, Boucher G, Foisy S, Alikashani A, Nkwimi H, David G, et al. Genome-wide expression profiling implicates a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients. Inflamm Bowel Dis. 2012;18:1072-80 pubmed publisher
Kim K, Wang J, Xu X, Wu S, Zhang W, Qin Z, et al. A chemical genomics screen to discover genes that modulate neural stem cell differentiation. J Biomol Screen. 2012;17:129-39 pubmed publisher
Plasilova M, Chattopadhyay C, Ghosh A, Wenzel F, Demougin P, Noppen C, et al. Discordant gene expression signatures and related phenotypic differences in lamin A- and A/C-related Hutchinson-Gilford progeria syndrome (HGPS). PLoS ONE. 2011;6:e21433 pubmed publisher
Zuo Z, Niu L, Kou Z, Zhu C, Wang W, Zhao X, et al. RU486 (mifepristone) ameliorates cognitive dysfunction and reverses the down-regulation of astrocytic N-myc downstream-regulated gene 2 in streptozotocin-induced type-1 diabetic rats. Neuroscience. 2011;190:156-65 pubmed publisher
Peters T, McClain K, Allen C. Neither IL-17A mRNA nor IL-17A protein are detectable in Langerhans cell histiocytosis lesions. Mol Ther. 2011;19:1433-9 pubmed publisher
Shao C, Mirra S, Sait H, Sacktor T, Sigurdsson E. Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced A? and tau pathology in transgenic mouse models of Alzheimer's disease. Acta Neuropathol. 2011;122:285-92 pubmed publisher
Patil S, Li K, Heo S, Hoger H, Lubec G. Proteins linked to spatial memory formation of CD1 mice in the multiple T-maze. Hippocampus. 2012;22:1075-86 pubmed publisher
Tabuchi T, Deplancke B, Osato N, Zhu L, Barrasa M, Harrison M, et al. Chromosome-biased binding and gene regulation by the Caenorhabditis elegans DRM complex. PLoS Genet. 2011;7:e1002074 pubmed publisher
Martrat G, Maxwell C, Tominaga E, Porta de la Riva M, Bonifaci N, Gómez Baldó L, et al. Exploring the link between MORF4L1 and risk of breast cancer. Breast Cancer Res. 2011;13:R40 pubmed publisher
Gencer S, Cebeci A, Irmak Yazicioglu M. Silencing of the MMP-3 gene by siRNA transfection in gastric cancer AGS cells. J Gastrointestin Liver Dis. 2011;20:19-26 pubmed
Rice S, Pellatt L, Bryan S, Whitehead S, Mason H. Action of metformin on the insulin-signaling pathway and on glucose transport in human granulosa cells. J Clin Endocrinol Metab. 2011;96:E427-35 pubmed publisher
Landsverk O, Barois N, Gregers T, Bakke O. Invariant chain increases the half-life of MHC II by delaying endosomal maturation. Immunol Cell Biol. 2011;89:619-29 pubmed publisher
McCormick C, Alexandre L, Thompson J, Mutungi G. Clenbuterol and formoterol decrease force production in isolated intact mouse skeletal muscle fiber bundles through a beta2-adrenoceptor-independent mechanism. J Appl Physiol (1985). 2010;109:1716-27 pubmed publisher
Delint Ramirez I, Fernández E, Bayés A, Kicsi E, Komiyama N, Grant S. In vivo composition of NMDA receptor signaling complexes differs between membrane subdomains and is modulated by PSD-95 and PSD-93. J Neurosci. 2010;30:8162-70 pubmed publisher
Matsumoto H, Sasazaki S, Fujiwara A, Ichihara N, Kikuchi T, Mannen H. Accumulation of caveolin-3 protein is limited in damaged muscle in chicken muscular dystrophy. Comp Biochem Physiol A Mol Integr Physiol. 2010;157:68-72 pubmed publisher
Williams J, Oh S, Jorgensen M, Steiger N, Darwiche H, Shupe T, et al. The role of the Wnt family of secreted proteins in rat oval "stem" cell-based liver regeneration: Wnt1 drives differentiation. Am J Pathol. 2010;176:2732-42 pubmed publisher
Lishko P, Botchkina I, Fedorenko A, Kirichok Y. Acid extrusion from human spermatozoa is mediated by flagellar voltage-gated proton channel. Cell. 2010;140:327-37 pubmed publisher
Hamdi M, Mutungi G. Dihydrotestosterone activates the MAPK pathway and modulates maximum isometric force through the EGF receptor in isolated intact mouse skeletal muscle fibres. J Physiol. 2010;588:511-25 pubmed publisher
Jabbour M, Campbell E, Fares H, Lybarger L. Discrete domains of MARCH1 mediate its localization, functional interactions, and posttranscriptional control of expression. J Immunol. 2009;183:6500-12 pubmed publisher
Ha S, Ham B, Mogridge J, Saftig P, Lin S, Kim S. Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm. J Biol Chem. 2010;285:2120-9 pubmed publisher
Rice S, Pellatt L, Ramanathan K, Whitehead S, Mason H. Metformin inhibits aromatase via an extracellular signal-regulated kinase-mediated pathway. Endocrinology. 2009;150:4794-801 pubmed publisher
Chen L, Yabuuchi A, Eminli S, Takeuchi A, Lu C, Hochedlinger K, et al. Cross-regulation of the Nanog and Cdx2 promoters. Cell Res. 2009;19:1052-61 pubmed publisher
Calado R, Yewdell W, Wilkerson K, Regal J, Kajigaya S, Stratakis C, et al. Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells. Blood. 2009;114:2236-43 pubmed publisher
Arnoni C, Lima C, Cristovam P, Maquigussa E, Vidotti D, Boim M. Regulation of glucose uptake in mesangial cells stimulated by high glucose: role of angiotensin II and insulin. Exp Biol Med (Maywood). 2009;234:1095-101 pubmed publisher
Gitcho M, Strider J, Carter D, Taylor Reinwald L, Forman M, Goate A, et al. VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. J Biol Chem. 2009;284:12384-98 pubmed publisher
Overgaard C, Sanzone K, Spiczka K, Sheff D, Sandra A, Yeaman C. Deciliation is associated with dramatic remodeling of epithelial cell junctions and surface domains. Mol Biol Cell. 2009;20:102-13 pubmed publisher
Nabti I, Reis A, Levasseur M, Stemmann O, Jones K. Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs. Dev Biol. 2008;321:379-86 pubmed publisher
Reis A, Madgwick S, Chang H, Nabti I, Levasseur M, Jones K. Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes. Nat Cell Biol. 2007;9:1192-8 pubmed
Bolinger C, Yilmaz A, Hartman T, Kovacic M, Fernandez S, Ye J, et al. RNA helicase A interacts with divergent lymphotropic retroviruses and promotes translation of human T-cell leukemia virus type 1. Nucleic Acids Res. 2007;35:2629-42 pubmed
von Einem J, Schumacher D, O Callaghan D, Osterrieder N. The alpha-TIF (VP16) homologue (ETIF) of equine herpesvirus 1 is essential for secondary envelopment and virus egress. J Virol. 2006;80:2609-20 pubmed
product information
Catalog Number :
ab3280
Product Name :
Actin antibody [ACTN05 (C4)]
Host Species :
Mouse
Clonality :
monoclonal
Product Type :
Primary antibodies
Size :
500 ul
SwissProtID :
P60709
Isotype :
IgG1
CrossReactivity :
Reacts with: Human, Mouse, Rat, Cow, Dictyostelium discoideum, Dog, Physarum polycephalum, Pig, Rabbit. Predicted to react with: Chicken.
Application Summary :
Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB
company information
Abcam
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