This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
FZR1 antibody [DH01 (DCS-266)]
catalog :
ab3242
quantity :
500 ul
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
DH01
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunoprecipitation, flow cytometry, western blot knockout validation
citations: 28
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; fig 2
Holt J, Lane S, Jennings P, Garcia Higuera I, Moreno S, Jones K. APC(FZR1) prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing. Mol Biol Cell. 2012;23:3970-81 pubmed publisher
  • western blot knockout validation; mouse; 1:500; fig 1
Holt J, Tran S, Stewart J, Minahan K, Garcia Higuera I, Moreno S, et al. The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes. Development. 2011;138:905-13 pubmed publisher
  • western blot; mouse; fig s3
van Ree J, Nam H, Jeganathan K, Kanakkanthara A, van Deursen J. Pten regulates spindle pole movement through Dlg1-mediated recruitment of Eg5 to centrosomes. Nat Cell Biol. 2016;18:814-21 pubmed publisher
  • immunohistochemistry; human; loading ...
Link L, Howley B, Hussey G, Howe P. PCBP1/HNRNP E1 Protects Chromosomal Integrity by Translational Regulation of CDC27. Mol Cancer Res. 2016;14:634-46 pubmed publisher
  • western blot; mouse; fig s8
Ahuja A, Jodkowska K, Teloni F, Bizard A, Zellweger R, Herrador R, et al. A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells. Nat Commun. 2016;7:10660 pubmed publisher
  • western blot; human; loading ...; fig 4a
Naylor R, Jeganathan K, Cao X, van Deursen J. Nuclear pore protein NUP88 activates anaphase-promoting complex to promote aneuploidy. J Clin Invest. 2016;126:543-59 pubmed publisher
  • western blot; human; loading ...; fig 1a
Greil C, Krohs J, Schnerch D, Follo M, Felthaus J, Engelhardt M, et al. The role of APC/C(Cdh1) in replication stress and origin of genomic instability. Oncogene. 2016;35:3062-70 pubmed publisher
  • western blot; human
  • western blot; mouse
Vassilopoulos A, Tominaga Y, Kim H, Lahusen T, Li B, Yu H, et al. WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis. Oncogene. 2015;34:3023-35 pubmed publisher
  • immunoprecipitation; human
Yalcin A, Clem B, Imbert Fernandez Y, Ozcan S, Peker S, O NEAL J, et al. 6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27. Cell Death Dis. 2014;5:e1337 pubmed publisher
  • immunohistochemistry; human; 1:100
  • western blot; human
Hu K, Liao D, Wu W, Han A, Shi H, Wang F, et al. Targeting the anaphase-promoting complex/cyclosome (APC/C)- bromodomain containing 7 (BRD7) pathway for human osteosarcoma. Oncotarget. 2014;5:3088-100 pubmed
  • western blot; human
Ly T, Ahmad Y, Shlien A, Soroka D, Mills A, Emanuele M, et al. A proteomic chronology of gene expression through the cell cycle in human myeloid leukemia cells. elife. 2014;3:e01630 pubmed publisher
Lee I, Hüttemann M, Kruger A, Bollig Fischer A, Malek M. (-)-Epicatechin combined with 8 weeks of treadmill exercise is associated with increased angiogenic and mitochondrial signaling in mice. Front Pharmacol. 2015;6:43 pubmed publisher
Vincent G, Lamon S, Gant N, Vincent P, Macdonald J, Markworth J, et al. Changes in mitochondrial function and mitochondria associated protein expression in response to 2-weeks of high intensity interval training. Front Physiol. 2015;6:51 pubmed publisher
Traboulsi H, Davoli S, Catez P, Egly J, Compe E. Dynamic partnership between TFIIH, PGC-1α and SIRT1 is impaired in trichothiodystrophy. PLoS Genet. 2014;10:e1004732 pubmed publisher
Gouspillou G, Sgarioto N, Norris B, Barbat Artigas S, Aubertin Leheudre M, Morais J, et al. The relationship between muscle fiber type-specific PGC-1α content and mitochondrial content varies between rodent models and humans. PLoS ONE. 2014;9:e103044 pubmed publisher
Gouspillou G, Sgarioto N, Kapchinsky S, Purves Smith F, Norris B, Pion C, et al. Increased sensitivity to mitochondrial permeability transition and myonuclear translocation of endonuclease G in atrophied muscle of physically active older humans. FASEB J. 2014;28:1621-33 pubmed publisher
Philp A, Mackenzie M, Belew M, Towler M, Corstorphine A, Papalamprou A, et al. Glycogen content regulates peroxisome proliferator activated receptor-∂ (PPAR-∂) activity in rat skeletal muscle. PLoS ONE. 2013;8:e77200 pubmed publisher
Listovsky T, Sale J. Sequestration of CDH1 by MAD2L2 prevents premature APC/C activation prior to anaphase onset. J Cell Biol. 2013;203:87-100 pubmed publisher
Dominy J, Puigserver P, Canto C. In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity. Methods Mol Biol. 2013;1077:217-37 pubmed publisher
Wan Z, Root McCaig J, Castellani L, Kemp B, Steinberg G, Wright D. Evidence for the role of AMPK in regulating PGC-1 alpha expression and mitochondrial proteins in mouse epididymal adipose tissue. Obesity (Silver Spring). 2014;22:730-8 pubmed publisher
Elias I, Franckhauser S, Ferre T, Vilà L, Tafuro S, Munoz S, et al. Adipose tissue overexpression of vascular endothelial growth factor protects against diet-induced obesity and insulin resistance. Diabetes. 2012;61:1801-13 pubmed publisher
Stephenson E, Camera D, Jenkins T, Kosari S, Lee J, Hawley J, et al. Skeletal muscle respiratory capacity is enhanced in rats consuming an obesogenic Western diet. Am J Physiol Endocrinol Metab. 2012;302:E1541-9 pubmed publisher
Philp A, Chen A, Lan D, Meyer G, Murphy A, Knapp A, et al. Sirtuin 1 (SIRT1) deacetylase activity is not required for mitochondrial biogenesis or peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) deacetylation following endurance exercise. J Biol Chem. 2011;286:30561-70 pubmed publisher
Holt J, Weaver J, Jones K. Spatial regulation of APCCdh1-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes. Development. 2010;137:1297-304 pubmed publisher
Williams D, Sutherland L, Bomhof M, Basaraba S, Thrush A, Dyck D, et al. Muscle-specific differences in the response of mitochondrial proteins to beta-GPA feeding: an evaluation of potential mechanisms. Am J Physiol Endocrinol Metab. 2009;296:E1400-8 pubmed publisher
Schindler K, Schultz R. CDC14B acts through FZR1 (CDH1) to prevent meiotic maturation of mouse oocytes. Biol Reprod. 2009;80:795-803 pubmed publisher
Yeo W, Lessard S, Chen Z, Garnham A, Burke L, Rivas D, et al. Fat adaptation followed by carbohydrate restoration increases AMPK activity in skeletal muscle from trained humans. J Appl Physiol (1985). 2008;105:1519-26 pubmed publisher
Reis A, Madgwick S, Chang H, Nabti I, Levasseur M, Jones K. Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes. Nat Cell Biol. 2007;9:1192-8 pubmed
product information
Catalog Number :
ab3242
Product Name :
FZR1 antibody [DH01 (DCS-266)]
Host Species :
Mouse
Clonality :
monoclonal
Product Type :
Primary antibodies
Size :
500 ul
SwissProtID :
Q9UM11
Isotype :
IgG1
CrossReactivity :
Reacts with: Human, Mouse.
Application Summary :
Flow Cyt, IP, WB
company information
Abcam
330 Cambridge Science Park
Cambridge
CB4 0FL UK
orders@abcam.com
44 (0)1223 696000

1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
us.orders@abcam.com
617 225 2272, 888-77-ABCAM (22226)

www.abcam.com
888-7722226
headquarters: UK