This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-SERCA2 ATPase antibody [2A7-A1]
catalog :
ab2861
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2A7-A1
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 4b
Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandia J, et al. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Mol Syst Biol. 2017;13:918 pubmed publisher
  • western blot; rat; 1:1000; fig 2e
Nandi S, Zheng H, Sharma N, Shahshahan H, Patel K, Mishra P. Lack of miR-133a Decreases Contractility of Diabetic Hearts: A Role for Novel Cross Talk Between Tyrosine Aminotransferase and Tyrosine Hydroxylase. Diabetes. 2016;65:3075-90 pubmed publisher
  • immunoprecipitation; mouse; fig 3
  • western blot; mouse; fig 3
Prathipati P, Metreveli N, Nandi S, Tyagi S, Mishra P. Ablation of Matrix Metalloproteinase-9 Prevents Cardiomyocytes Contractile Dysfunction in Diabetics. Front Physiol. 2016;7:93 pubmed publisher
  • western blot; rat; 1:1000; fig 3
Shinde V, Kotla P, Strang C, Gorbatyuk M. Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa. Cell Death Dis. 2016;7:e2085 pubmed publisher
  • immunocytochemistry; human; 1:50; fig 4
  • western blot; human; 1:1000; fig 3
Olsson K, Cheng A, Alam S, Al Ameri M, Rullman E, Westerblad H, et al. Intracellular Ca(2+)-handling differs markedly between intact human muscle fibers and myotubes. Skelet Muscle. 2015;5:26 pubmed publisher
  • immunocytochemistry; mouse; 1:500; tbl 1
Liu J, Xin L, Benson V, Allen D, Ju Y. Store-operated calcium entry and the localization of STIM1 and Orai1 proteins in isolated mouse sinoatrial node cells. Front Physiol. 2015;6:69 pubmed publisher
  • immunohistochemistry; rat; 1:200; fig 4
Eilers W, Jaspers R, de Haan A, Ferrié C, Valdivieso P, Flück M. CaMKII content affects contractile, but not mitochondrial, characteristics in regenerating skeletal muscle. BMC Physiol. 2014;14:7 pubmed publisher
  • western blot; rat; 1:1000; fig 2
Ramos S, Macpherson R, Turnbull P, Bott K, LeBlanc P, Ward W, et al. Higher PLIN5 but not PLIN3 content in isolated skeletal muscle mitochondria following acute in vivo contraction in rat hindlimb. Physiol Rep. 2014;2: pubmed publisher
  • western blot; mouse; 1:500
Benech J, Benech N, Zambrana A, Rauschert I, Bervejillo V, Oddone N, et al. Diabetes increases stiffness of live cardiomyocytes measured by atomic force microscopy nanoindentation. Am J Physiol Cell Physiol. 2014;307:C910-9 pubmed publisher
  • western blot; rat; 1:1000
Morgan K, Black L. Mimicking isovolumic contraction with combined electromechanical stimulation improves the development of engineered cardiac constructs. Tissue Eng Part A. 2014;20:1654-67 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong K. Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. PLoS ONE. 2013;8:e65963 pubmed publisher
Li Y, Ivica N, Dong T, Papageorgiou D, He Y, Brown D, et al. MFSD7C switches mitochondrial ATP synthesis to thermogenesis in response to heme. Nat Commun. 2020;11:4837 pubmed publisher
Li J, Akil O, Rouse S, McLaughlin C, Matthews I, Lustig L, et al. Deletion of Tmtc4 activates the unfolded protein response causing postnatalhearing loss. J Clin Invest. 2018;: pubmed publisher
Chen M, Yin D, Guo S, Xu D, Wang Z, Chen Z, et al. Sex-specific activation of SK current by isoproterenol facilitates action potential triangulation and arrhythmogenesis in rabbit ventricles. J Physiol. 2018;596:4299-4322 pubmed publisher
Zoladz J, Majerczak J, Grassi B, Szkutnik Z, Korostyński M, Gołda S, et al. Mechanisms of Attenuation of Pulmonary V'O2 Slow Component in Humans after Prolonged Endurance Training. PLoS ONE. 2016;11:e0154135 pubmed publisher
Li Y, Xuan Y, Liu S, Dong J, Luo J, Sun Z. Short‑term vagal nerve stimulation improves left ventricular function following chronic heart failure in rats. Mol Med Rep. 2015;12:1709-16 pubmed publisher
Piao H, Takahashi K, Yamaguchi Y, Wang C, Liu K, Naruse K. Transient receptor potential melastatin-4 is involved in hypoxia-reoxygenation injury in the cardiomyocytes. PLoS ONE. 2015;10:e0121703 pubmed publisher
Huang Y, He Q, Zhan L, Yang M. Sarcoplasmic phospholamban protein is involved in the mechanisms of postresuscitation myocardial dysfunction and the cardioprotective effect of nitrite during resuscitation. PLoS ONE. 2013;8:e82552 pubmed publisher
Pacini L, Suffredini S, Ponti D, Coppini R, Frati G, Ragona G, et al. Altered calcium regulation in isolated cardiomyocytes from Egr-1 knock-out mice. Can J Physiol Pharmacol. 2013;91:1135-42 pubmed publisher
Manrique C, Demarco V, Aroor A, Mugerfeld I, Garro M, Habibi J, et al. Obesity and insulin resistance induce early development of diastolic dysfunction in young female mice fed a Western diet. Endocrinology. 2013;154:3632-42 pubmed publisher
Jeyaraj D, Wan X, Ficker E, Stelzer J, Deschenes I, Liu H, et al. Ionic bases for electrical remodeling of the canine cardiac ventricle. Am J Physiol Heart Circ Physiol. 2013;305:H410-9 pubmed publisher
Fajardo V, McMeekin L, Basic A, Lamb G, Murphy R, Leblanc P. Isolation of sarcolemmal plasma membranes by mechanically skinning rat skeletal muscle fibers for phospholipid analysis. Lipids. 2013;48:421-30 pubmed publisher
Li L, Morimoto S, Take S, Zhan D, Du C, Wang Y, et al. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. J Mol Cell Cardiol. 2012;53:760-7 pubmed publisher
Sjåland C, Lunde P, Swift F, Munkvik M, Ericsson M, Lunde M, et al. Slowed relaxation and preserved maximal force in soleus muscles of mice with targeted disruption of the Serca2 gene in skeletal muscle. J Physiol. 2011;589:6139-55 pubmed publisher
Harris R, Bennett D, Levine M, Putman C. Tail muscle parvalbumin content is decreased in chronic sacral spinal cord injured rats with spasticity. Exp Physiol. 2011;96:1311-20 pubmed publisher
Hydock D, Lien C, Jensen B, Schneider C, Hayward R. Exercise preconditioning provides long-term protection against early chronic doxorubicin cardiotoxicity. Integr Cancer Ther. 2011;10:47-57 pubmed publisher
Ward M, Crossman D, Loiselle D, Cannell M. Non-steady-state calcium handling in failing hearts from the spontaneously hypertensive rat. Pflugers Arch. 2010;460:991-1001 pubmed publisher
Hougen K, Aronsen J, Stokke M, Enger U, Nygard S, Andersson K, et al. Cre-loxP DNA recombination is possible with only minimal unspecific transcriptional changes and without cardiomyopathy in Tg(alphaMHC-MerCreMer) mice. Am J Physiol Heart Circ Physiol. 2010;299:H1671-8 pubmed publisher
Heiny J, Kravtsova V, Mandel F, Radzyukevich T, Benziane B, Prokofiev A, et al. The nicotinic acetylcholine receptor and the Na,K-ATPase alpha2 isoform interact to regulate membrane electrogenesis in skeletal muscle. J Biol Chem. 2010;285:28614-26 pubmed publisher
Wang Y, Morimoto S, Du C, Lu Q, Zhan D, Tsutsumi T, et al. Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy. Cardiovasc Res. 2010;87:636-46 pubmed publisher
Jeong M, Walker J, Brown R, Moore R, Vinson C, Colucci W, et al. AFos inhibits phenylephrine-mediated contractile dysfunction by altering phospholamban phosphorylation. Am J Physiol Heart Circ Physiol. 2010;298:H1719-26 pubmed publisher
Liu J, Lieu D, Siu C, Fu J, Tse H, Li R. Facilitated maturation of Ca2+ handling properties of human embryonic stem cell-derived cardiomyocytes by calsequestrin expression. Am J Physiol Cell Physiol. 2009;297:C152-9 pubmed publisher
Adinolfi E, Callegari M, Cirillo M, Pinton P, Giorgi C, Cavagna D, et al. Expression of the P2X7 receptor increases the Ca2+ content of the endoplasmic reticulum, activates NFATc1, and protects from apoptosis. J Biol Chem. 2009;284:10120-8 pubmed publisher
Moshal K, Tipparaju S, Vacek T, Kumar M, Singh M, Frank I, et al. Mitochondrial matrix metalloproteinase activation decreases myocyte contractility in hyperhomocysteinemia. Am J Physiol Heart Circ Physiol. 2008;295:H890-7 pubmed publisher
Sathish V, Leblebici F, Kip S, Thompson M, Pabelick C, Prakash Y, et al. Regulation of sarcoplasmic reticulum Ca2+ reuptake in porcine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2008;294:L787-96 pubmed publisher
Gallo M, Maclean I, Tyreman N, Martins K, Syrotuik D, Gordon T, et al. Adaptive responses to creatine loading and exercise in fast-twitch rat skeletal muscle. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1319-28 pubmed publisher
Bencsik P, Kupai K, Giricz Z, Gorbe A, Huliák I, Furst S, et al. Cardiac capsaicin-sensitive sensory nerves regulate myocardial relaxation via S-nitrosylation of SERCA: role of peroxynitrite. Br J Pharmacol. 2008;153:488-96 pubmed
Liu J, Fu J, Siu C, Li R. Functional sarcoplasmic reticulum for calcium handling of human embryonic stem cell-derived cardiomyocytes: insights for driven maturation. Stem Cells. 2007;25:3038-44 pubmed
Liu C, Xu K, Xu X, Huang J, Xiao J, Zhang J, et al. 17Beta-oestradiol regulates the expression of Na+/K+-ATPase beta1-subunit, sarcoplasmic reticulum Ca2+-ATPase and carbonic anhydrase iv in H9C2 cells. Clin Exp Pharmacol Physiol. 2007;34:998-1004 pubmed
Timolati F, Ott D, Pentassuglia L, Giraud M, Perriard J, Suter T, et al. Neuregulin-1 beta attenuates doxorubicin-induced alterations of excitation-contraction coupling and reduces oxidative stress in adult rat cardiomyocytes. J Mol Cell Cardiol. 2006;41:845-54 pubmed
Chen K, Huang J, Zhang C, Huang S, Nunnari G, Wang F, et al. Alpha interferon potently enhances the anti-human immunodeficiency virus type 1 activity of APOBEC3G in resting primary CD4 T cells. J Virol. 2006;80:7645-57 pubmed
product information
CatalogNumber :
ab2861
ItemName :
Anti-SERCA2 ATPase antibody [2A7-A1]
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
2A7-A1
Size :
100 µl
SpeciesSummary :
Dog, Gpig, Hu, Ms, Pig, Rat, Rb, Shp, Xl
Purity :
Ascites
Application Summary :
Flow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK