This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-PINK1 antibody
catalog :
ab23707
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 33
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:2500; loading ...; fig 1a
Matsui H, Ito J, Matsui N, Uechi T, Onodera O, Kakita A. Cytosolic dsDNA of mitochondrial origin induces cytotoxicity and neurodegeneration in cellular and zebrafish models of Parkinson's disease. Nat Commun. 2021;12:3101 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3h
Tian F, Zhang Y. Overexpression of SERCA2a Alleviates Cardiac Microvascular Ischemic Injury by Suppressing Mfn2-Mediated ER/Mitochondrial Calcium Tethering. Front Cell Dev Biol. 2021;9:636553 pubmed publisher
  • western blot; rat; fig 7f
Huo S, Shi W, Ma H, Yan D, Luo P, Guo J, et al. Alleviation of Inflammation and Oxidative Stress in Pressure Overload-Induced Cardiac Remodeling and Heart Failure via IL-6/STAT3 Inhibition by Raloxifene. Oxid Med Cell Longev. 2021;2021:6699054 pubmed publisher
  • western blot; mouse; loading ...; fig 6d
Sun Q, Chen J, Xu L, Kang J, Wu X, Ren Y, et al. MUTYH Deficiency Is Associated with Attenuated Pulmonary Fibrosis in a Bleomycin-Induced Model. Oxid Med Cell Longev. 2020;2020:4828256 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 6a
Meza Torres C, Hernández Camacho J, Cortés Rodríguez A, Fang L, Bui Thanh T, Rodríguez Bies E, et al. Resveratrol Regulates the Expression of Genes Involved in CoQ Synthesis in Liver in Mice Fed with High Fat Diet. Antioxidants (Basel). 2020;9: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5f
Zhang S, Hu L, Jiang J, Li H, Wu Q, Ooi K, et al. HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia. J Neuroinflammation. 2020;17:15 pubmed publisher
  • flow cytometry; human; 1:100-1:200; loading ...; fig s5f
  • flow cytometry; mouse; 1:100-1:200; loading ...; fig s5e
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
  • western blot; human; loading ...; fig 1e
Malty R, Aoki H, Kumar A, Phanse S, Amin S, Zhang Q, et al. A Map of Human Mitochondrial Protein Interactions Linked to Neurodegeneration Reveals New Mechanisms of Redox Homeostasis and NF-κB Signaling. Cell Syst. 2017;5:564-577.e12 pubmed publisher
  • immunohistochemistry; human; fig 2
  • western blot; human; fig 2
Kobayashi K, Araya J, Minagawa S, Hara H, Saito N, Kadota T, et al. Involvement of PARK2-Mediated Mitophagy in Idiopathic Pulmonary Fibrosis Pathogenesis. J Immunol. 2016;197:504-16 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 5
  • western blot; human; 1:1000; fig 5
Qi Y, Qiu Q, Gu X, Tian Y, Zhang Y. ATM mediates spermidine-induced mitophagy via PINK1 and Parkin regulation in human fibroblasts. Sci Rep. 2016;6:24700 pubmed publisher
R xf6 nn T, Ofori J, Perfilyev A, Hamilton A, Pircs K, Eichelmann F, et al. Genes with epigenetic alterations in human pancreatic islets impact mitochondrial function, insulin secretion, and type 2 diabetes. Nat Commun. 2023;14:8040 pubmed publisher
Russo T, Kolisnyk B, Bs A, Kim T, Martin J, Plessis Belair J, et al. The SATB1-MIR22-GBA axis mediates glucocerebroside accumulation inducing a cellular senescence-like phenotype in dopaminergic neurons. bioRxiv. 2023;: pubmed publisher
Wang Y, Goh K, Chen Z, Lee W, Choy S, Fong J, et al. A Novel TP53 Gene Mutation Sustains Non-Small Cell Lung Cancer through Mitophagy. Cells. 2022;11: pubmed publisher
Alan P, Vandevoorde K, Joshi B, Cardoen B, Gao G, Mohammadzadeh Y, et al. Basal Gp78-dependent mitophagy promotes mitochondrial health and limits mitochondrial ROS. Cell Mol Life Sci. 2022;79:565 pubmed publisher
Ke P, Chang C, Hsiao Y. Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Cells. 2022;11: pubmed publisher
Krantz S, Kim Y, Srivastava S, Leasure J, Toth P, Marsboom G, et al. Mitophagy mediates metabolic reprogramming of induced pluripotent stem cells undergoing endothelial differentiation. J Biol Chem. 2021;297:101410 pubmed publisher
Larson Casey J, Gu L, Davis D, Cai G, Ding Q, He C, et al. Post-translational regulation of PGC-1α modulates fibrotic repair. FASEB J. 2021;35:e21675 pubmed publisher
Goljanek Whysall K, Soriano Arroquia A, McCormick R, Chinda C, McDonagh B. miR-181a regulates p62/SQSTM1, parkin, and protein DJ-1 promoting mitochondrial dynamics in skeletal muscle aging. Aging Cell. 2020;19:e13140 pubmed publisher
Zhou J, Xue Z, He H, Liu X, Yin S, Wu D, et al. Resveratrol delays postovulatory aging of mouse oocytes through activating mitophagy. Aging (Albany NY). 2019;11:11504-11519 pubmed publisher
Trevino M, Zhang X, Standley R, Wang M, Han X, Reis F, et al. Loss of mitochondrial energetics is associated with poor recovery of muscle function but not mass following disuse atrophy. Am J Physiol Endocrinol Metab. 2019;317:E899-E910 pubmed publisher
Thangaraj A, Periyasamy P, Guo M, Chivero E, Callen S, Buch S. Mitigation of cocaine-mediated mitochondrial damage, defective mitophagy and microglial activation by superoxide dismutase mimetics. Autophagy. 2019;:1-24 pubmed publisher
Rawat P, Teodorof Diedrich C, Spector S. Human immunodeficiency virus Type-1 single-stranded RNA activates the NLRP3 inflammasome and impairs autophagic clearance of damaged mitochondria in human microglia. Glia. 2019;67:802-824 pubmed publisher
Jing R, Corbett J, Cai J, Beeson G, Beeson C, CHAN S, et al. A Screen Using iPSC-Derived Hepatocytes Reveals NAD+ as a Potential Treatment for mtDNA Depletion Syndrome. Cell Rep. 2018;25:1469-1484.e5 pubmed publisher
Thai P, Daugherty D, Frederich B, Lu X, Deng W, Bers D, et al. Cardiac-specific Conditional Knockout of the 18-kDa Mitochondrial Translocator Protein Protects from Pressure Overload Induced Heart Failure. Sci Rep. 2018;8:16213 pubmed publisher
Araya J, Tsubouchi K, Sato N, Ito S, Minagawa S, Hara H, et al. PRKN-regulated mitophagy and cellular senescence during COPD pathogenesis. Autophagy. 2018;:1-17 pubmed publisher
Zhu W, Yuan Y, Liao G, Li L, Liu J, Chen Y, et al. Mesenchymal stem cells ameliorate hyperglycemia-induced endothelial injury through modulation of mitophagy. Cell Death Dis. 2018;9:837 pubmed publisher
Wang S, Zhao Z, Feng X, Cheng Z, Xiong Z, Wang T, et al. Melatonin activates Parkin translocation and rescues the impaired mitophagy activity of diabetic cardiomyopathy through Mst1 inhibition. J Cell Mol Med. 2018;22:5132-5144 pubmed publisher
Vincent A, Rosa H, Pabis K, Lawless C, Chen C, Grünewald A, et al. Subcellular origin of mitochondrial DNA deletions in human skeletal muscle. Ann Neurol. 2018;84:289-301 pubmed publisher
Thangaraj A, Periyasamy P, Liao K, Bendi V, Callen S, Pendyala G, et al. HIV-1 TAT-mediated microglial activation: role of mitochondrial dysfunction and defective mitophagy. Autophagy. 2018;14:1596-1619 pubmed publisher
Wang D, Sun H, Song G, Yang Y, Zou X, Han P, et al. Resveratrol Improves Muscle Atrophy by Modulating Mitochondrial Quality Control in STZ-Induced Diabetic Mice. Mol Nutr Food Res. 2018;62:e1700941 pubmed publisher
Wei L, Wang J, Chen A, Liu J, Feng X, Shao L. Involvement of PINK1/parkin-mediated mitophagy in ZnO nanoparticle-induced toxicity in BV-2 cells. Int J Nanomedicine. 2017;12:1891-1903 pubmed publisher
Bettoun A, Joffre C, Zago G, Surdez D, Vallerand D, Gundogdu R, et al. Mitochondrial clearance by the STK38 kinase supports oncogenic Ras-induced cell transformation. Oncotarget. 2016;7:44142-44160 pubmed publisher
Taneike M, Nishida K, Omiya S, Zarrinpashneh E, Misaka T, Kitazume Taneike R, et al. mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy. PLoS ONE. 2016;11:e0152628 pubmed publisher
product information
CatalogNumber :
ab23707
ItemName :
Anti-PINK1 antibody
Product Type :
Primary Antibodies
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Not Conjugated
Antigen Modification :
No Modifications
Size :
100 µg
SpeciesSummary :
Hu, Ms, Rat
Uses :
ICC/IF, IHC-P, WB
Size Note :
Other sizes available: 200 µg,300 µg
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK