This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-NLRP3 antibody
catalog :
ab214185
quantity :
100 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 23
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000; loading ...; fig 5d
Zhao J, Chen J, Li Y, Xia L, Wu Y. Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation. Int J Mol Med. 2021;48: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 7b
Ding R, Li H, Liu Y, Ou W, Zhang X, Chai H, et al. Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis. J Neuroinflammation. 2022;19:137 pubmed publisher
  • immunohistochemistry; mouse; 1:200
Poudel S, Dixit M, Yildirim G, Cordoba Chacon J, Gahete M, Yuji I, et al. Sexual dimorphic impact of adult-onset somatopause on life span and age-induced osteoarthritis. Aging Cell. 2021;20:e13427 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 1a
Su Y, Wang Y, Liu M, Chen H. Hydrogen sulfide attenuates renal I/R‑induced activation of the inflammatory response and apoptosis via regulating Nrf2‑mediated NLRP3 signaling pathway inhibition. Mol Med Rep. 2021;24: pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5b
Ni X, Zhang Y, Jia L, Lu W, Zhu Q, Ren J, et al. Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway. Aging (Albany NY). 2021;13:5164-5184 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 8
  • western blot; mouse; 1:1000; loading ...; fig 7a
Gao Y, Dai X, Li Y, Li G, Lin X, Ai C, et al. Role of Parkin-mediated mitophagy in the protective effect of polydatin in sepsis-induced acute kidney injury. J Transl Med. 2020;18:114 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 7a
Yu J, Wang W, Matei N, Li X, Pang J, Mo J, et al. Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats. Oxid Med Cell Longev. 2020;2020:4717258 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1c
Liu Y, Tie L. Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway. BMC Cardiovasc Disord. 2019;19:279 pubmed publisher
  • western blot; human; loading ...; fig 4h
Liu J, Yao L, Zhang M, Jiang J, Yang M, Wang Y. Downregulation of LncRNA-XIST inhibited development of non-small cell lung cancer by activating miR-335/SOD2/ROS signal pathway mediated pyroptotic cell death. Aging (Albany NY). 2019;11:7830-7846 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 11b
Song H, Li X, Liu Y, Lu W, Cui Z, Zhou L, et al. Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS. Int J Mol Med. 2018;42:193-207 pubmed publisher
  • western blot; rat; 1:500; loading ...; fig 5c
Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, et al. Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Stroke. 2018;49:175-183 pubmed publisher
Dang R, Yang M, Cui C, Wang C, Zhang W, Geng C, et al. Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling. Aging Cell. 2021;20:e13480 pubmed publisher
Wu H, Liu X, Gao Z, Lin M, Zhao X, Sun Y, et al. Icaritin Provides Neuroprotection in Parkinson's Disease by Attenuating Neuroinflammation, Oxidative Stress, and Energy Deficiency. Antioxidants (Basel). 2021;10: pubmed publisher
Liu X, Liu R, Fu D, Wu H, Zhao X, Sun Y, et al. Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model. Aging (Albany NY). 2021;13:3763-3778 pubmed publisher
Bai Y, Li Z, Liu W, Gao D, Liu M, Zhang P. Biochanin A attenuates myocardial ischemia/reperfusion injury through the TLR4/NF-κB/NLRP3 signaling pathway. Acta Cir Bras. 2019;34:e201901104 pubmed publisher
Cui L, Jiang X, Zhang C, Li D, Yu S, Wan F, et al. Ketamine induces endoplasmic reticulum stress in rats and SV-HUC-1 human uroepithelial cells by activating NLRP3/TXNIP aix. Biosci Rep. 2019;39: pubmed publisher
Rojas Morales P, Tapia E, León Contreras J, González Reyes S, Jiménez Osorio A, Trujillo J, et al. Mechanisms of Fasting-Mediated Protection against Renal Injury and Fibrosis Development after Ischemic Acute Kidney Injury. Biomolecules. 2019;9: pubmed publisher
Zhou L, Zhou J, Sheng B, Li X, Yuan Y. Dexmedetomidine exerts dual effects on human annulus fibrosus chondrocytes depending on the oxidative stress status. Biosci Rep. 2019;39: pubmed publisher
Ojeda D, Grasso D, Urquiza J, Till A, Vaccaro M, Quarleri J. Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells. Front Immunol. 2018;9:2633 pubmed publisher
Zheng B, Zhang S, Ying Y, Guo X, Li H, Xu L, et al. Administration of Dexmedetomidine inhibited NLRP3 inflammasome and microglial cell activities in hippocampus of traumatic brain injury rats. Biosci Rep. 2018;38: pubmed publisher
Chen H, Fang Y, Wu J, Chen H, Zou Z, Zhang X, et al. RIPK3-MLKL-mediated necroinflammation contributes to AKI progression to CKD. Cell Death Dis. 2018;9:878 pubmed publisher
Zhai Y, Meng X, Ye T, Xie W, Sun G, Sun X. Inhibiting the NLRP3 Inflammasome Activation with MCC950 Ameliorates Diabetic Encephalopathy in db/db Mice. Molecules. 2018;23: pubmed publisher
Ye Z, Li Q, Guo Q, Xiong Y, Guo D, Yang H, et al. Ketamine induces hippocampal apoptosis through a mechanism associated with the caspase-1 dependent pyroptosis. Neuropharmacology. 2018;128:63-75 pubmed publisher
product information
CatalogNumber :
ab214185
ItemName :
Anti-NLRP3 antibody
Product Type :
Primary Antibodies
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Not Conjugated
Antigen Modification :
No Modifications
Size :
100 µl
SpeciesSummary :
Hu, Ms, Rat
Uses :
IHC-P, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK