This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Hsc70 antibody [1B5]
catalog :
ab19136
quantity :
100 µg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
1B5
reactivity :
human, mouse, rat, dogs, chicken, bovine
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5a
Huang H, Liu R, Huang Y, Feng Y, Fu Y, Chen L, et al. Acetylation-mediated degradation of HSD17B4 regulates the progression of prostate cancer. Aging (Albany NY). 2020;12:14699-14717 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s6c
Wegmann S, Bennett R, Delorme L, Robbins A, Hu M, McKenzie D, et al. Experimental evidence for the age dependence of tau protein spread in the brain. Sci Adv. 2019;5:eaaw6404 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Ho P, Leung C, Liu H, Pang S, Lam C, Xian J, et al. Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA). Autophagy. 2019;:1-24 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 4d
Ganguly A, Han X, Das U, Wang L, Loi J, Sun J, et al. Hsc70 chaperone activity is required for the cytosolic slow axonal transport of synapsin. J Cell Biol. 2017;216:2059-2074 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 7B
Miles A, Burr S, Grice G, Nathan J. The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1? prolyl hydroxylation by regulating cellular iron levels. elife. 2017;6: pubmed publisher
  • western blot; human; loading ...; fig 3b
Suzuki J, Nakajima W, Suzuki H, Asano Y, Tanaka N. Chaperone-mediated autophagy promotes lung cancer cell survival through selective stabilization of the pro-survival protein, MCL1. Biochem Biophys Res Commun. 2017;482:1334-1340 pubmed publisher
  • western blot; human; fig s1
Rivera C, Saavedra F, Alvarez F, Díaz Celis C, Ugalde V, Li J, et al. Methylation of histone H3 lysine 9 occurs during translation. Nucleic Acids Res. 2015;43:9097-106 pubmed publisher
  • immunoprecipitation; human; fig 2
  • western blot; human; fig 1
Xie W, Zhang L, Jiao H, Guan L, Zha J, Li X, et al. Chaperone-mediated autophagy prevents apoptosis by degrading BBC3/PUMA. Autophagy. 2015;11:1623-35 pubmed publisher
  • western blot; mouse; loading ...; fig s1a
Merkestein M, Laber S, McMurray F, Andrew D, Sachse G, Sanderson J, et al. FTO influences adipogenesis by regulating mitotic clonal expansion. Nat Commun. 2015;6:6792 pubmed publisher
  • western blot; rat; fig 3
Tome M, Schaefer C, Jacobs L, Zhang Y, Herndon J, Matty F, et al. Identification of P-glycoprotein co-fractionating proteins and specific binding partners in rat brain microvessels. J Neurochem. 2015;134:200-10 pubmed publisher
  • western blot; rat; 1:10000
Lai A, Lan C, Hasan S, Brown M, McLaurin J. scyllo-Inositol promotes robust mutant Huntingtin protein degradation. J Biol Chem. 2014;289:3666-76 pubmed publisher
  • immunocytochemistry; human
Li L, Yang G, Ren C, Tanimoto R, Hirayama T, Wang J, et al. Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2. Mol Oncol. 2013;7:484-96 pubmed publisher
Adelöf J, Wiseman J, Zetterberg M, Hernebring M. PA28α overexpressing female mice maintain exploratory behavior and capacity to prevent protein aggregation in hippocampus as they age. Aging Cell. 2021;20:e13336 pubmed publisher
Hong Z, Xin X, Ying C, Yi L, Zhaogen C, Li D, et al. Chaperone-mediated autophagy governs progression of papillary thyroid carcinoma via PPARγ-SDF1/CXCR4 signaling. J Clin Endocrinol Metab. 2020;: pubmed publisher
Wu M, Ouyang Y, Wang Z, Zhang R, Huang P, Chen C, et al. Isolation of exosomes from whole blood by integrating acoustics and microfluidics. Proc Natl Acad Sci U S A. 2017;114:10584-10589 pubmed publisher
Wang B, Cai Z, Tao K, Zeng W, Lu F, Yang R, et al. Essential control of mitochondrial morphology and function by chaperone-mediated autophagy through degradation of PARK7. Autophagy. 2016;12:1215-28 pubmed publisher
Wang Q, Hu W, Lei M, Wang Y, Yan B, Liu J, et al. MiR-17-5p impairs trafficking of H-ERG K+ channel protein by targeting multiple er stress-related chaperones during chronic oxidative stress. PLoS ONE. 2013;8:e84984 pubmed publisher
Pellegrin S, Heesom K, Satchwell T, Hawley B, Daniels G, van den Akker E, et al. Differential proteomic analysis of human erythroblasts undergoing apoptosis induced by epo-withdrawal. PLoS ONE. 2012;7:e38356 pubmed publisher
McTaggart J, Lee S, Iberl M, Church C, Cox R, Ashcroft F. FTO is expressed in neurones throughout the brain and its expression is unaltered by fasting. PLoS ONE. 2011;6:e27968 pubmed publisher
Chen K, Luo Z, Zheng S. Gallus Heat shock cognate protein 70, a novel binding partner of Apoptin. Virol J. 2011;8:324 pubmed publisher
Alvarez F, Muñoz F, Schilcher P, Imhof A, Almouzni G, Loyola A. Sequential establishment of marks on soluble histones H3 and H4. J Biol Chem. 2011;286:17714-21 pubmed publisher
product information
CatalogNumber :
ab19136
ItemName :
Anti-Hsc70 antibody [1B5]
Product Type :
Antibody
Host Species :
Rat
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
1B5
Size :
100 µg
SpeciesSummary :
Chk, Cow, Dog, Gpig, Hm, Hu, Mk, Ms, Phy p, Pig, Rat, Rb, Shp
Purity :
Protein G purified
Application Summary :
Flow Cyt, ICC/IF, IHC-P, IP, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK