This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Cathepsin K antibody
catalog :
ab19027
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
citations: 20
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 4b
Zhang W, Dong Z, Li D, Li B, Liu Y, Zheng X, et al. Cathepsin K deficiency promotes alveolar bone regeneration by promoting jaw bone marrow mesenchymal stem cells proliferation and differentiation via glycolysis pathway. Cell Prolif. 2021;54:e13058 pubmed publisher
  • western blot; mouse; 1:3000; loading ...; fig 1i
Alesi N, Akl E, Khabibullin D, Liu H, Nidhiry A, Garner E, et al. TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanism. Nat Commun. 2021;12:4245 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Kim M, Kim J, Hong S, Kwon B, Kim E, Jung H, et al. Effects of Melandrium firmum Rohrbach on RANKL‑induced osteoclast differentiation and OVX rats. Mol Med Rep. 2021;24: pubmed publisher
  • western blot; mouse
Khan I, Del Guzzo C, Shao A, Cho J, Du R, Cohen A, et al. The CD200-CD200R Axis Promotes Squamous Cell Carcinoma Metastasis via Regulation of Cathepsin K. Cancer Res. 2021;81:5021-5032 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 6b
Yuan Y, Jagga S, Martins J, Rana R, Pajevic P, Liu E. Impaired 1,25 dihydroxyvitamin D3 action and hypophosphatemia underlie the altered lacuno-canalicular remodeling observed in the Hyp mouse model of XLH. PLoS ONE. 2021;16:e0252348 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig s7a
Lee S, Park K, Lee G, Kim S, Song W, Kwon S, et al. Hypoxia-inducible factor-2α mediates senescence-associated intrinsic mechanisms of age-related bone loss. Exp Mol Med. 2021;53:591-604 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 4d
Zarb Y, Sridhar S, Nassiri S, Utz S, Schaffenrath J, Maheshwari U, et al. Microglia control small vessel calcification via TREM2. Sci Adv. 2021;7: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:75; loading ...; fig 7d
Kegelman C, Coulombe J, Jordan K, Horan D, Qin L, Robling A, et al. YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling. J Bone Miner Res. 2020;35:196-210 pubmed publisher
  • immunohistochemistry - frozen section; human; 1:200; loading ...; fig 5f
  • immunohistochemistry; human; 1:500; loading ...; fig 6
Hira V, Wormer J, Kakar H, Breznik B, van der Swaan B, Hulsbos R, et al. Periarteriolar Glioblastoma Stem Cell Niches Express Bone Marrow Hematopoietic Stem Cell Niche Proteins. J Histochem Cytochem. 2018;66:155-173 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 1k
Haraguchi R, Kitazawa R, Mori K, Tachibana R, Kiyonari H, Imai Y, et al. sFRP4-dependent Wnt signal modulation is critical for bone remodeling during postnatal development and age-related bone loss. Sci Rep. 2016;6:25198 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50; fig s10
Li D, Liu J, Guo B, Liang C, Dang L, Lu C, et al. Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation. Nat Commun. 2016;7:10872 pubmed publisher
Dixit M, Duran Ortiz S, Yildirim G, Poudel S, Louis L, Bartke A, et al. Induction of somatopause in adult mice compromises bone morphology and exacerbates bone loss during aging. Aging Cell. 2021;20:e13505 pubmed publisher
Decker D, Higgins P, Hayes K, Bollinger C, Becker P, Wright D. Repository corticotropin injection attenuates collagen-induced arthritic joint structural damage and has enhanced effects in combination with etanercept. BMC Musculoskelet Disord. 2020;21:586 pubmed publisher
Alharbi M, Zhang C, Lu C, Milovanova T, Yi L, Ryu J, et al. FOXO1 Deletion Reverses the Effect of Diabetic-Induced Impaired Fracture Healing. Diabetes. 2018;67:2682-2694 pubmed publisher
Gao Y, Ge W. The histone methyltransferase DOT1L inhibits osteoclastogenesis and protects against osteoporosis. Cell Death Dis. 2018;9:33 pubmed publisher
Wang H, Tian L, Goldstein A, Liu J, Lo H, Sheng K, et al. Bone-in-culture array as a platform to model early-stage bone metastases and discover anti-metastasis therapies. Nat Commun. 2017;8:15045 pubmed publisher
Htoo H, Limsuvan S, Thamsermsang O, Hernandez J, Checler F, Govitrapong P, et al. The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing ?-Secretase Activities. PLoS ONE. 2017;12:e0170360 pubmed publisher
Jiang T, Liu F, Wang W, Jiang X, Wen X, Hu K, et al. Distribution of Cathepsin K in Late Stage of Tooth Germ Development and Its Function in Degrading Enamel Matrix Proteins in Mouse. PLoS ONE. 2017;12:e0169857 pubmed publisher
Lin Y, Jean Y, Lee H, Lin S, Pan C, Chen W, et al. Excavatolide B Attenuates Rheumatoid Arthritis through the Inhibition of Osteoclastogenesis. Mar Drugs. 2017;15: pubmed publisher
Chen A, Kim S, Shepardson N, Patel S, Hong S, Selkoe D. Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis. J Cell Biol. 2015;211:1157-76 pubmed publisher
product information
CatalogNumber :
ab19027
ItemName :
Anti-Cathepsin K antibody
Product Type :
Primary Antibodies
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Not Conjugated
Antigen Modification :
No Modifications
Size :
100 µg
SpeciesSummary :
Hu, Ms, Rat, Zfsh
Uses :
ICC/IF, IHC-Fr, IHC-P, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK