This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-XRCC1 antibody [33-2-5]
catalog :
ab1838
quantity :
250 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
33-2-5
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 37
Published Application/Species/Sample/DilutionReference
  • immunoprecipitation; human; loading ...; fig s2b
House N, Parasuram R, Layer J, Price B. Site-specific targeting of a light activated dCas9-KillerRed fusion protein generates transient, localized regions of oxidative DNA damage. PLoS ONE. 2020;15:e0237759 pubmed publisher
  • western blot; human; 1:200
Galanos P, Pappas G, Polyzos A, Kotsinas A, Svolaki I, Giakoumakis N, et al. Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol. 2018;19:37 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 2
  • western blot; human; loading ...; fig 1
Bj Rås K, Sousa M, Sharma A, Fonseca D, S Gaard C, Bj Rås M, et al. Monitoring of the spatial and temporal dynamics of BER/SSBR pathway proteins, including MYH, UNG2, MPG, NTH1 and NEIL1-3, during DNA replication. Nucleic Acids Res. 2017;45:8291-8301 pubmed publisher
  • immunocytochemistry; mouse; 1:50
Horton J, Gassman N, Dunigan B, Stefanick D, Wilson S. DNA polymerase β-dependent cell survival independent of XRCC1 expression. DNA Repair (Amst). 2015;26:23-9 pubmed publisher
  • immunocytochemistry; human; fig 5
  • western blot; human; fig s1
Abdou I, Poirier G, Hendzel M, Weinfeld M. DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair. Nucleic Acids Res. 2015;43:875-92 pubmed publisher
  • western blot; human; 1:500; fig s1d
Fang Q, Inanç B, Schamus S, Wang X, Wei L, Brown A, et al. HSP90 regulates DNA repair via the interaction between XRCC1 and DNA polymerase β. Nat Commun. 2014;5:5513 pubmed publisher
  • western blot; human
Prensner J, Chen W, Iyer M, Cao Q, Ma T, Han S, et al. PCAT-1, a long noncoding RNA, regulates BRCA2 and controls homologous recombination in cancer. Cancer Res. 2014;74:1651-60 pubmed publisher
  • immunocytochemistry; mouse; 1:50
Horton J, Stefanick D, Gassman N, Williams J, Gabel S, Cuneo M, et al. Preventing oxidation of cellular XRCC1 affects PARP-mediated DNA damage responses. DNA Repair (Amst). 2013;12:774-85 pubmed publisher
  • western blot; human; fig 4
Ebert F, Weiss A, Bültemeyer M, Hamann I, Hartwig A, Schwerdtle T. Arsenicals affect base excision repair by several mechanisms. Mutat Res. 2011;715:32-41 pubmed publisher
Huang W, Tang H, Wen F, Lu X, Li Q, Shu P. Jianpi-yangwei decoction inhibits DNA damage repair in the drug resistance of gastric cancer by reducing FEN1 expression. BMC Complement Med Ther. 2020;20:196 pubmed publisher
Wu Y, Li H, Ren Y, Zou D, Zhang K, Xiao X. The association of XRCC1 polymorphism with osteosarcoma risk, clinicopathologic features, and prognosis in a Chinese Han population. Cancer Manag Res. 2018;10:4959-4967 pubmed publisher
Saha L, Kim S, Kang H, Akter S, Choi K, Sakuma T, et al. Differential micronucleus frequency in isogenic human cells deficient in DNA repair pathways is a valuable indicator for evaluating genotoxic agents and their genotoxic mechanisms. Environ Mol Mutagen. 2018;59:529-538 pubmed publisher
Rehman I, Basu S, Das S, Bhattacharjee S, Ghosh A, Pommier Y, et al. PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes. Nucleic Acids Res. 2018;46:5601-5617 pubmed publisher
Wilhelm T, Ragu S, Magdalou I, Machon C, Dardillac E, Técher H, et al. Slow Replication Fork Velocity of Homologous Recombination-Defective Cells Results from Endogenous Oxidative Stress. PLoS Genet. 2016;12:e1006007 pubmed publisher
Ávila Arroyo S, Nuñez G, García Fernández L, Galmarini C. Synergistic Effect of Trabectedin and Olaparib Combination Regimen in Breast Cancer Cell Lines. J Breast Cancer. 2015;18:329-38 pubmed publisher
Xu Z, Zhang L, Zhang W, Meng D, Zhang H, Jiang Y, et al. SIRT6 rescues the age related decline in base excision repair in a PARP1-dependent manner. Cell Cycle. 2015;14:269-76 pubmed publisher
Weber A, Schuermann D, Schär P. Versatile recombinant SUMOylation system for the production of SUMO-modified protein. PLoS ONE. 2014;9:e102157 pubmed publisher
Das B, Huang S, Murai J, Rehman I, Ame J, Sengupta S, et al. PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage. Nucleic Acids Res. 2014;42:4435-49 pubmed publisher
Kristensen D, Nielsen J, Jørgensen A, Skakkebæk N, Rajpert De Meyts E, Almstrup K. Evidence that active demethylation mechanisms maintain the genome of carcinoma in situ cells hypomethylated in the adult testis. Br J Cancer. 2014;110:668-78 pubmed publisher
Masaoka A, Gassman N, Kedar P, Prasad R, Hou E, Horton J, et al. HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts. J Biol Chem. 2012;287:27648-58 pubmed publisher
Han L, Mao W, Yu K. X-ray repair cross-complementing protein 1 (XRCC1) deficiency enhances class switch recombination and is permissive for alternative end joining. Proc Natl Acad Sci U S A. 2012;109:4604-8 pubmed publisher
Mohni K, Mastrocola A, Bai P, Weller S, Heinen C. DNA mismatch repair proteins are required for efficient herpes simplex virus 1 replication. J Virol. 2011;85:12241-53 pubmed publisher
Fisher L, Bessho M, Wakasugi M, Matsunaga T, Bessho T. Role of interaction of XPF with RPA in nucleotide excision repair. J Mol Biol. 2011;413:337-46 pubmed publisher
Paul C, Nagano M, Robaire B. Aging results in differential regulation of DNA repair pathways in pachytene spermatocytes in the Brown Norway rat. Biol Reprod. 2011;85:1269-78 pubmed publisher
Hanssen Bauer A, Solvang Garten K, Sundheim O, Pena Diaz J, Andersen S, Slupphaug G, et al. XRCC1 coordinates disparate responses and multiprotein repair complexes depending on the nature and context of the DNA damage. Environ Mol Mutagen. 2011;52:623-35 pubmed publisher
Akbari M, Solvang Garten K, Hanssen Bauer A, Lieske N, Pettersen H, Pettersen G, et al. Direct interaction between XRCC1 and UNG2 facilitates rapid repair of uracil in DNA by XRCC1 complexes. DNA Repair (Amst). 2010;9:785-95 pubmed publisher
Peddi P, Loftin C, Dickey J, Hair J, Burns K, Aziz K, et al. DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells. Free Radic Biol Med. 2010;48:1435-43 pubmed publisher
Dieriks B, De Vos W, Derradji H, Baatout S, Van Oostveldt P. Medium-mediated DNA repair response after ionizing radiation is correlated with the increase of specific cytokines in human fibroblasts. Mutat Res. 2010;687:40-8 pubmed publisher
Byrne S, Cunniffe S, O Neill P, Lomax M. 5,6-Dihydrothymine impairs the base excision repair pathway of a closely opposed AP site or single-strand break. Radiat Res. 2009;172:537-49 pubmed publisher
Das B, Antony S, Gupta S, Dexheimer T, Redon C, Garfield S, et al. Optimal function of the DNA repair enzyme TDP1 requires its phosphorylation by ATM and/or DNA-PK. EMBO J. 2009;28:3667-80 pubmed publisher
Zarebski M, Wiernasz E, Dobrucki J. Recruitment of heterochromatin protein 1 to DNA repair sites. Cytometry A. 2009;75:619-25 pubmed publisher
Akbari M, Pena Diaz J, Andersen S, Liabakk N, Otterlei M, Krokan H. Extracts of proliferating and non-proliferating human cells display different base excision pathways and repair fidelity. DNA Repair (Amst). 2009;8:834-43 pubmed publisher
Sato S, Itamochi H, Kigawa J, Oishi T, Shimada M, Sato S, et al. Combination chemotherapy of oxaliplatin and 5-fluorouracil may be an effective regimen for mucinous adenocarcinoma of the ovary: a potential treatment strategy. Cancer Sci. 2009;100:546-51 pubmed publisher
Hong Z, Jiang J, Hashiguchi K, Hoshi M, Lan L, Yasui A. Recruitment of mismatch repair proteins to the site of DNA damage in human cells. J Cell Sci. 2008;121:3146-54 pubmed publisher
Visnes T, Akbari M, Hagen L, Slupphaug G, Krokan H. The rate of base excision repair of uracil is controlled by the initiating glycosylase. DNA Repair (Amst). 2008;7:1869-81 pubmed publisher
Mourgues S, Lomax M, O Neill P. Base excision repair processing of abasic site/single-strand break lesions within clustered damage sites associated with XRCC1 deficiency. Nucleic Acids Res. 2007;35:7676-87 pubmed
Mortusewicz O, Rothbauer U, Cardoso M, Leonhardt H. Differential recruitment of DNA Ligase I and III to DNA repair sites. Nucleic Acids Res. 2006;34:3523-32 pubmed
product information
CatalogNumber :
ab1838
ItemName :
Anti-XRCC1 antibody [33-2-5]
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
33-2-5
Size :
250 µl
SpeciesSummary :
ChHm, Hu, Rat
Purity :
Protein A purified
Application Summary :
Flow Cyt, ICC/IF, IHC-Fr, IHC-P, IP, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK