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- western blot; human; 1:500; loading ...; fig 5g, 5h
| Yan W, Han Q, Gong L, Zhan X, Li W, Guo Z, et al. MBD3 promotes hepatocellular carcinoma progression and metastasis through negative regulation of tumour suppressor TFPI2. Br J Cancer. 2022;: pubmed publisher
|
- western blot; human; 1:500; loading ...; fig 7a
| Huang J, Xiao R, Wang X, Khadka B, Fang Z, Yu M, et al. MicroRNA‑93 knockdown inhibits acute myeloid leukemia cell growth via inactivating the PI3K/AKT pathway by upregulating DAB2. Int J Oncol. 2021;59: pubmed publisher
|
- western blot; human; 1:1000; loading ...; fig 4a
| Li H, Xu W, Xia Z, Liu W, Pan G, Ding J, et al. Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling. Aging (Albany NY). 2021;13:4522-4551 pubmed publisher
|
| Guo L, Ding G, Xu W, Ge H, Jiang Y, Lu Y. Anti-PD-L1 Antibody Enhances T Cell Immune Responses and Reduces Resistance of Breast Cancer Cells to Radiotherapy. Oxid Med Cell Longev. 2022;2022:5938688 pubmed publisher
|
| Ma X, Zhang H, Li Q, Schiferle E, Qin Y, Xiao S, et al. FOXM1 Promotes Head and Neck Squamous Cell Carcinoma via Activation of the Linc-ROR/LMO4/AKT/PI3K Axis. Front Oncol. 2021;11:658712 pubmed publisher
|
| Wang L, Yang M, Jin H. PI3K/AKT phosphorylation activates ERRα by upregulating PGC‑1α and PGC‑1β in gallbladder cancer. Mol Med Rep. 2021;24: pubmed publisher
|
| Shi H, Li X, Chen Y, Zhang X, Wu Y, Wang Z, et al. Quercetin Induces Apoptosis via Downregulation of Vascular Endothelial Growth Factor/Akt Signaling Pathway in Acute Myeloid Leukemia Cells. Front Pharmacol. 2020;11:534171 pubmed publisher
|
| Hong G, Wu H, Ma S, Su Z. Catechins from oolong tea improve uterine defects by inhibiting STAT3 signaling in polycystic ovary syndrome mice. Chin Med. 2020;15:125 pubmed publisher
|
| Liu B, Sun W, Gao W, Li L, Cao Z, Yang X, et al. microRNA-451a promoter methylation regulated by DNMT3B expedites bladder cancer development via the EPHA2/PI3K/AKT axis. BMC Cancer. 2020;20:1019 pubmed publisher
|
| Zhou J, Zhang A, Fan L. HSPA12B Secreted by Tumor-Associated Endothelial Cells Might Induce M2 Polarization of Macrophages via Activating PI3K/Akt/mTOR Signaling. Onco Targets Ther. 2020;13:9103-9111 pubmed publisher
|
| Wang Y, Gao G, Wu Y, Wang Y, Wu X, Zhou Q. S100A4 Silencing Facilitates Corneal Wound Healing After Alkali Burns by Promoting Autophagy via Blocking the PI3K/Akt/mTOR Signaling Pathway. Invest Ophthalmol Vis Sci. 2020;61:19 pubmed publisher
|
| Wu S, Guo X, Zhou J, Zhu X, Chen H, Zhang K, et al. High expression of UNC5B enhances tumor proliferation, increases metastasis, and worsens prognosis in breast cancer. Aging (Albany NY). 2020;12:17079-17098 pubmed publisher
|
| Chen S, Li Y, Zhi S, Ding Z, Wang W, Peng Y, et al. WTAP promotes osteosarcoma tumorigenesis by repressing HMBOX1 expression in an m6A-dependent manner. Cell Death Dis. 2020;11:659 pubmed publisher
|
| Lei J, Yan W, Luo C, Guo Y, Zhang Y, Wang X, et al. Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway. World J Stem Cells. 2020;12:500-513 pubmed publisher
|
| Sedlic F, Seiwerth F, Sepac A, Sikiric S, Cindric M, Milavic M, et al. Mitochondrial ROS Induce Partial Dedifferentiation of Human Mesothelioma via Upregulation of NANOG. Antioxidants (Basel). 2020;9: pubmed publisher
|
| Zhao Q, Zhou J, Pan Y, Ju H, Zhu L, Liu Y, et al. The difference between steroid diabetes mellitus and type 2 diabetes mellitus: a whole-body 18F-FDG PET/CT study. Acta Diabetol. 2020;57:1383-1393 pubmed publisher
|
| Tian X, Liu M, Huang X, Zhu Q, Liu W, Chen W, et al. Noscapine Induces Apoptosis in Human Colon Cancer Cells by Regulating Mitochondrial Damage and Warburg Effect via PTEN/PI3K/mTOR Signaling Pathway. Onco Targets Ther. 2020;13:5419-5428 pubmed publisher
|
| Hao M, Sun J, Zhang Y, Zhang D, Han J, Zhang J, et al. Exploring the Role of SRC in Extraocular Muscle Fibrosis of the Graves' Ophthalmopathy. Front Bioeng Biotechnol. 2020;8:392 pubmed publisher
|
| Wang Y, Zhang J, Su Y, Wang C, Zhang G, Liu X, et al. miRNA-98-5p Targeting IGF2BP1 Induces Mesenchymal Stem Cell Apoptosis by Modulating PI3K/Akt and p53 in Immune Thrombocytopenia. Mol Ther Nucleic Acids. 2020;20:764-776 pubmed publisher
|
| Chen H, Gao L, Yuan J, Zhang Y, Liu P, Wang G, et al. Decrease in SHP-1 enhances myometrium remodeling via FAK activation leading to labor. Am J Physiol Endocrinol Metab. 2020;318:E930-E942 pubmed publisher
|
| He S, Guo Y, Zhao J, Xu X, Wang N, Liu Q. Ferulic Acid Ameliorates Lipopolysaccharide-Induced Barrier Dysfunction via MicroRNA-200c-3p-Mediated Activation of PI3K/AKT Pathway in Caco-2 Cells. Front Pharmacol. 2020;11:376 pubmed publisher
|
| Liu Y, Liu S, Wu C, Huang W, Xu B, Lian S, et al. PD-1-Mediated PI3K/Akt/mTOR, Caspase 9/Caspase 3 and ERK Pathways Are Involved in Regulating the Apoptosis and Proliferation of CD4+ and CD8+ T Cells During BVDV Infection in vitro. Front Immunol. 2020;11:467 pubmed publisher
|
| Xia W, Jie W. ZEB1-AS1/miR-133a-3p/LPAR3/EGFR axis promotes the progression of thyroid cancer by regulating PI3K/AKT/mTOR pathway. Cancer Cell Int. 2020;20:94 pubmed publisher
|
| Bao J, Chen Z, Xu L, Wu L, Xiong Y. Rapamycin protects chondrocytes against IL-18-induced apoptosis and ameliorates rat osteoarthritis. Aging (Albany NY). 2020;12:5152-5167 pubmed publisher
|
| Zhang Y, Cai W, Han G, Zhou S, Li J, Chen M, et al. Panax notoginseng saponins prevent senescence and inhibit apoptosis by regulating the PI3K‑AKT‑mTOR pathway in osteoarthritic chondrocytes. Int J Mol Med. 2020;45:1225-1236 pubmed publisher
|
| Zhang Y, Du P, Li Y, Zhu Q, Song X, Liu S, et al. TASP1 Promotes Gallbladder Cancer Cell Proliferation and Metastasis by Up-regulating FAM49B via PI3K/AKT Pathway. Int J Biol Sci. 2020;16:739-751 pubmed publisher
|
| Wu H, Wang Z, Shi F, Ren Z, Li L, Hu X, et al. Avβ3 Single-Stranded DNA Aptamer Attenuates Vascular Smooth Muscle Cell Proliferation and Migration via Ras-PI3K/MAPK Pathway. Cardiovasc Ther. 2020;2020:6869856 pubmed publisher
|
| Wu L, Xi Y, Kong Q. Dexmedetomidine protects PC12 cells from oxidative damage through regulation of miR-199a/HIF-1α. Artif Cells Nanomed Biotechnol. 2020;48:506-514 pubmed publisher
|
| Gu Y, Zhu Z, Pei H, Xu D, Jiang Y, Zhang L, et al. Long non-coding RNA NNT-AS1 promotes cholangiocarcinoma cells proliferation and epithelial-to-mesenchymal transition through down-regulating miR-203. Aging (Albany NY). 2020;12:2333-2346 pubmed publisher
|
| Tong X, Zeng H, Gu P, Wang K, Zhang H, Lin X. Monocyte chemoattractant protein‑1 promotes the proliferation, migration and differentiation potential of fibroblast‑like synoviocytes via the PI3K/P38 cellular signaling pathway. Mol Med Rep. 2020;21:1623-1632 pubmed publisher
|
| Liang C, Pang L, Ke Y, Ji W, Xiong J, Ding R, et al. LncRNA GAS6-AS2 facilitates tumor growth and metastasis of hepatocellular carcinoma by activating the PI3K/AKT/FoxO3a signaling pathway. Int J Clin Exp Pathol. 2019;12:4011-4023 pubmed
|
| Xu L, Li W, Shi Q, Wang M, Li H, Yang X, et al. MicroRNA‑936 inhibits the malignant phenotype of retinoblastoma by directly targeting HDAC9 and deactivating the PI3K/AKT pathway. Oncol Rep. 2020;43:635-645 pubmed publisher
|
| Chen Q, Gao Y, Yu Q, Tang F, Zhao P, Luo S, et al. miR-30a-3p inhibits the proliferation of liver cancer cells by targeting DNMT3a through the PI3K/AKT signaling pathway. Oncol Lett. 2020;19:606-614 pubmed publisher
|
| Yang Z, Li G, Ding C, Sun W, Zhang J. Long non-coding RNA HULC exerts oncogenic activity on papillary thyroid cancer in vitro and in vivo. Artif Cells Nanomed Biotechnol. 2020;48:326-335 pubmed publisher
|
| Chi G, Yang F, Xu D, Liu W. Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-199a-5p. Artif Cells Nanomed Biotechnol. 2020;48:188-196 pubmed publisher
|
| Lv W, Hu Y, Li Z, Zhang W, Pan Q. PAX3 silencing suppresses gastric cancer proliferation and angiogenesis via MET/PI3K signaling. Neoplasma. 2020;67:304-311 pubmed publisher
|
| Liu Y, Tie L. Apolipoprotein M and sphingosine-1-phosphate complex alleviates TNF-α-induced endothelial cell injury and inflammation through PI3K/AKT signaling pathway. BMC Cardiovasc Disord. 2019;19:279 pubmed publisher
|
| Xiao X, Zhang Y, Lin Q, Zhong K. The better effects of microbubble ultrasound transfection of miR-940 on cell proliferation inhibition and apoptosis promotion in human cervical cancer cells. Onco Targets Ther. 2019;12:6813-6824 pubmed publisher
|
| Guo L, Tan K, Luo Q, Bai X. Dihydromyricetin promotes autophagy and attenuates renal interstitial fibrosis by regulating miR-155-5p/PTEN signaling in diabetic nephropathy. Bosn J Basic Med Sci. 2020;20:372-380 pubmed publisher
|
| Deng W, Peng W, Wang T, Chen J, Qiu X, Fu L, et al. Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma. Oncol Rep. 2019;42:2738-2749 pubmed publisher
|
| Bi Y, Fu Y, Wang S, Chen X, Cai X. Schizandrin A exerts anti-tumor effects on A375 cells by down-regulating H19. Braz J Med Biol Res. 2019;52:e8385 pubmed publisher
|
| Zhang X, Hou G, Liu A, Xu H, Guan Y, Wu Y, et al. Matrine inhibits the development and progression of ovarian cancer by repressing cancer associated phosphorylation signaling pathways. Cell Death Dis. 2019;10:770 pubmed publisher
|
| Wu Y, Wu Y, Fang Z, Chen M, Wang Y, Wu C, et al. Danzhi Jiangtang Capsule Mediates NIT-1 Insulinoma Cell Proliferation and Apoptosis by GLP-1/Akt Signaling Pathway. Evid Based Complement Alternat Med. 2019;2019:5356825 pubmed publisher
|
| Xie X, Liu M, Meng Q. Angelica polysaccharide promotes proliferation and osteoblast differentiation of mesenchymal stem cells by regulation of long non-coding RNA H19: An animal study. Bone Joint Res. 2019;8:323-332 pubmed publisher
|
| Chen D, Cao G, Zhao H, Chen L, Yang T, Wang M, et al. Combined melatonin and poricoic acid A inhibits renal fibrosis through modulating the interaction of Smad3 and β-catenin pathway in AKI-to-CKD continuum. Ther Adv Chronic Dis. 2019;10:2040622319869116 pubmed publisher
|
| Tao D, Ni N, Zhang T, Li C, Sun Q, Wang L, et al. Accumulation of advanced glycation end products potentiate human retinal capillary endothelial cells mediated diabetic retinopathy. Mol Med Rep. 2019;20:3719-3727 pubmed publisher
|
| Ma H, Yuan J, Jinyu M, Ding J, Lin W, Wang X, et al. BMP7 improves insulin signal transduction in the liver. J Endocrinol. 2019;: pubmed publisher
|
| El Kott A, Shati A, Al Kahtani M, Alqahtani S. Acylated Ghrelin Renders Chemosensitive Ovarian Cancer Cells Resistant to Cisplatin Chemotherapy via Activation of the PI3K/Akt/mTOR Survival Pathway. Anal Cell Pathol (Amst). 2019;2019:9627810 pubmed publisher
|
| Liu W, Liu X, Pan Z, Wang D, Li M, Chen X, et al. Ailanthone Induces Cell Cycle Arrest and Apoptosis in Melanoma B16 and A375 Cells. Biomolecules. 2019;9: pubmed publisher
|
| Jia L, Zhu Z, Li H, Li Y. Shikonin inhibits proliferation, migration, invasion and promotes apoptosis in NCI-N87 cells via inhibition of PI3K/AKT signal pathway. Artif Cells Nanomed Biotechnol. 2019;47:2662-2669 pubmed publisher
|
| Ma Y, Ren Y, Guan J. Knockdown of GC binding factor 2 by RNA interference inhibits invasion and migration of vascular smooth muscle cells. Mol Med Rep. 2019;20:1781-1789 pubmed publisher
|
| Gong L, Xu H, Zhang X, Zhang T, Shi J, Chang H. Oridonin relieves hypoxia-evoked apoptosis and autophagy via modulating microRNA-214 in H9c2 cells. Artif Cells Nanomed Biotechnol. 2019;47:2585-2592 pubmed publisher
|
| Tang K, Tang H, Du Y, Tian T, Xiong S. PAR-2 promotes cell proliferation, migration and invasion through activating PI3K/AKT signaling pathway in oral squamous cell carcinoma. Biosci Rep. 2019;: pubmed publisher
|
| Liu B, Cao W, Ma H. Knockdown of lncRNA LSINCT5 suppresses growth and metastasis of human glioma cells via up-regulating miR-451. Artif Cells Nanomed Biotechnol. 2019;47:2507-2515 pubmed publisher
|
| Li C, Wang P, Fu Z, Li Y, Li S. Swainsonine inhibits proliferation and collagen synthesis of NIH-3T3 cells by declining miR-21. Artif Cells Nanomed Biotechnol. 2019;47:2256-2264 pubmed publisher
|
| Yang H, Liu J, Shang H, Lin S, Zhao J, Lin J. Qingjie Fuzheng granules inhibit colorectal cancer cell growth by the PI3K/AKT and ERK pathways. World J Gastrointest Oncol. 2019;11:377-392 pubmed publisher
|
| Du J, Yang S, Liu J, Zhang K, Leng J. Silence of LncRNA GAS5 Protects Cardiomyocytes H9c2 against Hypoxic Injury via Sponging miR-142-5p. Mol Cells. 2019;42:397-405 pubmed publisher
|
| Li D, Yuan Q, Yu K, Xiao T, Liu L, Dai Y, et al. Mg-Zn-Mn alloy extract induces the angiogenesis of human umbilical vein endothelial cells via FGF/FGFR signaling pathway. Biochem Biophys Res Commun. 2019;514:618-624 pubmed publisher
|
| Kobayashi K, Ichihara Y, Sato N, Umeda N, Fields L, Fukumitsu M, et al. On-site fabrication of Bi-layered adhesive mesenchymal stromal cell-dressings for the treatment of heart failure. Biomaterials. 2019;209:41-53 pubmed publisher
|
| Zhang Y, Zhang C, Min D. Ailanthone up-regulates miR-449a to restrain acute myeloid leukemia cells growth, migration and invasion. Exp Mol Pathol. 2019;108:114-120 pubmed publisher
|
| Wang W, Cao Y, Zhou X, Wei B, Zhan L, Sun S. Stimulative role of ST6GALNAC1 in proliferation, migration and invasion of ovarian cancer stem cells via the Akt signaling pathway. Cancer Cell Int. 2019;19:86 pubmed publisher
|
| Rui Q, Ma J, Liao Y, Dai J, Cai Z. Effect of lncRNA HULC knockdown on rat secreting pituitary adenoma GH3 cells. Braz J Med Biol Res. 2019;52:e7728 pubmed publisher
|
| Wu J, Liu H, Chu T, Jiang P, Li S. Neuregulin-1β attenuates sepsis-induced diaphragm atrophy by activating the PI3K/Akt signaling pathway. J Muscle Res Cell Motil. 2019;40:43-51 pubmed publisher
|
| Du Q, Zhang X, Zhang X, Wei M, Xu H, Wang S. Propofol inhibits proliferation and epithelial-mesenchymal transition of MCF-7 cells by suppressing miR-21 expression. Artif Cells Nanomed Biotechnol. 2019;47:1265-1271 pubmed publisher
|
| Wu H, Zou Q, He H, Liang Y, Lei M, Zhou Q, et al. Long non-coding RNA PCAT6 targets miR-204 to modulate the chemoresistance of colorectal cancer cells to 5-fluorouracil-based treatment through HMGA2 signaling. Cancer Med. 2019;8:2484-2495 pubmed publisher
|
| Cui C, Li S, Wu D. Znhit1 inhibits breast cancer by up-regulating PTEN to deactivate the PI3K/Akt/mTOR pathway. Life Sci. 2019;224:204-211 pubmed publisher
|
| Li X, Chen Y, Zhao J, Shi J, Wang M, Qiu S, et al. The Specific Inhibition of SOD1 Selectively Promotes Apoptosis of Cancer Cells via Regulation of the ROS Signaling Network. Oxid Med Cell Longev. 2019;2019:9706792 pubmed publisher
|
| Li B, Wang Z, Chen R, Hong J, Wu Q, Hu J, et al. Up regulation of isoleucyl-tRNA synthetase promotes vascular smooth muscle cells dysfunction via p38 MAPK/PI3K signaling pathways. Life Sci. 2019;224:51-57 pubmed publisher
|
| Danilucci T, Santos P, Pachane B, Pisani G, Lino R, Casali B, et al. Recombinant RGD-disintegrin DisBa-01 blocks integrin αvβ3 and impairs VEGF signaling in endothelial cells. Cell Commun Signal. 2019;17:27 pubmed publisher
|
| Sun L, Jin X, Xie L, Xu G, Cui Y, Chen Z. Swainsonine represses glioma cell proliferation, migration and invasion by reduction of miR-92a expression. BMC Cancer. 2019;19:247 pubmed publisher
|
| Li H, Huang D, Hang S. Salidroside inhibits the growth, migration and invasion of Wilms' tumor cells through down-regulation of miR-891b. Life Sci. 2019;222:60-68 pubmed publisher
|
| Tang T, Gao D, Yang X, Hua X, Li S, Sun H. Exogenous Netrin-1 Inhibits Autophagy of Ischemic Brain Tissues and Hypoxic Neurons via PI3K/mTOR Pathway in Ischemic Stroke. J Stroke Cerebrovasc Dis. 2019;28:1338-1345 pubmed publisher
|
| Jiang R, Hao P, Yu G, Liu C, Yu C, Huang Y, et al. Kaempferol protects chondrogenic ATDC5 cells against inflammatory injury triggered by lipopolysaccharide through down-regulating miR-146a. Int Immunopharmacol. 2019;69:373-381 pubmed publisher
|
| Chen L, Jiang X, Chen H, Han Q, Liu C, Sun M. microRNA-628 inhibits the proliferation of acute myeloid leukemia cells by directly targeting IGF-1R. Onco Targets Ther. 2019;12:907-919 pubmed publisher
|
| Dong Z, Li S, Wang X, Si L, Ma R, Bao L, et al. lncRNA GAS5 restrains CCl4-induced hepatic fibrosis by targeting miR-23a through the PTEN/PI3K/Akt signaling pathway. Am J Physiol Gastrointest Liver Physiol. 2019;316:G539-G550 pubmed publisher
|
| Xing Y, Li L. Gastrodin protects rat cardiomyocytes H9c2 from hypoxia-induced injury by up-regulation of microRNA-21. Int J Biochem Cell Biol. 2019;109:8-16 pubmed publisher
|
| Zhao L, Zhang J, Sherchan P, Krafft P, Zhao W, Wang S, et al. Administration of rCTRP9 Attenuates Neuronal Apoptosis Through AdipoR1/PI3K/Akt Signaling Pathway after ICH in Mice. Cell Transplant. 2019;28:756-766 pubmed publisher
|
| Dong H, Hu J, Zou K, Ye M, Chen Y, Wu C, et al. Activation of LncRNA TINCR by H3K27 acetylation promotes Trastuzumab resistance and epithelial-mesenchymal transition by targeting MicroRNA-125b in breast Cancer. Mol Cancer. 2019;18:3 pubmed publisher
|
| Cui L, Li C, Zhuo Y, Yang L, Cui N, Zhang S. Saikosaponin d ameliorates pancreatic fibrosis by inhibiting autophagy of pancreatic stellate cells via PI3K/Akt/mTOR pathway. Chem Biol Interact. 2019;300:18-26 pubmed publisher
|
| Liu Y, Zhang Y. Lycium barbarum polysaccharides alleviate hydrogen peroxide-induced injury by up-regulation of miR-4295 in human trabecular meshwork cells. Exp Mol Pathol. 2019;106:109-115 pubmed publisher
|
| Qi D, Wang M, Yu F. Knockdown of lncRNA-H19 inhibits cell viability, migration and invasion while promotes apoptosis via microRNA-143/RUNX2 axis in retinoblastoma. Biomed Pharmacother. 2019;109:798-805 pubmed publisher
|
| Xue F, Liu Z, Xu J, Xu X, Chen X, Tian F. Neferine inhibits growth and migration of gastrointestinal stromal tumor cell line GIST-T1 by up-regulation of miR-449a. Biomed Pharmacother. 2019;109:1951-1959 pubmed publisher
|
| Bao H, Sun D, Qi P, Jiang S. Astragaloside protects oxygen and glucose deprivation induced injury by regulation of microRNA-21 in retinal ganglion cell line RGC-5. Biomed Pharmacother. 2019;109:1826-1833 pubmed publisher
|
| Li H, Xie S, Qi Y, Li H, Zhang R, Lian Y. TNF-α increases the expression of inflammatory factors in synovial fibroblasts by inhibiting the PI3K/AKT pathway in a rat model of monosodium iodoacetate-induced osteoarthritis. Exp Ther Med. 2018;16:4737-4744 pubmed publisher
|
| Yuan Y, Zheng Z. Geniposide protects PC-12 cells against oxygen and glucose deprivation-induced injury by up-regulation of long-noncoding RNA H19. Life Sci. 2019;216:176-182 pubmed publisher
|
| Liu H, Deng H, Zhao Y, Li C, Liang Y. LncRNA XIST/miR-34a axis modulates the cell proliferation and tumor growth of thyroid cancer through MET-PI3K-AKT signaling. J Exp Clin Cancer Res. 2018;37:279 pubmed publisher
|
| Li Z, Ma Z, Xu X. Long non‑coding RNA MALAT1 correlates with cell viability and mobility by targeting miR‑22‑3p in renal cell carcinoma via the PI3K/Akt pathway. Oncol Rep. 2019;41:1113-1121 pubmed publisher
|
| Zhang X, Xiao C, Liu H. Ganoderic Acid A Protects Rat H9c2 Cardiomyocytes from Hypoxia-Induced Injury via Up-Regulating miR-182-5p. Cell Physiol Biochem. 2018;50:2086-2096 pubmed publisher
|
| Yin D, Li Y, Fu C, Feng Y. Pro-Angiogenic Role of LncRNA HULC in Microvascular Endothelial Cells via Sequestrating miR-124. Cell Physiol Biochem. 2018;50:2188-2202 pubmed publisher
|
| Jiang W, Meng L, Xu G, Lv C, Wang H, Tian H, et al. Wentilactone A induces cell apoptosis by targeting AKR1C1 gene via the IGF-1R/IRS1/PI3K/AKT/Nrf2/FLIP/Caspase-3 signaling pathway in small cell lung cancer. Oncol Lett. 2018;16:6445-6457 pubmed publisher
|
| Leng X, Shang J, Gao D, Wu J. Low-intensity pulsed ultrasound promotes proliferation and migration of HaCaT keratinocytes through the PI3K/AKT and JNK pathways. Braz J Med Biol Res. 2018;51:e7862 pubmed publisher
|
| Dai X, Wang L, Wu J, Shi Y, Li G, Yang X. Src kinase inhibitor PP2 regulates the biological characteristics of A549 cells via the PI3K/Akt signaling pathway. Oncol Lett. 2018;16:5059-5065 pubmed publisher
|
| Xu D, Chi G, Zhao C, Li D. Ligustrazine Inhibits Growth, Migration and Invasion of Medulloblastoma Daoy Cells by Up-Regulation of miR-211. Cell Physiol Biochem. 2018;49:2012-2021 pubmed publisher
|
| Yang R, Wang L, Xie J, Li X, Liu S, Qiu S, et al. Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A. Int J Mol Med. 2018;42:2329-2342 pubmed publisher
|
| Wang Y, Xie J, Liu W, Zhang R, Huang S, Xing Y. BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway. Mol Med Rep. 2018;18:4259-4270 pubmed publisher
|
| Bao J, Ye C, Zheng Z, Zhou Z. Fmr1 protects cardiomyocytes against lipopolysaccharide-induced myocardial injury. Exp Ther Med. 2018;16:1825-1833 pubmed publisher
|
| Wang J, Li H, Ren Y, Yao Y, Hu J, Zheng M, et al. Local Delivery of β-Elemene Improves Locomotor Functional Recovery by Alleviating Endoplasmic Reticulum Stress and Reducing Neuronal Apoptosis in Rats with Spinal Cord Injury. Cell Physiol Biochem. 2018;49:595-609 pubmed publisher
|
| Liang W, Zhang D, Kang J, Meng X, Yang J, Yang L, et al. Protective effects of rutin on liver injury in type 2 diabetic db/db mice. Biomed Pharmacother. 2018;107:721-728 pubmed publisher
|
| Zhu B, Liu Q, Han Q, Zeng B, Chen J, Xiao Q. Downregulation of Krüppel‑like factor 1 inhibits the metastasis and invasion of cervical cancer cells. Mol Med Rep. 2018;18:3932-3940 pubmed publisher
|
| Li J, You X. MicroRNA‑758 inhibits malignant progression of retinoblastoma by directly targeting PAX6. Oncol Rep. 2018;40:1777-1786 pubmed publisher
|
| Li J, Qi C, Liu X, Li C, Chen J, Shi M. Fibulin-3 knockdown inhibits cervical cancer cell growth and metastasis in vitro and in vivo. Sci Rep. 2018;8:10594 pubmed publisher
|
| Shen G, Ren H, Huang J, Zhang Z, Zhao W, Yu X, et al. Plastrum Testudinis Extracts Promote BMSC Proliferation and Osteogenic Differentiation by Regulating Let-7f-5p and the TNFR2/PI3K/AKT Signaling Pathway. Cell Physiol Biochem. 2018;47:2307-2318 pubmed publisher
|
| Pan H, Zhu L. Angelica sinensis polysaccharide protects rat cardiomyocytes H9c2 from hypoxia-induced injury by down-regulation of microRNA-22. Biomed Pharmacother. 2018;106:225-231 pubmed publisher
|
| Jin X, Jiang R, Xiang Y, Fan Z, Wu Z, Yang B, et al. Overexpression of retinoblastoma‑binding protein 4 contributes to the radiosensitivity of AGS gastric cancer cells via phosphoinositide3‑kinase/protein kinase B pathway suppression. Mol Med Rep. 2018;18:1571-1581 pubmed publisher
|
| Zhou Z, Zhang Y, Lin L, Zhou J. Apigenin suppresses the apoptosis of H9C2 rat cardiomyocytes subjected to myocardial ischemia‑reperfusion injury via upregulation of the PI3K/Akt pathway. Mol Med Rep. 2018;18:1560-1570 pubmed publisher
|
| Liu G, Zhang W. Long non-coding RNA HOTAIR promotes UVB-induced apoptosis and inflammatory injury by up-regulation of PKR in keratinocytes. Braz J Med Biol Res. 2018;51:e6896 pubmed publisher
|
| Yan R, Xu H, Fu X. Salidroside protects hypoxia-induced injury by up-regulation of miR-210 in rat neural stem cells. Biomed Pharmacother. 2018;103:1490-1497 pubmed publisher
|
| Xu Y, Deng W, Zhang W. Long non-coding RNA TUG1 protects renal tubular epithelial cells against injury induced by lipopolysaccharide via regulating microRNA-223. Biomed Pharmacother. 2018;104:509-519 pubmed publisher
|
| Yang T, Zhai H, Yan R, Zhou Z, Gao L, Wang L. lncRNA CCAT1 promotes cell proliferation, migration, and invasion by down-regulation of miR-143 in FTC-133 thyroid carcinoma cell line. Braz J Med Biol Res. 2018;51:e7046 pubmed publisher
|
| Liu X, Meng J. Tanshinone IIA ameliorates lipopolysaccharide-induced inflammatory response in bronchial epithelium cell line BEAS-2B by down-regulating miR-27a. Biomed Pharmacother. 2018;104:158-164 pubmed publisher
|
| Feng F, Qiu H. Effects of Artesunate on chondrocyte proliferation, apoptosis and autophagy through the PI3K/AKT/mTOR signaling pathway in rat models with rheumatoid arthritis. Biomed Pharmacother. 2018;102:1209-1220 pubmed publisher
|
| Xin Y, Zhang H, Jia Z, Ding X, Sun Y, Wang Q, et al. Resveratrol improves uric acid-induced pancreatic β-cells injury and dysfunction through regulation of miR-126. Biomed Pharmacother. 2018;102:1120-1126 pubmed publisher
|
| Zhai Y, Wang Q, Li Y, Cui J, Feng K, Kong X, et al. The higher osteoprotective activity of psoralidin in vivo than coumestrol is attributed by its presence of an isopentenyl group and through activated PI3K/Akt axis. Biomed Pharmacother. 2018;102:1015-1024 pubmed publisher
|
| Zhang X, Liu Y, He T, Yang T, Wu J, Cianflone K, et al. Anaphylatoxin C5a induces inflammation and reduces insulin sensitivity by activating TLR4/NF-kB/PI3K signaling pathway in 3T3-L1 adipocytes. Biomed Pharmacother. 2018;103:955-964 pubmed publisher
|
| Xu H, Lu H, Zhu X, Wang W, Zhang Z, Fu H, et al. Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro. Int J Mol Med. 2018;42:615-624 pubmed publisher
|
| Jeong J, Kang E. Effects of treadmill exercise on PI3K/AKT/GSK-3β pathway and tau protein in high-fat diet-fed rats. J Exerc Nutrition Biochem. 2018;22:9-14 pubmed publisher
|
| Song Y, Zhao Y, Ding X, Wang X. microRNA-532 suppresses the PI3K/Akt signaling pathway to inhibit colorectal cancer progression by directly targeting IGF-1R. Am J Cancer Res. 2018;8:435-449 pubmed
|
| Liao Z, Zhao J, Yang Y. Downregulation of lncRNA H19 inhibits the migration and invasion of melanoma cells by inactivating the NF‑κB and PI3K/Akt signaling pathways. Mol Med Rep. 2018;17:7313-7318 pubmed publisher
|
| Zhao J, Ma S. Downregulation of lncRNA H19 inhibits migration and invasion of human osteosarcoma through the NF-?B pathway. Mol Med Rep. 2018;17:7388-7394 pubmed publisher
|
| Cao Y, Holscher C, Hu M, Wang T, Zhao F, Bai Y, et al. DA5-CH, a novel GLP-1/GIP dual agonist, effectively ameliorates the cognitive impairments and pathology in the APP/PS1 mouse model of Alzheimer's disease. Eur J Pharmacol. 2018;827:215-226 pubmed publisher
|
| Chen H, Wang H, An J, Shang Q, Ma J. Plumbagin induces RPE cell cycle arrest and apoptosis via p38 MARK and PI3K/AKT/mTOR signaling pathways in PVR. BMC Complement Altern Med. 2018;18:89 pubmed publisher
|
| Zheng Y, Wang M, Shu X, Zheng P, Ji G. Autophagy activation by Jiang Zhi Granule protects against metabolic stress-induced hepatocyte injury. World J Gastroenterol. 2018;24:992-1003 pubmed publisher
|
| Xu J, Xia Y, Zhang H, Guo H, Feng K, Zhang C. Overexpression of long non-coding RNA H19 promotes invasion and autophagy via the PI3K/AKT/mTOR pathways in trophoblast cells. Biomed Pharmacother. 2018;101:691-697 pubmed publisher
|
| Wang Z, Chi X, Liu L, Wang Y, Mei X, Yang Y, et al. Long noncoding RNA maternally expressed gene 3 knockdown alleviates lipopolysaccharide-induced inflammatory injury by up-regulation of miR-203 in ATDC5 cells. Biomed Pharmacother. 2018;100:240-249 pubmed publisher
|
| Wang Y, Kong D. LncRNA GAS5 Represses Osteosarcoma Cells Growth and Metastasis via Sponging MiR-203a. Cell Physiol Biochem. 2018;45:844-855 pubmed publisher
|
| Kong D, Zhang D, Chu X, Wang J. Schizandrin A enhances chemosensitivity of colon carcinoma cells to 5-fluorouracil through up-regulation of miR-195. Biomed Pharmacother. 2018;99:176-183 pubmed publisher
|
| Chen L, Xiong Y, Xu J, Wang J, Meng Z, Hong Y. Juglanin inhibits lung cancer by regulation of apoptosis, ROS and autophagy induction. Oncotarget. 2017;8:93878-93898 pubmed publisher
|
| Sun T, Li X, Song H, Gao F, Zhou G, Li X, et al. MiR-146a Aggravates LPS-Induced Inflammatory Injury by Targeting CXCR4 in the Articular Chondrocytes. Cell Physiol Biochem. 2017;44:1282-1294 pubmed publisher
|
| Fu J, Zhu X, Wang W, Lu H, Zhang Z, Liu T, et al. 1, 6-di-O-caffeoyl-?-D-glucopyranoside, a natural compound from Callicarpa nudiflora Hook impairs P2Y12 and thromboxane A2 receptor-mediated amplification of platelet activation and aggregation. Phytomedicine. 2017;36:273-282 pubmed publisher
|
| Zhu W, Qiu W, Lu A. Cryptotanshinone exhibits therapeutical effects on cerebral stroke through the PI3K/AKT?eNOS signaling pathway. Mol Med Rep. 2017;16:9361-9366 pubmed publisher
|
| Li H, You Q, Xu L, Sun L, Abdul Majid A, Xia X, et al. Long Non-Coding RNA-MALAT1 Mediates Retinal Ganglion Cell Apoptosis Through the PI3K/Akt Signaling Pathway in Rats with Glaucoma. Cell Physiol Biochem. 2017;43:2117-2132 pubmed publisher
|
| Wang X, Zhang Y, Wang H, Zhao G, Fa X. MicroRNA-145 Aggravates Hypoxia-Induced Injury by Targeting Rac1 in H9c2 Cells. Cell Physiol Biochem. 2017;43:1974-1986 pubmed publisher
|
| Wu D, Zhang J, Wang J, Cui M, Jia J, Liu X, et al. MiR-1246 Promotes LPS-Induced Inflammatory Injury in Chondrogenic Cells ATDC5 by Targeting HNF4?. Cell Physiol Biochem. 2017;43:2010-2021 pubmed publisher
|
| Ji Q, Xu X, Li L, Goodman S, Bi W, Xu M, et al. miR-216a inhibits osteosarcoma cell proliferation, invasion and metastasis by targeting CDK14. Cell Death Dis. 2017;8:e3103 pubmed publisher
|
| Xie Z, Enkhjargal B, Wu L, Zhou K, Sun C, Hu X, et al. Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats. Neuropharmacology. 2018;128:142-151 pubmed publisher
|
| Sun N, Meng F, Xue N, Pang G, Wang Q, Ma H. Inducible miR-145 expression by HIF-1a protects cardiomyocytes against apoptosis via regulating SGK1 in simulated myocardial infarction hypoxic microenvironment. Cardiol J. 2018;25:268-278 pubmed publisher
|
| Xu X, Zhao W, Feng S, Sun C, Chen Q, Ni B, et al. Celastrol alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy. Mol Med Rep. 2017;16:7657-7664 pubmed publisher
|
| Wu J, Pan X, Fu H, Zheng Y, Dai Y, Yin Y, et al. Effect of curcumin on glycerol-induced acute kidney injury in rats. Sci Rep. 2017;7:10114 pubmed publisher
|
| Wu H, Yang S, Weng H, Chen Q, Zhao X, Fu W, et al. Autophagy-induced KDR/VEGFR-2 activation promotes the formation of vasculogenic mimicry by glioma stem cells. Autophagy. 2017;13:1528-1542 pubmed publisher
|
| Liu L, Yu J, Xu X. Kappa-opioid receptor agonist U50448H protects against renal ischemia-reperfusion injury in rats via activating the PI3K/Akt signaling pathway. Acta Pharmacol Sin. 2018;39:97-106 pubmed publisher
|
| Yan T, He B, Wan S, Xu M, Yang H, Xiao F, et al. Antidepressant-like effects and cognitive enhancement of Schisandra chinensis in chronic unpredictable mild stress mice and its related mechanism. Sci Rep. 2017;7:6903 pubmed publisher
|
| Zhou Y, Li S, Li J, Wang D, Li Q. Effect of microRNA-135a on Cell Proliferation, Migration, Invasion, Apoptosis and Tumor Angiogenesis Through the IGF-1/PI3K/Akt Signaling Pathway in Non-Small Cell Lung Cancer. Cell Physiol Biochem. 2017;42:1431-1446 pubmed publisher
|
| Zou B, Wang H, Liu Y, Qi P, Lei T, Sun M, et al. Mangiferin induces apoptosis in human ovarian adenocarcinoma OVCAR3 cells via the regulation of Notch3. Oncol Rep. 2017;38:1431-1441 pubmed publisher
|
| Zhou Q, Meng G, Teng F, Sun Q, Zhang Y. Effects of astragalus polysaccharide on apoptosis of myocardial microvascular endothelial cells in rats undergoing hypoxia/reoxygenation by mediation of the PI3K/Akt/eNOS signaling pathway. J Cell Biochem. 2018;119:806-816 pubmed publisher
|
| YANG H, Chen Y, Gao C, Cui Z, Yao J. Protective Effects of MicroRNA-126 on Human Cardiac Microvascular Endothelial Cells Against Hypoxia/Reoxygenation-Induced Injury and Inflammatory Response by Activating PI3K/Akt/eNOS Signaling Pathway. Cell Physiol Biochem. 2017;42:506-518 pubmed publisher
|
| Lu H, Mei H, Wang F, Zhao Q, Wang S, Liu L, et al. Decreased phosphorylation of PDGFR-β impairs the angiogenic potential of expanded endothelial progenitor cells via the inhibition of PI3K/Akt signaling. Int J Mol Med. 2017;39:1492-1504 pubmed publisher
|
| Liu Y, Marin A, Ejlerskov P, Rasmussen L, Prinz M, Issazadeh Navikas S. Neuronal IFN-beta-induced PI3K/Akt-FoxA1 signalling is essential for generation of FoxA1+Treg cells. Nat Commun. 2017;8:14709 pubmed publisher
|
| Liu Y, Liao R, Qiang Z, Zhang C. Pro-inflammatory cytokine-driven PI3K/Akt/Sp1 signalling and H2S production facilitates the pathogenesis of severe acute pancreatitis. Biosci Rep. 2017;37: pubmed publisher
|
| Zhang D, Wang S, Chen J, Liu H, Lu J, Jiang H, et al. Fibulin-4 promotes osteosarcoma invasion and metastasis by inducing epithelial to mesenchymal transition via the PI3K/Akt/mTOR pathway. Int J Oncol. 2017;50:1513-1530 pubmed publisher
|
| Huang G, Zou B, Lv J, Li T, Huai G, Xiang S, et al. Notoginsenoside R1 attenuates glucose-induced podocyte injury via the inhibition of apoptosis and the activation of autophagy through the PI3K/Akt/mTOR signaling pathway. Int J Mol Med. 2017;39:559-568 pubmed publisher
|
| Yu N, Zhang S, Lu J, Li Y, Yi X, Tang L, et al. Serum amyloid A, an acute phase protein, stimulates proliferative and proinflammatory responses of keratinocytes. Cell Prolif. 2017;50: pubmed publisher
|