| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; mouse; 1:500; loading ...; fig 2e
| Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, et al. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun. 2021;12:3005 pubmed publisher |
- western blot; mouse; loading ...; fig s4f
| Li Y, Chen L, Li L, Sottas C, Petrillo S, Lazaris A, et al. Cholesterol-binding translocator protein TSPO regulates steatosis and bile acid synthesis in nonalcoholic fatty liver disease. iScience. 2021;24:102457 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig s4a
| Zhang Z, Wen H, Peng B, Weng J, Zeng F. HFD-induced TRAF6 upregulation promotes liver cholesterol accumulation and fatty liver development via EZH2-mediated miR-429/PPARα axis. Mol Ther Nucleic Acids. 2021;24:711-727 pubmed publisher |
- western blot; mouse; loading ...; fig 2
| Kim Y, Oh S, Ahn J, Yook J, Kim C, Park S, et al. The Crucial Role of Xanthine Oxidase in CKD Progression Associated with Hypercholesterolemia. Int J Mol Sci. 2020;21: pubmed publisher |
- western blot; human; loading ...; fig 4e
| Zhou L, Wang Q, Zhang H, Li Y, Xie S, Xu M. YAP Inhibition by Nuciferine via AMPK-Mediated Downregulation of HMGCR Sensitizes Pancreatic Cancer Cells to Gemcitabine. Biomolecules. 2019;9: pubmed publisher |
- western blot; mouse; loading ...; fig 1b
| Su L, Zhou L, Chen F, Wang H, Qian H, Sheng Y, et al. Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. EMBO J. 2019;38: pubmed publisher |
- western blot; mouse; loading ...; fig 2a
| Vienken H, Mabrouki N, Grabau K, Claas R, Rudowski A, Schömel N, et al. Characterization of cholesterol homeostasis in sphingosine-1-phosphate lyase-deficient fibroblasts reveals a Niemann-Pick disease type C-like phenotype with enhanced lysosomal Ca2+ storage. Sci Rep. 2017;7:43575 pubmed publisher |
- western blot; mouse; loading ...; fig 3a
| Kong Q, Zhang H, Zhao T, Zhang W, Yan M, Dong X, et al. Tangshen formula attenuates hepatic steatosis by inhibiting hepatic lipogenesis and augmenting fatty acid oxidation in db/db mice. Int J Mol Med. 2016;38:1715-1726 pubmed publisher |
- western blot; mouse; fig 5
| Tao W, Moore R, Meng Y, Smith E, Xu X. Endocytic adaptors Arh and Dab2 control homeostasis of circulatory cholesterol. J Lipid Res. 2016;57:809-17 pubmed publisher |
- western blot; human; loading ...; fig s1c
| Sharma M, Tuaine J, McLaren B, Waters D, Black K, Jones L, et al. Chemotherapy Agents Alter Plasma Lipids in Breast Cancer Patients and Show Differential Effects on Lipid Metabolism Genes in Liver Cells. PLoS ONE. 2016;11:e0148049 pubmed publisher |
- immunohistochemistry - frozen section; mouse; 1:50; fig 8
| Rolyan H, Tyurina Y, Hernandez M, Amoscato A, Sparvero L, Nmezi B, et al. Defects of Lipid Synthesis Are Linked to the Age-Dependent Demyelination Caused by Lamin B1 Overexpression. J Neurosci. 2015;35:12002-17 pubmed publisher |
| Hu Y, Xu J, Chen Q, Liu M, Wang S, Yu H, et al. Regulation effects of total flavonoids in Morus alba L. on hepatic cholesterol disorders in orotic acid induced NAFLD rats. BMC Complement Med Ther. 2020;20:257 pubmed publisher |
| Kim G, Kan S, Kang H, Lee S, Ko H, Kim J, et al. Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells. Int J Mol Sci. 2019;20: pubmed publisher |
| Kang H, Oh T, Bahk Y, Kim G, Kan S, Shin D, et al. HSF1 Regulates Mevalonate and Cholesterol Biosynthesis Pathways. Cancers (Basel). 2019;11: pubmed publisher |
| Gong L, Xiao Y, Xia F, Wu P, Zhao T, Xie S, et al. The mevalonate coordinates energy input and cell proliferation. Cell Death Dis. 2019;10:327 pubmed publisher |
| Shi J, Li R, Liu Y, Lu H, Yu L, Zhang F. Shuangyu Tiaozhi Granule Attenuates Hypercholesterolemia through the Reduction of Cholesterol Synthesis in Rat Fed a High Cholesterol Diet. Biomed Res Int. 2019;2019:4805926 pubmed publisher |
| Menzies S, Volkmar N, van den Boomen D, Timms R, Dickson A, Nathan J, et al. The sterol-responsive RNF145 E3 ubiquitin ligase mediates the degradation of HMG-CoA reductase together with gp78 and Hrd1. elife. 2018;7: pubmed publisher |
| Dong L, Xue L, Zhang C, Li H, Cai Z, Guo R. HSP90 interacts with HMGCR and promotes the progression of hepatocellular carcinoma. Mol Med Rep. 2019;19:524-532 pubmed publisher |
| Kim Y, Lee Y, Oh T, Shin D, Kim G, Kan S, et al. Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism. Int J Mol Sci. 2018;19: pubmed publisher |
| Niu S, Li H, Chen W, Zhao J, Gao L, Bo T. Beta-Arrestin 1 Mediates Liver Thyrotropin Regulation of Cholesterol Conversion Metabolism via the Akt-Dependent Pathway. Int J Endocrinol. 2018;2018:4371396 pubmed publisher |
| Gao F, Li G, Liu C, Gao H, Wang H, Liu W, et al. Autophagy regulates testosterone synthesis by facilitating cholesterol uptake in Leydig cells. J Cell Biol. 2018;217:2103-2119 pubmed publisher |
| Radif Y, Ndiaye H, Kalantzi V, Jacobs R, Hall A, Minogue S, et al. The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells. Mol Cell Biochem. 2018;448:275-286 pubmed publisher |
| Wang X, Huang Z, Wu Q, Prager B, Mack S, Yang K, et al. MYC-Regulated Mevalonate Metabolism Maintains Brain Tumor-Initiating Cells. Cancer Res. 2017;77:4947-4960 pubmed publisher |
| Warita K, Warita T, Beckwitt C, Schurdak M, Vazquez A, Wells A, et al. Statin-induced mevalonate pathway inhibition attenuates the growth of mesenchymal-like cancer cells that lack functional E-cadherin mediated cell cohesion. Sci Rep. 2014;4:7593 pubmed publisher |
