This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-SOD2/MnSOD antibody [2A1]
catalog :
ab16956
quantity :
100 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2A1
reactivity :
human, mouse, rat, domestic sheep
application :
western blot, ELISA, immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 34
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 6a
Cumming K, Ellefsen S, Rønnestad B, Ugelstad I, Raastad T. Acute and long-term effects of blood flow restricted training on heat shock proteins and endogenous antioxidant systems. Scand J Med Sci Sports. 2017;27:1190-1201 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 10a
Nag T, Wadhwa S. Immunolocalisation pattern of complex I-V in ageing human retina: Correlation with mitochondrial ultrastructure. Mitochondrion. 2016;31:20-32 pubmed publisher
  • western blot; human; 1:2000; fig 5
Tian B, Maidana D, Dib B, Miller J, Bouzika P, Miller J, et al. miR-17-3p Exacerbates Oxidative Damage in Human Retinal Pigment Epithelial Cells. PLoS ONE. 2016;11:e0160887 pubmed publisher
  • western blot; mouse; fig 4
Gurt I, Artsi H, Cohen Kfir E, Hamdani G, Ben Shalom G, Feinstein B, et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS ONE. 2015;10:e0134391 pubmed publisher
  • immunohistochemistry; rat; 1:100; fig 5
Liu K, Chuang S, Long C, Lee Y, Wang C, Lu M, et al. Ketamine-induced ulcerative cystitis and bladder apoptosis involve oxidative stress mediated by mitochondria and the endoplasmic reticulum. Am J Physiol Renal Physiol. 2015;309:F318-31 pubmed publisher
  • western blot; domestic sheep; 1:1500; fig 1
Al Gubory K, Arianmanesh M, Garrel C, Fowler P. The conceptus regulates tryptophanyl-tRNA synthetase and superoxide dismutase 2 in the sheep caruncular endometrium during early pregnancy. Int J Biochem Cell Biol. 2015;60:112-8 pubmed publisher
  • western blot; human; 1:2000
Fiorini C, Cordani M, Gotte G, Picone D, Donadelli M. Onconase induces autophagy sensitizing pancreatic cancer cells to gemcitabine and activates Akt/mTOR pathway in a ROS-dependent manner. Biochim Biophys Acta. 2015;1853:549-60 pubmed publisher
  • western blot; human
Cumming K, Raastad T, Holden G, Bastani N, Schneeberger D, Paronetto M, et al. Effects of vitamin C and E supplementation on endogenous antioxidant systems and heat shock proteins in response to endurance training. Physiol Rep. 2014;2: pubmed publisher
  • immunohistochemistry - paraffin section; domestic sheep; 1:600; fig 9
  • western blot; domestic sheep; 1:1500; fig 5b
Al Gubory K, Arianmanesh M, Garrel C, Bhattacharya S, Cash P, Fowler P. Proteomic analysis of the sheep caruncular and intercaruncular endometrium reveals changes in functional proteins crucial for the establishment of pregnancy. Reproduction. 2014;147:599-614 pubmed publisher
Treml J, Leláková V, Smejkal K, Paulíčková T, Labuda Š, Granica S, et al. Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System. Biomolecules. 2019;9: pubmed publisher
Doğan S, Cerutti R, Benincá C, Brea Calvo G, Jacobs H, Zeviani M, et al. Perturbed Redox Signaling Exacerbates a Mitochondrial Myopathy. Cell Metab. 2018;28:764-775.e5 pubmed publisher
Cho J, Zhang Y, Park S, Joseph A, Han C, Park H, et al. Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. Nat Commun. 2017;8:14477 pubmed publisher
Kemp K, Cerminara N, Hares K, Redondo J, Cook A, Haynes H, et al. Cytokine therapy-mediated neuroprotection in a Friedreich's ataxia mouse model. Ann Neurol. 2017;81:212-226 pubmed publisher
Lohr K, Pachl F, Moghaddas Gholami A, Geillinger K, Daniel H, Kuster B, et al. Reduced mitochondrial mass and function add to age-related susceptibility toward diet-induced fatty liver in C57BL/6J mice. Physiol Rep. 2016;4: pubmed
Stauch K, Purnell P, Fox H. Aging synaptic mitochondria exhibit dynamic proteomic changes while maintaining bioenergetic function. Aging (Albany NY). 2014;6:320-34 pubmed
Villeneuve L, Tiede L, Morsey B, Fox H. Quantitative proteomics reveals oxygen-dependent changes in neuronal mitochondria affecting function and sensitivity to rotenone. J Proteome Res. 2013;12:4599-606 pubmed publisher
Korwar A, Bhonsle H, Ghole V, Gawai K, Koppikar C, Kulkarni M. Proteomic profiling and interactome analysis of ER-positive/HER2/neu negative invasive ductal carcinoma of the breast: towards proteomics biomarkers. OMICS. 2013;17:27-40 pubmed publisher
Sanchez Roman I, Gomez A, Pérez I, Sanchez C, Suarez H, Naudi A, et al. Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria. Biogerontology. 2012;13:399-411 pubmed publisher
Quintana Cabrera R, Fernandez Fernandez S, Bobo Jiménez V, Escobar J, Sastre J, Almeida A, et al. ?-Glutamylcysteine detoxifies reactive oxygen species by acting as glutathione peroxidase-1 cofactor. Nat Commun. 2012;3:718 pubmed publisher
De Pauw A, Demine S, Tejerina S, Dieu M, Delaive E, Kel A, et al. Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction. Am J Physiol Endocrinol Metab. 2012;302:E1123-41 pubmed publisher
Sanchez Roman I, Gomez A, Gomez J, Suarez H, Sanchez C, Naudi A, et al. Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart. J Bioenerg Biomembr. 2011;43:699-708 pubmed publisher
Glushakova L, Judge S, Cruz A, Pourang D, Mathews C, Stacpoole P. Increased superoxide accumulation in pyruvate dehydrogenase complex deficient fibroblasts. Mol Genet Metab. 2011;104:255-60 pubmed publisher
Haorah J, Floreani N, Knipe B, Persidsky Y. Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach. Free Radic Biol Med. 2011;51:1601-9 pubmed publisher
Egan B, Dowling P, O Connor P, Henry M, Meleady P, Zierath J, et al. 2-D DIGE analysis of the mitochondrial proteome from human skeletal muscle reveals time course-dependent remodelling in response to 14 consecutive days of endurance exercise training. Proteomics. 2011;11:1413-28 pubmed publisher
Vanhorebeek I, Gunst J, Derde S, Derese I, Boussemaere M, Guiza F, et al. Insufficient activation of autophagy allows cellular damage to accumulate in critically ill patients. J Clin Endocrinol Metab. 2011;96:E633-45 pubmed publisher
Connell B, Saleh M, Khan B, Saleh T. Lipoic acid protects against reperfusion injury in the early stages of cerebral ischemia. Brain Res. 2011;1375:128-36 pubmed publisher
Tripathy D, Yin X, Sanchez A, Luo J, Martinez J, Grammas P. Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging. J Neuroinflammation. 2010;7:63 pubmed publisher
Thomas R, Khan S, Portell F, Smigrodzki R, Bennett J. Recombinant human mitochondrial transcription factor A stimulates mitochondrial biogenesis and ATP synthesis, improves motor function after MPTP, reduces oxidative stress and increases survival after endotoxin. Mitochondrion. 2011;11:108-18 pubmed publisher
Marengo B, De Ciusis C, Ricciarelli R, Romano P, Passalacqua M, Marinari U, et al. DNA oxidative damage of neoplastic rat liver lesions. Oncol Rep. 2010;23:1241-6 pubmed
Ye H, Jeong S, Ghosh M, Kovtunovych G, Silvestri L, Ortillo D, et al. Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. J Clin Invest. 2010;120:1749-61 pubmed publisher
Crooks D, Ghosh M, Haller R, Tong W, Rouault T. Posttranslational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery. Blood. 2010;115:860-9 pubmed publisher
Ye H, Wang A, Lee B, Yu T, Sheng S, Peng T, et al. Proteomic based identification of manganese superoxide dismutase 2 (SOD2) as a metastasis marker for oral squamous cell carcinoma. Cancer Genomics Proteomics. 2008;5:85-94 pubmed
Bogunovic B, Stojakovic M, Chen L, Maric M. An unexpected functional link between lysosomal thiol reductase and mitochondrial manganese superoxide dismutase. J Biol Chem. 2008;283:8855-62 pubmed publisher
Marengo B, De Ciucis C, Verzola D, Pistoia V, Raffaghello L, Patriarca S, et al. Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma. Free Radic Biol Med. 2008;44:474-82 pubmed
product information
CatalogNumber :
ab16956
ItemName :
Anti-SOD2/MnSOD antibody [2A1]
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
2A1
Size :
100 µl
SpeciesSummary :
DCV, Hu, Ms, Rat, Xl
Application Summary :
ELISA, Flow Cyt, IHC-P, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK