| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; loading ...; fig 3B
| Shan Z, Tian R, Zhang M, Gui Z, Wu J, Ding M, et al. miR128-1 inhibits the growth of glioblastoma multiforme and glioma stem-like cells via targeting BMI1 and E2F3. Oncotarget. 2016;7:78813-78826 pubmed publisher |
- chromatin immunoprecipitation; human; fig 4
| Kushwaha R, Jagadish N, Kustagi M, Mendiratta G, Seandel M, Soni R, et al. Mechanism and Role of SOX2 Repression in Seminoma: Relevance to Human Germline Specification. Stem Cell Reports. 2016;6:772-783 pubmed publisher |
- western blot; human; loading ...; fig 1c
| Jo S, Lee Y, Kim S, Lee H, Chung H. PCGF2 negatively regulates arsenic trioxide-induced PML-RARA protein degradation via UBE2I inhibition in NB4 cells. Biochim Biophys Acta. 2016;1863:1499-509 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:50; fig 1
| Kim S, Yang W, Min Y, Ko Y, Yoon S. The role of the polycomb repressive complex pathway in T and NK cell lymphoma: biological and prognostic implications. Tumour Biol. 2016;37:2037-47 pubmed publisher |
- western blot; human; 1:1000
| Adhikary G, Grun D, Balasubramanian S, Kerr C, Huang J, Eckert R. Survival of skin cancer stem cells requires the Ezh2 polycomb group protein. Carcinogenesis. 2015;36:800-10 pubmed publisher |
- chromatin immunoprecipitation; human; fig 3f
| Bhatnagar S, Gazin C, Chamberlain L, Ou J, Zhu X, Tushir J, et al. TRIM37 is a new histone H2A ubiquitin ligase and breast cancer oncoprotein. Nature. 2014;516:116-20 pubmed publisher |
- ChIP-Seq; human
- chromatin immunoprecipitation; human
| Englert N, Luo G, Goldstein J, Surapureddi S. Epigenetic modification of histone 3 lysine 27: mediator subunit MED25 is required for the dissociation of polycomb repressive complex 2 from the promoter of cytochrome P450 2C9. J Biol Chem. 2015;290:2264-78 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Benard A, Goossens Beumer I, van Hoesel A, Horati H, Putter H, Zeestraten E, et al. Prognostic value of polycomb proteins EZH2, BMI1 and SUZ12 and histone modification H3K27me3 in colorectal cancer. PLoS ONE. 2014;9:e108265 pubmed publisher |
- chromatin immunoprecipitation; human
| Shen H, Chen Z, Ding X, Qi X, Cen J, Wang Y, et al. BMI1 reprogrammes histone acetylation and enhances c-fos pathway via directly binding to Zmym3 in malignant myeloid progression. J Cell Mol Med. 2014;18:1004-17 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:100
| Dalley A, Pitty L, Major A, Abdulmajeed A, Farah C. Expression of ABCG2 and Bmi-1 in oral potentially malignant lesions and oral squamous cell carcinoma. Cancer Med. 2014;3:273-83 pubmed publisher |
- western blot; human; 1:1000
| Adhikary G, Grun D, Kerr C, Balasubramanian S, Rorke E, Vemuri M, et al. Identification of a population of epidermal squamous cell carcinoma cells with enhanced potential for tumor formation. PLoS ONE. 2013;8:e84324 pubmed publisher |
- immunocytochemistry; human
| Martin N, Popov N, Aguilo F, O Loghlen A, Raguz S, Snijders A, et al. Interplay between Homeobox proteins and Polycomb repressive complexes in p16INK?a regulation. EMBO J. 2013;32:982-95 pubmed publisher |
| Traynor S, Møllegaard N, Jørgensen M, Brückmann N, Pedersen C, Terp M, et al. Remodeling and destabilization of chromosome 1 pericentromeric heterochromatin by SSX proteins. Nucleic Acids Res. 2019;47:6668-6684 pubmed publisher |
| Adhikary G, Grun D, Alexander H, Friedberg J, Xu W, Keillor J, et al. Transglutaminase is a mesothelioma cancer stem cell survival protein that is required for tumor formation. Oncotarget. 2018;9:34495-34505 pubmed publisher |
| Chow H, Dong B, Valencia C, Zeng C, Koch J, Prudnikova T, et al. Group I Paks are essential for epithelial- mesenchymal transition in an Apc-driven model of colorectal cancer. Nat Commun. 2018;9:3473 pubmed publisher |
| Sun Z, Zhang Y, Liu F, Chen J, Chen D, Liu H, et al. A fusion protein composed of the DSL domain of Dll1 and RGD motif protects cryptic stem cells in irradiation injury. Biosci Rep. 2018;38: pubmed publisher |
| Zhang Y, Kim M, Jia B, Yan J, Zuniga Hertz J, Han C, et al. Hypothalamic stem cells control ageing speed partly through exosomal miRNAs. Nature. 2017;548:52-57 pubmed publisher |
| Khan I, Baeesa S, Bangash M, Schulten H, Alghamdi F, Qashqari H, et al. Pleomorphism and drug resistant cancer stem cells are characteristic of aggressive primary meningioma cell lines. Cancer Cell Int. 2017;17:72 pubmed publisher |
| Toth Z, Papp B, Brulois K, Choi Y, Gao S, Jung J. LANA-Mediated Recruitment of Host Polycomb Repressive Complexes onto the KSHV Genome during De Novo Infection. PLoS Pathog. 2016;12:e1005878 pubmed publisher |
| Srinivasan T, Walters J, Bu P, Than E, Tung K, Chen K, et al. NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer-Initiating Cells. Cancer Res. 2016;76:3411-21 pubmed publisher |
| Zheng S, Hedl M, Abraham C. Twist1 and Twist2 Contribute to Cytokine Downregulation following Chronic NOD2 Stimulation of Human Macrophages through the Coordinated Regulation of Transcriptional Repressors and Activators. J Immunol. 2015;195:217-26 pubmed publisher |
| Ma L, Wang H, Yao H, Zhu L, Liu W, Zhou Z. Bmi1 expression in oral lichen planus and the risk of progression to oral squamous cell carcinoma. Ann Diagn Pathol. 2013;17:327-30 pubmed publisher |
| Corvetta D, Chayka O, Gherardi S, D Acunto C, Cantilena S, Valli E, et al. Physical interaction between MYCN oncogene and polycomb repressive complex 2 (PRC2) in neuroblastoma: functional and therapeutic implications. J Biol Chem. 2013;288:8332-41 pubmed publisher |
| Cliffe A, Coen D, Knipe D. Kinetics of facultative heterochromatin and polycomb group protein association with the herpes simplex viral genome during establishment of latent infection. MBio. 2013;4: pubmed publisher |
| Mochida G, Ganesh V, de Michelena M, Dias H, Atabay K, Kathrein K, et al. CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development. Nat Genet. 2012;44:1260-4 pubmed publisher |
| Balasubramanian S, Kanade S, Han B, Eckert R. A proteasome inhibitor-stimulated Nrf1 protein-dependent compensatory increase in proteasome subunit gene expression reduces polycomb group protein level. J Biol Chem. 2012;287:36179-89 pubmed publisher |
| Feng J, Xu Z, Shi L, Wu L, Liu W, Zhou Z. Expression of cancer stem cell markers ALDH1 and Bmi1 in oral erythroplakia and the risk of oral cancer. J Oral Pathol Med. 2013;42:148-53 pubmed publisher |
| Volkel P, Le Faou P, Vandamme J, Pira D, Angrand P. A human Polycomb isoform lacking the Pc box does not participate to PRC1 complexes but forms protein assemblies and represses transcription. Epigenetics. 2012;7:482-91 pubmed publisher |
| Liu W, Feng J, Shen X, Wang H, Liu Y, Zhou Z. Two stem cell markers, ATP-binding cassette, G2 subfamily (ABCG2) and BMI-1, predict the transformation of oral leukoplakia to cancer: a long-term follow-up study. Cancer. 2012;118:1693-700 pubmed publisher |
| Finnberg N, Hart L, Dolloff N, Rodgers Z, Dicker D, El Deiry W. High-resolution imaging and antitumor effects of GFP(+) bone marrow-derived cells homing to syngeneic mouse colon tumors. Am J Pathol. 2011;179:2169-76 pubmed publisher |
| Choudhury S, Balasubramanian S, Chew Y, Han B, Marquez V, Eckert R. (-)-Epigallocatechin-3-gallate and DZNep reduce polycomb protein level via a proteasome-dependent mechanism in skin cancer cells. Carcinogenesis. 2011;32:1525-32 pubmed publisher |
| Joensuu K, Hagstrom J, Leidenius M, Haglund C, Andersson L, Sariola H, et al. Bmi-1, c-myc, and Snail expression in primary breast cancers and their metastases--elevated Bmi-1 expression in late breast cancer relapses. Virchows Arch. 2011;459:31-9 pubmed publisher |
| So A, Jung J, Lee S, Kim H, Kang K. DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs. PLoS ONE. 2011;6:e19503 pubmed publisher |
| Kim H, Kim K, Roh T, Park J, Jung K, Lee J, et al. Gene silencing in HIV-1 latency by polycomb repressive group. Virol J. 2011;8:179 pubmed publisher |
| Tsai L, Yu C, Chang Y, Yu C, Chou M. Markedly increased Oct4 and Nanog expression correlates with cisplatin resistance in oral squamous cell carcinoma. J Oral Pathol Med. 2011;40:621-8 pubmed publisher |
| Lee M, Lee H, Kim M, Kim E, Lee J, Heo J, et al. p16Ink4a suppression of lung adenocarcinoma by Bmi-1 in the presence of p38 activation. J Thorac Oncol. 2011;6:423-31 pubmed publisher |
| Liu Y, Yang Y, Xu H, Dong X. Implication of USP22 in the regulation of BMI-1, c-Myc, p16INK4a, p14ARF, and cyclin D2 expression in primary colorectal carcinomas. Diagn Mol Pathol. 2010;19:194-200 pubmed publisher |
| Iliopoulos D, Lindahl Allen M, Polytarchou C, Hirsch H, Tsichlis P, Struhl K. Loss of miR-200 inhibition of Suz12 leads to polycomb-mediated repression required for the formation and maintenance of cancer stem cells. Mol Cell. 2010;39:761-72 pubmed publisher |
| García Escudero V, Gargini R, Gallego Hernández M, García Gómez A, Martín Bermejo M, Simon D, et al. A neuroregenerative human ensheathing glia cell line with conditional rapid growth. Cell Transplant. 2011;20:153-66 pubmed publisher |
| Chatoo W, Abdouh M, Duparc R, Bernier G. Bmi1 distinguishes immature retinal progenitor/stem cells from the main progenitor cell population and is required for normal retinal development. Stem Cells. 2010;28:1412-23 pubmed publisher |
| Argiropoulos B, Yung E, Xiang P, Lo C, Kuchenbauer F, Palmqvist L, et al. Linkage of the potent leukemogenic activity of Meis1 to cell-cycle entry and transcriptional regulation of cyclin D3. Blood. 2010;115:4071-82 pubmed publisher |
| Häyry V, Mäkinen L, Atula T, Sariola H, Makitie A, Leivo I, et al. Bmi-1 expression predicts prognosis in squamous cell carcinoma of the tongue. Br J Cancer. 2010;102:892-7 pubmed publisher |
| Balasubramanian S, Adhikary G, Eckert R. The Bmi-1 polycomb protein antagonizes the (-)-epigallocatechin-3-gallate-dependent suppression of skin cancer cell survival. Carcinogenesis. 2010;31:496-503 pubmed publisher |
| Kheradmand Kia S, Solaimani Kartalaei P, Farahbakhshian E, Pourfarzad F, von Lindern M, Verrijzer C. EZH2-dependent chromatin looping controls INK4a and INK4b, but not ARF, during human progenitor cell differentiation and cellular senescence. Epigenetics Chromatin. 2009;2:16 pubmed publisher |
| Yue R, Kang J, Zhao C, Hu W, Tang Y, Liu X, et al. Beta-arrestin1 regulates zebrafish hematopoiesis through binding to YY1 and relieving polycomb group repression. Cell. 2009;139:535-46 pubmed publisher |
| Chan K, Espinosa I, Chao M, Wong D, Ailles L, Diehn M, et al. Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. Proc Natl Acad Sci U S A. 2009;106:14016-21 pubmed publisher |
| Maertens G, El Messaoudi Aubert S, Racek T, Stock J, Nicholls J, Rodriguez Niedenführ M, et al. Several distinct polycomb complexes regulate and co-localize on the INK4a tumor suppressor locus. PLoS ONE. 2009;4:e6380 pubmed publisher |
| Boukarabila H, Saurin A, Batsche E, Mossadegh N, Van Lohuizen M, Otte A, et al. The PRC1 Polycomb group complex interacts with PLZF/RARA to mediate leukemic transformation. Genes Dev. 2009;23:1195-206 pubmed publisher |
| Ganguli Indra G, Wasylyk C, Liang X, Millon R, Leid M, Wasylyk B, et al. CTIP2 expression in human head and neck squamous cell carcinoma is linked to poorly differentiated tumor status. PLoS ONE. 2009;4:e5367 pubmed publisher |
| Kerosuo L, Piltti K, Fox H, Angers Loustau A, Häyry V, Eilers M, et al. Myc increases self-renewal in neural progenitor cells through Miz-1. J Cell Sci. 2008;121:3941-50 pubmed publisher |
| Noer A, Lindeman L, Collas P. Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells. Stem Cells Dev. 2009;18:725-36 pubmed publisher |
| Häyry V, Tynninen O, Haapasalo H, Wolfer J, Paulus W, Hasselblatt M, et al. Stem cell protein BMI-1 is an independent marker for poor prognosis in oligodendroglial tumours. Neuropathol Appl Neurobiol. 2008;34:555-63 pubmed publisher |
| Kia S, Gorski M, Giannakopoulos S, Verrijzer C. SWI/SNF mediates polycomb eviction and epigenetic reprogramming of the INK4b-ARF-INK4a locus. Mol Cell Biol. 2008;28:3457-64 pubmed publisher |
| Gazin C, Wajapeyee N, Gobeil S, Virbasius C, Green M. An elaborate pathway required for Ras-mediated epigenetic silencing. Nature. 2007;449:1073-7 pubmed |
| Lee K, Adhikary G, Balasubramanian S, Gopalakrishnan R, McCormick T, Dimri G, et al. Expression of Bmi-1 in epidermis enhances cell survival by altering cell cycle regulatory protein expression and inhibiting apoptosis. J Invest Dermatol. 2008;128:9-17 pubmed |
| Leeb M, Wutz A. Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells. J Cell Biol. 2007;178:219-29 pubmed |
| Prince M, Sivanandan R, Kaczorowski A, Wolf G, Kaplan M, Dalerba P, et al. Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A. 2007;104:973-8 pubmed |
| Sasaki M, Ikeda H, Sato Y, Nakanuma Y. Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis. Am J Pathol. 2006;169:831-45 pubmed |
