This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-NUMB antibody
catalog :
ab14140
quantity :
25 µg
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dog
application :
western blot, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 15
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; fig 3d
Su S, Chen J, Yao H, Liu J, Yu S, Lao L, et al. CD10+GPR77+ Cancer-Associated Fibroblasts Promote Cancer Formation and Chemoresistance by Sustaining Cancer Stemness. Cell. 2018;172:841-856.e16 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 1a
  • western blot; human; loading ...; fig 1a
García Heredia J, Lucena Cacace A, Verdugo Sivianes E, Pérez M, Carnero A. The Cargo Protein MAP17 (PDZK1IP1) Regulates the Cancer Stem Cell Pool Activating the Notch Pathway by Abducting NUMB. Clin Cancer Res. 2017;23:3871-3883 pubmed publisher
  • immunocytochemistry; mouse; fig 1
Verbist K, Guy C, Milasta S, Liedmann S, Kaminski M, Wang R, et al. Metabolic maintenance of cell asymmetry following division in activated T lymphocytes. Nature. 2016;532:389-93 pubmed publisher
  • western blot; human; 1:250; fig 5
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies F, et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun. 2016;7:10533 pubmed publisher
  • immunocytochemistry; mouse; fig 5e
  • western blot; mouse; fig 5d
Yu C, Rafiq N, Cao F, Zhou Y, Krishnasamy A, Biswas K, et al. Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force. Nat Commun. 2015;6:8672 pubmed publisher
  • immunocytochemistry; dog; fig s2a
Archibald A, Al Masri M, Liew Spilger A, McCaffrey L. Atypical protein kinase C induces cell transformation by disrupting Hippo/Yap signaling. Mol Biol Cell. 2015;26:3578-95 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig st13
  • immunoprecipitation; human; loading ...; fig st13
  • immunocytochemistry; human; 1:200; loading ...; fig st13
  • western blot; human; 1:1000; loading ...; fig st13
Hwang W, Jiang J, Yang S, Huang T, Lan H, Teng H, et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-80 pubmed publisher
Hwang W, Lan H, Cheng W, Huang S, Yang M. Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol. 2019;12:10 pubmed publisher
Ye L, Lou F, Yu F, Zhang D, Wang C, Wu F, et al. NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts. Bone Res. 2018;6:32 pubmed publisher
Zhang Z, Qu J, Zheng C, Zhang P, Zhou W, Cui W, et al. Nrf2 antioxidant pathway suppresses Numb-mediated epithelial-mesenchymal transition during pulmonary fibrosis. Cell Death Dis. 2018;9:83 pubmed publisher
Stypulkowski E, Asangani I, Witze E. The depalmitoylase APT1 directs the asymmetric partitioning of Notch and Wnt signaling during cell division. Sci Signal. 2018;11: pubmed publisher
Riether C, Schürch C, Bührer E, Hinterbrandner M, Huguenin A, Hoepner S, et al. CD70/CD27 signaling promotes blast stemness and is a viable therapeutic target in acute myeloid leukemia. J Exp Med. 2017;214:359-380 pubmed publisher
Wang C, Feng W, Zhang C. The Expression and Function of NUMB in Endometrial Cancer and the Interaction with HDM2 and P53. J Cancer. 2015;6:1030-40 pubmed publisher
Li H, Ramachandran A, Gao Q, Ravindran S, Song Y, Evans C, et al. Expression and function of NUMB in odontogenesis. Biomed Res Int. 2013;2013:182965 pubmed publisher
Kwon C, Cheng P, King I, Andersen P, Shenje L, Nigam V, et al. Notch post-translationally regulates ?-catenin protein in stem and progenitor cells. Nat Cell Biol. 2011;13:1244-51 pubmed publisher
product information
CatalogNumber :
ab14140
ItemName :
Anti-NUMB antibody
Product Type :
Primary Antibodies
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugate :
Not Conjugated
Antigen Modification :
No Modifications
Size :
25 µg
SpeciesSummary :
Hu, Ms, Rat, Zfsh
Uses :
ICC/IF, IHC - Wmt, IHC-Fr, IHC-P, IP, WB
Size Note :
Other sizes available: 100 µg,100 µl,200 ml,200 µl,500 µl
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK