This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
N Cadherin antibody
catalog :
ab12221
quantity :
100 ug
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, chicken, cow, pig, zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 58
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5a
Ragni C, Diguet N, Le Garrec J, Novotova M, Resende T, Pop S, et al. Amotl1 mediates sequestration of the Hippo effector Yap1 downstream of Fat4 to restrict heart growth. Nat Commun. 2017;8:14582 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 3c
Hu C, Gan J. TRIM37 promotes epithelial?mesenchymal transition in colorectal cancer. Mol Med Rep. 2017;15:1057-1062 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; loading ...
Virág J, Haberler C, Baksa G, Piurko V, Hegedûs Z, Reiniger L, et al. Region Specific Differences of Claudin-5 Expression in Pediatric Intracranial Ependymomas: Potential Prognostic Role in Supratentorial Cases. Pathol Oncol Res. 2017;23:245-252 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; fig 1
Ju X, Hou Q, Sheng A, Wu K, Zhou Y, Jin Y, et al. The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice. elife. 2016;5: pubmed publisher
  • western blot; human; fig 4
Kazantseva J, Sadam H, Neuman T, Palm K. Targeted alternative splicing of TAF4: a new strategy for cell reprogramming. Sci Rep. 2016;6:30852 pubmed publisher
  • western blot; human; 1:1000; fig 2
Wu J, Ivanov A, Fisher P, Fu Z. Polo-like kinase 1 induces epithelial-to-mesenchymal transition and promotes epithelial cell motility by activating CRAF/ERK signaling. elife. 2016;5: pubmed publisher
  • western blot; human; 1:250; fig 3
Wu X, Qi H, Yang Y, Yin Y, Ma D, Li H, et al. Downregulation of matrix metalloproteinase‑19 induced by respiratory syncytial viral infection affects the interaction between epithelial cells and fibroblasts. Mol Med Rep. 2016;13:167-73 pubmed publisher
  • immunocytochemistry; mouse; fig 2d
Loriot C, Domingues M, Berger A, Menara M, Ruel M, Morin A, et al. Deciphering the molecular basis of invasiveness in Sdhb-deficient cells. Oncotarget. 2015;6:32955-65 pubmed publisher
  • western blot; human; 1:2000; fig 1
Cho M, Park J, Choi H, Park M, Won H, Park Y, et al. DOT1L cooperates with the c-Myc-p300 complex to epigenetically derepress CDH1 transcription factors in breast cancer progression. Nat Commun. 2015;6:7821 pubmed publisher
  • western blot; human; fig 1
Zhao L, Liu S, Che X, Hou K, Ma Y, Li C, et al. Bufalin inhibits TGF-β-induced epithelial-to-mesenchymal transition and migration in human lung cancer A549 cells by downregulating TGF-β receptors. Int J Mol Med. 2015;36:645-52 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 6
Whish S, Dziegielewska K, Møllgård K, Noor N, Liddelow S, Habgood M, et al. The inner CSF-brain barrier: developmentally controlled access to the brain via intercellular junctions. Front Neurosci. 2015;9:16 pubmed publisher
  • immunohistochemistry; mouse; 1:200
WANG Y, McAllister F, Bailey J, Scott S, Hendley A, Leach S, et al. Dicer is required for maintenance of adult pancreatic acinar cell identity and plays a role in Kras-driven pancreatic neoplasia. PLoS ONE. 2014;9:e113127 pubmed publisher
  • western blot; human
McLane J, Rivet C, Gilbert R, Ligon L. A biomaterial model of tumor stromal microenvironment promotes mesenchymal morphology but not epithelial to mesenchymal transition in epithelial cells. Acta Biomater. 2014;10:4811-4821 pubmed publisher
  • immunocytochemistry; pig
Francisco A, Hwang P, Jeong C, Jing L, Chen J, Setton L. Photocrosslinkable laminin-functionalized polyethylene glycol hydrogel for intervertebral disc regeneration. Acta Biomater. 2014;10:1102-11 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
  • western blot; human; 1:500
Bao W, Qiu H, Yang T, Luo X, Zhang H, Wan X. Upregulation of TrkB promotes epithelial-mesenchymal transition and anoikis resistance in endometrial carcinoma. PLoS ONE. 2013;8:e70616 pubmed publisher
  • immunocytochemistry; mouse
  • immunohistochemistry; mouse
Christoforou N, Liau B, Chakraborty S, Chellapan M, Bursac N, Leong K. Induced pluripotent stem cell-derived cardiac progenitors differentiate to cardiomyocytes and form biosynthetic tissues. PLoS ONE. 2013;8:e65963 pubmed publisher
Hong X, Margariti A, Le Bras A, Jacquet L, Kong W, Hu Y, et al. Transdifferentiated Human Vascular Smooth Muscle Cells are a New Potential Cell Source for Endothelial Regeneration. Sci Rep. 2017;7:5590 pubmed publisher
Fukuda R, Gunawan F, Beisaw A, Jiménez Amilburu V, Maischein H, Kostin S, et al. Proteolysis regulates cardiomyocyte maturation and tissue integration. Nat Commun. 2017;8:14495 pubmed publisher
Calibasi Kocal G, Güven S, Foygel K, Goldman A, Chen P, Sengupta S, et al. Dynamic Microenvironment Induces Phenotypic Plasticity of Esophageal Cancer Cells Under Flow. Sci Rep. 2016;6:38221 pubmed publisher
Casco Robles M, Islam M, Inami W, Tanaka H, Kunahong A, Yasumuro H, et al. Turning the fate of reprogramming cells from retinal disorder to regeneration by Pax6 in newts. Sci Rep. 2016;6:33761 pubmed publisher
Chen Y, Liu W, Wang P, Hou H, Liu N, Gong L, et al. Halofuginone inhibits radiotherapy-induced epithelial-mesenchymal transition in lung cancer. Oncotarget. 2016;7:71341-71352 pubmed publisher
Rodgers L, O Hainmhire E, Young A, Burdette J. Loss of PAX8 in high-grade serous ovarian cancer reduces cell survival despite unique modes of action in the fallopian tube and ovarian surface epithelium. Oncotarget. 2016;7:32785-95 pubmed publisher
Ali J, Lagasse B, Minuk A, Love A, Moraya A, Lam L, et al. Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells. Int J Cancer. 2015;136:E455-69 pubmed publisher
Bock C, Rack B, Huober J, Andergassen U, Jeschke U, Doisneau Sixou S. Distinct expression of cytokeratin, N-cadherin and CD133 in circulating tumor cells of metastatic breast cancer patients. Future Oncol. 2014;10:1751-65 pubmed publisher
Lee H, Lee D, Park S, Cho K, Bae H, Park J. Nuclear factor I-C (NFIC) regulates dentin sialophosphoprotein (DSPP) and E-cadherin via control of Krüppel-like factor 4 (KLF4) during dentinogenesis. J Biol Chem. 2014;289:28225-36 pubmed publisher
Liu S, Cui J, Liao G, Zhang Y, Ye K, Lu T, et al. MiR-137 regulates epithelial-mesenchymal transition in gastrointestinal stromal tumor. Tumour Biol. 2014;35:9131-8 pubmed publisher
Schiavone M, Rampazzo E, Casari A, Battilana G, Persano L, Moro E, et al. Zebrafish reporter lines reveal in vivo signaling pathway activities involved in pancreatic cancer. Dis Model Mech. 2014;7:883-94 pubmed publisher
Nery L, Eltz N, Martins L, Guerim L, Pereira T, Bogo M, et al. Sustained behavioral effects of lithium exposure during early development in zebrafish: involvement of the Wnt-?-catenin signaling pathway. Prog Neuropsychopharmacol Biol Psychiatry. 2014;55:101-8 pubmed publisher
Jian S, Hsiao C, Chen S, Weng C, Kuo T, Wu D, et al. Utilization of liquid chromatography mass spectrometry analyses to identify LKB1-APC interaction in modulating Wnt/?-catenin pathway of lung cancer cells. Mol Cancer Res. 2014;12:622-35 pubmed publisher
Prunskaite Hyyryläinen R, Shan J, Railo A, Heinonen K, Miinalainen I, Yan W, et al. Wnt4, a pleiotropic signal for controlling cell polarity, basement membrane integrity, and antimüllerian hormone expression during oocyte maturation in the female follicle. FASEB J. 2014;28:1568-81 pubmed publisher
Hoppensack A, Kazanecki C, Colter D, Gosiewska A, Schanz J, Walles H, et al. A human in vitro model that mimics the renal proximal tubule. Tissue Eng Part C Methods. 2014;20:599-609 pubmed publisher
Becker T, Caixeiro N, Lim S, Tognela A, Kienzle N, Scott K, et al. New frontiers in circulating tumor cell analysis: A reference guide for biomolecular profiling toward translational clinical use. Int J Cancer. 2014;134:2523-33 pubmed publisher
Nasarre P, Gemmill R, Potiron V, Roche J, Lu X, Baron A, et al. Neuropilin-2 Is upregulated in lung cancer cells during TGF-?1-induced epithelial-mesenchymal transition. Cancer Res. 2013;73:7111-21 pubmed publisher
Yang C, Chen H, Tan G, Gao W, Cheng L, Jiang X, et al. FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer. Cancer Lett. 2013;340:104-12 pubmed publisher
Chen Y, Ho C, Chen P, Chen Y, Chang C. Anterior gradient 2: a novel sensitive tumor marker for metastatic oral cancer. Cancer Lett. 2013;339:270-8 pubmed publisher
Su H, Weng C, Hsiao P, Chen L, Kuo T, Chen Y, et al. Stem cell marker nestin is critical for TGF-?1-mediated tumor progression in pancreatic cancer. Mol Cancer Res. 2013;11:768-79 pubmed publisher
Kingham E, White K, Gadegaard N, Dalby M, Oreffo R. Nanotopographical cues augment mesenchymal differentiation of human embryonic stem cells. Small. 2013;9:2140-51 pubmed publisher
Saadatmand S, de Kruijf E, Sajet A, Dekker Ensink N, van Nes J, Putter H, et al. Expression of cell adhesion molecules and prognosis in breast cancer. Br J Surg. 2013;100:252-60 pubmed publisher
Maru S, Ishigaki Y, Shinohara N, Takata T, Tomosugi N, Nonomura K. Inhibition of mTORC2 but not mTORC1 up-regulates E-cadherin expression and inhibits cell motility by blocking HIF-2? expression in human renal cell carcinoma. J Urol. 2013;189:1921-9 pubmed publisher
Hance M, Dole K, Gopal U, Bohonowych J, Jezierska Drutel A, Neumann C, et al. Secreted Hsp90 is a novel regulator of the epithelial to mesenchymal transition (EMT) in prostate cancer. J Biol Chem. 2012;287:37732-44 pubmed publisher
Chen M. Two-dimensional gel electrophoresis revealed antipsychotic drugs induced protein expression modulations in C6 glioma cells. Prog Neuropsychopharmacol Biol Psychiatry. 2013;40:1-11 pubmed publisher
Balasubramanian P, Lang J, Jatana K, Miller B, Ozer E, Old M, et al. Multiparameter analysis, including EMT markers, on negatively enriched blood samples from patients with squamous cell carcinoma of the head and neck. PLoS ONE. 2012;7:e42048 pubmed publisher
Marsick B, San Miguel Ruiz J, Letourneau P. Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors. J Neurosci. 2012;32:282-96 pubmed publisher
Wong G, Baudet M, Norden C, Leung L, Harris W. Slit1b-Robo3 signaling and N-cadherin regulate apical process retraction in developing retinal ganglion cells. J Neurosci. 2012;32:223-8 pubmed publisher
Yamakoshi S, Bai R, Chaen T, Ideta A, Aoyagi Y, Sakurai T, et al. Expression of mesenchymal-related genes by the bovine trophectoderm following conceptus attachment to the endometrial epithelium. Reproduction. 2012;143:377-87 pubmed publisher
Conant J, Peng Z, Evans M, Naud S, Cooper K. Sarcomatoid renal cell carcinoma is an example of epithelial--mesenchymal transition. J Clin Pathol. 2011;64:1088-92 pubmed publisher
Saghizadeh M, Soleymani S, Harounian A, Bhakta B, Troyanovsky S, Brunken W, et al. Alterations of epithelial stem cell marker patterns in human diabetic corneas and effects of c-met gene therapy. Mol Vis. 2011;17:2177-90 pubmed
Curtis M, Sharma S, Desai T, Russell B. Hypertrophy, gene expression, and beating of neonatal cardiac myocytes are affected by microdomain heterogeneity in 3D. Biomed Microdevices. 2010;12:1073-85 pubmed publisher
Lokar M, Iglic A, Veranic P. Protruding membrane nanotubes: attachment of tubular protrusions to adjacent cells by several anchoring junctions. Protoplasma. 2010;246:81-7 pubmed publisher
Schaeffer D, Assi K, Chan K, Buczkowski A, Chung S, Scudamore C, et al. Tumor expression of integrin-linked kinase (ILK) correlates with the expression of the E-cadherin repressor snail: an immunohistochemical study in ductal pancreatic adenocarcinoma. Virchows Arch. 2010;456:261-8 pubmed publisher
Pozharskaya V, Torres Gonzalez E, Rojas M, Gal A, Amin M, Dollard S, et al. Twist: a regulator of epithelial-mesenchymal transition in lung fibrosis. PLoS ONE. 2009;4:e7559 pubmed publisher
Hartland S, Murphy F, Aucott R, Abergel A, Zhou X, Waung J, et al. Active matrix metalloproteinase-2 promotes apoptosis of hepatic stellate cells via the cleavage of cellular N-cadherin. Liver Int. 2009;29:966-78 pubmed publisher
Kim J, Kang Y, Park G, Kim M, Park Y, Kim H, et al. Identification of a stroma-mediated Wnt/beta-catenin signal promoting self-renewal of hematopoietic stem cells in the stem cell niche. Stem Cells. 2009;27:1318-29 pubmed publisher
Latefi N, Pedraza L, Schohl A, Li Z, Ruthazer E. N-cadherin prodomain cleavage regulates synapse formation in vivo. Dev Neurobiol. 2009;69:518-29 pubmed publisher
Shah G, Muralidharan A, Gokulgandhi M, Soan K, Thomas S. Cadherin switching and activation of beta-catenin signaling underlie proinvasive actions of calcitonin-calcitonin receptor axis in prostate cancer. J Biol Chem. 2009;284:1018-30 pubmed publisher
Pontoriero G, Smith A, Miller L, Radice G, West Mays J, Lang R. Co-operative roles for E-cadherin and N-cadherin during lens vesicle separation and lens epithelial cell survival. Dev Biol. 2009;326:403-17 pubmed publisher
Sangaletti S, Di Carlo E, Gariboldi S, Miotti S, Cappetti B, Parenza M, et al. Macrophage-derived SPARC bridges tumor cell-extracellular matrix interactions toward metastasis. Cancer Res. 2008;68:9050-9 pubmed publisher
Lyngholm M, Høyer P, Vorum H, Nielsen K, Ehlers N, Møllgård K. Immunohistochemical markers for corneal stem cells in the early developing human eye. Exp Eye Res. 2008;87:115-21 pubmed publisher
product information
Catalog Number :
ab12221
Product Name :
N Cadherin antibody
Host Species :
Rabbit
Clonality :
polyclonal
Product Type :
Primary antibodies
Size :
100 ug
SwissProtID :
P19022
Isotype :
IgG
CrossReactivity :
Reacts with: Human, Mouse, Rat, Chicken, Cow, Zebrafish.
Application Summary :
ICC, ICC/IF, IHC-Fr, IHC-P, WB
company information
Abcam
330 Cambridge Science Park
Cambridge
CB4 0FL UK
orders@abcam.com
44 (0)1223 696000

1 Kendall Square, Ste 341
Cambridge, MA 02139-1517
USA
us.orders@abcam.com
617 225 2272, 888-77-ABCAM (22226)

www.abcam.com
888-7722226
headquarters: UK