This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-VCP antibody [5]
catalog :
ab11433
quantity :
50 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5
reactivity :
human, mouse, rat, dogs, bovine
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 26
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig 4a
Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, et al. Stress- and ubiquitylation-dependent phase separation of the proteasome. Nature. 2020;578:296-300 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 6c
Bayindir Buchhalter I, Wolff G, Lerch S, Sijmonsma T, Schuster M, Gronych J, et al. Cited4 is a sex-biased mediator of the antidiabetic glitazone response in adipocyte progenitors. EMBO Mol Med. 2018;10: pubmed publisher
  • immunoprecipitation; human; loading ...; fig 7a
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, et al. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 2018;37: pubmed publisher
  • immunoprecipitation; human; loading ...; fig s2a
Nguyen T, Li J, Lu C, Mamrosh J, Lu G, Cathers B, et al. p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A. 2017;114:3565-3571 pubmed publisher
  • western blot; human; 1:1000; fig 6
Franz A, Pirson P, Pilger D, Halder S, Achuthankutty D, Kashkar H, et al. Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression. Nat Commun. 2016;7:10612 pubmed publisher
  • western blot; human; 1:2000; fig 4
  • immunohistochemistry - paraffin section; mouse; 1:250; fig 3
  • western blot; mouse; 1:2000; fig 2
Fusser M, Kernstock S, Aileni V, Egge Jacobsen W, Falnes P, Klungland A. Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice. PLoS ONE. 2015;10:e0141472 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 3c
Berry G, Asokan A. Chemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction. J Biol Chem. 2016;291:939-47 pubmed publisher
  • western blot; mouse; fig s3
Okun J, Conway S, Schmidt K, Schumacher J, Wang X, de Guia R, et al. Molecular regulation of urea cycle function by the liver glucocorticoid receptor. Mol Metab. 2015;4:732-40 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 1:4000; fig 1
  • western blot; dogs; fig 1
Nadeau M, Rico C, Tsoi M, Vivancos M, Filimon S, Paquet M, et al. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells. BMC Cancer. 2015;15:479 pubmed publisher
  • western blot; mouse; fig 3
Stoy C, Sundaram A, Rios Garcia M, Wang X, Seibert O, Zota A, et al. Transcriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy. EMBO Mol Med. 2015;7:1048-62 pubmed publisher
  • western blot; mouse
Mössenböck K, Vegiopoulos A, Rose A, Sijmonsma T, Herzig S, Schafmeier T. Browning of white adipose tissue uncouples glucose uptake from insulin signaling. PLoS ONE. 2014;9:e110428 pubmed publisher
Rampello A, Laudermilch E, Vishnoi N, Prophet S, Shao L, Zhao C, et al. Torsin ATPase deficiency leads to defects in nuclear pore biogenesis and sequestration of MLF2. J Cell Biol. 2020;219: pubmed publisher
Parzych K, Saavedra García P, Valbuena G, Al Sadah H, Robinson M, Penfold L, et al. The coordinated action of VCP/p97 and GCN2 regulates cancer cell metabolism and proteostasis during nutrient limitation. Oncogene. 2019;38:3216-3231 pubmed publisher
McLelland G, Goiran T, Yi W, Dorval G, Chen C, Lauinger N, et al. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. elife. 2018;7: pubmed publisher
Thinon E, Fernandez J, Molina H, Hang H. Selective Enrichment and Direct Analysis of Protein S-Palmitoylation Sites. J Proteome Res. 2018;17:1907-1922 pubmed publisher
Baranes Bachar K, Levy Barda A, Oehler J, Reid D, Soria Bretones I, Voss T, et al. The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair. Mol Cell. 2018;69:866-878.e7 pubmed publisher
Skrott Z, Mistrik M, Andersen K, Friis S, Majera D, Gursky J, et al. Alcohol-abuse drug disulfiram targets cancer via p97 segregase adaptor NPL4. Nature. 2017;552:194-199 pubmed publisher
van den Berg D, Azzarelli R, Oishi K, Martynoga B, Urbán N, Dekkers D, et al. Nipbl Interacts with Zfp609 and the Integrator Complex to Regulate Cortical Neuron Migration. Neuron. 2017;93:348-361 pubmed publisher
Xue L, Blythe E, Freiberger E, Mamrosh J, Hebert A, Reitsma J, et al. Valosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor. Mol Cell Proteomics. 2016;15:2970-86 pubmed publisher
Fuhrmeister J, Zota A, Sijmonsma T, Seibert O, Cıngır Å, Schmidt K, et al. Fasting-induced liver GADD45β restrains hepatic fatty acid uptake and improves metabolic health. EMBO Mol Med. 2016;8:654-69 pubmed publisher
Parrish R, Buckingham S, Mascia K, Johnson J, Matyjasik M, Lockhart R, et al. Methionine increases BDNF DNA methylation and improves memory in epilepsy. Ann Clin Transl Neurol. 2015;2:401-16 pubmed publisher
Wöltje K, Jabs M, Fischer A. Serum induces transcription of Hey1 and Hey2 genes by Alk1 but not Notch signaling in endothelial cells. PLoS ONE. 2015;10:e0120547 pubmed publisher
Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, et al. Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant. Acta Neuropathol Commun. 2014;2:172 pubmed publisher
Penno C, Morgan S, Rose A, Herzig S, Lavery G, Odermatt A. 11?-Hydroxysteroid dehydrogenase-1 is involved in bile acid homeostasis by modulating fatty acid transport protein-5 in the liver of mice. Mol Metab. 2014;3:554-64 pubmed publisher
Laguë M, Romieu Mourez R, Bonneil E, Boyer A, Pouletty N, Mes Masson A, et al. Proteomic profiling of a mouse model for ovarian granulosa cell tumor identifies VCP as a highly sensitive serum tumor marker in several human cancers. PLoS ONE. 2012;7:e42470 pubmed publisher
Sahab Z, Hall M, Zhang L, Cheema A, Byers S. Tumor Suppressor RARRES1 Regulates DLG2, PP2A, VCP, EB1, and Ankrd26. J Cancer. 2010;1:14-22 pubmed
product information
CatalogNumber :
ab11433
ItemName :
Anti-VCP antibody [5]
Product Type :
Antibody
Host Species :
Mouse
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
5
Size :
50 µl
SpeciesSummary :
Cow, Hu, Ms, Rat, Shp
Purity :
Ascites
Application Summary :
ELISA, Flow Cyt, ICC, ICC/IF, IHC-Fr, IHC-P, IP, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK