This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Caspase-1 antibody [EPR4321]
catalog :
ab108362
quantity :
10 µl, 100 µl
clonality :
monoclonal
host :
rabbit
conjugate :
nonconjugated
clone name :
EPR4321
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry - paraffin section, western blot knockout validation
citations: 14
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; loading ...; fig 3e
Lan P, Fan Y, Zhao Y, Lou X, Monsour H, Zhang X, et al. TNF superfamily receptor OX40 triggers invariant NKT cell pyroptosis and liver injury. J Clin Invest. 2017;127:2222-2234 pubmed publisher
  • western blot; human; loading ...; fig 6e
Kim M, Song J, Koh D, Kim J, Hatano M, Jeon B, et al. Reciprocal negative regulation between the tumor suppressor protein p53 and B cell CLL/lymphoma 6 (BCL6) via control of caspase-1 expression. J Biol Chem. 2019;294:299-313 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 1c
Guo W, Liu W, Chen Z, Gu Y, Peng S, Shen L, et al. Tyrosine phosphatase SHP2 negatively regulates NLRP3 inflammasome activation via ANT1-dependent mitochondrial homeostasis. Nat Commun. 2017;8:2168 pubmed publisher
  • western blot; mouse; loading ...; fig 3b
Zhang H, Luo J, Alcorn J, Chen K, Fan S, Pilewski J, et al. AIM2 Inflammasome Is Critical for Influenza-Induced Lung Injury and Mortality. J Immunol. 2017;198:4383-4393 pubmed publisher
  • western blot; mouse; loading ...; fig 8
Hu Z, Zhang Y, Wang J, Mao P, Lv X, Yuan S, et al. Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. Cell Death Dis. 2016;7:e2468 pubmed publisher
  • western blot; mouse; loading ...; fig 5a
Peng S, Gao J, Liu W, Jiang C, Yang X, Sun Y, et al. Andrographolide ameliorates OVA-induced lung injury in mice by suppressing ROS-mediated NF-κB signaling and NLRP3 inflammasome activation. Oncotarget. 2016;7:80262-80274 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 5a
Wang L, Cano M, Datta S, Wei H, Ebrahimi K, Gorashi Y, et al. Pentraxin 3 recruits complement factor H to protect against oxidative stress-induced complement and inflammasome overactivation. J Pathol. 2016;240:495-506 pubmed publisher
  • western blot; mouse; fig 3
Ravindran R, Loebbermann J, Nakaya H, Khan N, Ma H, Gama L, et al. The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation. Nature. 2016;531:523-527 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:300
Liu R, Wang A, To E, Gao J, Cao S, Cui J, et al. Vinpocetine inhibits amyloid-beta induced activation of NF-?B, NLRP3 inflammasome and cytokine production in retinal pigment epithelial cells. Exp Eye Res. 2014;127:49-58 pubmed publisher
  • western blot; human; 1:1000
Zhen J, Zhang L, Pan J, Ma S, Yu X, Li X, et al. AIM2 mediates inflammation-associated renal damage in hepatitis B virus-associated glomerulonephritis by regulating caspase-1, IL-1?, and IL-18. Mediators Inflamm. 2014;2014:190860 pubmed publisher
Ojeda D, Grasso D, Urquiza J, Till A, Vaccaro M, Quarleri J. Cell Death Is Counteracted by Mitophagy in HIV-Productively Infected Astrocytes but Is Promoted by Inflammasome Activation Among Non-productively Infected Cells. Front Immunol. 2018;9:2633 pubmed publisher
Zhang J, Lai X, Chen M, Guo Y. Tim-3 exacerbates kidney ischaemia/reperfusion injury through the TLR-4/NF-κB signalling pathway and an NLR-C4 inflammasome activation. Clin Exp Immunol. 2018;193:113-129 pubmed publisher
Khalafalla M, Woods L, Camden J, Khan A, Limesand K, Petris M, et al. P2X7 receptor antagonism prevents IL-1? release from salivary epithelial cells and reduces inflammation in a mouse model of autoimmune exocrinopathy. J Biol Chem. 2017;292:16626-16637 pubmed publisher
Zhao J, Mou Y, Bernstock J, Klimanis D, Wang S, Spatz M, et al. Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats. PLoS ONE. 2015;10:e0140772 pubmed publisher
product information
CatalogNumber :
ab108362
ItemName :
Anti-Caspase-1 antibody [EPR4321]
Category :
Antibody
Host :
Rabbit
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
EPR4321
Size :
10 µl, 100 µl
SpeciesSummary :
Hu, Rat
Application Summary :
IHC-P, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
https://www.abcam.com
888-7722226
headquarters: UK