This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Hes1 antibody
catalog :
Ab71559
quantity :
100µL
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 18
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:200; loading ...; fig 3f
  • immunohistochemistry; mouse; loading ...; fig 5c
Zhang X, Tao J, Yu J, Hu N, Zhang X, Wang G, et al. Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis. Cell Death Dis. 2021;12:867 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Xiao Z, Yang X, Liu Z, Shao Z, Song C, Zhang K, et al. GASC1 promotes glioma progression by enhancing NOTCH1 signaling. Mol Med Rep. 2021;23: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:300; loading ...; fig 1e
  • western blot; mouse; 1:1000; loading ...; fig 1b
  • immunohistochemistry - paraffin section; human; 1:300; loading ...; fig 2b
Ni X, Zhang Y, Jia L, Lu W, Zhu Q, Ren J, et al. Inhibition of Notch1-mediated inflammation by intermedin protects against abdominal aortic aneurysm via PI3K/Akt signaling pathway. Aging (Albany NY). 2021;13:5164-5184 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 6g
Dabelsteen S, Pallesen E, Marinova I, Nielsen M, Adamopoulou M, Rømer T, et al. Essential Functions of Glycans in Human Epithelia Dissected by a CRISPR-Cas9-Engineered Human Organotypic Skin Model. Dev Cell. 2020;54:669-684.e7 pubmed publisher
  • western blot; human; loading ...; fig s2c, s2d, s2e, s2f
Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, et al. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019;18:156 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5e
Wu K, Zou J, Lin C, Jie Z. MicroRNA-140-5p inhibits cell proliferation, migration and promotes cell apoptosis in gastric cancer through the negative regulation of THY1-mediated Notch signaling. Biosci Rep. 2019;: pubmed publisher
  • western blot; human; 1:50; loading ...; fig 4b
Pan B, Wu L, Pan L, Yang Y, Li H, Dai Y, et al. Up-regulation of microRNA-340 promotes osteosarcoma cell apoptosis while suppressing proliferation, migration, and invasion by inactivating the CTNNB1-mediated Notch signaling pathway. Biosci Rep. 2018;38: pubmed publisher
  • western blot; human; loading ...; fig 1i
Kim W, Khan S, Gvozdenovic Jeremic J, Kim Y, Dahlman J, Kim H, et al. Hippo signaling interactions with Wnt/?-catenin and Notch signaling repress liver tumorigenesis. J Clin Invest. 2017;127:137-152 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 1
  • western blot; human; 1:250; fig 1
Wu X, Fleming A, Ricketts T, Pavel M, Virgin H, Menzies F, et al. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis. Nat Commun. 2016;7:10533 pubmed publisher
  • western blot; mouse; fig 4
Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, et al. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 2016;113:E71-80 pubmed publisher
Lei Y, Shen H, Li Q, Yang S, Xie H, Li X, et al. Hairy gene homolog increases nasopharyngeal carcinoma cell stemness by upregulating Bmi-1. Aging (Albany NY). 2023;15:4391-4410 pubmed publisher
Xu J, Xu W, Yang X, Liu Z, Sun Q. LncRNA HCG11/miR-579-3p/MDM2 axis modulates malignant biological properties in pancreatic carcinoma via Notch/Hes1 signaling pathway. Aging (Albany NY). 2021;13:16471-16484 pubmed publisher
Morrugares R, Correa Sáez A, Moreno R, Garrido Rodríguez M, Munoz E, de La Vega L, et al. Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2. Cell Mol Life Sci. 2019;: pubmed publisher
Cheng S, Liu T, Hu Y, Xia Y, Hou J, Huang C, et al. Conditional Inactivation of Pen-2 in the Developing Neocortex Leads to Rapid Switch of Apical Progenitors to Basal Progenitors. J Neurosci. 2019;39:2195-2207 pubmed publisher
Zhang H, Wang L, Wong E, Tsang S, Xu P, Lendahl U, et al. An Eya1-Notch axis specifies bipotential epibranchial differentiation in mammalian craniofacial morphogenesis. elife. 2017;6: pubmed publisher
Sun L, Ke J, He Z, Chen Z, Huang Q, Ai W, et al. HES1 Promotes Colorectal Cancer Cell Resistance To 5-Fu by Inducing Of EMT and ABC Transporter Proteins. J Cancer. 2017;8:2802-2808 pubmed publisher
Lina T, Dunphy P, Luo T, McBride J. Ehrlichia chaffeensis TRP120 Activates Canonical Notch Signaling To Downregulate TLR2/4 Expression and Promote Intracellular Survival. MBio. 2016;7: pubmed publisher
Tang J, Zhu Y, Xie K, Zhang X, Zhi X, Wang W, et al. The role of the AMOP domain in MUC4/Y-promoted tumour angiogenesis and metastasis in pancreatic cancer. J Exp Clin Cancer Res. 2016;35:91 pubmed publisher
product information
Catalog Number :
ab71559
Product Name :
Anti-Hes1 antibody
Product Type :
Primary Antibody
Swiss-Prot ID :
Q14469
Host Species :
Rabbit
Clonality :
Polyclonal
Size :
100µL
Application Summary :
ICC/IF, IHC-Fr, IHC-P, WB
Isotype :
IgG
Reactivity :
Human, Mouse
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
Stefan.Pritchard@abcam.com, eCommerce@abcam.com, Vicky.Yang@abcam.com
https://www.abcam.com
888-7722226
headquarters: UK