This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-Telomerase reverse transcriptase antibody [Y182]
catalog :
Ab32020
quantity :
10 µl, 100 µl
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
Y182
reactivity :
human, bovine
application :
western blot, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
citations: 17
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; 1:150; loading ...; fig 5a
  • western blot; human; loading ...; fig 2c
Wang R, Li J, Zhang C, Guan X, Qin B, Jin R, et al. Lactate Dehydrogenase B Is Required for Pancreatic Cancer Cell Immortalization Through Activation of Telomerase Activity. Front Oncol. 2022;12:821620 pubmed publisher
  • western blot; human; loading ...; fig 4e
Lee J, Hong J, Zhang Z, de la Peña Avalos B, Proietti C, Deamicis A, et al. Regulation of telomere homeostasis and genomic stability in cancer by N 6-adenosine methylation (m6A). Sci Adv. 2021;7: pubmed publisher
  • immunoprecipitation; human; fig 4c
  • western blot; human; 1:1000; fig 1b
Tang S, Wu W, Wan H, Wu X, Chen H. Knockdown of NHP2 inhibits hepatitis B virus X protein-induced hepatocarcinogenesis via repressing TERT expression and disrupting the stability of telomerase complex. Aging (Albany NY). 2020;12:19365-19374 pubmed publisher
  • western blot; human; loading ...; fig 1c
Cheng L, Yuan B, Ying S, Niu C, Mai H, Guan X, et al. PES1 is a critical component of telomerase assembly and regulates cellular senescence. Sci Adv. 2019;5:eaav1090 pubmed publisher
  • immunocytochemistry; human; fig 2b
Schmidt J, Zaug A, Cech T. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. 2016;166:1188-1197.e9 pubmed publisher
Amin A, Morello M, Petrara M, Rizzo B, Argenton F, De Rossi A, et al. Short-Term TERT Inhibition Impairs Cellular Proliferation via a Telomere Length-Independent Mechanism and Can Be Exploited as a Potential Anticancer Approach. Cancers (Basel). 2023;15: pubmed publisher
Delyon J, Vallet A, Bernard Cacciarella M, Kuzniak I, Reger de Moura C, Louveau B, et al. TERT Expression Induces Resistance to BRAF and MEK Inhibitors in BRAF-Mutated Melanoma In Vitro. Cancers (Basel). 2023;15: pubmed publisher
Klump B, Perez G, Patrick E, Adams Boone K, Cohen S, Han L, et al. TCAB1 prevents nucleolar accumulation of the telomerase RNA to facilitate telomerase assembly. Cell Rep. 2023;42:112577 pubmed publisher
Kant S, Tran K, Kvandová M, Caliz A, Yoo H, Learnard H, et al. PGC1α Regulates the Endothelial Response to Fluid Shear Stress via Telomerase Reverse Transcriptase Control of Heme Oxygenase-1. Arterioscler Thromb Vasc Biol. 2022;42:19-34 pubmed publisher
Zhang Z, Han Z, Guo Y, Liu X, Gao Y, Zhang Y. Establishment of an Efficient Immortalization Strategy Using HMEJ-Based bTERT Insertion for Bovine Cells. Int J Mol Sci. 2021;22: pubmed publisher
Liu R, Tan J, Shen X, Jiang K, Wang C, Zhu G, et al. Therapeutic targeting of FOS in mutant TERT cancers through removing TERT suppression of apoptosis via regulating survivin and TRAIL-R2. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
Hau R, Miller S, Wright S, Cherrington N. Generation of a hTERT-Immortalized Human Sertoli Cell Model to Study Transporter Dynamics at the Blood-Testis Barrier. Pharmaceutics. 2020;12: pubmed publisher
Kotla S, Le N, Vu H, Ko K, Gi Y, Thomas T, et al. Endothelial senescence-associated secretory phenotype (SASP) is regulated by Makorin-1 ubiquitin E3 ligase. Metabolism. 2019;100:153962 pubmed publisher
Jo D, Park R, Kim H, Jang M, Lee E, Jang I, et al. AMP-activated protein kinase regulates the expression of human telomerase reverse transcriptase. PLoS ONE. 2018;13:e0207864 pubmed publisher
Petkov S, Kahland T, Shomroni O, Lingner T, Salinas G, Fuchs S, et al. Immortalization of common marmoset monkey fibroblasts by piggyBac transposition of hTERT. PLoS ONE. 2018;13:e0204580 pubmed publisher
Panneer Selvam S, Roth B, Nganga R, Kim J, Cooley M, Helke K, et al. Balance between senescence and apoptosis is regulated by telomere damage-induced association between p16 and caspase-3. J Biol Chem. 2018;293:9784-9800 pubmed publisher
Saha D, Singh A, Hussain T, Srivastava V, Sengupta S, Kar A, et al. Epigenetic suppression of human telomerase (hTERT) is mediated by the metastasis suppressor NME2 in a G-quadruplex-dependent fashion. J Biol Chem. 2017;292:15205-15215 pubmed publisher
product information
CatalogNumber :
ab32020
ItemName :
Anti-Telomerase reverse transcriptase antibody [Y182]
Category :
Antibody
Host :
Rabbit
Clonality :
Monoclonal
Conjugate :
Unconjugated
Clone Name :
Y182
Size :
10 µl, 100 µl
SpeciesSummary :
Cow, Hu
Application Summary :
Flow Cyt, IHC-Fr, IHC-P, IP, WB
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
Stefan.Pritchard@abcam.com, eCommerce@abcam.com, Vicky.Yang@abcam.com
https://www.abcam.com
888-7722226
headquarters: UK