This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abcam
other brands :
Epitomics, Ascent Scientific, MitoSciences
product type :
antibody
product name :
Anti-LAMP1 antibody - Lysosome Marker
catalog :
AB24170
quantity :
100µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
African green monkey, human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section
citations: 143
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 4i
Gao H, Sun H, Yan N, Zhao P, Xu H, Zheng W, et al. ATP13A2 Declines Zinc-Induced Accumulation of α-Synuclein in a Parkinson's Disease Model. Int J Mol Sci. 2022;23: pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 13e
Stoffel W, Binczek E, Schmidt Soltau I, Brodesser S, Wegner I. High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis-inactivated Δ6-fatty acid desaturase-deficient mouse. Mol Metab. 2021;54:101335 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 2j
Zin E, Han D, Tran J, Morisson Welch N, Visel M, Kuronen M, et al. Outcomes of progranulin gene therapy in the retina are dependent on time and route of delivery. Mol Ther Methods Clin Dev. 2021;22:40-51 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 3
Ashok A, Chaudhary S, Wise A, Rana N, McDonald D, Kritikos A, et al. Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study. Antioxidants (Basel). 2021;10: pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 6d
  • western blot; mouse; 1:20; loading ...; fig 6c
Park G, Lee J, Han H, An H, Jin Z, Jeong E, et al. Ablation of dynamin-related protein 1 promotes diabetes-induced synaptic injury in the hippocampus. Cell Death Dis. 2021;12:445 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 5a
Pramanick A, Chakraborti S, Mahata T, Basak M, Das K, Verma S, et al. G protein β5-ATM complexes drive acetaminophen-induced hepatotoxicity. Redox Biol. 2021;43:101965 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8e
Wang J, Liu B, Xu Y, Yang M, Wang C, Song M, et al. Activation of CREB-mediated autophagy by thioperamide ameliorates β-amyloid pathology and cognition in Alzheimer's disease. Aging Cell. 2021;20:e13333 pubmed publisher
  • immunohistochemistry - free floating section; rat; 1:500; loading ...; fig 3a
De Miranda B, Castro S, Rocha E, Bodle C, Johnson K, Greenamyre J. The industrial solvent trichloroethylene induces LRRK2 kinase activity and dopaminergic neurodegeneration in a rat model of Parkinson's disease. Neurobiol Dis. 2021;153:105312 pubmed publisher
  • western blot; rat; loading ...; fig 1a
Li T, Yin Y, Mu N, Wang Y, Liu M, Chen M, et al. Metformin-Enhanced Cardiac AMP-Activated Protein Kinase/Atrogin-1 Pathways Inhibit Charged Multivesicular Body Protein 2B Accumulation in Ischemia-Reperfusion Injury. Front Cell Dev Biol. 2020;8:621509 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...
Tang C, Han J, Dalvi S, Manian K, Winschel L, Volland S, et al. A human model of Batten disease shows role of CLN3 in phagocytosis at the photoreceptor-RPE interface. Commun Biol. 2021;4:161 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:2000; loading ...; fig 1d
Fleming Martinez A, D xf6 ppler H, Bastea L, Edenfield B, Patel T, Leitges M, et al. Dysfunctional EGFR and oxidative stress-induced PKD1 signaling drive formation of DCLK1+ pancreatic stem cells. iScience. 2021;24:102019 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig 3c
  • western blot; human; 1:1000; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig 1a
Kong Y, Zhao X, Qiu M, Lin Y, Feng P, Li S, et al. Tubular Mas receptor mediates lipid-induced kidney injury. Cell Death Dis. 2021;12:110 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 8a
Choi G, Lee H, Chae C, Cho J, Jung Y, Kim J, et al. BNIP3L/NIX-mediated mitophagy protects against glucocorticoid-induced synapse defects. Nat Commun. 2021;12:487 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s14d
Bengoa Vergniory N, Faggiani E, Ramos Gonzalez P, Kirkiz E, Connor Robson N, Brown L, et al. CLR01 protects dopaminergic neurons in vitro and in mouse models of Parkinson's disease. Nat Commun. 2020;11:4885 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 3a
  • immunohistochemistry; human; 1:200; loading ...; fig 1d
Long Z, Chen J, Zhao Y, Zhou W, Yao Q, Wang Y, et al. Dynamic changes of autophagic flux induced by Abeta in the brain of postmortem Alzheimer's disease patients, animal models and cell models. Aging (Albany NY). 2020;12:10912-10930 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 8a
Zhang S, Hu L, Jiang J, Li H, Wu Q, Ooi K, et al. HMGB1/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia. J Neuroinflammation. 2020;17:15 pubmed publisher
  • immunohistochemistry - free floating section; mouse; loading ...; fig s1g
Cserép C, Pósfai B, Lénárt N, Fekete R, László Z, Lele Z, et al. Microglia monitor and protect neuronal function through specialized somatic purinergic junctions. Science. 2020;367:528-537 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 5d
Buchwalter A, Schulte R, Tsai H, Capitanio J, Hetzer M. Selective clearance of the inner nuclear membrane protein emerin by vesicular transport during ER stress. elife. 2019;8: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig e1a
Majer O, Liu B, Woo B, Kreuk L, Van Dis E, Barton G. Release from UNC93B1 reinforces the compartmentalized activation of select TLRs. Nature. 2019;575:371-374 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig e3c
Majer O, Liu B, Kreuk L, Krogan N, Barton G. UNC93B1 recruits syntenin-1 to dampen TLR7 signalling and prevent autoimmunity. Nature. 2019;575:366-370 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 5b
Yagensky O, Kohansal Nodehi M, Gunaseelan S, Rabe T, Zafar S, Zerr I, et al. Increased expression of heme-binding protein 1 early in Alzheimer's disease is linked to neurotoxicity. elife. 2019;8: pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 3g
Theisen D, Davidson J, Briseño C, Gargaro M, Lauron E, Wang Q, et al. WDFY4 is required for cross-presentation in response to viral and tumor antigens. Science. 2018;362:694-699 pubmed publisher
  • western blot; mouse; 1:800; loading ...; fig 2b
Qiu T, Pei P, Yao X, Jiang L, Wei S, Wang Z, et al. Taurine attenuates arsenic-induced pyroptosis and nonalcoholic steatohepatitis by inhibiting the autophagic-inflammasomal pathway. Cell Death Dis. 2018;9:946 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1g
Kim H, Mun Y, Lee K, Park Y, Park J, Park J, et al. T cell microvilli constitute immunological synaptosomes that carry messages to antigen-presenting cells. Nat Commun. 2018;9:3630 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 2c
Massaro G, Mattar C, Wong A, Sirka E, Buckley S, Herbert B, et al. Fetal gene therapy for neurodegenerative disease of infants. Nat Med. 2018;24:1317-1323 pubmed publisher
  • immunocytochemistry; mouse; loading ...; fig 3g
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher
  • immunocytochemistry; mouse; 1:200; loading ...; fig s5a
Leeman D, Hebestreit K, Ruetz T, Webb A, McKay A, Pollina E, et al. Lysosome activation clears aggregates and enhances quiescent neural stem cell activation during aging. Science. 2018;359:1277-1283 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5a
Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4
Cox C, Lu R, Salcin K, Wilson J. The Endosomal Protein Endotubin Is Required for Enterocyte Differentiation. Cell Mol Gastroenterol Hepatol. 2018;5:145-156 pubmed publisher
  • immunohistochemistry; rat; 1:200; loading ...; fig 1c
  • western blot; rat; 1:1000; loading ...; fig 5c
Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, et al. Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Stroke. 2018;49:175-183 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5a
Lee S, Bazick H, Chittoor Vinod V, Al Salihi M, Xia G, Notterpek L. Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A Patients. Am J Pathol. 2018;188:728-738 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5c
Jimenez Orgaz A, Kvainickas A, Nägele H, Denner J, Eimer S, Dengjel J, et al. Control of RAB7 activity and localization through the retromer-TBC1D5 complex enables RAB7-dependent mitophagy. EMBO J. 2018;37:235-254 pubmed publisher
  • western blot; mouse; loading ...; fig 4a
Rong X, Wang B, Palladino E, de Aguiar Vallim T, Ford D, Tontonoz P. ER phospholipid composition modulates lipogenesis during feeding and in obesity. J Clin Invest. 2017;127:3640-3651 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4m
Marwaha R, Arya S, Jagga D, Kaur H, Tuli A, Sharma M. The Rab7 effector PLEKHM1 binds Arl8b to promote cargo traffic to lysosomes. J Cell Biol. 2017;216:1051-1070 pubmed publisher
  • immunohistochemistry; rat; 1:100; loading ...; tbl 1
Kim J, Hyun H, Min S, Kang T. Sustained HSP25 Expression Induces Clasmatodendrosis via ER Stress in the Rat Hippocampus. Front Cell Neurosci. 2017;11:47 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig 6a
Pi H, Li M, Tian L, Yang Z, Yu Z, Zhou Z. Enhancing lysosomal biogenesis and autophagic flux by activating the transcription factor EB protects against cadmium-induced neurotoxicity. Sci Rep. 2017;7:43466 pubmed publisher
  • immunocytochemistry; African green monkey; 1:600; loading ...; fig s1a
Hofhuis J, Bersch K, Büssenschütt R, Drzymalski M, Liebetanz D, Nikolaev V, et al. Dysferlin mediates membrane tubulation and links T-tubule biogenesis to muscular dystrophy. J Cell Sci. 2017;130:841-852 pubmed publisher
  • western blot; mouse; fig 8
Luo Y, Duan H, Qian Y, Feng L, Wu Z, Wang F, et al. Macrophagic CD146 promotes foam cell formation and retention during atherosclerosis. Cell Res. 2017;27:352-372 pubmed publisher
  • immunocytochemistry; human; 1:200; fig s4
Walenbergh S, Houben T, Rensen S, Bieghs V, Hendrikx T, van Gorp P, et al. Plasma cathepsin D correlates with histological classifications of fatty liver disease in adults and responds to intervention. Sci Rep. 2016;6:38278 pubmed publisher
  • immunocytochemistry; human; fig 2
Justis A, Hansen B, Beare P, King K, Heinzen R, Gilk S. Interactions between the Coxiella burnetii parasitophorous vacuole and the endoplasmic reticulum involve the host protein ORP1L. Cell Microbiol. 2017;19: pubmed publisher
  • immunocytochemistry; mouse; 1:500; fig 1
Marquer C, Tian H, Yi J, Bastien J, Dall Armi C, Yang Klingler Y, et al. Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism. Nat Commun. 2016;7:11919 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:100; loading ...; fig 1d
Ko A, Hyun H, Min S, Kim J. The Differential DRP1 Phosphorylation and Mitochondrial Dynamics in the Regional Specific Astroglial Death Induced by Status Epilepticus. Front Cell Neurosci. 2016;10:124 pubmed publisher
  • immunocytochemistry; mouse; fig 5
Bao J, Zheng L, Zhang Q, Li X, Zhang X, Li Z, et al. Deacetylation of TFEB promotes fibrillar A? degradation by upregulating lysosomal biogenesis in microglia. Protein Cell. 2016;7:417-33 pubmed publisher
  • western blot; rat; fig 10
  • western blot; mouse; fig 8
Song J, Sun Y, Peluso I, Zeng Y, Yu X, Lu J, et al. A novel curcumin analog binds to and activates TFEB in vitro and in vivo independent of MTOR inhibition. Autophagy. 2016;12:1372-89 pubmed publisher
  • immunocytochemistry; human; 1:750; fig 5
De Filippis L, Halikere A, McGowan H, Moore J, Tischfield J, Hart R, et al. Ethanol-mediated activation of the NLRP3 inflammasome in iPS cells and iPS cells-derived neural progenitor cells. Mol Brain. 2016;9:51 pubmed publisher
  • western blot; human; fig s2
Corcelle Termeau E, Vindeløv S, Hämälistö S, Mograbi B, Keldsbo A, Bräsen J, et al. Excess sphingomyelin disturbs ATG9A trafficking and autophagosome closure. Autophagy. 2016;12:833-49 pubmed publisher
  • immunocytochemistry; human; 1 ug/ml; fig 10
Hiraku Y, Guo F, Ma N, Yamada T, Wang S, Kawanishi S, et al. Multi-walled carbon nanotube induces nitrative DNA damage in human lung epithelial cells via HMGB1-RAGE interaction and Toll-like receptor 9 activation. Part Fibre Toxicol. 2016;13:16 pubmed publisher
  • western blot; human; 1:1000; fig 2s1
Gschweitl M, Ulbricht A, Barnes C, Enchev R, Stoffel Studer I, Meyer Schaller N, et al. A SPOPL/Cullin-3 ubiquitin ligase complex regulates endocytic trafficking by targeting EPS15 at endosomes. elife. 2016;5:e13841 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 4
Ouimet M, Hennessy E, van Solingen C, Koelwyn G, Hussein M, Ramkhelawon B, et al. miRNA Targeting of Oxysterol-Binding Protein-Like 6 Regulates Cholesterol Trafficking and Efflux. Arterioscler Thromb Vasc Biol. 2016;36:942-951 pubmed publisher
  • immunocytochemistry; human; 10 ug/ml; fig 3
Khazen R, Müller S, Gaudenzio N, Espinosa E, Puissegur M, Valitutti S. Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse. Nat Commun. 2016;7:10823 pubmed publisher
  • immunocytochemistry; human; 1:20; loading ...; fig 7d
Yamaguchi T, Lu C, Ida L, Yanagisawa K, Usukura J, Cheng J, et al. ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1. Nat Commun. 2016;7:10060 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; fig 3
Lyu L, Whitcomb E, Jiang S, Chang M, Gu Y, Duncan M, et al. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract. FASEB J. 2016;30:1087-95 pubmed publisher
  • immunocytochemistry; rat; 1:100; fig 5
Kaneko Y, Sullivan R, Dailey T, Vale F, Tajiri N, Borlongan C. Kainic Acid-Induced Golgi Complex Fragmentation/Dispersal Shifts the Proteolysis of Reelin in Primary Rat Neuronal Cells: An In Vitro Model of Early Stage Epilepsy. Mol Neurobiol. 2016;53:1874-1883 pubmed publisher
Phadke R, Kruzich E, Fournier L, Brack A, Sha M, Picard I, et al. C4 induces pathological synaptic loss by impairing AMPAR trafficking. bioRxiv. 2023;: pubmed publisher
Muranaka M, Takamatsu S, Ouchida T, Kanazawa Y, Kondo J, Nakagawa T, et al. Vesicular Integral-Membrane Protein 36 Is Involved in the Selective Secretion of Fucosylated Proteins into Bile Duct-like Structures in HepG2 Cells. Int J Mol Sci. 2023;24: pubmed publisher
Zack S, Nikolaienko R, Cook B, Melki R, Zima A, Campbell E. Vacuole Membrane Protein 1 (VMP1) Restricts NLRP3 Inflammasome Activation by Modulating SERCA Activity and Autophagy. Res Sq. 2023;: pubmed publisher
Madhu V, Hernandez Meadows M, Boneski P, Qiu Y, Guntur A, Kurland I, et al. The mitophagy receptor BNIP3 is critical for the regulation of metabolic homeostasis and mitochondrial function in the nucleus pulposus cells of the intervertebral disc. Autophagy. 2023;19:1821-1843 pubmed publisher
Lu Y, Chen X, Liu X, Shi Y, Wei Z, Feng L, et al. Endothelial TFEB signaling-mediated autophagic disturbance initiates microglial activation and cognitive dysfunction. Autophagy. 2023;:1-18 pubmed publisher
Radulovic M, Wenzel E, Gilani S, Holland L, Lystad A, Phuyal S, et al. Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair. EMBO J. 2022;41:e112677 pubmed publisher
Wakao S, Oguma Y, Kushida Y, Kuroda Y, Tatsumi K, Dezawa M. Phagocytosing differentiated cell-fragments is a novel mechanism for controlling somatic stem cell differentiation within a short time frame. Cell Mol Life Sci. 2022;79:542 pubmed publisher
Lim H, Wubben J, Garcia C, Cruz Gómez S, Deng J, Mak J, et al. A specialized tyrosine-based endocytosis signal in MR1 controls antigen presentation to MAIT cells. J Cell Biol. 2022;221: pubmed publisher
Du X, Di Malta C, Fang Z, Shen T, Niu X, Chen M, et al. Nuciferine protects against high-fat diet-induced hepatic steatosis and insulin resistance via activating TFEB-mediated autophagy-lysosomal pathway. Acta Pharm Sin B. 2022;12:2869-2886 pubmed publisher
Pereira P, Mandleywala K, Monette S, Lumish M, Tully K, Panikar S, et al. Caveolin-1 temporal modulation enhances antibody drug efficacy in heterogeneous gastric cancer. Nat Commun. 2022;13:2526 pubmed publisher
Belaidi A, Masaldan S, Southon A, Kalinowski P, Acevedo K, Appukuttan A, et al. Apolipoprotein E potently inhibits ferroptosis by blocking ferritinophagy. Mol Psychiatry. 2022;: pubmed publisher
Plescia C, Lindstrom A, Quintero M, Keiser P, Anantpadma M, Davey R, et al. Evaluation of Phenol-Substituted Diphyllin Derivatives as Selective Antagonists for Ebola Virus Entry. ACS Infect Dis. 2022;8:942-957 pubmed publisher
Barral D, Staiano L, Guimas Almeida C, Cutler D, Eden E, Futter C, et al. Current methods to analyze lysosome morphology, positioning, motility and function. Traffic. 2022;23:238-269 pubmed publisher
Herskovitz J, Hasan M, Patel M, Blomberg W, Cohen J, Machhi J, et al. CRISPR-Cas9 Mediated Exonic Disruption for HIV-1 Elimination. EBioMedicine. 2021;73:103678 pubmed publisher
Tong B, Wu A, Huang A, Dong R, Malampati S, Iyaswamy A, et al. Lysosomal TPCN (two pore segment channel) inhibition ameliorates beta-amyloid pathology and mitigates memory impairment in Alzheimer disease. Autophagy. 2021;:1-19 pubmed publisher
Hilverling A, Szego E, Dinter E, Cozma D, Saridaki T, Falkenburger B. Maturing Autophagosomes are Transported Towards the Cell Periphery. Cell Mol Neurobiol. 2021;: pubmed publisher
Yamamoto Y, Chino H, Tsukamoto S, Ode K, Ueda H, Mizushima N. NEK9 regulates primary cilia formation by acting as a selective autophagy adaptor for MYH9/myosin IIA. Nat Commun. 2021;12:3292 pubmed publisher
Hać A, Pierzynowska K, Herman Antosiewicz A. S6K1 Is Indispensible for Stress-Induced Microtubule Acetylation and Autophagic Flux. Cells. 2021;10: pubmed publisher
Nakatsuka A, Yamaguchi S, Eguchi J, Kakuta S, Iwakura Y, Sugiyama H, et al. A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease. Commun Biol. 2021;4:373 pubmed publisher
Kanfer G, Sarraf S, Maman Y, Baldwin H, Domínguez Martín E, Johnson K, et al. Image-based pooled whole-genome CRISPRi screening for subcellular phenotypes. J Cell Biol. 2021;220: pubmed publisher
Shin H, Jeong E, Lee J, An H, Jang H, Ahn Y, et al. Lipocalin-2 Deficiency Reduces Oxidative Stress and Neuroinflammation and Results in Attenuation of Kainic Acid-Induced Hippocampal Cell Death. Antioxidants (Basel). 2021;10: pubmed publisher
Yazdankhah M, Ghosh S, Shang P, Stepicheva N, Hose S, Liu H, et al. BNIP3L-mediated mitophagy is required for mitochondrial remodeling during the differentiation of optic nerve oligodendrocytes. Autophagy. 2021;:1-20 pubmed publisher
Yang C, Chen X, Li Z, Wu H, Jing K, Huang X, et al. SMAD3 promotes autophagy dysregulation by triggering lysosome depletion in tubular epithelial cells in diabetic nephropathy. Autophagy. 2020;:1-20 pubmed publisher
Adnan G, Rubikaite A, Khan M, Reber M, Suetterlin P, Hindges R, et al. The GTPase Arl8B Plays a Principle Role in the Positioning of Interstitial Axon Branches by Spatially Controlling Autophagosome and Lysosome Location. J Neurosci. 2020;40:8103-8118 pubmed publisher
Herbst S, Campbell P, Harvey J, Bernard E, Papayannopoulos V, Wood N, et al. LRRK2 activation controls the repair of damaged endomembranes in macrophages. EMBO J. 2020;:e104494 pubmed publisher
Lang Y, Li Y, Yu H, Lin L, Chen X, Wang S, et al. HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson's disease by elevating NPTX2 via miR-221-3p binding. Aging (Albany NY). 2020;12:7660-7678 pubmed publisher
Mozzi A, Biolatti M, Cagliani R, Forni D, Dell Oste V, Pontremoli C, et al. Past and ongoing adaptation of human cytomegalovirus to its host. PLoS Pathog. 2020;16:e1008476 pubmed publisher
Martin S, Smolders S, Van den Haute C, Heeman B, van Veen S, Crosiers D, et al. Mutated ATP10B increases Parkinson's disease risk by compromising lysosomal glucosylceramide export. Acta Neuropathol. 2020;139:1001-1024 pubmed publisher
van Veen S, Martin S, Van den Haute C, Benoy V, Lyons J, Vanhoutte R, et al. ATP13A2 deficiency disrupts lysosomal polyamine export. Nature. 2020;578:419-424 pubmed publisher
Shelke G, Yin Y, Jang S, Lässer C, Wennmalm S, Hoffmann H, et al. Endosomal signalling via exosome surface TGFβ-1. J Extracell Vesicles. 2019;8:1650458 pubmed publisher
Sun L, Lian Y, Ding J, Meng Y, Li C, Chen L, et al. The role of chaperone-mediated autophagy in neurotoxicity induced by alpha-synuclein after methamphetamine exposure. Brain Behav. 2019;9:e01352 pubmed publisher
Zhang X, Li F, Cui Y, Liu S, Sun H. Mst1 overexpression combined with Yap knockdown augments thyroid carcinoma apoptosis via promoting MIEF1-related mitochondrial fission and activating the JNK pathway. Cancer Cell Int. 2019;19:143 pubmed publisher
Chino H, Hatta T, Natsume T, Mizushima N. Intrinsically Disordered Protein TEX264 Mediates ER-phagy. Mol Cell. 2019;74:909-921.e6 pubmed publisher
Zhao Q, Wang W, Cui J. Melatonin enhances TNF-α-mediated cervical cancer HeLa cells death via suppressing CaMKII/Parkin/mitophagy axis. Cancer Cell Int. 2019;19:58 pubmed publisher
Valoskova K, Biebl J, Roblek M, Emtenani S, Gyoergy A, Misova M, et al. A conserved major facilitator superfamily member orchestrates a subset of O-glycosylation to aid macrophage tissue invasion. elife. 2019;8: pubmed publisher
Araki K, Kawauchi K, Sugimoto W, Tsuda D, Oda H, Yoshida R, et al. Mitochondrial protein E2F3d, a distinctive E2F3 product, mediates hypoxia-induced mitophagy in cancer cells. Commun Biol. 2019;2:3 pubmed publisher
Larson C, Sandoz K, Cockrell D, Heinzen R. Noncanonical Inhibition of mTORC1 by Coxiella burnetii Promotes Replication within a Phagolysosome-Like Vacuole. MBio. 2019;10: pubmed publisher
Lin A, Gill K, Castañeda M, Matucci I, Eder N, Claxton S, et al. Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase. Life Sci Alliance. 2018;1:e201800118 pubmed publisher
Cioni J, Lin J, Holtermann A, Koppers M, Jakobs M, Azizi A, et al. Late Endosomes Act as mRNA Translation Platforms and Sustain Mitochondria in Axons. Cell. 2019;176:56-72.e15 pubmed publisher
Martínez Fábregas J, Prescott A, van Kasteren S, Pedrioli D, McLean I, Moles A, et al. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nat Commun. 2018;9:5343 pubmed publisher
Liu W, Ye C, Cheng Q, Zhang X, Yao L, Li Q, et al. Macrophage Raptor Deficiency-Induced Lysosome Dysfunction Exacerbates Nonalcoholic Steatohepatitis. Cell Mol Gastroenterol Hepatol. 2019;7:211-231 pubmed publisher
Tian S, Muneeruddin K, Choi M, Tao L, Bhuiyan R, Ohmi Y, et al. Genome-wide CRISPR screens for Shiga toxins and ricin reveal Golgi proteins critical for glycosylation. PLoS Biol. 2018;16:e2006951 pubmed publisher
Schaaf G, van Gestel T, In t Groen S, de Jong B, Boomaars B, Tarallo A, et al. Satellite cells maintain regenerative capacity but fail to repair disease-associated muscle damage in mice with Pompe disease. Acta Neuropathol Commun. 2018;6:119 pubmed publisher
Troncoso M, Bannoud N, Carvelli L, Asensio J, Seltzer A, Sosa M. Hypoxia-ischemia alters distribution of lysosomal proteins in rat cortex and hippocampus. Biol Open. 2018;7: pubmed publisher
Medina Cano D, Ucuncu E, Nguyen L, Nicouleau M, Lipecka J, Bizot J, et al. High N-glycan multiplicity is critical for neuronal adhesion and sensitizes the developing cerebellum to N-glycosylation defect. elife. 2018;7: pubmed publisher
Civiletto G, Doğan S, Cerutti R, Fagiolari G, Moggio M, Lamperti C, et al. Rapamycin rescues mitochondrial myopathy via coordinated activation of autophagy and lysosomal biogenesis. EMBO Mol Med. 2018;10: pubmed publisher
Hirt J, Porter K, Dixon A, McKinnon S, Liton P. Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA/2J spontaneous glaucoma mouse model. Cell Death Discov. 2018;4:14 pubmed publisher
Dudvarski Stankovic N, Bicker F, Keller S, Jones D, Harter P, Kienzle A, et al. EGFL7 enhances surface expression of integrin α5β1 to promote angiogenesis in malignant brain tumors. EMBO Mol Med. 2018;10: pubmed publisher
Li R, Xin T, Li D, Wang C, Zhu H, Zhou H. Therapeutic effect of Sirtuin 3 on ameliorating nonalcoholic fatty liver disease: The role of the ERK-CREB pathway and Bnip3-mediated mitophagy. Redox Biol. 2018;18:229-243 pubmed publisher
Matsui T, Jiang P, Nakano S, Sakamaki Y, Yamamoto H, Mizushima N. Autophagosomal YKT6 is required for fusion with lysosomes independently of syntaxin 17. J Cell Biol. 2018;217:2633-2645 pubmed publisher
Cheng X, Xie Y, Zhou B, Huang N, Farfel Becker T, Sheng Z. Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons. J Cell Biol. 2018;217:3127-3139 pubmed publisher
Fitzpatrick L, Hawkins K, Delhove J, Fernandez E, Soldati C, Bullen L, et al. NF-?B Activity Initiates Human ESC-Derived Neural Progenitor Cell Differentiation by Inducing a Metabolic Maturation Program. Stem Cell Reports. 2018;10:1766-1781 pubmed publisher
Petti L, Marlatt S, Luo Y, Scheideman E, Shelar A, DiMaio D. Regulation of C-C chemokine receptor 5 (CCR5) stability by Lys197 and by transmembrane protein aptamers that target it for lysosomal degradation. J Biol Chem. 2018;293:8787-8801 pubmed publisher
Herbener P, Schönfeld K, König M, Germer M, Przyborski J, Bernöster K, et al. Functional relevance of in vivo half antibody exchange of an IgG4 therapeutic antibody-drug conjugate. PLoS ONE. 2018;13:e0195823 pubmed publisher
Lee J, Han S, Park M, Baek B, Song I, Choi M, et al. Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease. Nat Commun. 2018;9:1479 pubmed publisher
Sun Y, Liu M, Lei X, YU X. SFTS phlebovirus promotes LC3-II accumulation and nonstructural protein of SFTS phlebovirus co-localizes with autophagy proteins. Sci Rep. 2018;8:5287 pubmed publisher
Ferguson R, Subramanian V. The cellular uptake of angiogenin, an angiogenic and neurotrophic factor is through multiple pathways and largely dynamin independent. PLoS ONE. 2018;13:e0193302 pubmed publisher
Singh N, Kansal P, Ahmad Z, Baid N, Kushwaha H, Khatri N, et al. Antimycobacterial effect of IFNG (interferon gamma)-induced autophagy depends on HMOX1 (heme oxygenase 1)-mediated increase in intracellular calcium levels and modulation of PPP3/calcineurin-TFEB (transcription factor EB) axis. Autophagy. 2018;14:972-991 pubmed publisher
Borroni A, Emanuelli A, Shah P, Ilic N, Apel Sarid L, Paolini B, et al. Smurf2 regulates stability and the autophagic-lysosomal turnover of lamin A and its disease-associated form progerin. Aging Cell. 2018;17: pubmed publisher
Kim C, Zhang X, Witola W. Small GTPase Immunity-Associated Proteins Mediate Resistance to Toxoplasma gondii Infection in Lewis Rat. Infect Immun. 2018;86: pubmed publisher
Chen X, He Z, Fu M, Wang Y, Wu H, Li X, et al. The E3 Ubiquitin Ligase Siah-1 Suppresses Avian Reovirus Infection by Targeting p10 for Degradation. J Virol. 2018;92: pubmed publisher
Yaseen I, Choudhury M, Sritharan M, Khosla S. Histone methyltransferase SUV39H1 participates in host defense by methylating mycobacterial histone-like protein HupB. EMBO J. 2018;37:183-200 pubmed publisher
Le Guerroué F, Eck F, Jung J, Starzetz T, Mittelbronn M, Kaulich M, et al. Autophagosomal Content Profiling Reveals an LC3C-Dependent Piecemeal Mitophagy Pathway. Mol Cell. 2017;68:786-796.e6 pubmed publisher
Rostami J, Holmqvist S, Lindström V, Sigvardson J, Westermark G, Ingelsson M, et al. Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes. J Neurosci. 2017;37:11835-11853 pubmed publisher
Stoeck I, Lee J, Tabata K, Romero Brey I, Paul D, Schult P, et al. Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis. J Virol. 2018;92: pubmed publisher
Baksi S, Singh N. α-Synuclein impairs ferritinophagy in the retinal pigment epithelium: Implications for retinal iron dyshomeostasis in Parkinson's disease. Sci Rep. 2017;7:12843 pubmed publisher
Köster S, Upadhyay S, Chandra P, Papavinasasundaram K, Yang G, Hassan A, et al. Mycobacterium tuberculosis is protected from NADPH oxidase and LC3-associated phagocytosis by the LCP protein CpsA. Proc Natl Acad Sci U S A. 2017;114:E8711-E8720 pubmed publisher
Kvainickas A, Jimenez Orgaz A, Nägele H, Hu Z, Dengjel J, Steinberg F. Cargo-selective SNX-BAR proteins mediate retromer trimer independent retrograde transport. J Cell Biol. 2017;216:3677-3693 pubmed publisher
Bartolomeo R, Cinque L, De Leonibus C, Forrester A, Salzano A, Monfregola J, et al. mTORC1 hyperactivation arrests bone growth in lysosomal storage disorders by suppressing autophagy. J Clin Invest. 2017;127:3717-3729 pubmed publisher
Siddiqui S, Springer S, Verhagen A, Sundaramurthy V, Alisson Silva F, Jiang W, et al. The Alzheimer's disease-protective CD33 splice variant mediates adaptive loss of function via diversion to an intracellular pool. J Biol Chem. 2017;292:15312-15320 pubmed publisher
Goo M, Sancho L, Slepak N, Boassa D, Deerinck T, Ellisman M, et al. Activity-dependent trafficking of lysosomes in dendrites and dendritic spines. J Cell Biol. 2017;216:2499-2513 pubmed publisher
Haure Mirande J, Audrain M, Fanutza T, Kim S, Klein W, Glabe C, et al. Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology. Acta Neuropathol. 2017;134:769-788 pubmed publisher
Ramkumar A, Murthy D, Raja D, Singh A, Krishnan A, Khanna S, et al. Classical autophagy proteins LC3B and ATG4B facilitate melanosome movement on cytoskeletal tracks. Autophagy. 2017;13:1331-1347 pubmed publisher
McKnight K, Xie L, González López O, Rivera Serrano E, Chen X, Lemon S. Protein composition of the hepatitis A virus quasi-envelope. Proc Natl Acad Sci U S A. 2017;114:6587-6592 pubmed publisher
Gopal P, Nirschl J, Klinman E, Holzbaur E. Amyotrophic lateral sclerosis-linked mutations increase the viscosity of liquid-like TDP-43 RNP granules in neurons. Proc Natl Acad Sci U S A. 2017;114:E2466-E2475 pubmed publisher
Dauner K, Eid W, Raghupathy R, Presley J, Zha X. mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery. J Biol Chem. 2017;292:5737-5747 pubmed publisher
Pipalia N, Subramanian K, Mao S, Ralph H, Hutt D, Scott S, et al. Histone deacetylase inhibitors correct the cholesterol storage defect in most Niemann-Pick C1 mutant cells. J Lipid Res. 2017;58:695-708 pubmed publisher
Zhitomirsky B, Assaraf Y. Lysosomal accumulation of anticancer drugs triggers lysosomal exocytosis. Oncotarget. 2017;8:45117-45132 pubmed publisher
Kretzer N, Theisen D, Tussiwand R, Briseño C, Grajales Reyes G, Wu X, et al. RAB43 facilitates cross-presentation of cell-associated antigens by CD8?+ dendritic cells. J Exp Med. 2016;213:2871-2883 pubmed
Sambri I, D Alessio R, Ezhova Y, Giuliano T, Sorrentino N, Cacace V, et al. Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases. EMBO Mol Med. 2017;9:112-132 pubmed publisher
Li Y, Ozment T, Wright G, Peterson J. Identification of Putative Receptors for the Novel Adipokine CTRP3 Using Ligand-Receptor Capture Technology. PLoS ONE. 2016;11:e0164593 pubmed publisher
Elhenawy W, Bording Jorgensen M, Valguarnera E, Haurat M, Wine E, Feldman M. LPS Remodeling Triggers Formation of Outer Membrane Vesicles in Salmonella. MBio. 2016;7: pubmed publisher
Dong W, Embury C, Lu Y, Whitmire S, Dyavarshetty B, Gelbard H, et al. The mixed-lineage kinase 3 inhibitor URMC-099 facilitates microglial amyloid-β degradation. J Neuroinflammation. 2016;13:184 pubmed publisher
Olsen A, Chen Y, Ji Q, Zhu G, De Silva A, Vilchèze C, et al. Targeting Mycobacterium tuberculosis Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines. MBio. 2016;7: pubmed publisher
Haka A, Barbosa Lorenzi V, Lee H, Falcone D, Hudis C, Dannenberg A, et al. Exocytosis of macrophage lysosomes leads to digestion of apoptotic adipocytes and foam cell formation. J Lipid Res. 2016;57:980-92 pubmed publisher
Patel A, Mohl B, Roy P. Entry of Bluetongue Virus Capsid Requires the Late Endosome-specific Lipid Lysobisphosphatidic Acid. J Biol Chem. 2016;291:12408-19 pubmed publisher
Liu J, Liu W, Yang J. ATP-containing vesicles in stria vascular marginal cell cytoplasms in neonatal rat cochlea are lysosomes. Sci Rep. 2016;6:20903 pubmed publisher
Zhang J, Wu Y, Zhao S, Liu Z, Zeng S, Zhang G. Lysosomes are involved in induction of steroidogenic acute regulatory protein (StAR) gene expression and progesterone synthesis through low-density lipoprotein in cultured bovine granulosa cells. Theriogenology. 2015;84:811-7 pubmed publisher
Forbester J, Goulding D, Vallier L, Hannan N, Hale C, Pickard D, et al. Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells. Infect Immun. 2015;83:2926-34 pubmed publisher
Sagiv Y, Bai L, Wei D, Agami R, Savage P, Teyton L, et al. A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d. J Exp Med. 2007;204:921-8 pubmed
product information
Catalog Number :
ab24170
Product Name :
Anti-LAMP1 antibody - Lysosome Marker
Product Type :
Primary Antibody
Swiss-Prot ID :
P11279
Host Species :
Rabbit
Clonality :
Polyclonal
Size :
100µg
Application Summary :
IHC-P, WB
Isotype :
IgG
Reactivity :
Human
company information
Abcam
Discovery Drive
Cambridge Biomedical Campus
Cambridge
CB20AX
Stefan.Pritchard@abcam.com, eCommerce@abcam.com, Vicky.Yang@abcam.com
https://www.abcam.com
888-7722226
headquarters: UK