Pan-Cadherin Antibody | Abbiotec 251786 product information

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product summary

company name :

Abbiotec

product type :

antibody

product name :

Pan-Cadherin Antibody

catalog :

251786

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat, chicken

application :

western blot, ELISA, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; fig 6	Sarma P, Bag I, Ramaiah M, Kamal A, Bhadra U, Pal Bhadra M. Bisindole-PBD regulates breast cancer cell proliferation via SIRT-p53 axis. Cancer Biol Ther. 2015;16:1486-501 pubmed publisher

product information

Product Name :

Pan-Cadherin Antibody

Product Subcategory :

Mouse Monoclonal Antibody

Catalog No :

251786

Unit :

0.1 mg

Product Category :

Antibodies

Protein Family :

Cell Adhesion Molecules, CAM Ligands, Cellular Antigens

Pathway and Disease :

Signaling Molecules and Interaction

Description :

Cadherins are calcium dependent cell adhesion proteins. Cadherins preferentially interact with themselves in a homophilic manner in connecting cells. Cadherins contribute to the sorting of heterogeneous cell types. N-cadherin functions during gastrulation and is required for establishment of left-right asymmetry. N-Cadherin is commonly found in cancer cells and provides a mechanism for transendothelial migration. When a cancer cell adheres to the endothelial cells of a blood vessel it up-regulates the src kinase pathway which phosphorylates beta-catenins attached to both N-cadherin and E-cadherins.

Format :

Each vial contains 0.1 mg IgG in 0.1 ml (1 mg/ml) of PBS pH7.4, 2% BSA with 0.09% sodium azide. Antibody was purified by Protein-G affinity chromatography.

Applications :

E, WB, IHC

Alternate Names :

Pan-Cadherin; Cadherin; CDH; Cadherin-2; DH2; Neural cadherin; N-cadherin

Accession No :

P10288

Clonality :

PC-79

Isotype :

Mouse IgG1

Antigen :

KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of chicken pan-cadherin.

Species Reactivity :

H, M, R, Rb, Ck

Application Notes :

E: 1:500-1:1,000; WB: 1:100-1:500; IHC: 1:100-1:500

Storage :

Store at -20°C. Minimize freeze-thaw cycles. Product is guaranteed one year from the date of shipment.