This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abbexa
product type :
antibody
product name :
Cellular Tumor Antigen P53 (TP53) Antibody
catalog :
abx034998
quantity :
80 µl
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA
product information
Catalogue Code :
abx034998
Target :
Cellular Tumor Antigen P53 (TP53)
Product Name :
Cellular Tumor Antigen P53 (TP53) Antibody
Short Name :
TP53
Category :
Primary Antibodies
Host :
Mouse
Clonality :
Monoclonal
Conjugation :
Unconjugated
Isotype :
IgG1 Kappa
Size 1 :
80 µl
Size 2 :
400 µl
Description :
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Implicated in Notch signaling cross-over. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Isoform 2 enhances the transactivation activity of isoform 1 from some but not all TP53-inducible promoters. Isoform 4 suppresses transactivation activity and impairs growth suppression mediated by isoform 1. Isoform 7 inhibits isoform 1-mediated apoptosis.
UniProt Primary AC :
P04637
UniProt Entry Name :
P53_HUMAN
NCBI Accession :
NP_000537.3, NP_001119584.1, NP_001119585.1, NP_001119586.1, NP_001119587.1, NP_001119588.1, NP_001119589.1, NP_001119590.1, NP_001263624.1, NP_001263625.1, NP_001263626.1, NP_001263627.1, NP_001263628.1, NP_00126
KEGG :
hsa:7157
String :
9606.ENSP00000269305
Purification :
Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Buffer :
PBS containing 0.09% sodium azide.
Tested Applications :
ELISA, WB
Storage :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Form :
Liquid
UNSPSC Code :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
company information
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
headquarters: UK
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.