This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Abbexa
product type :
antibody
product name :
Thyroxine 5-Deiodinase (DIO3) Antibody
catalog :
abx034409
quantity :
80 µl
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry
product information
Catalogue Code :
abx034409
Target :
Thyroxine 5-Deiodinase (DIO3)
Product Name :
Thyroxine 5-Deiodinase (DIO3) Antibody
Short Name :
DIO3
Category :
Primary Antibodies
Host :
Rabbit
Clonality :
Polyclonal
Conjugation :
Unconjugated
Isotype :
IgG
Size 1 :
80 µl
Size 2 :
400 µl
Description :
DIO3 belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3, 3', 5-triiodothyronine (T3) to inactive metabolites, 3, 3', 5'-triiodothyronine (RT3) and 3, 3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal.
UniProt Primary AC :
P55073
UniProt Entry Name :
IOD3_HUMAN
NCBI Accession :
NP_001353.4
KEGG :
hsa:1735
String :
9606.ENSP00000427336
Purification :
Purified through a protein A column, followed by peptide affinity purification.
Buffer :
PBS containing 0.09% sodium azide.
Tested Applications :
ELISA, WB, IHC
Storage :
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Form :
Liquid
UNSPSC Code :
12352203
Availability :
Shipped within 5-10 working days.
DryIce :
No
company information
Abbexa
Abbexa LTD, Cambridge, UK
Abbexa LLC, Houston, USA
info@abbexa.com
https://www.abbexa.com
44 (0)1223 75595
1 832 327 7413
headquarters: UK
Abbexa is a biotechnology company based in Cambridge, UK, specializing in high quality, reliable research reagents for scientific research. We work in partnership with academic institutions, hospitals and laboratories across the world to bring an integrated source of antibodies, proteins, ELISA kits and other biological reagents. We are dedicated to providing excellent customer service, quality and affordable products to enable scientists to do better science. For more information, please visit http://www.abbexa.com/.